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Dose\u2013response curves for perfluoroalkyl carboxylic acids (PFNA, PFOA, PFPeA, and PFBA), perfluoroalkyl sulfonic acids (PFOS and PFBS), perfluoroalkyl sulfonamides (PFOSA and PFBSA), fluoroether carboxylic acids (GenX and PFMOAA), fluoroether sulfonic acid (PFEESA), and fluorotelomers (6:2 FTCA and 6:2 FTS) were determined in the C. elegans laboratory reference strain, N2, and 11 genetically diverse wild strains. Body length was quantified after 48\u2009h of developmental exposure of L1 arrest-synchronized larvae to estimate effective concentration values (EC50). PFAS toxicity ranged by 3 orders of magnitude. Long-chain PFAS had greater toxicity than short-chain. Fluorosulfonamides were more toxic than carboxylic and sulfonic acids. Genetic variation resulted in variation in susceptibility among 12 strains to almost all chemicals. Different C. elegans strains varied in susceptibility to different PFAS, which suggests distinct molecular responses to specific structural attributes. Harnessing the natural genetic diversity of C. elegans and the structural complexity of PFAS is a powerful approach that can be used to investigate mechanisms of toxicity which may identify potentially susceptible individuals or populations and predict toxicity of untested PFAS to inform regulatory policies and improve human and environmental health.<\/jats:p>","DOI":"10.1093\/toxsci\/kfaf014","type":"journal-article","created":{"date-parts":[[2025,2,22]],"date-time":"2025-02-22T06:42:11Z","timestamp":1740206531000},"page":"205-219","source":"Crossref","is-referenced-by-count":4,"title":["Structure-specific variation in per- and polyfluoroalkyl substances toxicity among genetically diverse <i>Caenorhabditis elegans<\/i> strains"],"prefix":"10.1093","volume":"205","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8501-3473","authenticated-orcid":false,"given":"Tess C","family":"Leuthner","sequence":"first","affiliation":[{"name":"Department of Biology, Duke University , Durham, NC 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