{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T23:58:31Z","timestamp":1790294311659,"version":"4.1.0"},"reference-count":73,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T00:00:00Z","timestamp":1739491200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["R01 ES025721"],"award-info":[{"award-number":["R01 ES025721"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"name":"University of Rochester Environmental Health Science Center","award":["P30 ES001247"],"award-info":[{"award-number":["P30 ES001247"]}]},{"name":"Medical Scientist Training Program"},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"NIGMS","doi-asserted-by":"publisher","award":["T32 GM007356"],"award-info":[{"award-number":["T32 GM007356"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"NIEHS","doi-asserted-by":"publisher","award":["T32 ES007026"],"award-info":[{"award-number":["T32 ES007026"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"name":"IRACDA","award":["K12GM106997"],"award-info":[{"award-number":["K12GM106997"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Prenatal methylmercury (MeHg) exposure presents a heightened concern in early human development, as has been exemplified in historic cases of congenital minimata disease (CMD). Children who experience CMD characteristically present with various degrees of cognitive and motor symptoms and signs, much like cerebral palsy. MeHg has thus been characterized as a neurotoxicant, where motor deficits are ascribed to central nervous system targets. Skeletal muscle as a post-synaptic MeHg target and contributor to the etiology of CMD has garnered far less attention. Prior studies using Drosophila to model CMD revealed that developmental exposure of MeHg in the larval\/pupal stages can elicit graded and latent dose responses affecting adult flight behavior at lower doses (0.4\u20132.5\u2009ppm in food) and eclosion (emergence from the pupa case) at higher doses (&amp;gt;2.5\u2009ppm in food). The latter phenotype is accompanied by dysmorphogenesis of skeletal muscles. Here, we investigate respective roles for muscle and neural targets in MeHg toxicity. Using RNA-seq analysis, we find that developmental MeHg exposure produces 10 times as many differentially expressed transcripts in indirect flight muscle compared to the ventral nerve cord. Among known MeHg response genes, Nrf2 antioxidant response pathway genes showed muscle-specific MeHg-induced expression changes. Within the muscle transcriptome, the most enriched and significant Gene Ontology terms identified genes required for mitochondrial ribosomal translation at the pupa stage and mitochondrial function (respiratory chain complex I) and vesicle trafficking (ESCRT III) pathways in adults, all showing decreased expression with MeHg exposure. By using an intact, whole-animal developmental model, we identify preferential candidates to evaluate a novel role for muscle-specific mitochondria and intercellular vesicular communication mechanisms as targets in MeHg toxicity and the etiology of CMD.<\/jats:p>","DOI":"10.1093\/toxsci\/kfaf018","type":"journal-article","created":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T16:49:36Z","timestamp":1739551776000},"page":"106-123","source":"Crossref","is-referenced-by-count":7,"title":["Transcriptomic analysis identifies muscle-specific mitochondrial and vesicular transport genes as methylmercury toxicity targets in a <i>Drosophila<\/i> model of congenital Minamata disease"],"prefix":"10.1093","volume":"205","author":[{"given":"Catherine R","family":"Beamish","sequence":"first","affiliation":[{"name":"Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry , Rochester, NY 14620,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Becker","sequence":"additional","affiliation":[{"name":"Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry , Rochester, NY 14620,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lok Ming","family":"Tam","sequence":"additional","affiliation":[{"name":"Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry , Rochester, NY 14620,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7154-0229","authenticated-orcid":false,"given":"Tanzy","family":"Love","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Computational Biology, University of Rochester School of Medicine and Dentistry , Rochester, NY 14642,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7871-0895","authenticated-orcid":false,"given":"Matthew D","family":"Rand","sequence":"additional","affiliation":[{"name":"Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry , Rochester, NY 14620,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,2,14]]},"reference":[{"key":"2025042903524193800_kfaf018-B1","doi-asserted-by":"crossref","first-page":"67002","DOI":"10.1289\/EHP4949","article-title":"Environmental electrophile-mediated toxicity in mice lacking Nrf2, CSE, or both","volume":"127","author":"Akiyama","year":"2019","journal-title":"Environ Health Perspect"},{"key":"2025042903524193800_kfaf018-B2","doi-asserted-by":"crossref","first-page":"2441","DOI":"10.1093\/hmg\/ddad069","article-title":"Multi-omics identifies large mitoribosomal subunit instability caused by pathogenic mrpl39 variants as a cause of pediatric onset mitochondrial disease","volume":"32","author":"Amarasekera","year":"2023","journal-title":"Hum Mol Genet"},{"key":"2025042903524193800_kfaf018-B3","first-page":"1070","article-title":"Perinatal methylmercury poisoning in Iraq","volume":"130","author":"Amin-Zaki","year":"1976","journal-title":"Am J Dis Child"},{"key":"2025042903524193800_kfaf018-B4","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1001\/archpedi.1979.02130020064013","article-title":"Prenatal methylmercury poisoning","volume":"133","author":"Amin-Zaki","year":"1979","journal-title":"Am J Dis Child"},{"key":"2025042903524193800_kfaf018-B5","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.cell.2017.12.022","article-title":"Retrovirus-like gag protein arc1 binds RNA and traffics across synaptic boutons","volume":"172","author":"Ashley","year":"2018","journal-title":"Cell"},{"key":"2025042903524193800_kfaf018-B6","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1007\/s002449900291","article-title":"Concentration of mercury in hair of indigenous mothers and infants from the amazon basin","volume":"34","author":"Barbosa","year":"1998","journal-title":"Arch Environ Contam Toxicol"},{"key":"2025042903524193800_kfaf018-B7","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1080\/15622975.2023.2211653","article-title":"Multiple genes encoding mitochondrial ribosomes are downregulated in brain and blood samples of individuals with schizophrenia","volume":"24","author":"Bartal","year":"2023","journal-title":"World J Biol Psychiatry"},{"key":"2025042903524193800_kfaf018-B8","doi-asserted-by":"crossref","first-page":"12131","DOI":"10.3390\/ijms222212131","article-title":"Developmental toxicology of metal mixtures in Drosophila: unique properties of potency and interactions of mercury isoforms","volume":"22","author":"Beamish","year":"2021","journal-title":"Int J Mol Sci"},{"key":"2025042903524193800_kfaf018-B9","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1016\/j.bbrc.2004.08.028","article-title":"MGluRs regulate the expression of neuronal calcium sensor proteins ncs-1 and vilip-1 and the immediate early gene Arg3.1\/Arc in the hippocampus in vivo","volume":"322","author":"Brackmann","year":"2004","journal-title":"Biochem Biophys Res Commun"},{"key":"2025042903524193800_kfaf018-B10","doi-asserted-by":"crossref","first-page":"D1251","DOI":"10.1093\/nar\/gkv1003","article-title":"Mitocarta2.0: an updated inventory of mammalian mitochondrial proteins","volume":"44","author":"Calvo","year":"2016","journal-title":"Nucleic Acids Res"},{"key":"2025042903524193800_kfaf018-B11","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1146\/annurev-genom-082509-141720","article-title":"The mitochondrial proteome and human disease","volume":"11","author":"Calvo","year":"2010","journal-title":"Annu Rev Genomics Hum Genet"},{"key":"2025042903524193800_kfaf018-B12","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.31659.025","article-title":"Neurexin and neuroligin-based adhesion complexes drive axonal arborisation growth independent of synaptic activity","author":"Constance","year":"2018","journal-title":"Elife"},{"key":"2025042903524193800_kfaf018-B13","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1016\/j.cub.2009.08.016","article-title":"Extension of Drosophila life span by RNAi of the mitochondrial respiratory chain","volume":"19","author":"Copeland","year":"2009","journal-title":"Curr Biol"},{"key":"2025042903524193800_kfaf018-B14","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1007\/s10653-017-9993-7","article-title":"Vulnerability associated with \u201csymptoms similar to those of mercury poisoning\u201d in communities from xingu river, amazon basin","volume":"40","author":"Da Silva-Junior","year":"2018","journal-title":"Environ Geochem Health"},{"key":"2025042903524193800_kfaf018-B15","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.neuro.2023.10.008","article-title":"Keap1 polymorphisms and neurodevelopmental outcomes in children with exposure to prenatal mehg from the Seychelles child development study nutrition cohort 2","volume":"99","author":"de Paula","year":"2023","journal-title":"Neurotoxicology"},{"key":"2025042903524193800_kfaf018-B16","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.mito.2022.02.006","article-title":"Mitochondrial ribosomal protein genes connected with Alzheimer\u2019s and tellurite toxicity","volume":"64","author":"Del Giudice","year":"2022","journal-title":"Mitochondrion"},{"key":"2025042903524193800_kfaf018-B17","doi-asserted-by":"crossref","first-page":"e39","DOI":"10.1371\/journal.pcbi.0030039","article-title":"Discovering motifs in ranked lists of DNA sequences","volume":"3","author":"Eden","year":"2007","journal-title":"PLoS Comput Biol"},{"key":"2025042903524193800_kfaf018-B18","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/1471-2105-10-48","article-title":"Gorilla: a tool for discovery and visualization of enriched go terms in ranked gene lists","volume":"10","author":"Eden","year":"2009","journal-title":"BMC Bioinformatics"},{"key":"2025042903524193800_kfaf018-B19","doi-asserted-by":"crossref","first-page":"2098","DOI":"10.1007\/s12035-022-02726-5","article-title":"Ghrelin attenuates methylmercury-induced oxidative stress in neuronal cells","volume":"59","author":"Ferrer","year":"2022","journal-title":"Mol Neurobiol"},{"key":"2025042903524193800_kfaf018-B20","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nature12929","article-title":"De novo mutations in schizophrenia implicate synaptic networks","volume":"506","author":"Fromer","year":"2014","journal-title":"Nature"},{"key":"2025042903524193800_kfaf018-B21","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1142\/S0219720005001375","article-title":"Noise-robust soft clustering of gene expression time-course data","volume":"3","author":"Futschik","year":"2005","journal-title":"J Bioinform Comput Biol"},{"key":"2025042903524193800_kfaf018-B22","first-page":"113","article-title":"Pairwise multiple comparison procedures with unequal n\u2019s and\/or variances: a Monte Carlo study","volume":"1","author":"Games","year":"1976","journal-title":"J Educ Stat"},{"key":"2025042903524193800_kfaf018-B23","first-page":"69","article-title":"Varying mercury exposure with varying food source in a James Bay Cree community","volume":"55","author":"Girard","year":"1996","journal-title":"Arctic Med Res"},{"key":"2025042903524193800_kfaf018-B24","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.cell.2010.01.026","article-title":"The Angelman syndrome protein Ube3A regulates synapse development by ubiquitinating arc","volume":"140","author":"Greer","year":"2010","journal-title":"Cell"},{"key":"2025042903524193800_kfaf018-B25","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.neuron.2005.08.036","article-title":"Genome-wide transcriptional changes associated with enhanced activity in the Drosophila nervous system","volume":"48","author":"Guan","year":"2005","journal-title":"Neuron"},{"key":"2025042903524193800_kfaf018-B26","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1093\/toxsci\/kfab114","article-title":"Neuroligin-1 is a mediator of methylmercury neuromuscular toxicity","volume":"184","author":"Gunderson","year":"2021","journal-title":"Toxicol Sci"},{"key":"2025042903524193800_kfaf018-B27","doi-asserted-by":"crossref","first-page":"4007","DOI":"10.1007\/s00204-020-02879-z","article-title":"Tissue-specific Nrf2 signaling protects against methylmercury toxicity in Drosophila neuromuscular development","volume":"94","author":"Gunderson","year":"2020","journal-title":"Arch Toxicol"},{"key":"2025042903524193800_kfaf018-B28","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1002\/tera.1420180216","article-title":"Congenital minamata disease: Intrauterine methylmercury poisoning","volume":"18","author":"Harada","year":"1978","journal-title":"Teratology"},{"key":"2025042903524193800_kfaf018-B29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/10408449509089885","article-title":"Minamata disease: methylmercury poisoning in Japan caused by environmental pollution","volume":"25","author":"Harada","year":"1995","journal-title":"Crit Rev Toxicol"},{"key":"2025042903524193800_kfaf018-B30","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1186\/s12859-015-0611-3","article-title":"Interactivenn: a web-based tool for the analysis of sets through venn diagrams","volume":"16","author":"Heberle","year":"2015","journal-title":"BMC Bioinformatics"},{"key":"2025042903524193800_kfaf018-B31","doi-asserted-by":"crossref","first-page":"2295","DOI":"10.1042\/BCJ20160009","article-title":"Unravelling the mechanisms regulating muscle mitochondrial biogenesis","volume":"473","author":"Hood","year":"2016","journal-title":"Biochem J"},{"key":"2025042903524193800_kfaf018-B32","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/978-1-4757-9071-9_28","volume-title":"Advannces inn mercury toxicology","author":"Igata","year":"1991"},{"key":"2025042903524193800_kfaf018-B33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-1-0716-2541-5_1","article-title":"Using flybase: a database of Drosophila genes and genetics","volume":"2540","author":"Jenkins","year":"2022","journal-title":"Methods Mol Biol"},{"key":"2025042903524193800_kfaf018-B34","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.envres.2017.06.025","article-title":"A total diet study and probabilistic assessment risk assessment of dietary mercury exposure among first nations living on-reserve in Ontario, Canada","volume":"158","author":"Juric","year":"2017","journal-title":"Environ Res"},{"key":"2025042903524193800_kfaf018-B35","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1073\/pnas.0806518106","article-title":"Synaptic activity-responsive element in the Arc\/Arg3.1 promoter essential for synapse-to-nucleus signaling in activated neurons","volume":"106","author":"Kawashima","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"2025042903524193800_kfaf018-B36","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1177\/088307380001500707","article-title":"Congenital minamata disease: warnings from Japan\u2019s experience","volume":"15","author":"Kondo","year":"2000","journal-title":"J Child Neurol"},{"key":"2025042903524193800_kfaf018-B37","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1038\/s41556-023-01244-3","article-title":"Regulators of mitonuclear balance link mitochondrial metabolism to mtDNA expression","volume":"25","author":"Kramer","year":"2023","journal-title":"Nat Cell Biol"},{"key":"2025042903524193800_kfaf018-B38","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1093\/toxsci\/kfac105","article-title":"Targeted intracellular demethylation of methylmercury enhances elimination kinetics and reduces developmental toxicity in transgenic Drosophila","volume":"190","author":"Krout","year":"2022","journal-title":"Toxicol Sci"},{"key":"2025042903524193800_kfaf018-B39","doi-asserted-by":"crossref","first-page":"5","DOI":"10.6026\/97320630002005","article-title":"Mfuzz: a software package for soft clustering of microarray data","volume":"2","author":"Kumar","year":"2007","journal-title":"Bioinformation"},{"key":"2025042903524193800_kfaf018-B40","first-page":"278","volume-title":"Robust tests for equality of variances","author":"Levene","year":"1960"},{"key":"2025042903524193800_kfaf018-B41","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1093\/toxsci\/kfq097","article-title":"Identification of methylmercury tolerance gene candidates in Drosophila","volume":"116","author":"Mahapatra","year":"2010","journal-title":"Toxicol Sci"},{"key":"2025042903524193800_kfaf018-B42","doi-asserted-by":"crossref","first-page":"2116","DOI":"10.1016\/j.celrep.2016.07.044","article-title":"Genetic disruption of Arc\/Arg3.1 in mice causes alterations in dopamine and neurobehavioral phenotypes related to schizophrenia","volume":"16","author":"Manago","year":"2016","journal-title":"Cell Rep"},{"key":"2025042903524193800_kfaf018-B43","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1016\/j.neuron.2013.04.036","article-title":"Arc\/arg3.1 is a postsynaptic mediator of activity-dependent synapse elimination in the developing cerebellum","volume":"78","author":"Mikuni","year":"2013","journal-title":"Neuron"},{"key":"2025042903524193800_kfaf018-B44","doi-asserted-by":"crossref","first-page":"e110375","DOI":"10.1371\/journal.pone.0110375","article-title":"Genome-wide association analysis of tolerance to methylmercury toxicity in Drosophila implicates myogenic and neuromuscular developmental pathways","volume":"9","author":"Montgomery","year":"2014","journal-title":"PLoS One"},{"key":"2025042903524193800_kfaf018-B45","doi-asserted-by":"crossref","first-page":"170","DOI":"10.3390\/sports7070170","article-title":"Exercise-induced mitohormesis for the maintenance of skeletal muscle and healthspan extension","volume":"7","author":"Musci","year":"2019","journal-title":"Sports (Basel)"},{"key":"2025042903524193800_kfaf018-B46","doi-asserted-by":"crossref","first-page":"e3002575","DOI":"10.1371\/journal.pbio.3002575","article-title":"Bruno 1\/CELF regulates splicing and cytoskeleton dynamics to ensure correct sarcomere assembly in Drosophila flight muscles","volume":"22","author":"Nikonova","year":"2024","journal-title":"PLoS Biol"},{"key":"2025042903524193800_kfaf018-B47","doi-asserted-by":"crossref","first-page":"2592","DOI":"10.1038\/s41598-019-39292-1","article-title":"Activity-regulated cytoskeleton-associated protein (Arc\/Arg3.1) is transiently expressed after heat shock stress and suppresses heat shock factor 1","volume":"9","author":"Park","year":"2019","journal-title":"Sci Rep"},{"key":"2025042903524193800_kfaf018-B48","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.cell.2017.12.024","article-title":"The neuronal gene arc encodes a repurposed retrotransposon gag protein that mediates intercellular RNA transfer","volume":"172","author":"Pastuzyn","year":"2018","journal-title":"Cell"},{"key":"2025042903524193800_kfaf018-B49","doi-asserted-by":"crossref","first-page":"234","DOI":"10.3389\/fnmol.2017.00234","article-title":"Activity-dependent arc expression and homeostatic synaptic plasticity are altered in neurons from a mouse model of Angelman syndrome","volume":"10","author":"Pastuzyn","year":"2017","journal-title":"Front Mol Neurosci"},{"key":"2025042903524193800_kfaf018-B50","doi-asserted-by":"crossref","first-page":"107037","DOI":"10.1016\/j.ntt.2021.107037","article-title":"Latent effects of early-life methylmercury exposure on motor function in Drosophila","volume":"88","author":"Peppriell","year":"2021","journal-title":"Neurotoxicol Teratol"},{"key":"2025042903524193800_kfaf018-B51","doi-asserted-by":"crossref","first-page":"152561","DOI":"10.1016\/j.tox.2020.152561","article-title":"Methylmercury myotoxicity targets formation of the myotendinous junction","volume":"443","author":"Peppriell","year":"2020","journal-title":"Toxicology"},{"key":"2025042903524193800_kfaf018-B52","doi-asserted-by":"crossref","first-page":"143196","DOI":"10.1016\/j.scitotenv.2020.143196","article-title":"Seasonal variations in exposure to methylmercury and its dietary sources among pregnant inuit women in nunavik, Canada","volume":"755","author":"Pontual","year":"2021","journal-title":"Sci Total Environ"},{"key":"2025042903524193800_kfaf018-B53","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.jneumeth.2007.08.029","article-title":"Neuritetracer: a novel Imagej plugin for automated quantification of neurite outgrowth","volume":"168","author":"Pool","year":"2008","journal-title":"J Neurosci Methods"},{"key":"2025042903524193800_kfaf018-B54","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1093\/toxsci\/kfu095","article-title":"Target organ specific activity of Drosophila mrp (ABCC1) moderates developmental toxicity of methylmercury","volume":"140","author":"Prince","year":"2014","journal-title":"Toxicol Sci"},{"key":"2025042903524193800_kfaf018-B55","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/nrm.2016.23","article-title":"Mitonuclear communication in homeostasis and stress","volume":"17","author":"Quiros","year":"2016","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2025042903524193800_kfaf018-B56","doi-asserted-by":"crossref","first-page":"666","DOI":"10.3389\/fgene.2019.00666","article-title":"Drosophotoxicology: elucidating kinetic and dynamic pathways of methylmercury toxicity in a Drosophila model","volume":"10","author":"Rand","year":"2019","journal-title":"Front Genet"},{"key":"2025042903524193800_kfaf018-B57","first-page":"583","article-title":"Evidence for delayed neurotoxicity produced by methylmercury","volume":"17","author":"Rice","year":"1996","journal-title":"Neurotoxicology"},{"key":"2025042903524193800_kfaf018-B58","doi-asserted-by":"crossref","first-page":"929","DOI":"10.3389\/fphys.2019.00929","article-title":"Skeletal muscle-released extracellular vesicles: State of the art","volume":"10","author":"Rome","year":"2019","journal-title":"Front Physiol"},{"key":"2025042903524193800_kfaf018-B59","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1242\/jcs.050021","article-title":"How do ESCRT proteins control autophagy?","volume":"122","author":"Rusten","year":"2009","journal-title":"J Cell Sci"},{"key":"2025042903524193800_kfaf018-B60","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1038\/nn.2708","article-title":"New views of arc, a master regulator of synaptic plasticity","volume":"14","author":"Shepherd","year":"2011","journal-title":"Nat Neurosci"},{"key":"2025042903524193800_kfaf018-B61","doi-asserted-by":"crossref","first-page":"178","DOI":"10.15252\/embr.201439791","article-title":"The RNA-binding protein arrest (Bruno) regulates alternative splicing to enable myofibril maturation in Drosophila flight muscle","volume":"16","author":"Spletter","year":"2015","journal-title":"EMBO Rep"},{"key":"2025042903524193800_kfaf018-B62","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.34058","article-title":"A transcriptomics resource reveals a transcriptional transition during ordered sarcomere morphogenesis in flight muscle","volume":"7","author":"Spletter","year":"2018","journal-title":"Elife"},{"key":"2025042903524193800_kfaf018-B63","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1016\/j.yexcr.2008.10.013","article-title":"ESCRT proteins in physiology and disease","volume":"315","author":"Stuffers","year":"2009","journal-title":"Exp Cell Res"},{"key":"2025042903524193800_kfaf018-B64","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1097\/01.GIM.0000117333.21213.17","article-title":"Mitochondrial ribosomal proteins: candidate genes for mitochondrial disease","volume":"6","author":"Sylvester","year":"2004","journal-title":"Genet Med"},{"key":"2025042903524193800_kfaf018-B65","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1007\/s00204-024-03724-3","article-title":"Review: Myogenic and muscle toxicity targets of environmental methylmercury exposure","volume":"98","author":"Tam","year":"2024","journal-title":"Arch Toxicol"},{"key":"2025042903524193800_kfaf018-B66","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1093\/toxsci\/kfx033","article-title":"Editor\u2019s highlight: Glutathione s-transferase activity moderates methylmercury toxicity during development in Drosophila","volume":"157","author":"Vorojeikina","year":"2017","journal-title":"Toxicol Sci"},{"key":"2025042903524193800_kfaf018-B67","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.envint.2018.03.015","article-title":"Maternal polymorphisms in glutathione-related genes are associated with maternal mercury concentrations and early child neurodevelopment in a population with a fish-rich diet","volume":"115","author":"Wahlberg","year":"2018","journal-title":"Environ Int"},{"key":"2025042903524193800_kfaf018-B68","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1523\/JNEUROSCI.18-01-00026.1998","article-title":"Differential intracellular sorting of immediate early gene mrnas depends on signals in the mRNA sequence","volume":"18","author":"Wallace","year":"1998","journal-title":"J Neurosci"},{"key":"2025042903524193800_kfaf018-B69","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1093\/toxsci\/kfn201","article-title":"Methylmercury toxicity and Nrf2-dependent detoxification in astrocytes","volume":"107","author":"Wang","year":"2009","journal-title":"Toxicol Sci"},{"key":"2025042903524193800_kfaf018-B70","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.cell.2011.09.036","article-title":"Arc\/Arg3.1 regulates an endosomal pathway essential for activity-dependent beta-amyloid generation","volume":"147","author":"Wu","year":"2011","journal-title":"Cell"},{"key":"2025042903524193800_kfaf018-B71","doi-asserted-by":"crossref","first-page":"4143","DOI":"10.1016\/j.cub.2024.07.079","article-title":"Mechanoresponsive regulation of myogenesis by the force-sensing transcriptional regulator tono","volume":"34","author":"Zhang","year":"2024","journal-title":"Curr Biol"},{"key":"2025042903524193800_kfaf018-B72","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1007\/s12519-023-00729-3","article-title":"Delayed-onset adenosine deaminase deficiency with a novel synonymous mutation and a case series from China","volume":"19","author":"Zhang","year":"2023","journal-title":"World J Pediatr"},{"key":"2025042903524193800_kfaf018-B73","doi-asserted-by":"crossref","first-page":"4403","DOI":"10.1073\/pnas.062059699","article-title":"Adenosine deaminase-related growth factors stimulate cell proliferation in Drosophila by depleting extracellular adenosine","volume":"99","author":"Zurovec","year":"2002","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["Toxicological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/toxsci\/advance-article-pdf\/doi\/10.1093\/toxsci\/kfaf018\/61899641\/kfaf018.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/toxsci\/article-pdf\/205\/1\/106\/61899641\/kfaf018.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/toxsci\/article-pdf\/205\/1\/106\/61899641\/kfaf018.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T07:53:07Z","timestamp":1745913187000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/toxsci\/article\/205\/1\/106\/8015633"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,14]]},"references-count":73,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,2,14]]},"published-print":{"date-parts":[[2025,5,1]]}},"URL":"https:\/\/doi.org\/10.1093\/toxsci\/kfaf018","relation":{},"ISSN":["1096-6080","1096-0929"],"issn-type":[{"value":"1096-6080","type":"print"},{"value":"1096-0929","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,5]]},"published":{"date-parts":[[2025,2,14]]}}}