{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T01:05:36Z","timestamp":1790816736581,"version":"4.1.0"},"reference-count":54,"publisher":"Oxford University Press (OUP)","issue":"2","funder":[{"DOI":"10.13039\/100002491","name":"BMS","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002491","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Rutgers University COVID-19 Dissertation Completion Fellowship"},{"DOI":"10.13039\/100005751","name":"New Jersey Space Grant Consortium","doi-asserted-by":"publisher","award":["T32 ES007148"],"award-info":[{"award-number":["T32 ES007148"]}],"id":[{"id":"10.13039\/100005751","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005751","name":"New Jersey Space Grant Consortium","doi-asserted-by":"publisher","award":["GM135258"],"award-info":[{"award-number":["GM135258"]}],"id":[{"id":"10.13039\/100005751","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005751","name":"New Jersey Space Grant Consortium","doi-asserted-by":"publisher","award":["ES029258"],"award-info":[{"award-number":["ES029258"]}],"id":[{"id":"10.13039\/100005751","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005751","name":"New Jersey Space Grant Consortium","doi-asserted-by":"publisher","award":["DK122725"],"award-info":[{"award-number":["DK122725"]}],"id":[{"id":"10.13039\/100005751","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005751","name":"New Jersey Space Grant Consortium","doi-asserted-by":"publisher","award":["BX002741"],"award-info":[{"award-number":["BX002741"]}],"id":[{"id":"10.13039\/100005751","id-type":"DOI","asserted-by":"publisher"}]},{"name":"ASPET Summer Intern Program","award":["ES020721"],"award-info":[{"award-number":["ES020721"]}]},{"name":"ASPET Summer Intern Program","award":["ES005022"],"award-info":[{"award-number":["ES005022"]}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Bile acid (BA) signaling dysregulation is an important etiology for the development of metabolic dysfunction-associated steatotic liver disease (MASLD). As diverse signaling molecules synthesized in the liver by pathways initiated with CYP7A1 and CYP27A1, BAs are endogenous modulators of farnesoid x receptor (FXR). FXR activation is crucial in maintaining BA homeostasis, regulating lipid metabolism, and suppressing inflammation. Additionally, BAs interact with membrane receptors and gut microbiota to regulate energy expenditure and intestinal health. Complex modulation of BAs in vivo and the lack of suitable animal models impede our understanding of the functions of individual BAs, especially during MASLD development. Previously, we determined that acute feeding of individual BAs differentially affects lipid, inflammation, and oxidative stress pathways in a low-BA mouse model, Cyp7a1\/Cyp27a1 double knockout (DKO) mice. Currently, we investigated to what degree cholic acid (CA), deoxycholic acid (DCA), or ursodeoxycholic acid (UDCA) at physiological concentrations impact MASLD development in DKO mice. The results showed that these 3 BAs varied in the ability to activate hepatic and intestinal FXR, disrupt lipid homeostasis, and modulate inflammation and fibrosis. Additionally, UDCA activated intestinal FXR in these low-BA mice. Significant alterations in lipid uptake and metabolism in DKO mice following CA and DCA feeding indicate differences in cholesterol and lipid handling across genotypes. Overall, the DKO were less susceptible to weight gain, but more susceptible to MASH diet induced inflammation and fibrosis on CA and DCA supplements, whereas WT mice were more vulnerable to CA-induced fibrosis on the control diet.<\/jats:p>","DOI":"10.1093\/toxsci\/kfae110","type":"journal-article","created":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T19:24:40Z","timestamp":1726687480000},"page":"179-195","source":"Crossref","is-referenced-by-count":8,"title":["Effects of therapeutically approved individual bile acids on the development of metabolic dysfunction-associated steatohepatitis a low bile acid mouse model"],"prefix":"10.1093","volume":"202","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0561-3653","authenticated-orcid":false,"given":"Rulaiha","family":"Taylor","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers University , Piscataway, NJ 08854,","place":["United 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08854,","place":["United States"]},{"name":"Rutgers Center for Lipid Research, Rutgers University , New Brunswick, NJ 08901,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5426-2266","authenticated-orcid":false,"given":"Troy","family":"Roepke","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers University , Piscataway, NJ 08854,","place":["United States"]},{"name":"Environmental and Occupational Health Science Institute, Rutgers University , Piscataway, NJ 08854,","place":["United States"]},{"name":"Rutgers Center for Lipid Research, Rutgers University , New Brunswick, NJ 08901,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Buckley","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers University 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