{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T19:47:14Z","timestamp":1784922434387,"version":"3.55.0"},"reference-count":73,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2025,5,10]],"date-time":"2025-05-10T00:00:00Z","timestamp":1746835200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["R35ES028366"],"award-info":[{"award-number":["R35ES028366"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"name":"UNC Neuroscience Microscopy Core","award":["SCR_019060"],"award-info":[{"award-number":["SCR_019060"]}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"NINDS","doi-asserted-by":"publisher","award":["P30 NS045892"],"award-info":[{"award-number":["P30 NS045892"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007857","name":"Intellectual and Developmental Disabilities Research Center","doi-asserted-by":"publisher","award":["P50 HD103573"],"award-info":[{"award-number":["P50 HD103573"]}],"id":[{"id":"10.13039\/100007857","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Environmental exposures can impact brain development and contribute to neurodevelopmental disorder risk. In this study, we leveraged insights from in vitro high-throughput screening studies that examined the developmental toxicity of environmental chemicals to select 47 chemicals for in vivo testing as complex random mixtures in pregnant female mice. Our objectives were to identify mixtures that impact key neurodevelopmental endpoints\u2014embryonic body, brain, and placenta weight\u2014and subsequently to use mass spectrometry to ascertain which chemicals from each active mixture entered the developing brain following gestational exposure. We identified 3 chemicals that entered the embryonic brain and reduced embryonic brain weight: Perfluorooctanoic acid (PFOA), fenpyroximate, and 4-tert-octylphenol. Given its effect on embryonic brain weight and its widespread presence in environmental samples, we selected PFOA for further study using single-nuclei RNA sequencing. We found that PFOA altered neural progenitor cell proliferation and neuronal differentiation in the developing mouse cerebral cortex. Furthermore, we found that gestational exposure to PFOA disrupted neurodevelopment by altering the cell cycle in neural progenitor cells of males and females. In conclusion, we identified environmental chemicals that impact neurodevelopmental processes in vivo and found that single-nuclei RNA sequencing can provide new insights into the cellular mechanisms of neurotoxicity.<\/jats:p>","DOI":"10.1093\/toxsci\/kfaf067","type":"journal-article","created":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T07:39:49Z","timestamp":1746689989000},"page":"433-444","source":"Crossref","is-referenced-by-count":5,"title":["Identifying environmental chemicals impacting neurodevelopment using a random mixture-based screening approach"],"prefix":"10.1093","volume":"206","author":[{"given":"Wenxin","family":"Hu","sequence":"first","affiliation":[{"name":"UNC Neuroscience Center, The University of North Carolina at Chapel Hill , Chapel Hill, NC 27599,","place":["United States"]},{"name":"Department of Cell Biology & Physiology, The University of North Carolina at Chapel Hill , Chapel Hill, NC 27599,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Xing","sequence":"additional","affiliation":[{"name":"UNC Neuroscience Center, The University of North Carolina at Chapel Hill , Chapel Hill, NC 27599,","place":["United States"]},{"name":"Department of Cell Biology & Physiology, The University of North Carolina at Chapel Hill , Chapel Hill, NC 27599,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jieun","family":"Park","sequence":"additional","affiliation":[{"name":"UNC Neuroscience Center, The University of North Carolina at Chapel Hill , Chapel Hill, NC 27599,","place":["United States"]},{"name":"Carolina Institute for Developmental Disabilities, The University of North Carolina at Chapel Hill , Chapel Hill, NC 27599,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bonnie","family":"Taylor-Blake","sequence":"additional","affiliation":[{"name":"UNC Neuroscience Center, The University of North Carolina at Chapel Hill , Chapel Hill, NC 27599,","place":["United States"]},{"name":"Department of Cell Biology & Physiology, The University of North Carolina at Chapel Hill , Chapel Hill, NC 27599,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James L","family":"Krantz","sequence":"additional","affiliation":[{"name":"UNC Neuroscience Center, The University of North Carolina at Chapel Hill , Chapel Hill, NC 27599,","place":["United States"]},{"name":"Department of Cell Biology & Physiology, The University of North Carolina at Chapel Hill , Chapel Hill, NC 27599,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-Chung","family":"Hsiao","sequence":"additional","affiliation":[{"name":"Department of Environmental Sciences and Engineering, The University of North Carolina at Chapel Hill , Chapel Hill, NC 27599,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih-Wei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Environmental Sciences and Engineering, The University of North Carolina at Chapel Hill , Chapel Hill, NC 27599,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia U","family":"Lamberti","sequence":"additional","affiliation":[{"name":"UNC Neuroscience Center, The University of North Carolina at Chapel Hill , Chapel Hill, NC 27599,","place":["United States"]},{"name":"Department of Cell Biology & Physiology, The University of North Carolina at Chapel Hill , Chapel Hill, NC 27599,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Environmental Sciences and Engineering, The University of North Carolina at Chapel Hill , Chapel Hill, NC 27599,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark J","family":"Zylka","sequence":"additional","affiliation":[{"name":"UNC Neuroscience Center, The University of North Carolina at Chapel Hill , Chapel Hill, NC 27599,","place":["United States"]},{"name":"Department of Cell Biology & Physiology, The University of North Carolina at Chapel Hill , Chapel Hill, NC 27599,","place":["United States"]},{"name":"Carolina Institute for Developmental Disabilities, The University of North Carolina at Chapel Hill , Chapel Hill, NC 27599,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,5,10]]},"reference":[{"key":"2025081219524691600_kfaf067-B1","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.neuro.2022.05.009","article-title":"Fenpyroximate induced cytotoxicity and genotoxicity in Wistar rat brain and in human neuroblastoma (SH-SY5Y) cells: involvement of oxidative stress and apoptosis","volume":"91","author":"Ayed-Boussema","year":"2022","journal-title":"Neurotoxicology"},{"key":"2025081219524691600_kfaf067-B2","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.chroma.2015.11.040","article-title":"Development of sample extraction and clean-up strategies for target and non-target analysis of environmental contaminants in biological matrices","volume":"1426","author":"Baduel","year":"2015","journal-title":"J Chromatogr A"},{"key":"2025081219524691600_kfaf067-B3","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.ntt.2009.06.006","article-title":"Interpreting epidemiologic studies of developmental neurotoxicity: conceptual and analytic issues","volume":"31","author":"Bellinger","year":"2009","journal-title":"Neurotoxicol Teratol"},{"key":"2025081219524691600_kfaf067-B4","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1021\/ci800249s","article-title":"How similar are similarity searching methods? A principal component analysis of molecular descriptor space","volume":"49","author":"Bender","year":"2009","journal-title":"J Chem Inf Model"},{"key":"2025081219524691600_kfaf067-B5","doi-asserted-by":"crossref","first-page":"27006","DOI":"10.1289\/EHP6233","article-title":"Evaluation of maternal, embryo, and placental effects in CD-1 mice following gestational exposure to perfluorooctanoic acid (PFOA) or hexafluoropropylene oxide dimer acid (HFPO-DA or GenX)","volume":"128","author":"Blake","year":"2020","journal-title":"Environ Health Perspect"},{"key":"2025081219524691600_kfaf067-B6","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1016\/j.neuron.2019.07.009","article-title":"Development and arealization of the cerebral cortex","volume":"103","author":"Cadwell","year":"2019","journal-title":"Neuron"},{"key":"2025081219524691600_kfaf067-B7","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1146\/annurev-pathol-012414-040405","article-title":"The emerging picture of autism spectrum disorder: genetics and pathology","volume":"10","author":"Chen","year":"2015","journal-title":"Annu Rev Pathol"},{"key":"2025081219524691600_kfaf067-B8","first-page":"7:e42474","article-title":"Perfluorinated compounds in umbilical cord blood and adverse birth outcomes","author":"Chen","year":"2012","journal-title":"PLoS One"},{"key":"2025081219524691600_kfaf067-B9","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/j.marpolbul.2009.04.021","article-title":"Alkylphenols in marine environments: distribution monitoring strategies and detection considerations","volume":"58","author":"David","year":"2009","journal-title":"Mar Pollut Bull"},{"key":"2025081219524691600_kfaf067-B10","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/nm.4071","article-title":"Advancing the understanding of autism disease mechanisms through genetics","volume":"22","author":"de la Torre-Ubieta","year":"2016","journal-title":"Nat Med"},{"key":"2025081219524691600_kfaf067-B11","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/S1473-3099(17)30398-5","article-title":"Infectious causes of microcephaly: epidemiology, pathogenesis, diagnosis, and management","volume":"18","author":"Devakumar","year":"2018","journal-title":"Lancet Infect Dis"},{"key":"2025081219524691600_kfaf067-B12","doi-asserted-by":"crossref","first-page":"106982","DOI":"10.1016\/j.envint.2021.106982","article-title":"Impairment of human dopaminergic neurons at different developmental stages by perfluoro-octanoic acid (PFOA) and differential human brain areas accumulation of perfluoroalkyl chemicals","volume":"158","author":"Di Nisio","year":"2022","journal-title":"Environ Int"},{"key":"2025081219524691600_kfaf067-B13","doi-asserted-by":"crossref","first-page":"687","DOI":"10.2105\/AJPH.2020.306014","article-title":"Neurotoxicity of ortho-phthalates: recommendations for critical policy reforms to protect brain development in children","volume":"111","author":"Engel","year":"2021","journal-title":"Am J Public Health"},{"key":"2025081219524691600_kfaf067-B14","volume-title":"Drinking water health advisory for perfluorooctane sulfonate (PFOS). Office of Water (4304T)","author":"US EPA","year":"2016"},{"key":"2025081219524691600_kfaf067-B15","doi-asserted-by":"crossref","first-page":"eabg9065","DOI":"10.1126\/science.abg9065","article-title":"Per-and polyfluoroalkyl substances in the environment","volume":"375","author":"Evich","year":"2022","journal-title":"Science"},{"key":"2025081219524691600_kfaf067-B16","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1002\/etc.4890","article-title":"Per-and polyfluoroalkyl substance toxicity and human health review: current state of knowledge and strategies for informing future research","volume":"40","author":"Fenton","year":"2021","journal-title":"Environ Toxicol Chem"},{"key":"2025081219524691600_kfaf067-B17","doi-asserted-by":"crossref","first-page":"2790","DOI":"10.1021\/acs.est.0c07033","article-title":"The exposome in the era of one health","volume":"55","author":"Gao","year":"2021","journal-title":"Environ Sci Technol"},{"key":"2025081219524691600_kfaf067-B18","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1101\/gr.276521.121","article-title":"Precision environmental health monitoring by longitudinal exposome and multi-omics profiling","volume":"32","author":"Gao","year":"2022","journal-title":"Genome Res"},{"key":"2025081219524691600_kfaf067-B19","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1016\/j.scitotenv.2015.10.017","article-title":"Prenatal exposure to perfluorinated chemicals and neurodevelopment in early infancy: the Hokkaido study","volume":"541","author":"Goudarzi","year":"2016","journal-title":"Sci Total Environ"},{"key":"2025081219524691600_kfaf067-B20","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1289\/ehp.0800408","article-title":"Childhood lead poisoning: conservative estimates of the social and economic benefits of lead hazard control","volume":"117","author":"Gould","year":"2009","journal-title":"Environ Health Perspect"},{"key":"2025081219524691600_kfaf067-B21","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/S1474-4422(13)70278-3","article-title":"Neurobehavioural effects of developmental toxicity","volume":"13","author":"Grandjean","year":"2014","journal-title":"Lancet Neurol"},{"key":"2025081219524691600_kfaf067-B22","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1038\/nrn3586","article-title":"Molecular logic of neocortical projection neuron specification, development and diversity","volume":"14","author":"Greig","year":"2013","journal-title":"Nat Rev Neurosci"},{"key":"2025081219524691600_kfaf067-B23","doi-asserted-by":"crossref","first-page":"8151","DOI":"10.1021\/es103712g","article-title":"Perfluorochemical (PFC) exposure in children: associations with impaired response inhibition","volume":"45","author":"Gump","year":"2011","journal-title":"Environ Sci Technol"},{"key":"2025081219524691600_kfaf067-B24","doi-asserted-by":"crossref","first-page":"133873","DOI":"10.1016\/j.chemosphere.2022.133873","article-title":"Concentrations of per-and polyfluoroalkyl substances (PFAS) in human placental tissues and associations with birth outcomes","volume":"295","author":"Hall","year":"2022","journal-title":"Chemosphere"},{"key":"2025081219524691600_kfaf067-B25","doi-asserted-by":"crossref","first-page":"3573","DOI":"10.1016\/j.cell.2021.04.048","article-title":"Integrated analysis of multimodal single-cell data","volume":"184","author":"Hao","year":"2021","journal-title":"Cell"},{"key":"2025081219524691600_kfaf067-B26","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1038\/s41592-022-01408-3","article-title":"Alevin-fry unlocks rapid, accurate and memory-frugal quantification of single-cell RNA-seq data","volume":"19","author":"He","year":"2022","journal-title":"Nat Methods"},{"key":"2025081219524691600_kfaf067-B27","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1038\/nrn4021","article-title":"Proliferation control in neural stem and progenitor cells","volume":"16","author":"Homem","year":"2015","journal-title":"Nat Rev Neurosci"},{"key":"2025081219524691600_kfaf067-B28","doi-asserted-by":"crossref","first-page":"4061","DOI":"10.1021\/acs.est.7b00872","article-title":"Activation of peroxisome proliferator-activated receptor gamma and disruption of progesterone synthesis of 2-ethylhexyl diphenyl phosphate in human placental choriocarcinoma cells: comparison with triphenyl phosphate","volume":"51","author":"Hu","year":"2017","journal-title":"Environ Sci Technol"},{"key":"2025081219524691600_kfaf067-B29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/10643389.2022.2050147","article-title":"Endocrine disrupting toxicity of aryl organophosphate esters and mode of action","volume":"53","author":"Hu","year":"2023","journal-title":"Crit Rev Environ Sci Technol"},{"key":"2025081219524691600_kfaf067-B30","doi-asserted-by":"crossref","first-page":"e27980","DOI":"10.1016\/j.heliyon.2024.e27980","article-title":"Co-detection of azoxystrobin and thiabendazole fungicides in mold and mildew resistant wallboards and in children","volume":"10","author":"Hu","year":"2024","journal-title":"Heliyon"},{"key":"2025081219524691600_kfaf067-B31","doi-asserted-by":"crossref","first-page":"27013","DOI":"10.1289\/EHP9808","article-title":"Detection of azoxystrobin fungicide and metabolite azoxystrobin-acid in pregnant women and children, estimation of daily intake, and evaluation of placental and lactational transfer in mice","volume":"130","author":"Hu","year":"2022","journal-title":"Environ Health Perspect"},{"key":"2025081219524691600_kfaf067-B32","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/s13229-021-00438-6","article-title":"Chd8 haploinsufficiency impairs early brain development and protein homeostasis later in life (vol 11)","volume":"12","author":"Jimenez","year":"2021","journal-title":"Molecular Autism"},{"key":"2025081219524691600_kfaf067-B33","doi-asserted-by":"crossref","first-page":"5555","DOI":"10.1038\/s41598-022-09533-x","article-title":"Developmental pyrethroid exposure and age influence phenotypes in a Chd8 haploinsufficient autism mouse model","volume":"12","author":"Jim\u00e9nez","year":"2022","journal-title":"Sci Rep"},{"key":"2025081219524691600_kfaf067-B34","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s11689-020-09353-y","article-title":"Controlling litter effects to enhance rigor and reproducibility with rodent models of neurodevelopmental disorders","volume":"13","author":"Jim\u00e9nez","year":"2021","journal-title":"J Neurodev Disord"},{"key":"2025081219524691600_kfaf067-B35","doi-asserted-by":"crossref","first-page":"8037","DOI":"10.1021\/es1043613","article-title":"Trends in exposure to polyfluoroalkyl chemicals in the US population: 1999\u2009\u2212\u20092008","volume":"45","author":"Kato","year":"2011","journal-title":"Environ Sci Technol"},{"key":"2025081219524691600_kfaf067-B36","doi-asserted-by":"crossref","DOI":"10.12688\/f1000research.24956.2","article-title":"gprofiler2\u2014an R package for gene list functional enrichment analysis and namespace conversion toolset g: Profiler","volume":"9","author":"Kolberg","year":"2020","journal-title":"F1000Res"},{"key":"2025081219524691600_kfaf067-B37","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1007\/s00204-019-02636-x","article-title":"Concentration\u2013response evaluation of ToxCast compounds for multivariate activity patterns of neural network function","volume":"94","author":"Kosnik","year":"2020","journal-title":"Arch Toxicol"},{"key":"2025081219524691600_kfaf067-B38","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1101\/gr.192237.115","article-title":"Single-cell RNA-seq reveals changes in cell cycle and differentiation programs upon aging of hematopoietic stem cells","volume":"25","author":"Kowalczyk","year":"2015","journal-title":"Genome Res"},{"key":"2025081219524691600_kfaf067-B39","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1093\/toxsci\/kfm128","article-title":"Perfluoroalkyl acids: a review of monitoring and toxicological findings","volume":"99","author":"Lau","year":"2007","journal-title":"Toxicol Sci"},{"key":"2025081219524691600_kfaf067-B40","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1093\/toxsci\/kfj105","article-title":"Effects of perfluorooctanoic acid exposure during pregnancy in the mouse","volume":"90","author":"Lau","year":"2006","journal-title":"Toxicol Sci"},{"key":"2025081219524691600_kfaf067-B41","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1038\/s41467-018-08079-9","article-title":"Single-cell transcriptomic analysis of mouse neocortical development","volume":"10","author":"Loo","year":"2019","journal-title":"Nat Commun"},{"key":"2025081219524691600_kfaf067-B42","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1007\/s00204-012-0822-6","article-title":"Neurotoxic effects of perfluoroalkylated compounds: mechanisms of action and environmental relevance","volume":"86","author":"Mariussen","year":"2012","journal-title":"Arch Toxicol"},{"key":"2025081219524691600_kfaf067-B43","author":"MERCURY","year":"1997"},{"key":"2025081219524691600_kfaf067-B44","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1038\/nrn2151","article-title":"Neuronal subtype specification in the cerebral cortex","volume":"8","author":"Molyneaux","year":"2007","journal-title":"Nat Rev Neurosci"},{"key":"2025081219524691600_kfaf067-B45","doi-asserted-by":"crossref","first-page":"1179069518759332","DOI":"10.1177\/1179069518759332","article-title":"Untangling cortical complexity during development","volume":"12","author":"Mukhtar","year":"2018","journal-title":"J Exp Neurosci"},{"key":"2025081219524691600_kfaf067-B46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12940-019-0493-3","article-title":"Prenatal plasma concentrations of perfluoroalkyl and polyfluoroalkyl substances and neuropsychological development in children at four years of age","volume":"18","author":"Niu","year":"2019","journal-title":"Environ Health"},{"key":"2025081219524691600_kfaf067-B47","doi-asserted-by":"crossref","first-page":"110939","DOI":"10.1016\/j.envres.2021.110939","article-title":"Prenatal exposure to per-and polyfluoroalkyl substances and cognitive development in infancy and toddlerhood","volume":"196","author":"Oh","year":"2021","journal-title":"Environ Res"},{"key":"2025081219524691600_kfaf067-B48","doi-asserted-by":"crossref","first-page":"107215","DOI":"10.1016\/j.envint.2022.107215","article-title":"Perfluorooctanoate and perfluorooctane sulfonate in umbilical cord blood and child cognitive development: Hamamatsu birth cohort for mothers and children (HBC study)","volume":"163","author":"Oh","year":"2022","journal-title":"Environ Int"},{"key":"2025081219524691600_kfaf067-B49","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1289\/ehp.10009","article-title":"Half-life of serum elimination of perfluorooctanesulfonate, perfluorohexanesulfonate, and perfluorooctanoate in retired fluorochemical production workers","volume":"115","author":"Olsen","year":"2007","journal-title":"Environ Health Perspect"},{"key":"2025081219524691600_kfaf067-B50","doi-asserted-by":"crossref","first-page":"932","DOI":"10.3390\/ijerph14080932","article-title":"Urinary levels of 4-nonylphenol and 4-t-octylphenol in a representative sample of the Korean adult population","volume":"14","author":"Park","year":"2017","journal-title":"Int J Environ Res Public Health"},{"key":"2025081219524691600_kfaf067-B51","doi-asserted-by":"crossref","first-page":"11173","DOI":"10.1038\/ncomms11173","article-title":"Identification of chemicals that mimic transcriptional changes associated with autism, brain aging and neurodegeneration","volume":"7","author":"Pearson","year":"2016","journal-title":"Nat Commun"},{"key":"2025081219524691600_kfaf067-B52","doi-asserted-by":"crossref","first-page":"126001","DOI":"10.1289\/EHP5133","article-title":"Identifying and prioritizing chemicals with uncertain burden of exposure: opportunities for biomonitoring and health-related research","volume":"127","author":"Pellizzari","year":"2019","journal-title":"Environ Health Perspect"},{"key":"2025081219524691600_kfaf067-B53","doi-asserted-by":"crossref","first-page":"3893","DOI":"10.1007\/s00204-020-02848-6","article-title":"Perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) induce epigenetic alterations and promote human breast cell carcinogenesis in vitro","volume":"94","author":"Pierozan","year":"2020","journal-title":"Arch Toxicol"},{"key":"2025081219524691600_kfaf067-B54","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1007\/s00204-018-2181-4","article-title":"Perfluorooctanoic acid (PFOA) exposure promotes proliferation, migration and invasion potential in human breast epithelial cells","volume":"92","author":"Pierozan","year":"2018","journal-title":"Arch Toxicol"},{"key":"2025081219524691600_kfaf067-B55","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.toxlet.2021.06.004","article-title":"Differential susceptibility of rat primary neurons and neural stem cells to PFOS and PFOA toxicity","volume":"349","author":"Pierozan","year":"2021","journal-title":"Toxicol Lett"},{"key":"2025081219524691600_kfaf067-B56","author":"National Toxicology Program","year":"2012"},{"key":"2025081219524691600_kfaf067-B57","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1093\/cercor\/13.6.541","article-title":"Developmental and evolutionary adaptations of cortical radial glia","volume":"13","author":"Rakic","year":"2003","journal-title":"Cereb Cortex"},{"key":"2025081219524691600_kfaf067-B58","doi-asserted-by":"crossref","first-page":"1960","DOI":"10.1096\/fj.14-260901","article-title":"Developmental pesticide exposure reproduces features of attention deficit hyperactivity disorder","volume":"29","author":"Richardson","year":"2015","journal-title":"Faseb J"},{"key":"2025081219524691600_kfaf067-B59","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1126\/science.aam8999","article-title":"SPLiT-seq reveals cell types and lineages in the developing brain and spinal cord","volume":"360","author":"Rosenberg","year":"2018","journal-title":"Science"},{"key":"2025081219524691600_kfaf067-B60","doi-asserted-by":"crossref","first-page":"2415","DOI":"10.1073\/pnas.0712168105","article-title":"A chemical method for fast and sensitive detection of DNA synthesis in vivo","volume":"105","author":"Salic","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2025081219524691600_kfaf067-B61","doi-asserted-by":"crossref","first-page":"114444","DOI":"10.1016\/j.envpol.2020.114444","article-title":"The association between prenatal exposure to perfluoroalkyl substances and childhood neurodevelopment","volume":"263","author":"Spratlen","year":"2020","journal-title":"Environ Pollut"},{"key":"2025081219524691600_kfaf067-B62","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1016\/j.cell.2019.05.031","article-title":"Comprehensive integration of single-cell data","volume":"177","author":"Stuart","year":"2019","journal-title":"Cell"},{"key":"2025081219524691600_kfaf067-B63","doi-asserted-by":"crossref","first-page":"8875604","DOI":"10.1155\/2020\/8875604","article-title":"4-tert-Octylphenol exposure disrupts brain development and subsequent motor, cognition, social, and behavioral functions","volume":"2020","author":"Tran","year":"2020","journal-title":"Oxid Med Cell Longev"},{"key":"2025081219524691600_kfaf067-B64","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.chemosphere.2018.11.126","article-title":"Choice of vehicle affects pyraclostrobin toxicity in mice","volume":"218","author":"Tuttle","year":"2019","journal-title":"Chemosphere"},{"key":"2025081219524691600_kfaf067-B67","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1126\/science.aay3164","article-title":"The exposome and health: where chemistry meets biology","volume":"367","author":"Vermeulen","year":"2020","journal-title":"Science"},{"key":"2025081219524691600_kfaf067-B68","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1126\/science.aba7127","article-title":"Nontargeted mass-spectral detection of chloroperfluoropolyether carboxylates in New Jersey soils","volume":"368","author":"Washington","year":"2020","journal-title":"Science"},{"key":"2025081219524691600_kfaf067-B69","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1096\/fba.2021-00163","article-title":"ToxCast chemical library Wnt screen identifies diethanolamine as an activator of neural progenitor proliferation","volume":"4","author":"Wolter","year":"2022","journal-title":"FASEB Bioadv"},{"key":"2025081219524691600_kfaf067-B70","doi-asserted-by":"crossref","first-page":"112706","DOI":"10.1016\/j.celrep.2023.112706","article-title":"Autism-linked UBE3A gain-of-function mutation causes interneuron and behavioral phenotypes when inherited maternally or paternally in mice","volume":"42","author":"Xing","year":"2023","journal-title":"Cell Rep"},{"key":"2025081219524691600_kfaf067-B71","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.envint.2019.02.009","article-title":"Relationship between perfluorooctanoate and perfluorooctane sulfonate blood concentrations in the general population and routine drinking water exposure","volume":"126","author":"Zhang","year":"2019","journal-title":"Environ Int"},{"key":"2025081219524691600_kfaf067-B72","doi-asserted-by":"crossref","first-page":"13429","DOI":"10.1021\/acs.est.3c05026","article-title":"Urine excretion, organ distribution, and placental transfer of 6PPD and 6PPD-quinone in mice and potential developmental toxicity through nuclear receptor pathways","volume":"57","author":"Zhao","year":"2023","journal-title":"Environ Sci Technol"},{"key":"2025081219524691600_kfaf067-B73","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.envpol.2017.05.043","article-title":"Neurotoxicity of low bisphenol A (BPA) exposure for young male mice: implications for children exposed to environmental levels of BPA","volume":"229","author":"Zhou","year":"2017","journal-title":"Environ Pollut"},{"key":"2025081219524691600_kfaf067-B74","doi-asserted-by":"crossref","first-page":"571","DOI":"10.3390\/toxics11070571","article-title":"Research progress on neurodevelopmental toxicity in offspring after indirect exposure to PFASs in early life","volume":"11","author":"Zhuchen","year":"2023","journal-title":"Toxics"},{"key":"2025081219524691600_kfaf067-B75","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1093\/toxsci\/kfaa014","article-title":"Profiling the ToxCast library with a pluripotent human (H9) stem cell line-based biomarker assay for developmental toxicity","volume":"174","author":"Zurlinden","year":"2020","journal-title":"Toxicol Sci"}],"container-title":["Toxicological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/toxsci\/advance-article-pdf\/doi\/10.1093\/toxsci\/kfaf067\/63134823\/kfaf067.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/toxsci\/article-pdf\/206\/2\/433\/63134823\/kfaf067.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/toxsci\/article-pdf\/206\/2\/433\/63134823\/kfaf067.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T23:53:01Z","timestamp":1755042781000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/toxsci\/article\/206\/2\/433\/8127757"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,10]]},"references-count":73,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,5,10]]},"published-print":{"date-parts":[[2025,8,1]]}},"URL":"https:\/\/doi.org\/10.1093\/toxsci\/kfaf067","relation":{},"ISSN":["1096-6080","1096-0929"],"issn-type":[{"value":"1096-6080","type":"print"},{"value":"1096-0929","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,8]]},"published":{"date-parts":[[2025,5,10]]}}}