{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T08:05:15Z","timestamp":1785139515298,"version":"3.55.0"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,4,26]],"date-time":"2025-04-26T00:00:00Z","timestamp":1745625600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100004763","name":"Inner Mongolia Natural Science Foundation","doi-asserted-by":"publisher","award":["2024QN08009"],"award-info":[{"award-number":["2024QN08009"]}],"id":[{"id":"10.13039\/501100004763","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Although acute cardiovascular effects of silicon nanoparticles (SiNPs) have been reported, the long-term impact of human-relevant exposure on cardiac hypertrophy remains unclear. The rats were randomly assigned to 2 groups: The SiNPs exposure group and the control group, receiving intratracheal instillations of SiNPs suspension or saline, respectively, once a week for 6\u00a0mo (24 doses total). Both groups then underwent a 6-mo recovery period without further intervention to assess postexposure effects. The results revealed significant hypertrophic remodeling, as evidenced by increased left ventricular anterior wall thickness, systolic dysfunction (reduced FS%), and diastolic impairment (prolonged IVRT and IVCT). Ultrastructural analysis indicated mitochondrial disorganization and swelling in myocardial tissue. At the molecular level, SiNPs exposure upregulated hypertrophic markers (\u03b2-MHC, ANP), inflammatory cytokines (IL-18, IL-1\u03b2), and oxidative stress markers MDA, while reducing SOD levels. Both classical (Caspase-1) and nonclassical (Caspase-4, Caspase-5) pyroptosis pathways were activated, with elevated levels of Cleaved-Caspase-1, ASC, and N-GSDMD. This study is the first to identify nonclassical pyroptosis as a contributor to SiNPs-induced cardiac hypertrophy. Importantly, cardiac hypertrophy was significantly reduced after exposure cessation, with no further pyroptosis-mediated inflammatory damage observed. These findings underscore the importance of stricter public health regulations to limit SiNPs exposure, given its long-term cardiovascular risks.<\/jats:p>","DOI":"10.1093\/toxsci\/kfaf046","type":"journal-article","created":{"date-parts":[[2025,4,26]],"date-time":"2025-04-26T17:12:59Z","timestamp":1745687579000},"page":"158-168","source":"Crossref","is-referenced-by-count":1,"title":["Long-term exposure to silica nanoparticles induces cardiac hypertrophy through the pyroptosis pathway"],"prefix":"10.1093","volume":"206","author":[{"given":"Fenghong","family":"Wang","sequence":"first","affiliation":[{"name":"School of Public Health, Inner Mongolia Medical University , Hohhot 010110,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanan","family":"Li","sequence":"additional","affiliation":[{"name":"School of Public Health, Inner Mongolia Medical University , Hohhot 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