{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T01:56:39Z","timestamp":1787795799448,"version":"build-2784847793"},"reference-count":62,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T00:00:00Z","timestamp":1693872000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000066","name":"National Institutes of Environmental Health Sciences","doi-asserted-by":"publisher","award":["R00ES029986"],"award-info":[{"award-number":["R00ES029986"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Trichloroethylene (TCE) is one of the most pervasive environmental contaminants in the world and is associated with Parkinson disease (PD) risk. Experimental models in rodents show that TCE is selectively toxic to dopaminergic neurons at high doses of ingestion, however, TCE is a highly volatile toxicant, and the primary pathway of human exposure is inhalation. As TCE is a highly lipophilic, volatile organic compound (VOC), inhalation exposure results in rapid diffusion throughout the brain, avoiding first-pass hepatic metabolism that necessitated high doses to recapitulate exposure conditions observed in human populations. We hypothesized that inhalation of TCE would induce significantly more potent neurodegeneration than ingestion and better recapitulate environmental conditions of vapor intrusion or off gassing from liquid TCE. To this end, we developed a novel, whole-body passive exposure inhalation chamber in which we exposed 10-month-old male and female Lewis rats to 50\u2009ppm TCE (time weighted average, TWA) or filtered room air (control) over 8\u2009weeks. In addition, we exposed 12-month-old male and female C57Bl\/6 mice to 100\u2009ppm TCE (TWA) or control over 12\u2009weeks. Both rats and mice exposed to chronic TCE inhalation showed significant degeneration of nigrostriatal dopaminergic neurons as well as motor and gait impairments. TCE exposure also induced accumulation of pSer129-\u03b1Syn in dopaminergic neurons as well as microglial activation within the substantia nigra of rats. Collectively, these data indicate that TCE inhalation causes highly potent dopaminergic neurodegeneration and recapitulates some of the observed neuropathology associated with PD, providing a future platform for insight into the mechanisms and environmental conditions that influence PD risk from TCE exposure.<\/jats:p>","DOI":"10.1093\/toxsci\/kfad090","type":"journal-article","created":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T12:27:07Z","timestamp":1693916827000},"page":"218-228","source":"Crossref","is-referenced-by-count":34,"title":["Low-dose inhalation exposure to trichloroethylene induces dopaminergic neurodegeneration in rodents"],"prefix":"10.1093","volume":"196","author":[{"given":"Ashley","family":"Adamson","sequence":"first","affiliation":[{"name":"Department of Neurology, Center for Neurodegeneration and Experimental Therapeutics, The University of Alabama at Birmingham , Birmingham, Alabama 35294,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neda","family":"Ilieva","sequence":"additional","affiliation":[{"name":"Department of Neurology, Center for Neurodegeneration and Experimental Therapeutics, The University of Alabama at Birmingham , Birmingham, Alabama 35294,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William J","family":"Stone","sequence":"additional","affiliation":[{"name":"Department of Neurology, Center for Neurodegeneration and Experimental Therapeutics, The University of Alabama at Birmingham , Birmingham, Alabama 35294,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8817-327X","authenticated-orcid":false,"given":"Briana R","family":"De Miranda","sequence":"additional","affiliation":[{"name":"Department of Neurology, Center for Neurodegeneration and Experimental Therapeutics, The University of Alabama at Birmingham , Birmingham, Alabama 35294,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,9,5]]},"reference":[{"key":"2024102110193107000_kfad090-B1","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1007\/s40572-022-00380-6","article-title":"Sex differences in dopaminergic vulnerability to environmental toxicants \u2013 Implications for Parkinson\u2019s disease","volume":"9","author":"Adamson","year":"2022","journal-title":"Curr. Environ. Health Rep"},{"key":"2024102110193107000_kfad090-B22","author":"Agency for Toxic Substances and Disease Registry","year":"1997"},{"key":"2024102110193107000_kfad090-B2","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S1382-6689(02)00032-7","article-title":"Chronic exposure to trichloroethylene affects neuronal plasticity in rat hippocampal slices","volume":"12","author":"Altmann","year":"2002","journal-title":"Environ. Toxicol. Pharmacol"},{"key":"2024102110193107000_kfad090-B4","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1080\/10934529.2015.1064275","article-title":"Relationship between vapor intrusion and human exposure to trichloroethylene","volume":"50","author":"Archer","year":"2015","journal-title":"J. Environ. Sci. Health. A Tox. Hazard. Subst. Environ. Eng"},{"key":"2024102110193107000_kfad090-B5","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.jconhyd.2006.02.011","article-title":"Flux-based assessment at a manufacturing site contaminated with trichloroethylene","volume":"86","author":"Basu","year":"2006","journal-title":"J. Contam. Hydrol"},{"key":"2024102110193107000_kfad090-B6","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/s41582-021-00486-9","article-title":"Prodromal Parkinson disease subtypes \u2013 Key to understanding heterogeneity","volume":"17","author":"Berg","year":"2021","journal-title":"Nat. Rev. Neurol"},{"key":"2024102110193107000_kfad090-B7","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/1476-069X-13-68","article-title":"Mortality study of civilian employees exposed to contaminated drinking water at USMC Base Camp Lejeune: A retrospective cohort study","volume":"13","author":"Bove","year":"2014","journal-title":"Environ. Health"},{"key":"2024102110193107000_kfad090-B8","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1093\/toxsci\/kfq362","article-title":"Interstrain differences in the liver effects of trichloroethylene in a multistrain panel of inbred mice","volume":"120","author":"Bradford","year":"2011","journal-title":"Toxicol. Sci"},{"key":"2024102110193107000_kfad090-B9","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/1750-1326-5-42","article-title":"Fc\u03b3 receptors are required for NF-\u03baB signaling, microglial activation and dopaminergic neurodegeneration in an AAV-synuclein mouse model of Parkinson\u2019s disease","volume":"5","author":"Cao","year":"2010","journal-title":"Mol. Neurodegener"},{"key":"2024102110193107000_kfad090-B10","doi-asserted-by":"crossref","first-page":"S9","DOI":"10.3233\/JPD-181493","article-title":"The search for environmental causes of Parkinson\u2019s disease: Moving forward","volume":"8","author":"Chen","year":"2018","journal-title":"J. Parkinsons Dis"},{"key":"2024102110193107000_kfad090-B11","doi-asserted-by":"crossref","first-page":"105601","DOI":"10.1016\/j.nbd.2021.105601","article-title":"Environmental triggers of Parkinson\u2019s disease \u2013 Implications of the Braak and dual-hit hypotheses","volume":"163","author":"Chen","year":"2022","journal-title":"Neurobiol. Dis"},{"key":"2024102110193107000_kfad090-B12","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1289\/ehp.1307623","article-title":"Physiologically based pharmacokinetic (PBPK) modeling of interstrain variability in trichloroethylene metabolism in the mouse","volume":"122","author":"Chiu","year":"2014","journal-title":"Environ. Health Perspect"},{"key":"2024102110193107000_kfad090-B13","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.taap.2009.07.032","article-title":"Characterizing uncertainty and population variability in the toxicokinetics of trichloroethylene and metabolites in mice, rats, and humans using an updated database, physiologically based pharmacokinetic (PBPK) model, and Bayesian approach","volume":"241","author":"Chiu","year":"2009","journal-title":"Toxicol. Appl. Pharmacol"},{"key":"2024102110193107000_kfad090-B14","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1124\/jpet.116.232629","article-title":"Target organ metabolism, toxicity, and mechanisms of trichloroethylene and perchloroethylene: Key similarities, differences, and data gaps","volume":"359","author":"Cichocki","year":"2016","journal-title":"J. Pharmacol. Exp. Ther"},{"key":"2024102110193107000_kfad090-B15","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.neuron.2010.04.034","article-title":"Genetic animal models of Parkinson\u2019s disease","volume":"66","author":"Dawson","year":"2010","journal-title":"Neuron"},{"key":"2024102110193107000_kfad090-B16","doi-asserted-by":"crossref","first-page":"105312","DOI":"10.1016\/j.nbd.2021.105312","article-title":"The industrial solvent trichloroethylene induces LRRK2 kinase activity and dopaminergic neurodegeneration in a rat model of Parkinson\u2019s disease","volume":"153","author":"De Miranda","year":"2021","journal-title":"Neurobiol. Dis"},{"key":"2024102110193107000_kfad090-B17","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/978-3-319-42139-1_6","volume-title":"Mitochondrial Mechanisms of Degeneration and Repair in Parkinson\u2019s Disease","author":"De Miranda","year":"2016"},{"key":"2024102110193107000_kfad090-B18","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/1750-1326-8-37","article-title":"Modeling Alzheimer\u2019s disease in transgenic rats","volume":"8","author":"Do Carmo","year":"2013","journal-title":"Mol. Neurodegener"},{"key":"2024102110193107000_kfad090-B19","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1006\/enfo.2000.0010","article-title":"A history of the production and use of carbon tetrachloride, tetrachloroethylene, trichloroethylene and 1,1,1-trichloroethane in the United States: Part 1\u2014Historical background; carbon tetrachloride and tetrachloroethylene","volume":"1","author":"Doherty","year":"2000","journal-title":"Environ. Forensics"},{"key":"2024102110193107000_kfad090-B20","doi-asserted-by":"crossref","first-page":"203","DOI":"10.3233\/JPD-225047","article-title":"Trichloroethylene: An invisible cause of Parkinson\u2019s disease?","volume":"13","author":"Dorsey","year":"2023","journal-title":"J. Parkinsons Dis"},{"key":"2024102110193107000_kfad090-B21","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1242\/dmm.026120","article-title":"Rodent models in neuroscience research: Is it a rat race?","volume":"9","author":"Ellenbroek","year":"2016","journal-title":"Dis. Model. Mech"},{"key":"2024102110193107000_kfad090-B23","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1289\/ehp.1103884","article-title":"Adverse birth outcomes and maternal exposure to trichloroethylene and tetrachloroethylene through soil vapor intrusion in New York State","volume":"120","author":"Forand","year":"2012","journal-title":"Environ. Health Perspect"},{"key":"2024102110193107000_kfad090-B24","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1002\/ana.21288","article-title":"Trichloroethylene: Parkinsonism and complex 1 mitochondrial neurotoxicity","volume":"63","author":"Gash","year":"2008","journal-title":"Ann. Neurol"},{"key":"2024102110193107000_kfad090-B25","doi-asserted-by":"crossref","first-page":"104947","DOI":"10.1016\/j.nbd.2020.104947","article-title":"Developmental exposure to the organochlorine pesticide dieldrin causes male-specific exacerbation of alpha-synuclein-preformed fibril-induced toxicity and motor deficits","volume":"141","author":"Gezer","year":"2020","journal-title":"Neurobiol. Dis"},{"key":"2024102110193107000_kfad090-B26","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1001\/jamaneurol.2023.1168","article-title":"Risk of Parkinson disease among service members at Marine Corps Base Camp Lejeune","volume":"80","author":"Goldman","year":"2023","journal-title":"JAMA Neurol"},{"key":"2024102110193107000_kfad090-B27","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1046\/j.1468-1331.1999.650609.x","article-title":"Trichloroethylene and parkinsonism: A human and experimental observation","volume":"6","author":"Guehl","year":"1999","journal-title":"Eur. J. Neurol"},{"key":"2024102110193107000_kfad090-B28","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1002\/mds.27105","article-title":"The nasal and gut microbiome in Parkinson\u2019s disease and idiopathic rapid eye movement sleep behavior disorder","volume":"33","author":"Heintz-Buschart","year":"2018","journal-title":"Mov. Disord"},{"key":"2024102110193107000_kfad090-B29","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/BF00366179","article-title":"Carcinogenicity study of trichloroethylene by longterm inhalation in three animal species","volume":"43","author":"Henschler","year":"1980","journal-title":"Arch. Toxicol"},{"key":"2024102110193107000_kfad090-B30","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1111\/jnc.14919","article-title":"Neurochemical organization of the ventral striatum\u2019s olfactory tubercle","volume":"152","author":"Hillary","year":"2020","journal-title":"J. Neurochem"},{"key":"2024102110193107000_kfad090-B31","first-page":"75","article-title":"Trichloroethylene","volume":"63","author":"IARC","year":"1995","journal-title":"IARC Monogr. Eval. Carcinog. Risks Hum"},{"key":"2024102110193107000_kfad090-B32","first-page":"116176","article-title":"Oral ingestion of the environmental toxicant trichloroethylene in rats induces alterations in the gut microbiome: Relevance to idiopathic parkinson\u2019s disease","volume":"451","author":"Ilieva","year":"2022","journal-title":"."},{"key":"2024102110193107000_kfad090-B33","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.tins.2018.09.007","article-title":"Triggers, facilitators, and aggravators: Redefining Parkinson\u2019s disease pathogenesis","volume":"42","author":"Johnson","year":"2019","journal-title":"Trends Neurosci"},{"key":"2024102110193107000_kfad090-B34","doi-asserted-by":"crossref","first-page":"134437","DOI":"10.1016\/j.neulet.2019.134437","article-title":"Trichloroethylene and its metabolite TaClo lead to degeneration of substantia nigra dopaminergic neurones: Effects in wild type and human A30P mutant \u03b1-synuclein mice","volume":"711","author":"Keane","year":"2019","journal-title":"Neurosci. Lett"},{"key":"2024102110193107000_kfad090-B35","doi-asserted-by":"crossref","first-page":"7454","DOI":"10.1021\/acs.est.2c07247","article-title":"Identifying toxic consumer products: A novel data set reveals air emissions of potent carcinogens, reproductive toxicants, and developmental toxicants","volume":"57","author":"Knox","year":"2023","journal-title":"Environ. Sci. Technol"},{"key":"2024102110193107000_kfad090-B36","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/978-1-4615-0135-0_29","volume-title":"Developments in Tryptophan and Serotonin Metabolism","author":"Kochen","year":"2003"},{"key":"2024102110193107000_kfad090-B37","doi-asserted-by":"crossref","first-page":"801","DOI":"10.3389\/fgene.2019.00801","article-title":"A novel application of mixed effects models for reconciling base-pair resolution 5-methylcytosine and 5-hydroxymethylcytosine data in neuroepigenetics","volume":"10","author":"Kochmanski","year":"2019","journal-title":"Front. Genet"},{"key":"2024102110193107000_kfad090-B38","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/0892-0362(87)90095-X","article-title":"The effects of chronic trichloroethylene exposure on neurobehavioral functioning in the rat","volume":"9","author":"Kulig","year":"1987","journal-title":"Neurotoxicol. Teratol"},{"key":"2024102110193107000_kfad090-B39","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1289\/ehp.00108s2177","article-title":"Metabolism of trichloroethylene","volume":"108(Suppl 2)","author":"Lash","year":"2000","journal-title":"Environ. Health Perspect"},{"key":"2024102110193107000_kfad090-B40","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.gaitpost.2009.10.013","article-title":"Arm swing magnitude and asymmetry during gait in the early stages of Parkinson\u2019s disease","volume":"31","author":"Lewek","year":"2010","journal-title":"Gait Posture"},{"key":"2024102110193107000_kfad090-B41","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1111\/j.1471-4159.2009.06497.x","article-title":"Trichloroethylene induces dopaminergic neurodegeneration in Fisher 344 rats","volume":"112","author":"Liu","year":"2010","journal-title":"J. Neurochem"},{"key":"2024102110193107000_kfad090-B42","doi-asserted-by":"crossref","first-page":"6201","DOI":"10.1007\/s12035-017-0830-x","article-title":"Trichloroethylene and Parkinson\u2019s disease: Risk assessment","volume":"55","author":"Liu","year":"2018","journal-title":"Mol. Neurobiol"},{"key":"2024102110193107000_kfad090-B43","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/j.neuro.2011.12.001","article-title":"Neurological impacts from inhalation of pollutants and the nose\u2013brain connection","volume":"33","author":"Lucchini","year":"2012","journal-title":"NeuroToxicology"},{"key":"2024102110193107000_kfad090-B44","doi-asserted-by":"crossref","first-page":"681","DOI":"10.3233\/JPD-150685","article-title":"The concept of prodromal Parkinson\u2019s disease","volume":"5","author":"Mahlknecht","year":"2015","journal-title":"J. Parkinsons Dis"},{"key":"2024102110193107000_kfad090-B45","first-page":"449","article-title":"Reconstructing historical VOC concentrations in drinking water for epidemiological studies at a U.S. Military base: Summary of results","volume":"8","author":"Maslia","year":"2016","journal-title":"Water (Basel)"},{"key":"2024102110193107000_kfad090-B46","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0378-4274(01)00545-8","article-title":"Renal toxicity after chronic inhalation exposure of rats to trichloroethylene","volume":"128","author":"Mensing","year":"2002","journal-title":"Toxicol. Lett"},{"key":"2024102110193107000_kfad090-B47","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/B978-012507751-4\/50034-3","volume-title":"Environmental Forensics","author":"Morrison","year":"1964"},{"key":"2024102110193107000_kfad090-B48","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.taap.2018.09.043","article-title":"Effect of dose and exposure protocol on the toxicokinetics and first-pass elimination of trichloroethylene and 1,1,1-trichloroethane","volume":"360","author":"Mortuza","year":"2018","journal-title":"Toxicol. Appl. Pharmacol"},{"key":"2024102110193107000_kfad090-B49","doi-asserted-by":"crossref","first-page":"27","DOI":"10.4103\/0976-0105.177703","article-title":"A simple practice guide for dose conversion between animals and human","volume":"7","author":"Nair","year":"2016","journal-title":"J. Basic Clin. Pharm"},{"key":"2024102110193107000_kfad090-B50","author":"National Institute for Occupational Health and Safety","year":"2018"},{"key":"2024102110193107000_kfad090-B51","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.nbd.2016.12.013","article-title":"The olfactory bulb as the entry site for prion-like propagation in neurodegenerative diseases","volume":"109","author":"Nolwen","year":"2018","journal-title":"Neurobiol. Dis"},{"key":"2024102110193107000_kfad090-B52","author":"Occupational Safety and Health Administration","year":"2021"},{"key":"2024102110193107000_kfad090-B53","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1080\/10937404.2015.1134371","article-title":"A systematic review of evidence and implications of spatial and seasonal variations of volatile organic compounds (VOC) in indoor human environments","volume":"19","author":"Paci\u00eancia","year":"2016","journal-title":"J. Toxicol. Environ. Health. B Crit. Rev"},{"key":"2024102110193107000_kfad090-B54","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0014-2999(02)01308-0","article-title":"Biochemical and pharmacological characterization of 1-trichloromethyl-1,2,3,4-tetrahydro-\u03b2-carboline: A biologically relevant neurotoxin?","volume":"442","author":"Riederer","year":"2002","journal-title":"Eur. J. Pharmacol"},{"key":"2024102110193107000_kfad090-B55","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.expneurol.2011.12.012","article-title":"Traumatic brain injury and trichloroethylene exposure interact and produce functional, histological, and mitochondrial deficits","volume":"234","author":"Sauerbeck","year":"2012","journal-title":"Exp. Neurol"},{"key":"2024102110193107000_kfad090-B56","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1039\/C9EM00567F","article-title":"Comparison of modeled and measured indoor air trichloroethene (TCE) concentrations at a vapor intrusion site: Influence of wind, temperature, and building characteristics","volume":"22","author":"Shirazi","year":"2020","journal-title":"Environ. Sci. Process. Impacts"},{"key":"2024102110193107000_kfad090-B57","author":"Todd","year":"2019"},{"key":"2024102110193107000_kfad090-B58","doi-asserted-by":"crossref","first-page":"117009","DOI":"10.1289\/EHP12006","article-title":"Reanalysis of trichloroethylene and tetrachloroethylene metabolism to glutathione conjugates using human, rat, and mouse liver in vitro models to improve precision in risk characterization","volume":"130","author":"Valdiviezo","year":"2022","journal-title":"Environ. Health Perspect"},{"key":"2024102110193107000_kfad090-B59","doi-asserted-by":"crossref","first-page":"117242","DOI":"10.1016\/j.lfs.2019.117242","article-title":"Correlation between mouse age and human age in anti-tumor research: Significance and method establishment","volume":"242","author":"Wang","year":"2020","journal-title":"Life Sci"},{"key":"2024102110193107000_kfad090-B60","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1289\/ehp.00108s2359","article-title":"Exposure assessment of trichloroethylene","volume":"108(Suppl 2)","author":"Wu","year":"2000","journal-title":"Environ. Health Perspect"},{"key":"2024102110193107000_kfad090-B61","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.chemosphere.2019.05.203","article-title":"Application of molecular biological tools for monitoring efficiency of trichloroethylene remediation","volume":"233","author":"Wu","year":"2019","journal-title":"Chemosphere"},{"key":"2024102110193107000_kfad090-B62","doi-asserted-by":"crossref","first-page":"123807","DOI":"10.1016\/j.jhazmat.2020.123807","article-title":"The effects of temperature and relative humidity on trichloroethylene sorption capacities of building materials under conditions relevant to vapor intrusion","volume":"401","author":"Xie","year":"2021","journal-title":"J. Hazard. Mater"},{"key":"2024102110193107000_kfad090-B63","author":"Zogorski","year":"2006"}],"container-title":["Toxicological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/toxsci\/advance-article-pdf\/doi\/10.1093\/toxsci\/kfad090\/51521613\/kfad090.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/toxsci\/article-pdf\/196\/2\/218\/59924734\/kfad090.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/toxsci\/article-pdf\/196\/2\/218\/59924734\/kfad090.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,21]],"date-time":"2024-10-21T06:20:17Z","timestamp":1729491617000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/toxsci\/article\/196\/2\/218\/7260540"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,5]]},"references-count":62,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2023,9,5]]},"published-print":{"date-parts":[[2023,11,28]]}},"URL":"https:\/\/doi.org\/10.1093\/toxsci\/kfad090","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2023.07.12.548754","asserted-by":"object"}]},"ISSN":["1096-6080","1096-0929"],"issn-type":[{"value":"1096-6080","type":"print"},{"value":"1096-0929","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,12,1]]},"published":{"date-parts":[[2023,9,5]]}}}