{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T13:57:23Z","timestamp":1774879043058,"version":"3.50.1"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2023,8,4]],"date-time":"2023-08-04T00:00:00Z","timestamp":1691107200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["#17H06396"],"award-info":[{"award-number":["#17H06396"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["#19H04279"],"award-info":[{"award-number":["#19H04279"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,9,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Acrylamide is a neurotoxicant in human and experimental animals. Interleukin-1\u03b2 (IL-1\u03b2) is a proinflammatory cytokine known as a critical component of brain reaction to any insult or neurodegenerative pathologies, though its role in electrophile-induced neurotoxicity remains elusive. The aim of this study was to investigate the role of IL-1\u03b2 in acrylamide-induced neurotoxicity in mice. Ten-week-old male wild-type and IL-1\u03b2 knock-out mice were allocated into 3 groups each and exposed to acrylamide at 0, 12.5, 25\u2009mg\/kg body weight by oral gavage for 28\u2009days. Compared with wild-type mice, the results showed a significant increase in landing foot spread test and a significant decrease in density of cortical noradrenergic axons in IL-1\u03b2 KO mice exposed to acrylamide at 25\u2009mg\/kg body weight. Exposure to acrylamide at 25\u2009mg\/kg significantly increased cortical gene expression of Gclc, Gpx1, and Gpx4 in wild-type mice but decreased them in IL-1\u03b2 KO mice. The same exposure level significantly increased total glutathione and oxidized glutathione (GSSG) in the cerebellum of wild-type mice but did not change total glutathione and decreased GSSG in the cerebellum of IL-1\u03b2 KO mice. The basal level of malondialdehyde in the cerebellum was higher in IL-1\u03b2 KO mice than in wild-type mice. The results suggest that IL-1\u03b2 protects the mouse brain against acrylamide-induced neurotoxicity, probably through suppression of oxidative stress by glutathione synthesis and peroxidation. This unexpected result provides new insight on the protective role of IL-1\u03b2 in acrylamide-induced neurotoxicity.<\/jats:p>","DOI":"10.1093\/toxsci\/kfad077","type":"journal-article","created":{"date-parts":[[2023,8,3]],"date-time":"2023-08-03T12:16:22Z","timestamp":1691064982000},"page":"246-256","source":"Crossref","is-referenced-by-count":9,"title":["Deletion of <i>IL-1\u03b2<\/i> exacerbates acrylamide-induced neurotoxicity in mice"],"prefix":"10.1093","volume":"195","author":[{"given":"Alzahraa","family":"Fergany","sequence":"first","affiliation":[{"name":"Department of Occupational and Environmental Health, Faculty of Pharmaceutical Sciences, Tokyo University of Science , Noda, Japan"},{"name":"Laboratory of Genetics and Genetic Engineering in Department of Animal Husbandry and Animal Wealth Development, Faculty of Veterinary Medicine, Alexandria University , Alexandria, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cai","family":"Zong","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health, Faculty of Pharmaceutical Sciences, Tokyo University of Science , Noda, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7181-7091","authenticated-orcid":false,"given":"Frederick Adams","family":"Ekuban","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health, Faculty of Pharmaceutical Sciences, Tokyo University of Science , Noda, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aina","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health, Faculty of Pharmaceutical Sciences, Tokyo University of Science , Noda, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2213-0968","authenticated-orcid":false,"given":"Yusuke","family":"Kimura","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health, Faculty of Pharmaceutical Sciences, Tokyo University of Science , Noda, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sahoko","family":"Ichihara","sequence":"additional","affiliation":[{"name":"Department of Environmental and Preventive Medicine, Jichi Medical University School of Medicine , Shimotsuke, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoichiro","family":"Iwakura","sequence":"additional","affiliation":[{"name":"Division of Experimental Animal Immunology, Research Institute for Biomedical Sciences, Tokyo University of Science , Noda, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaku","family":"Ichihara","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health, Faculty of Pharmaceutical Sciences, Tokyo University of Science , Noda, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,8,4]]},"reference":[{"key":"2023102422031574800_kfad077-B1","doi-asserted-by":"crossref","first-page":"2633105520947081","DOI":"10.1177\/2633105520947081","article-title":"Interferon-gamma and interleukin-1beta enhance the secretion of brain-derived neurotrophic factor and promotes the survival of cortical neurons in brain injury","volume":"15","author":"Abd-El-Basset","year":"2020","journal-title":"Neurosci. 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