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We exposed human airway epithelial cells to smoke condensates from burn pit waste materials. Single and repeated exposure to condensates triggered unique and common responses in terms of gene expression that were sustained through the recovery phase. Source material and combustion condition influenced the outcome. Intensified response in female donor cells indicated a determining role of biological sex. The observations indicate a lasting impact of burn pit smoke exposure on epithelial gene expression, potentially contributing to disease pathogenesis.<\/jats:p>","DOI":"10.1093\/toxsci\/kfae161","type":"journal-article","created":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T23:24:39Z","timestamp":1734045879000},"page":"2-8","source":"Crossref","is-referenced-by-count":2,"title":["Simulated burn pit smoke condensates cause sustained impact on human airway epithelial cells"],"prefix":"10.1093","volume":"204","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9550-1366","authenticated-orcid":false,"given":"Arunava","family":"Ghosh","sequence":"first","affiliation":[{"name":"Center for Environmental Medicine, Asthma, and Lung Biology, University of North Carolina at Chapel Hill , Chapel Hill, NC 27599,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith L","family":"Rogers Jr.","sequence":"additional","affiliation":[{"name":"Curriculum 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