{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T11:09:42Z","timestamp":1779188982376,"version":"3.51.4"},"reference-count":57,"publisher":"Oxford University Press (OUP)","issue":"1","funder":[{"DOI":"10.13039\/100013316","name":"Strategic Environmental Research and Development Program","doi-asserted-by":"publisher","award":["ER-2625"],"award-info":[{"award-number":["ER-2625"]}],"id":[{"id":"10.13039\/100013316","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Perfluorononanoic acid (PFNA) is a commercially relevant, long-chain (8 fully fluorinated carbon) perfluorinated carboxylic acid. PFNA has limited terrestrial ecotoxicity data and is detected in humans, animals, and the environment. This study is the fourth in a series with the objective of investigating the toxicity of a suite of per- and polyfluoroalkyl substances (PFAS) detected on military installations in a mammal indigenous to North America. Peromyscus leucopus (white-footed mice, \u223c25\/sex\/dose) were exposed via oral gavage to either 0, 0.03, 0.14, 1, or 3\u2009mg PFNA\/kg-d for 112 consecutive days (4\u2009wk premating exposure followed by an additional 12\u2009wk of exposure after onset of mating). Parental generation animals were assessed for potential reproductive and developmental effects, organ weight changes, thyroid modulation, and immunotoxicity. Pup weight and survival were assessed at postnatal days 0, 1, 4, 7, and 10. Change in liver weight was determined to yield the most sensitive dose response according to benchmark dose analysis, and serves as the most protective point of departure (BMDL\u2009=\u20090.37\u2009mg\/kg-d PFNA). Other effects of PFNA exposure included reduced formation of plaque-forming cells, which are indicative of functional immune deficits (BMDL\u2009=\u20092.31\u2009mg\/kg-d); decreased serum thyroxine (BMDL\u2009=\u20090.93\u2009mg\/kg-d) without changes in some other hormones; and increased stillbirths (BMDL\u2009=\u20090.61\u2009mg\/kg-d PFNA). Pup weight and survival were not affected by PFNA exposure. Combined with data from previous studies, data from Peromyscus provide a One Health perspective on health effects of PFAS.<\/jats:p>","DOI":"10.1093\/toxsci\/kfae077","type":"journal-article","created":{"date-parts":[[2024,6,13]],"date-time":"2024-06-13T05:34:07Z","timestamp":1718256847000},"page":"38-47","source":"Crossref","is-referenced-by-count":2,"title":["Threshold for increased liver weight is protective of other effects in <i>Peromyscus<\/i> exposed to PFNA"],"prefix":"10.1093","volume":"201","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5191-2200","authenticated-orcid":false,"given":"Allison M","family":"Narizzano","sequence":"first","affiliation":[{"name":"Toxicology Directorate, Defense Centers for Public Health\u2014Aberdeen , Aberdeen Proving Ground, MD 21010, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily May","family":"Lent","sequence":"additional","affiliation":[{"name":"Toxicology Directorate, Defense Centers for Public Health\u2014Aberdeen , Aberdeen Proving Ground, MD 21010, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8890-8376","authenticated-orcid":false,"given":"Andrew G","family":"East","sequence":"additional","affiliation":[{"name":"Toxicology Directorate, Defense Centers for Public Health\u2014Aberdeen , Aberdeen Proving Ground, MD 21010, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0233-8510","authenticated-orcid":false,"given":"Meredith E","family":"Bohannon","sequence":"additional","affiliation":[{"name":"Toxicology Directorate, Defense Centers for Public Health\u2014Aberdeen , Aberdeen Proving Ground, MD 21010, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr","given":"Michael J","family":"Quinn","sequence":"additional","affiliation":[{"name":"Toxicology Directorate, Defense Centers for Public Health\u2014Aberdeen , Aberdeen Proving Ground, MD 21010, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,6,14]]},"reference":[{"key":"2024082707510601400_kfae077-B1","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.jconhyd.2018.11.011","article-title":"Partitioning of poly- and perfluoroalkyl substances from soil to groundwater within aqueous film-forming foam source zones","volume":"220","author":"Anderson","year":"2019","journal-title":"J Contam Hydrol"},{"key":"2024082707510601400_kfae077-B2","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/j.chemosphere.2016.01.014","article-title":"Occurrence of select perfluoroalkyl substances at U.S. Air Force aqueous film-forming foam release sites other than fire-training areas: field-validation of critical fate and transport properties","volume":"150","author":"Anderson","year":"2016","journal-title":"Chemosphere"},{"key":"2024082707510601400_kfae077-B3","volume-title":"Toxicological profile for perfluoralkyls","author":"ATSDR","year":"2021"},{"issue":"4","key":"2024082707510601400_kfae077-B4","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1080\/01926230490465874","article-title":"Relationships between organ weight and body\/brain weight in the rat: what is the best analytical endpoint?","volume":"32","author":"Bailey","year":"2004","journal-title":"Toxicol Pathol"},{"issue":"1","key":"2024082707510601400_kfae077-B5","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1093\/toxsci\/kfad006","article-title":"Next-generation PFAS 6:2 fluorotelomer sulfonate reduces plaque formation in exposed white-footed mice","volume":"192","author":"Bohannon","year":"2023","journal-title":"Toxicol Sci"},{"issue":"5","key":"2024082707510601400_kfae077-B6","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1002\/ieam.4450","article-title":"Identification and classification of commercially relevant per- and poly-fluoroalkyl substances (PFAS)","volume":"17","author":"Buck","year":"2021","journal-title":"Integr Environ Assess Manag"},{"key":"2024082707510601400_kfae077-B7","volume-title":"Toxic Substances and Control Act (TSCA) 792 \u2013 good laboratory practice standards. Title 40","author":"CFR","year":"2011"},{"issue":"7","key":"2024082707510601400_kfae077-B8","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.trecan.2018.05.004","article-title":"The value of outbred rodent models in cancer research","volume":"4","author":"Chatzistamou","year":"2018","journal-title":"Trends Cancer"},{"key":"2024082707510601400_kfae077-B9","doi-asserted-by":"crossref","first-page":"612320","DOI":"10.3389\/fendo.2020.612320","article-title":"Thyroid disrupting effects of old and new generation PFAS","volume":"11","author":"Coperchini","year":"2020","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"4","key":"2024082707510601400_kfae077-B10","doi-asserted-by":"crossref","first-page":"46001","DOI":"10.1289\/EHP10092","article-title":"Exposure to per- and polyfluoroalkyl substances and markers of liver injury: a systematic review and meta-analysis","volume":"130","author":"Costello","year":"2022","journal-title":"Environ Health Perspect"},{"issue":"3-4","key":"2024082707510601400_kfae077-B11","first-page":"531","article-title":"Evolution in microcosm: the rapid somatic diversification of lymphocytes","volume":"127","author":"Cunningham","year":"1976","journal-title":"Ann Immunol (Paris)"},{"key":"2024082707510601400_kfae077-B12","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.reprotox.2014.12.012","article-title":"Developmental toxicity of perfluorononanoic acid in mice","volume":"51","author":"Das","year":"2015","journal-title":"Reprod Toxicol"},{"key":"2024082707510601400_kfae077-B13","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.tox.2016.12.007","article-title":"Perfluoroalkyl acids-induced liver steatosis: effects on genes controlling lipid homeostasis","volume":"378","author":"Das","year":"2017","journal-title":"Toxicology"},{"issue":"Suppl 12","key":"2024082707510601400_kfae077-B14","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1289\/ehp.94102s1265a","article-title":"Toxicological foundations of ecological risk assessment: biomarker development and interpretation based on laboratory and wildlife species","volume":"102","author":"Dickerson","year":"1994","journal-title":"Environ Health Perspect"},{"issue":"3","key":"2024082707510601400_kfae077-B15","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1002\/etc.4893","article-title":"Per- and polyfluoroalkyl substances (PFAS) in surface water near us air force bases: prioritizing individual chemicals and mixtures for toxicity testing and risk assessment","volume":"40","author":"East","year":"2021","journal-title":"Environ Toxicol Chem"},{"issue":"11","key":"2024082707510601400_kfae077-B16","doi-asserted-by":"crossref","first-page":"2364","DOI":"10.1002\/etc.5714","article-title":"Comparative toxicity of seven aqueous film-forming foam to in vitro systems and Mus","volume":"42","author":"East","year":"2023","journal-title":"Environ Toxicol Chem"},{"issue":"6580","key":"2024082707510601400_kfae077-B17","doi-asserted-by":"crossref","first-page":"eabg9065","DOI":"10.1126\/science.abg9065","article-title":"Per- and polyfluoroalkyl substances in the environment","volume":"375","author":"Evich","year":"2022","journal-title":"Science"},{"issue":"2","key":"2024082707510601400_kfae077-B18","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1093\/toxsci\/kfp019","article-title":"Alterations of cytokines and MAPK signaling pathways are related to the immunotoxic effect of perfluorononanoic acid","volume":"108","author":"Fang","year":"2009","journal-title":"Toxicol Sci"},{"issue":"1-3","key":"2024082707510601400_kfae077-B19","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.tox.2009.10.020","article-title":"Perfluorononanoic acid-induced apoptosis in rat spleen involves oxidative stress and the activation of caspase-independent death pathway","volume":"267","author":"Fang","year":"2010","journal-title":"Toxicology"},{"issue":"2","key":"2024082707510601400_kfae077-B20","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.etap.2012.06.011","article-title":"In vitro and in vivo studies of the toxic effects of perfluorononanoic acid on rat hepatocytes and Kupffer cells","volume":"34","author":"Fang","year":"2012","journal-title":"Environ Toxicol Pharmacol"},{"issue":"2","key":"2024082707510601400_kfae077-B21","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1093\/toxsci\/kfn127","article-title":"Immunotoxic effects of perfluorononanoic acid on BALB\/C mice","volume":"105","author":"Fang","year":"2008","journal-title":"Toxicol Sci"},{"issue":"3","key":"2024082707510601400_kfae077-B22","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.reprotox.2010.05.010","article-title":"Effects of PFNA exposure on expression of junction-associated molecules and secretory function in rat Sertoli cells","volume":"30","author":"Feng","year":"2010","journal-title":"Reprod Toxicol"},{"issue":"2","key":"2024082707510601400_kfae077-B23","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.toxlet.2009.07.020","article-title":"Perfluorononanoic acid induces apoptosis involving the FAS death receptor signaling pathway in rat testis","volume":"190","author":"Feng","year":"2009","journal-title":"Toxicol Lett"},{"issue":"3","key":"2024082707510601400_kfae077-B24","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1002\/etc.4890","article-title":"Per- and polyfluoroalkyl substance toxicity and human health review: current state of knowledge and strategies for informing future research","volume":"40","author":"Fenton","year":"2021","journal-title":"Environ Toxicol Chem"},{"issue":"1425","key":"2024082707510601400_kfae077-B25","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1098\/rstb.2002.1129","article-title":"Population growth rate as a basis for ecological risk assessment of toxic chemicals","volume":"357","author":"Forbes","year":"2002","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"issue":"11","key":"2024082707510601400_kfae077-B26","doi-asserted-by":"crossref","first-page":"2302","DOI":"10.1002\/etc.5729","article-title":"Research priorities for the environmental risk assessment of per- and polyfluorinated substances","volume":"42","author":"Gkika","year":"2023","journal-title":"Environ Toxicol Chem"},{"issue":"7","key":"2024082707510601400_kfae077-B27","doi-asserted-by":"crossref","first-page":"077018","DOI":"10.1289\/EHP275","article-title":"Serum vaccine antibody concentrations in adolescents exposed to perfluorinated compounds","volume":"125","author":"Grandjean","year":"2017","journal-title":"Environ Health Perspect"},{"issue":"1","key":"2024082707510601400_kfae077-B28","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1080\/1547691X.2017.1360968","article-title":"Estimated exposures to perfluorinated compounds in infancy predict attenuated vaccine antibody concentrations at age 5-years","volume":"14","author":"Grandjean","year":"2017","journal-title":"J Immunotoxicol"},{"issue":"9","key":"2024082707510601400_kfae077-B29","doi-asserted-by":"crossref","first-page":"4164","DOI":"10.1021\/es3048043","article-title":"Subsurface transport potential of perfluoroalkyl acids at aqueous film-forming foam (AFFF)-impacted sites","volume":"47","author":"Guelfo","year":"2013","journal-title":"Environ Sci Technol"},{"key":"2024082707510601400_kfae077-B30","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.semcdb.2016.06.020","article-title":"Peromyscus as a model of human disease","volume":"61","author":"Havighorst","year":"2017","journal-title":"Semin Cell Dev Biol"},{"issue":"Pt 1","key":"2024082707510601400_kfae077-B31","doi-asserted-by":"crossref","first-page":"117297","DOI":"10.1016\/j.envres.2023.117297","article-title":"Serum per- and polyfluoroalkyl substance concentrations and longitudinal change in post-infection and post-vaccination SARS-COV-2 antibodies","volume":"239","author":"Hollister","year":"2023","journal-title":"Environ Res"},{"issue":"1","key":"2024082707510601400_kfae077-B32","doi-asserted-by":"crossref","first-page":"6625","DOI":"10.1038\/s41598-020-63465-y","article-title":"Determining organ weight toxicity with Bayesian causal models: improving on the analysis of relative organ weights","volume":"10","author":"Lazic","year":"2020","journal-title":"Sci Rep"},{"issue":"24","key":"2024082707510601400_kfae077-B33","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1080\/15287394.2016.1219893","article-title":"An extended one-generation reproductive toxicity test of 1,2,4-triazol-5-one (NTO) in rats","volume":"79","author":"Lent","year":"2016","journal-title":"J Toxicol Environ Health A"},{"issue":"4","key":"2024082707510601400_kfae077-B34","doi-asserted-by":"crossref","first-page":"47007","DOI":"10.1289\/EHP6202","article-title":"Maternal plasma perfluoroalkyl substances and miscarriage: a nested case-control study in the Danish National Birth Cohort","volume":"128","author":"Liew","year":"2020","journal-title":"Environ Health Perspect"},{"key":"2024082707510601400_kfae077-B35","volume-title":"Multi-species hormone magnetic bead panel","author":"Millipore","year":"2013"},{"key":"2024082707510601400_kfae077-B36","doi-asserted-by":"crossref","first-page":"108421","DOI":"10.1016\/j.reprotox.2023.108421","article-title":"Reproductive and immune effects emerge at similar thresholds of PFHxS in deer mice","volume":"120","author":"Narizzano","year":"2023","journal-title":"Reprod Toxicol"},{"issue":"10","key":"2024082707510601400_kfae077-B37","doi-asserted-by":"crossref","first-page":"2886","DOI":"10.1002\/etc.5151","article-title":"Patterns in serum toxicokinetics in Peromyscus exposed to per- and polyfluoroalkyl substances","volume":"40","author":"Narizzano","year":"2021","journal-title":"Environ Toxicol Chem"},{"key":"2024082707510601400_kfae077-B38","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.reprotox.2022.08.011","article-title":"Reproductive and developmental toxicity of perfluorooctane sulfonate (PFOS) in the white-footed mouse (Peromyscus leucopus)","volume":"113","author":"Narizzano","year":"2022","journal-title":"Reprod Toxicol"},{"issue":"1","key":"2024082707510601400_kfae077-B39","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1021\/acs.est.0c04473","article-title":"Spatial trends of anionic, zwitterionic, and cationic PFASs at an AFFF-impacted site","volume":"55","author":"Nickerson","year":"2021","journal-title":"Environ Sci Technol"},{"key":"2024082707510601400_kfae077-B40","volume-title":"Guide for the care and use of laboratory animals","author":"NRC","year":"2011"},{"key":"2024082707510601400_kfae077-B41","volume-title":"Technical report on the toxicity studies of perfluoroalkyl carboxylates administered by gavage to Sprague Dawley (HSD:Sprague Dawley SD) rats. Toxicity Report 97","author":"NTP","year":"2019"},{"key":"2024082707510601400_kfae077-B42","doi-asserted-by":"crossref","DOI":"10.1787\/1a14ad6c-en","volume-title":"Toward a new comprehensive global database on per- and polyfluoroalkyl substances (PFASs): summary report on updating the OECD 2007 list of per- and polyfluoroalkyl substances (PFASs)","author":"OECD","year":"2018"},{"issue":"41","key":"2024082707510601400_kfae077-B43","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/1742-9994-11-41","article-title":"Litter size manipulation in laboratory mice: an example of how proteomic analysis can uncover new mechanisms underlying the cost of reproduction","volume":"11","author":"Plumel","year":"2014","journal-title":"Front Zool"},{"issue":"1","key":"2024082707510601400_kfae077-B44","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1021\/es0512475","article-title":"Sources, fate and transport of perfluorocarboxylates","volume":"40","author":"Prevedouros","year":"2006","journal-title":"Environ Sci Technol"},{"issue":"3","key":"2024082707510601400_kfae077-B45","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1002\/ieam.2024","article-title":"A framework for linking population model development with ecological risk assessment objectives","volume":"14","author":"Raimondo","year":"2018","journal-title":"Integr Environ Assess Manag"},{"key":"2024082707510601400_kfae077-B46","first-page":"S4-002","article-title":"Acute immunotoxic effects of perfluorononanoic acid (PFNA) in C57BL\/6 mice","author":"Rockwell","year":"2013","journal-title":"Clin Exp Pharmacol"},{"issue":"8","key":"2024082707510601400_kfae077-B47","doi-asserted-by":"crossref","first-page":"e41402","DOI":"10.1371\/journal.pone.0041402","article-title":"Calcium availability influences litter size and sex ratio in white-footed mice (Peromyscus leucopus)","volume":"7","author":"Schmidt","year":"2012","journal-title":"PLoS One"},{"key":"2024082707510601400_kfae077-B48","first-page":"179159","article-title":"Peromyscus as a mammalian epigenetic model","volume":"2012","author":"Shorter","year":"2012","journal-title":"Genet Res Int"},{"issue":"4","key":"2024082707510601400_kfae077-B49","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/0300-483X(82)90105-6","article-title":"Acute toxicity of methanol in the folate-deficient acatalasemic mouse","volume":"25","author":"Smith","year":"1982","journal-title":"Toxicology"},{"issue":"2","key":"2024082707510601400_kfae077-B50","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1038\/pr.2015.213","article-title":"Perfluoroalkyl and polyfluoroalkyl substances and indicators of immune function in children aged 12-19 y: national health and nutrition examination survey","volume":"79","author":"Stein","year":"2016","journal-title":"Pediatr Res"},{"key":"2024082707510601400_kfae077-B51","doi-asserted-by":"crossref","DOI":"10.1201\/9781420012569","volume-title":"Ecological risk assessment","author":"Suter","year":"2016"},{"key":"2024082707510601400_kfae077-B52","volume-title":"Drinking water health advisory for perfluorooctane sulfonate (PFOS).","author":"USEPA","year":"2016"},{"key":"2024082707510601400_kfae077-B53","volume-title":"Drinking water health advisory for perfluorooctanoic acid (PFOA).","author":"USEPA","year":"2016"},{"key":"2024082707510601400_kfae077-B54","volume-title":"Interim drinking water health advisory: perfluorooctane sulfonic acid (PFOS) CASRN 1763-23-1","author":"USEPA","year":"2022"},{"key":"2024082707510601400_kfae077-B55","volume-title":"Interim drinking water health advisory: perfluorooctanoic acid (PFOA) CASRN 335-67-1","author":"USEPA","year":"2022"},{"key":"2024082707510601400_kfae077-B56","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.envint.2014.04.006","article-title":"Global emission inventories for C4-C14 perfluoroalkyl carboxylic acid (PFCA) homologues from 1951 to 2030, part II: the remaining pieces of the puzzle","volume":"69","author":"Wang","year":"2014","journal-title":"Environ Int"},{"issue":"1","key":"2024082707510601400_kfae077-B57","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1093\/toxsci\/kfx237","article-title":"Alteration of bile acid and cholesterol biosynthesis and transport by perfluorononanoic acid (PFNA) in mice","volume":"162","author":"Zhang","year":"2018","journal-title":"Toxicol Sci"}],"container-title":["Toxicological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/toxsci\/advance-article-pdf\/doi\/10.1093\/toxsci\/kfae077\/58345129\/kfae077.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/toxsci\/article-pdf\/201\/1\/38\/58912160\/kfae077.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/toxsci\/article-pdf\/201\/1\/38\/58912160\/kfae077.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T10:24:01Z","timestamp":1724754241000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/toxsci\/article\/201\/1\/38\/7693701"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,14]]},"references-count":57,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,6,14]]},"published-print":{"date-parts":[[2024,9,1]]}},"URL":"https:\/\/doi.org\/10.1093\/toxsci\/kfae077","relation":{},"ISSN":["1096-6080","1096-0929"],"issn-type":[{"value":"1096-6080","type":"print"},{"value":"1096-0929","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,9]]},"published":{"date-parts":[[2024,6,14]]}}}