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Acute pancreatitis (AP) and chronic pancreatitis (CP) models were induced in this study by intraperitoneal injection of caerulein. The aim was to investigate the impact of BDE-47 on pancreatitis by exposing the animals to acute (1\u2009week) or chronic (8\u2009weeks) doses of BDE-47 (30\u2009mg\/kg in the low-concentration group and 100\u2009mg\/kg in the high-concentration group). Additionally, BDE-47 was utilized to stimulate mouse bone marrow-derived macrophages, pancreatic primary stellate cells, and acinar cells in order to investigate the impact of BDE-47 on pancreatitis. In vivo experiments conducted on mice revealed that chronic exposure to BDE-47, rather than acute exposure, exacerbated the histopathological damage of AP and CP, leading to elevated fibrosis in pancreatic tissue and increased infiltration of inflammatory cells in the pancreas. In vitro experiments showed that BDE-47 can promote the expression of the inflammatory cytokines Tnf-\u03b1 and Il-6 in M1 macrophages, as well as promote acinar cell apoptosis through the activation of the PERK and JNK pathways via endoplasmic reticulum stress. The findings of this study imply chronic exposure to BDE-47 may exacerbate the progression of both AP and CP by inducing acinar cell apoptosis and dysregulating inflammatory responses.<\/jats:p>","DOI":"10.1093\/toxsci\/kfae024","type":"journal-article","created":{"date-parts":[[2024,2,26]],"date-time":"2024-02-26T11:48:26Z","timestamp":1708948106000},"page":"120-131","source":"Crossref","is-referenced-by-count":8,"title":["Chronic exposure to BDE-47 aggravates acute pancreatitis and chronic pancreatitis by promoting acinar cell apoptosis and inflammation"],"prefix":"10.1093","volume":"199","author":[{"given":"Xiaoyan","family":"Qi","sequence":"first","affiliation":[{"name":"Department of General Surgery, The Second Xiangya Hospital, Central South University , Changsha, Hunan 410011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Stomatology, The Second Xiangya Hospital, Central South University , Changsha, Hunan 410011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuxing","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of General Surgery, The Second Xiangya Hospital, Central South University , Changsha, Hunan 410011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuyang","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of General Surgery, The Second Xiangya Hospital, Central South University , Changsha, Hunan 410011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhong","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of General Surgery, The Second Xiangya Hospital, Central South University , Changsha, Hunan 410011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin","family":"Sun","sequence":"additional","affiliation":[{"name":"Institute of Pharmaceutical Pharmacology, University of South China , Hengyang, Hunan 421200, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of General Surgery, The Second Xiangya Hospital, Central South University , Changsha, Hunan 410011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leping","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of General Surgery, The Second Xiangya Hospital, Central South University , Changsha, Hunan 410011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"He","sequence":"additional","affiliation":[{"name":"Department of General Surgery, The Second Xiangya Hospital, Central South University , Changsha, Hunan 410011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuijie","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of General Surgery, The Second Xiangya Hospital, Central South University , Changsha, Hunan 410011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,2,24]]},"reference":[{"key":"2024042916131152700_kfae024-B1","doi-asserted-by":"crossref","first-page":"110976","DOI":"10.1016\/j.biopha.2020.110976","article-title":"Vinpocetine ameliorates L-arginine induced acute pancreatitis via Sirt1\/Nrf2\/TNF pathway and inhibition of oxidative stress, inflammation, and apoptosis","volume":"133","author":"Abdelzaher","year":"2021","journal-title":"Biomed. 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