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The potential for heat stress (HS) to influence PFOA partitioning, potentially through intestinal hyperpermeability and alterations in systemic blood flow, also warrants investigation. This study investigated PFOA uptake, accumulation, and distribution in thermal neutral (TN) and heat-stressed gilts. Pigs (n\u2009=\u200948) were estrus synchronized and experienced TN (20\u2009\u00b0C) or HS (26.6 to 32.2\u2009\u00b0C) conditions during which they consumed 70\u2009ng\/kg bodyweight PFOA via cookie dough as vehicle control daily. Plasma was collected on d 1, 15, and 20. Liver, ovary, and follicular fluid were collected at euthanasia (d 20). Post-exposure, PFOA was detected in serum, liver, ovary, and follicular fluid. HS increased (P\u2009&amp;lt;\u20090.05) plasma PFOA compared with TN pigs on d 15, but on d 20, plasma PFOA levels in TN and HS pigs were similar. Liver PFOA concentrations were similar between TN and HS pigs. Ovarian PFOA levels tended (P\u2009=\u20090.06) to be higher in TN relative to HS pigs, with an opposing pattern in follicular fluid, in which PFOA concentrations were greater (P\u2009&amp;lt;\u20090.05) in HS pigs. These findings suggest that PFOA apportions to plasma, liver, ovary, and follicular fluid of exposed pigs and that HS alters PFOA distribution, which could negatively impact reproductive health. This study underscores the need to consider the interaction of HS and toxicant exposure in environmental health risk assessments.<\/jats:p>","DOI":"10.1093\/toxsci\/kfaf013","type":"journal-article","created":{"date-parts":[[2025,2,4]],"date-time":"2025-02-04T04:57:51Z","timestamp":1738645071000},"page":"143-153","source":"Crossref","is-referenced-by-count":8,"title":["Distribution of perfluorooctanoic acid in exposed female postpubertal pigs in thermal neutral or heat-stressed conditions"],"prefix":"10.1093","volume":"205","author":[{"given":"Samantha L","family":"Good","sequence":"first","affiliation":[{"name":"Department of Civil, Construction, and Environmental Engineering, Iowa State University , Ames, IA 50011,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Collins","family":"Antwi-Boasiako","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Iowa State University , Ames, IA 50011,","place":["United 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