{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T17:54:47Z","timestamp":1793123687836,"version":"4.5.0"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T00:00:00Z","timestamp":1715731200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Integrated Molecular Analysis Core"},{"name":"UNM Center for Metals in Biology and Medicine","award":["NIH P20 GM130422"],"award-info":[{"award-number":["NIH P20 GM130422"]}]},{"name":"Academic Science Education and Research Training","award":["K12 GM088021"],"award-info":[{"award-number":["K12 GM088021"]}]},{"name":"NMINSPIRES"},{"DOI":"10.13039\/100000066","name":"NIEHS","doi-asserted-by":"publisher","award":["1P30ES032755"],"award-info":[{"award-number":["1P30ES032755"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The ubiquitous existence of microplastics and nanoplastics raises concerns about their potential impact on the human reproductive system. Limited data exists on microplastics within the human reproductive system and their potential consequences on sperm quality. Our objectives were to quantify and characterize the prevalence and composition of microplastics within both canine and human testes and investigate potential associations with the sperm count, and weights of testis and epididymis. Using advanced sensitive pyrolysis-gas chromatography\/mass spectrometry, we quantified 12 types of microplastics within 47 canine and 23 human testes. Data on reproductive organ weights, and sperm count in dogs were collected. Statistical analyses, including descriptive analysis, correlational analysis, and multivariate linear regression analyses were applied to investigate the association of microplastics with reproductive functions. Our study revealed the presence of microplastics in all canine and human testes, with significant inter-individual variability. Mean total microplastic levels were 122.63\u2009\u00b5g\/g in dogs and 328.44\u2009\u00b5g\/g in humans. Both humans and canines exhibit relatively similar proportions of the major polymer types, with PE being dominant. Furthermore, a negative correlation between specific polymers such as PVC and PET and the normalized weight of the testis was observed. These findings highlight the pervasive presence of microplastics in the male reproductive system in both canine and human testes, with potential consequences on male fertility.<\/jats:p>","DOI":"10.1093\/toxsci\/kfae060","type":"journal-article","created":{"date-parts":[[2024,5,3]],"date-time":"2024-05-03T00:14:23Z","timestamp":1714695263000},"page":"235-240","source":"Crossref","is-referenced-by-count":244,"title":["Microplastic presence in dog and human testis and its potential association with sperm count and weights of testis and epididymis"],"prefix":"10.1093","volume":"200","author":[{"given":"Chelin Jamie","family":"Hu","sequence":"first","affiliation":[{"name":"College of Nursing, University of New Mexico , Albuquerque, New Mexico 87106, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus A","family":"Garcia","sequence":"additional","affiliation":[{"name":"College of Pharmacy, University of New Mexico , Akbuquerque, New Mexico 87106, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Nihart","sequence":"additional","affiliation":[{"name":"College of Pharmacy, University of New Mexico , Akbuquerque, New Mexico 87106, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Pharmacy, University of New Mexico , Akbuquerque, New Mexico 87106, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Yin","sequence":"additional","affiliation":[{"name":"Reprotox Biotech , Albuquerque, New Mexico 87131, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie","family":"Adolphi","sequence":"additional","affiliation":[{"name":"Office of the Medical Investigator, University of New Mexico , Albuquerque, New Mexico 87106, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel F","family":"Gallego","sequence":"additional","affiliation":[{"name":"Office of the Medical Investigator, University of New Mexico , Albuquerque, New Mexico 87106, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huining","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Biostatistics Shared Resource of UNM Comprehensive Cancer Center, University of New Mexico , Albuquerque, New Mexico 87106, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J","family":"Campen","sequence":"additional","affiliation":[{"name":"College of Pharmacy, University of New Mexico , Akbuquerque, New Mexico 87106, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5523-9583","authenticated-orcid":false,"given":"Xiaozhong","family":"Yu","sequence":"additional","affiliation":[{"name":"College of Nursing, University of New Mexico , Albuquerque, New Mexico 87106, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,5,15]]},"reference":[{"key":"2024072914594919600_kfae060-B1","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/s41585-022-00626-w","article-title":"Spatiotemporal trends in human semen quality","volume":"19","author":"Auger","year":"2022","journal-title":"Nat. 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