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Due to its toxicological effects and ease of mass production, FA is also recognized as a significant chemical threat by the U.S. Department of Homeland Security. This study investigates the role of mast cells in the pulmonary inflammatory response to acute high-dose FA exposure. Using wild-type (C57BL\/6J) and mast cell-deficient (KitW-sh) mouse models, we assessed the impact of oropharyngeal aspiration of FA on lung pathology. Our findings reveal that C57BL\/6J mice experienced significant increases in cellular infiltration, altered immune cell populations, and changes in lipid mediator profiles. In contrast, KitW-sh mice exhibited significantly reduced inflammatory responses. Notably, the presence of mast cells was associated with enhanced dendritic cell migration and differential production of bioactive lipid mediators, such as specialized pro-resolving mediators and pro-inflammatory leukotrienes in C57BL\/6J mice. These results highlight the crucial role of mast cells in the immune response to FA and suggest they could be therapeutic targets for treating FA-induced lung inflammation.<\/jats:p>","DOI":"10.1093\/toxsci\/kfaf025","type":"journal-article","created":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T15:03:14Z","timestamp":1740409394000},"page":"180-190","source":"Crossref","is-referenced-by-count":2,"title":["Mast cells are key mediators in the pulmonary inflammatory response to formaldehyde exposure"],"prefix":"10.1093","volume":"205","author":[{"given":"Matthew","family":"Gibb","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus , Aurora, CO 80045,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela N","family":"Reinert","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, 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