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The pharmacologically active compounds in Cannabis, such as delta-9-tetrahydrocannabinol and cannabidiol, exhibit diverse immunomodulatory properties. Although studies have explored the effects of cannabinoids on immune function, their specific interactions with the thymus, a primary immune organ critical for T-cell development and maturation, remain an intriguing area of investigation. As the thymus plays a fundamental role in shaping the immune repertoire, understanding the interplay between cannabinoids and thymic function may shed light on potential benefits or concerns associated with Cannabis-based therapies. This article aims to provide an overview of the current scientific knowledge regarding the impact of medicinal Cannabis on the thymus and its implications for disease treatment and immune health.<\/jats:p>","DOI":"10.1093\/toxsci\/kfae114","type":"journal-article","created":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T20:07:57Z","timestamp":1725912477000},"page":"1-12","source":"Crossref","is-referenced-by-count":0,"title":["Exploring the interplay between cannabinoids and thymic functions"],"prefix":"10.1093","volume":"202","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4247-0345","authenticated-orcid":false,"given":"Marvin Paulo","family":"Lins","sequence":"first","affiliation":[{"name":"Laboratory of Immunology, Department of Basic Sciences in Health, Faculty of Medicine, Federal University of Mato Grosso , Cuiab\u00e1-MT, 78060-900,","place":["Brazil"]},{"name":"Brazilian National Institute of Science and Technology on Neuroimmunomodulation (INCT-NIM), Oswaldo Cruz Institute, Oswaldo Cruz Foundation , Rio de Janeiro, 21040-360,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8758-3613","authenticated-orcid":false,"given":"Igor Santana","family":"de Melo","sequence":"additional","affiliation":[{"name":"Laboratory of Neuropharmacology and Integrative Physiology, Institute of Biological and Health Sciences, Federal University of Alagoas , Macei\u00f3, 57072-900,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,9,9]]},"reference":[{"key":"2024102816313262500_kfae114-B1","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1016\/J.PHYTOCHEM.2015.04.007","article-title":"Minor oxygenated cannabinoids from high potency Cannabis sativa L","volume":"117","author":"Ahmed","year":"2015","journal-title":"Phytochemistry"},{"key":"2024102816313262500_kfae114-B2","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1016\/j.nbd.2004.04.001","article-title":"A cell-based screen for drugs to treat Huntington\u2019s disease","volume":"16","author":"Aiken","year":"2004","journal-title":"Neurobiol Dis"},{"key":"2024102816313262500_kfae114-B3","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1038\/s41385-021-00455-x","article-title":"Cannabinoids induce functional Tregs by promoting tolerogenic DCs via autophagy and metabolic reprograming","volume":"15","author":"Angelina","year":"2021","journal-title":"Mucosal Immunol"},{"key":"2024102816313262500_kfae114-B4","doi-asserted-by":"publisher","first-page":"1427","DOI":"10.1021\/np8002673","article-title":"Antibacterial cannabinoids from Cannabis sativa\u202f: a structure\u2212activity study","volume":"71","author":"Appendino","year":"2008","journal-title":"J Nat Prod"},{"key":"2024102816313262500_kfae114-B5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1684\/EPD.2020.1141","article-title":"Epilepsy and cannabidiol: a guide to treatment","volume":"22","author":"Arzimanoglou","year":"2020","journal-title":"Epileptic Disord"},{"key":"2024102816313262500_kfae114-B6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1159\/000137763","article-title":"Effects of Delta 9-tetrahydrocannabinol, cannabinol and cannabidiol on the immune system in mice. 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