{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T22:45:50Z","timestamp":1789512350647,"version":"build-2803163510"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T00:00:00Z","timestamp":1742515200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 DK135649"],"award-info":[{"award-number":["R01 DK135649"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["F32DK121423"],"award-info":[{"award-number":["F32DK121423"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 DK135752"],"award-info":[{"award-number":["R01 DK135752"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000199","name":"United States Department of Agriculture","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000199","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005825","name":"National Institute of Food and Agriculture","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005825","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Albert C. and Lois E. Dehn Endowment to Michigan State University for Veterinary Medicine"},{"name":"Pathobiology and Diagnostic Investigation"},{"name":"Michigan State University College of Natural Sciences"},{"name":"Family of John A. Penner"},{"name":"John A. Penner Endowed Research Fellowship"},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Macrophages displaying a pro-repair and anti-inflammatory polarization have been implicated in resolution of acute liver injury. Macrophage receptor with collagenous structure (MARCO) expression marks tolerogenic hepatic macrophages and is expressed by pro-resolution macrophages in the injured liver. We tested the hypothesis that MARCO promotes repair of the acetaminophen (APAP)-injured liver. Robust and sustained induction of MARCO mRNA and protein expression was evident in livers of mice challenged with a hepatotoxic dose of APAP (i.e. 300\u2009mg\/kg), whereas hepatic MARCO induction failed in mice with APAP-induced liver failure (i.e. 600\u2009mg\/kg). Serum proteomics identified a significant increase in serum MARCO levels in surviving acute liver failure (ALF) patients, but not in ALF patients who died. MARCO expression was high in F480+ liver macrophages, and MARCO deficiency reduced macrophage expression of pro-resolution markers such as Gpnmb and Mertk during the repair phase (i.e. 48\u2009h). The results suggested a delay in necrosis resolution along with a trend toward increased mortality in APAP-challenged MARCO\u2212\/\u2212 mice. Notably, a robust increase in peak hepatic injury (i.e. 6- to 24-h post-APAP challenge) was evident in MARCO\u2212\/\u2212 mice, which could not be ascribed to differences in NAPQI\/APAP-adduct generation nor changes in hepatic neutrophil\/macrophage numbers. Interestingly, a reduction in hepatic CD11c+ cells, shown previously to limit APAP-induced liver injury, was evident 24\u2009h after APAP challenge in MARCO\u2212\/\u2212 mice. The results indicate that MARCO deficiency worsens APAP-induced acute liver injury in mice and provide experimental and initial translational evidence linking MARCO induction to positive outcomes in acute liver injury.<\/jats:p>","DOI":"10.1093\/toxsci\/kfaf037","type":"journal-article","created":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T00:21:05Z","timestamp":1742343665000},"page":"417-427","source":"Crossref","is-referenced-by-count":5,"title":["Kupffer cell expression of macrophage receptor with collagenous structure modulates macrophage gene induction and limits acute liver injury"],"prefix":"10.1093","volume":"205","author":[{"given":"Lauren G","family":"Poole","sequence":"first","affiliation":[{"name":"Department of Pathobiology & Diagnostic Investigation, Michigan State University , East Lansing, MI 48824,","place":["United States"]},{"name":"Institute for Integrative Toxicology, Michigan State University , East Lansing, MI 48824,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zimu","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Pathobiology & Diagnostic Investigation, Michigan State University , East Lansing, MI 48824,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Schulte","sequence":"additional","affiliation":[{"name":"Department of Pathobiology & Diagnostic Investigation, Michigan State University , East Lansing, MI 48824,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holly M","family":"Cline","sequence":"additional","affiliation":[{"name":"Department of Pathobiology & Diagnostic Investigation, Michigan State University , East Lansing, MI 48824,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew P","family":"Bernard","sequence":"additional","affiliation":[{"name":"Department of Pharmacology & Toxicology, Michigan State University , East Lansing, MI 48824,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4077-5014","authenticated-orcid":false,"given":"John P","family":"Buchweitz","sequence":"additional","affiliation":[{"name":"Department of Pathobiology & Diagnostic Investigation, Michigan State University , East Lansing, MI 48824,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0401-0463","authenticated-orcid":false,"given":"Mitchell R","family":"McGill","sequence":"additional","affiliation":[{"name":"Department of Environmental Health Sciences, Fay W. Boozman College of Public Health, University of Arkansas for Medical Sciences , Little Rock, AR 72205,","place":["United States"]},{"name":"Department of Pharmacology and Toxicology, College of Medicine, University of Arkansas for Medical Sciences , Little Rock, AR 72205,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James P","family":"Luyendyk","sequence":"additional","affiliation":[{"name":"Department of Pathobiology & Diagnostic Investigation, Michigan State University , East Lansing, MI 48824,","place":["United States"]},{"name":"Institute for Integrative Toxicology, Michigan State University , East Lansing, MI 48824,","place":["United States"]},{"name":"Department of Pharmacology & Toxicology, Michigan State University , East Lansing, MI 48824,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,3,21]]},"reference":[{"key":"2026032020014058800_kfaf037-B1","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/j.stem.2022.04.008","article-title":"The spatiotemporal program of zonal liver regeneration following acute injury","volume":"29","author":"Ben-Moshe","year":"2022","journal-title":"Cell Stem Cell"},{"key":"2026032020014058800_kfaf037-B2","doi-asserted-by":"crossref","first-page":"3013","DOI":"10.1016\/j.ajpath.2014.07.019","article-title":"Pro-regenerative signaling after acetaminophen-induced acute liver injury in mice identified using a novel incremental dose model","volume":"184","author":"Bhushan","year":"2014","journal-title":"Am J Pathol"},{"key":"2026032020014058800_kfaf037-B3","doi-asserted-by":"crossref","first-page":"8173","DOI":"10.4049\/jimmunol.175.12.8173","article-title":"Defective microarchitecture of the spleen marginal zone and impaired response to a thymus-independent type 2 antigen in mice lacking scavenger receptors MARCO and SR-A","volume":"175","author":"Chen","year":"2005","journal-title":"J Immunol"},{"key":"2026032020014058800_kfaf037-B4","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1002\/eji.200939891","article-title":"A regulatory role for macrophage class a scavenger receptors in TLR4-mediated LPS responses","volume":"40","author":"Chen","year":"2010","journal-title":"Eur J Immunol"},{"key":"2026032020014058800_kfaf037-B5","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1002\/hep.24429","article-title":"Dendritic cell depletion exacerbates acetaminophen hepatotoxicity","volume":"54","author":"Connolly","year":"2011","journal-title":"Hepatology"},{"key":"2026032020014058800_kfaf037-B6","doi-asserted-by":"crossref","first-page":"626","DOI":"10.3389\/fimmu.2017.00626","article-title":"Ly6C(hi) monocytes and their macrophage descendants regulate neutrophil function and clearance 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