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The prevalence of BACs raises the concern that BAC exposure could disrupt the gastrointestinal microbiota, thus interfering with the beneficial functions of the microbes. We hypothesize that BAC exposure can alter the gut microbiome diversity and composition, which will disrupt bile acid (BA) homeostasis along the gut-liver axis. In this study, male and female mice were exposed orally to d7-C12- and d7-C16-BACs at 120\u2009\u00b5g\/g\/d for 1 wk. UPLC-MS\/MS analysis of liver, blood, and fecal samples of BAC-treated mice demonstrated the absorption and metabolism of BACs. Both parent BACs and their metabolites were detected in all exposed samples. Additionally, 16S rRNA sequencing was carried out on the bacterial DNA isolated from the cecum intestinal content. For female mice, and to a lesser extent in males, we found that treatment with either d7-C12- or d7-C16-BAC led to decreased alpha diversity and differential composition of gut bacteria with notably decreased actinobacteria phylum. Lastly, through a targeted BA quantitation analysis, we observed decreases in secondary BAs in BAC-treated mice, which was more pronounced in the female mice. This finding is supported by decreases in bacteria known to metabolize primary BAs into secondary BAs, such as the families of Ruminococcaceae and Lachnospiraceae. Together, these data signify the potential impact of BACs on human health through disturbance of the gut microbiome and gut-liver interactions.<\/jats:p>","DOI":"10.1093\/toxsci\/kfae116","type":"journal-article","created":{"date-parts":[[2024,10,2]],"date-time":"2024-10-02T15:19:50Z","timestamp":1727882390000},"page":"265-277","source":"Crossref","is-referenced-by-count":2,"title":["Oral exposure to benzalkonium chlorides in male and female mice reveals alteration of the gut microbiome and bile acid profile"],"prefix":"10.1093","volume":"202","author":[{"given":"Vanessa A","family":"Lopez","sequence":"first","affiliation":[{"name":"Department of Medicinal Chemistry, University of Washington , Seattle, WA 98195,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joe J","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Environmental and Occupational Health Sciences, University of Washington , Seattle, WA 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