{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:09:03Z","timestamp":1792786143282,"version":"4.5.0"},"reference-count":55,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T00:00:00Z","timestamp":1773360000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82360672"],"award-info":[{"award-number":["82360672"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U1812403"],"award-info":[{"award-number":["U1812403"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Guizhou Medical University of China","award":["21NSFCP01"],"award-info":[{"award-number":["21NSFCP01"]}],"id":[{"id":"https:\/\/ror.org\/035y7a716","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Chronic fluorosis can cause injury to the central nervous system. Because fat mass and obesity-associated protein (FTO) connected with demethylation of N6-methyladenosine (m6A) plays a crucial role in maintaining brain function, we examined whether FTO might help resist the neurotoxicity of fluoride. Sprague-Dawley rats with chronic fluorosis and cultured nerve cells exposed to fluoride with overexpression or knockdown of FTO were employed. The Morris water maze test was employed to assess learning and memory. Expressions of FTO, m6A, postsynaptic density protein 95 (PSD95) and \u03b1-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs) and its subunit GluR2 mRNA stability, apoptosis, and reactive oxygen species (ROS) were determined by Western blotting, RT-PCR, and biochemical methods, respectively. The results showed that the impaired learning and memory of rats with chronic fluorosis, the decreased FTO, PSD95 and AMPARs, the elevated m6A, and the disrupted synapse morphology as well as apoptosis in their brains were determined. Similar abnormal changes were further confirmed in primary neurons and SH-SY5Y cells exposed to fluoride, accompanied by a significant decline of GluR2 and high ROS. Notably, overexpression of FTO reduced m6A, enhanced GluR2, and attenuated neurotoxicity induced by fluoride, whereas knockdown had the opposite effects. FTO can alleviate the neurotoxicity induced by fluoride, in which the mechanism may be involved in its regulating m6A to enhance expression of GluR2.<\/jats:p>","DOI":"10.1093\/toxsci\/kfag031","type":"journal-article","created":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T12:50:10Z","timestamp":1772628610000},"source":"Crossref","is-referenced-by-count":1,"title":["Alleviating effects of fat mass and obesity-associated protein on fluoride-induced neurotoxicity in rat brain, primary neurons, and SH-SY5Y cells"],"prefix":"10.1093","volume":"209","author":[{"given":"Xiao-Xiao","family":"Zeng","sequence":"first","affiliation":[{"name":"Department of Pathology at the Affiliated Hospital, Guizhou Medical University , Guiyang 550004, P. R. of","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Wen","family":"He","sequence":"additional","affiliation":[{"name":"Department of Pathology at the Affiliated Hospital, Guizhou Medical University , Guiyang 550004, P. R. of","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Pathology at the Affiliated Hospital, Guizhou Medical University , Guiyang 550004, P. R. of","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Pathology at the Affiliated Hospital, Guizhou Medical University , Guiyang 550004, P. R. of","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Tu","sequence":"additional","affiliation":[{"name":"Department of Pathology at the Affiliated Hospital, Guizhou Medical University , Guiyang 550004, P. R. of","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Deng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Endemic and Ethnic Diseases (Guizhou Medical University) of the Ministry of Education and Provincial Key Laboratory of Medical Molecular Biology , Guiyang 550004, P. R. of","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Lan","family":"Qi","sequence":"additional","affiliation":[{"name":"Key Laboratory of Endemic and Ethnic Diseases (Guizhou Medical University) of the Ministry of Education and Provincial Key Laboratory of Medical Molecular Biology , Guiyang 550004, P. R. of","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang-Ting","family":"Dong","sequence":"additional","affiliation":[{"name":"Key Laboratory of Endemic and Ethnic Diseases (Guizhou Medical University) of the Ministry of Education and Provincial Key Laboratory of Medical Molecular Biology , Guiyang 550004, P. R. of","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Hong","sequence":"additional","affiliation":[{"name":"Key Laboratory of Endemic and Ethnic Diseases (Guizhou Medical University) of the Ministry of Education and Provincial Key Laboratory of Medical Molecular Biology , Guiyang 550004, P. R. of","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"He","sequence":"additional","affiliation":[{"name":"Key Laboratory of Endemic and Ethnic Diseases (Guizhou Medical University) of the Ministry of Education and Provincial Key Laboratory of Medical Molecular Biology , Guiyang 550004, P. R. of","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Xiao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Endemic and Ethnic Diseases (Guizhou Medical University) of the Ministry of Education and Provincial Key Laboratory of Medical Molecular Biology , Guiyang 550004, P. R. of","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Pathology at the Affiliated Hospital, Guizhou Medical University , Guiyang 550004, P. R. of","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Zhong","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of Pathology at the Affiliated Hospital, Guizhou Medical University , Guiyang 550004, P. R. of","place":["China"]},{"name":"Key Laboratory of Endemic and Ethnic Diseases (Guizhou Medical University) of the Ministry of Education and Provincial Key Laboratory of Medical Molecular Biology , Guiyang 550004, P. R. of","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,3,13]]},"reference":[{"key":"2026100207222402100_kfag031-B1","doi-asserted-by":"crossref","first-page":"717","DOI":"10.3390\/ijms22020717","article-title":"Oxidative stress underlies the ischemia\/reperfusion-induced internalization and degradation of AMPA receptors","volume":"22","author":"Achzet","year":"2021","journal-title":"Int J Mol Sci"},{"key":"2026100207222402100_kfag031-B2","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1080\/10408444.2020.1722061","article-title":"Inorganic fluoride and functions of brain","volume":"50","author":"Agalakova","year":"2020","journal-title":"Crit Rev Toxicol"},{"key":"2026100207222402100_kfag031-B3","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1093\/toxsci\/kfy172","article-title":"m6A demethylase FTO regulates dopaminergic neurotransmission deficits caused by arsenite","volume":"165","author":"Bai","year":"2018","journal-title":"Toxicol Sci"},{"key":"2026100207222402100_kfag031-B4","doi-asserted-by":"crossref","first-page":"116005","DOI":"10.1016\/j.celrep.2025.116005","article-title":"Alzheimer\u2019s genetic risk factor Bin1 controls synapse vesicle exo-endocytosis in inhibitory synapses","volume":"44","author":"Barata","year":"2025","journal-title":"Cell Rep"},{"key":"2026100207222402100_kfag031-B5","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1038\/s41580-020-0270-8","article-title":"Emerging connectivity of programmed cell death pathways and its physiological implications","volume":"21","author":"Bedoui","year":"2020","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2026100207222402100_kfag031-B6","doi-asserted-by":"crossref","first-page":"19535","DOI":"10.1073\/pnas.0608492103","article-title":"Synapse-specific regulation of AMPA receptor function by PSD-95","volume":"103","author":"B\u00e9\u00efque","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"2026100207222402100_kfag031-B7","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1093\/hmg\/ddz274","article-title":"Dynamic effects of FTO in regulating the proliferation and differentiation of adult neural stem cells of mice","volume":"29","author":"Cao","year":"2020","journal-title":"Hum Mol Genet"},{"key":"2026100207222402100_kfag031-B8","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1161\/STROKEAHA.122.040401","article-title":"Cerebroprotective role of n6-methyladenosine demethylase FTO (fat mass and obesity-associated protein) after experimental stroke","volume":"54","author":"Chokkalla","year":"2023","journal-title":"Stroke"},{"key":"2026100207222402100_kfag031-B9","doi-asserted-by":"crossref","first-page":"2655","DOI":"10.1113\/JP279029","article-title":"Ca2+-permeable AMPA receptors and their auxiliary subunits in synaptic plasticity and disease","volume":"599","author":"Cull-Candy","year":"2021","journal-title":"J Physiol"},{"key":"2026100207222402100_kfag031-B10","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.neuron.2018.10.018","article-title":"The AMPA receptor code of synaptic plasticity","volume":"100","author":"Diering","year":"2018","journal-title":"Neuron"},{"key":"2026100207222402100_kfag031-B11","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1007\/s00204-014-1408-2","article-title":"Deficit in learning and memory of rats with chronic fluorosis correlates with the decreased expressions of M1 and M3 muscarinic acetylcholine receptors","volume":"89","author":"Dong","year":"2015","journal-title":"Arch Toxicol"},{"key":"2026100207222402100_kfag031-B12","doi-asserted-by":"crossref","first-page":"e14005","DOI":"10.1371\/journal.pone.0014005","article-title":"The fat mass and obesity associated gene FTO functions in the brain to regulate postnatal growth in mice","volume":"5","author":"Gao","year":"2010","journal-title":"PLoS One"},{"key":"2026100207222402100_kfag031-B13","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1126\/science.1151710","article-title":"The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase","volume":"318","author":"Gerken","year":"2007","journal-title":"Science"},{"key":"2026100207222402100_kfag031-B14","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.neuron.2017.04.009","article-title":"Structural and functional architecture of AMPA-Type glutamate receptors and their auxiliary proteins","volume":"94","author":"Greger","year":"2017","journal-title":"Neuron"},{"key":"2026100207222402100_kfag031-B15","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-981-16-1498-9_1","volume-title":"Coal-burning type of endemic fluorosis: pathophysiology and clinical treatments","author":"Guan","year":"2021"},{"key":"2026100207222402100_kfag031-B16","doi-asserted-by":"crossref","first-page":"711564","DOI":"10.3389\/fncir.2021.711564","article-title":"Calcium permeable-AMPA receptors and excitotoxicity in neurologicaldisorders","volume":"15","author":"Guo","year":"2021","journal-title":"Front Neural Circuits"},{"key":"2026100207222402100_kfag031-B17","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1038\/nn.3449","article-title":"The fat mass and obesity associated gene (FTO) regulates activity of the dopaminergic midbrain circuitry","volume":"16","author":"Hess","year":"2013","journal-title":"Nat Neurosci"},{"key":"2026100207222402100_kfag031-B18","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s13105-022-00929-x","article-title":"FTO inhibits oxidative stress by mediating m6A demethylation of Nrf2 to alleviate cerebral ischemia\/reperfusion injury","volume":"79","author":"Hou","year":"2023","journal-title":"J Physiol Biochem"},{"key":"2026100207222402100_kfag031-B19","doi-asserted-by":"crossref","first-page":"116816","DOI":"10.1016\/j.ecoenv.2024.116816","article-title":"Fluoride exposure-induced gut microbiota alteration mediates colonic ferroptosis through N6-methyladenosine (m6A) mediated silencing of SLC7A11","volume":"283","author":"Huang","year":"2024","journal-title":"Ecotoxicol Environ Saf"},{"key":"2026100207222402100_kfag031-B20","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s13046-022-02254-z","article-title":"FTO suppresses glycolysis and growth of papillary thyroid cancer via decreasing stability of APOE mRNA in an N6-methyladenosine-dependent manner","volume":"41","author":"Huang","year":"2022","journal-title":"J. Exp. Clin. Cancer Res"},{"key":"2026100207222402100_kfag031-B21","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/j.neuron.2007.06.001","article-title":"The role of the GluR2 subunit in AMPA receptor function and synaptic plasticity","volume":"54","author":"Isaac","year":"2007","journal-title":"Neuron"},{"key":"2026100207222402100_kfag031-B22","doi-asserted-by":"crossref","first-page":"4784","DOI":"10.1038\/s41467-023-40422-7","article-title":"Modulation of translational decoding by m6A modification of mRNA","volume":"14","author":"Jain","year":"2023","journal-title":"Nat Commun"},{"key":"2026100207222402100_kfag031-B23","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1007\/s00204-020-02687-5","article-title":"Principles of fluoride toxicity and the cellular response: a review","volume":"94","author":"Johnston","year":"2020","journal-title":"Arch Toxicol"},{"key":"2026100207222402100_kfag031-B24","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1038\/427801a","article-title":"Glutamate receptors: RNA editing and death of motor neurons","volume":"427","author":"Kawahara","year":"2004","journal-title":"Nature"},{"key":"2026100207222402100_kfag031-B25","first-page":"ZC10","article-title":"Relationship between dental fluorosis and intelligence quotient of school going children in and around Lucknow district: a cross-sectional study","volume":"9","author":"Khan","year":"2015","journal-title":"J Clin Diagn Res"},{"key":"2026100207222402100_kfag031-B26","doi-asserted-by":"crossref","first-page":"2398","DOI":"10.1093\/hmg\/ddx128","article-title":"Fat mass and obesity-associated (FTO) protein regulates adult neurogenesis","volume":"26","author":"Li","year":"2017","journal-title":"Hum Mol Genet"},{"key":"2026100207222402100_kfag031-B27","doi-asserted-by":"crossref","first-page":"113682","DOI":"10.1016\/j.ecoenv.2022.113682","article-title":"Gestational exposure to fluoride impairs cognition in C57 BL\/6 J male offspring mice via the p-Creb1-BDNF-TrkB signaling pathway","volume":"239","author":"Li","year":"2022","journal-title":"Ecotoxicol Environ Saf"},{"key":"2026100207222402100_kfag031-B28","doi-asserted-by":"crossref","first-page":"D194","DOI":"10.1093\/nar\/gkad691","article-title":"m6A-Atlas v2.0: updated resources for unraveling the N6-methyladenosine (m6A) epitranscriptome among multiple species","volume":"52","author":"Liang","year":"2024","journal-title":"Nucleic Acids Res"},{"key":"2026100207222402100_kfag031-B29","doi-asserted-by":"crossref","first-page":"6937","DOI":"10.1038\/s41467-021-27044-7","article-title":"Fat mass and obesity-associated protein regulates RNA methylation associated with depression-like behavior in mice","volume":"12","author":"Liu","year":"2021","journal-title":"Nat Commun"},{"key":"2026100207222402100_kfag031-B30","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.tins.2007.01.006","article-title":"Ca2+-permeable AMPA receptors in synaptic plasticity and neuronal death","volume":"30","author":"Liu","year":"2007","journal-title":"Trends Neurosci"},{"key":"2026100207222402100_kfag031-B31","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1007\/s00204-012-0942-z","article-title":"The influence of chronic fluorosis on mitochondrial dynamics morphology and distribution in cortical neurons of the rat brain","volume":"87","author":"Lou","year":"2013","journal-title":"Arch Toxicol"},{"key":"2026100207222402100_kfag031-B32","doi-asserted-by":"crossref","first-page":"1973","DOI":"10.1007\/s00467-008-0890-2","article-title":"The effect of fluoride on enamel and dentin formation in the uremic rat incisor","volume":"23","author":"Lyaruu","year":"2008","journal-title":"Pediatr Nephrol"},{"key":"2026100207222402100_kfag031-B33","doi-asserted-by":"crossref","first-page":"7141","DOI":"10.1038\/s41380-021-01282-z","article-title":"Modifying the m6A brain methylome by ALKBH5-mediated demethylation: a new contender for synaptic tagging","volume":"26","author":"Martinez De La Cruz","year":"2021","journal-title":"Mol Psychiatry"},{"key":"2026100207222402100_kfag031-B34","doi-asserted-by":"crossref","first-page":"11796","DOI":"10.3390\/ijms252111796","article-title":"AMPA and NMDA receptors in hippocampus of rats with fluoride-induced cognitive decline","volume":"25","author":"Nadei","year":"2024","journal-title":"Int J Mol Sci"},{"key":"2026100207222402100_kfag031-B35","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/978-1-4939-8808-2_20","article-title":"Dot blot analysis for measuring global N6-methyladenosine modification of RNA","volume":"1870","author":"Nagarajan","year":"2019","journal-title":"Methods Mol Biol"},{"key":"2026100207222402100_kfag031-B36","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/j.chemosphere.2017.12.027","article-title":"Effects of fluoride on synapse morphology and myelin damage in mouse hippocampus","volume":"194","author":"Niu","year":"2018","journal-title":"Chemosphere"},{"key":"2026100207222402100_kfag031-B37","doi-asserted-by":"crossref","first-page":"3724","DOI":"10.1007\/s12011-024-04433-9","article-title":"Effect of voluntary wheel running on anxiety- and depression-like behaviors in fluoride-exposed mice","volume":"203","author":"Qi","year":"2025","journal-title":"Biol Trace Elem Res"},{"key":"2026100207222402100_kfag031-B38","doi-asserted-by":"crossref","first-page":"128099","DOI":"10.1016\/j.jhazmat.2021.128099","article-title":"Protective role of mRNA demethylase FTO on axon guidance molecules of nigro-striatal projection system in manganese-induced parkinsonism","volume":"426","author":"Qi","year":"2022","journal-title":"J Hazard Mater"},{"key":"2026100207222402100_kfag031-B39","doi-asserted-by":"crossref","first-page":"2327","DOI":"10.1007\/s00204-025-04003-5","article-title":"Dose-dependent developmental fluoride exposure leads to neurotoxicity and impairs excitatory synapse development","volume":"99","author":"Qiu","year":"2025","journal-title":"Arch Toxicol"},{"key":"2026100207222402100_kfag031-B40","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1111\/cns.14090","article-title":"The influence of NQO2 on the dysfunctional autophagy and oxidative stress induced in the hippocampus of rats and in SH-SY5Y cells by fluoride","volume":"29","author":"Ran","year":"2023","journal-title":"CNS Neurosci Ther"},{"key":"2026100207222402100_kfag031-B41","doi-asserted-by":"crossref","first-page":"114021","DOI":"10.1016\/j.ecoenv.2022.114021","article-title":"Effects of chronic fluorosis on the brain","volume":"244","author":"Ren","year":"2022","journal-title":"Ecotoxicol Environ Saf"},{"key":"2026100207222402100_kfag031-B42","doi-asserted-by":"crossref","first-page":"3094","DOI":"10.1038\/s41467-019-10910-w","article-title":"AMPA receptor GluA2 subunit defects are a cause of neurodevelopmental disorders","volume":"10","author":"Salpietro","year":"2019","journal-title":"Nat Commun"},{"key":"2026100207222402100_kfag031-B43","doi-asserted-by":"crossref","first-page":"47008","DOI":"10.1289\/EHP14534","article-title":"Prenatal and childhood exposure to fluoride and cognitive development: findings from the longitudinal MINIMat cohort in rural Bangladesh","volume":"133","author":"Singh","year":"2025","journal-title":"Environ Health Perspect"},{"key":"2026100207222402100_kfag031-B44","doi-asserted-by":"crossref","first-page":"150601","DOI":"10.1016\/j.scitotenv.2021.150601","article-title":"Fluoride occurrences, health problems, detection, and remediation methods for drinking water: a comprehensive review","volume":"807","author":"Solanki","year":"2022","journal-title":"Sci Total Environ"},{"key":"2026100207222402100_kfag031-B45","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1177\/0960327117693067","article-title":"Maternal fluoride exposure during gestation and lactation decreased learning and memory ability, and glutamate receptor mRNA expressions of mouse pups","volume":"37","author":"Sun","year":"2018","journal-title":"Hum Exp Toxicol"},{"key":"2026100207222402100_kfag031-B46","doi-asserted-by":"crossref","first-page":"e70263","DOI":"10.1111\/acel.70263","article-title":"The m6A demethylase FTO enhances susceptibility to atrial fibrillation by demethylating Kcne1 in aging mice","volume":"24","author":"Tan","year":"2025","journal-title":"Aging Cell"},{"key":"2026100207222402100_kfag031-B47","doi-asserted-by":"crossref","first-page":"e2201889","DOI":"10.1002\/advs.202201889","article-title":"APAF1-binding long noncoding RNA promotes tumor growth and multidrug resistance in gastric cancer by blocking apoptosome assembly","volume":"9","author":"Wang","year":"2022","journal-title":"Adv. Sci. (Weinh)"},{"key":"2026100207222402100_kfag031-B48","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1016\/j.cell.2015.05.014","article-title":"N(6)-methyladenosine modulates messenger RNA translation efficiency","volume":"161","author":"Wang","year":"2015","journal-title":"Cell"},{"key":"2026100207222402100_kfag031-B49","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/j.molcel.2018.08.011","article-title":"Differential m6A, m6Am, and m1A demethylation mediated by FTO in the cell nucleus and cytoplasm","volume":"71","author":"Wei","year":"2018","journal-title":"Mol Cell"},{"key":"2026100207222402100_kfag031-B50","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1038\/s41588-021-00890-3","article-title":"Genetic drivers of m6A methylation in human brain, lung, heart and muscle","volume":"53","author":"Xiong","year":"2021","journal-title":"Nat. Genet"},{"key":"2026100207222402100_kfag031-B51","doi-asserted-by":"crossref","first-page":"3759","DOI":"10.1007\/s12035-021-02363-4","article-title":"Comprehensive analysis of differential m6A RNA methylomes in the hippocampus of cocaine-conditioned mice","volume":"58","author":"Xue","year":"2021","journal-title":"Mol Neurobiol"},{"key":"2026100207222402100_kfag031-B52","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s12929-021-00734-6","article-title":"The m6A epitranscriptome on neural development and degeneration","volume":"28","author":"Yen","year":"2021","journal-title":"J Biomed Sci"},{"key":"2026100207222402100_kfag031-B53","doi-asserted-by":"crossref","first-page":"126475","DOI":"10.1016\/j.jtemb.2020.126475","article-title":"Protections against toxicity in the brains of rat with chronic fluorosis and primary neurons exposed to fluoride by resveratrol involves nicotinic acetylcholine receptors","volume":"60","author":"Zeng","year":"2020","journal-title":"J Trace Elem Med Biol"},{"key":"2026100207222402100_kfag031-B54","doi-asserted-by":"crossref","first-page":"794766","DOI":"10.3389\/fgene.2021.794766","article-title":"Case report: a novel de novo missense mutation of the GRIA2 gene in a Chinese case of neurodevelopmental disorder with language impairment","volume":"12","author":"Zhou","year":"2021","journal-title":"Front Genet"},{"key":"2026100207222402100_kfag031-B55","doi-asserted-by":"crossref","first-page":"e91","DOI":"10.1093\/nar\/gkw104","article-title":"SRAMP: prediction of mammalian N6-methyladenosine (m6A) sites based on sequence-derived features","volume":"44","author":"Zhou","year":"2016","journal-title":"Nucleic Acids Res"}],"container-title":["Toxicological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/toxsci\/advance-article-pdf\/doi\/10.1093\/toxsci\/kfag031\/67349610\/kfag031.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/toxsci\/article-pdf\/209\/4\/kfag031\/71574588\/kfag031.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/toxsci\/article-pdf\/209\/4\/kfag031\/71574588\/kfag031.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T11:22:33Z","timestamp":1790940153000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/toxsci\/article\/doi\/10.1093\/toxsci\/kfag031\/8520919"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,13]]},"references-count":55,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4,7]]}},"URL":"https:\/\/doi.org\/10.1093\/toxsci\/kfag031","relation":{},"ISSN":["1096-0929"],"issn-type":[{"value":"1096-0929","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,4]]},"published":{"date-parts":[[2026,3,13]]},"article-number":"kfag031"}}