{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T18:15:20Z","timestamp":1784139320851,"version":"3.55.0"},"reference-count":75,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01 DK122028"],"award-info":[{"award-number":["R01 DK122028"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["T32 ES026568"],"award-info":[{"award-number":["T32 ES026568"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ray Nesbitt Chair endowment"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Aryl hydrocarbon receptor nuclear translocator 2 is a member of the basic helix-loop-helix\/Per-ARNT-Sim family of transcription factors involved in responding to various environmental, metabolic, and chemical signals. Initially known for its involvement in neurodevelopment, ARNT2 is now recognized as an essential binding partner for other transcription factors, including single-minded homologs 1 and 2, neuronal PAS domain protein 4, hypoxia-inducible factor 1, and plausibly Aryl hydrocarbon receptor to regulate stress adaptation, synaptic plasticity, immune signaling, and energy balance pathways. The role of ARNT2 has also been implicated in a plethora of pathologies, including inflammation, cardiovascular diseases, neurological disorders, metabolic diseases, and cancers. This review summarizes the current knowledge of ARNT2\u2019s structure, regulation, interacting partners, and its toxicopathological significance. A better understanding of ARNT2 biology may open new avenues for its characterization as a molecular target and designing novel therapeutic strategies across multiple diseases.<\/jats:p>","DOI":"10.1093\/toxsci\/kfag078","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T23:38:50Z","timestamp":1782862730000},"source":"Crossref","is-referenced-by-count":0,"title":["Aryl hydrocarbon receptor nuclear translocator 2: a forgotten per-ARNT-Sim transcription factor"],"prefix":"10.1093","volume":"209","author":[{"given":"Israt","family":"Jahan","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Biophysics, Texas A&M University , College Station, TX 77843,","place":["United States"]},{"name":"Department of Veterinary Physiology and Pharmacology, Texas A&M University , College Station, TX 77843,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yadeliz A","family":"Serrano Matos","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering, Texas A&M University , College Station, TX 77843,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arul","family":"Jayaraman","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering, Texas A&M University , College Station, TX 77843,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5208-5144","authenticated-orcid":false,"given":"Aditya D","family":"Joshi","sequence":"additional","affiliation":[{"name":"Department of Veterinary Physiology and Pharmacology, Texas A&M University , College Station, TX 77843,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,6,30]]},"reference":[{"key":"2026071514004229400_kfag078-B1","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1177\/002215540305100106","article-title":"Expression of ARNT and ARNT2 mRNA in developing murine tissues","volume":"51","author":"Aitola","year":"2003","journal-title":"J Histochem Cytochem"},{"key":"2026071514004229400_kfag078-B2","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1002\/tera.10062","article-title":"Aryl hydrocarbon receptor nuclear translocator 2 (ARNT2): structure, gene mapping, polymorphisms, and candidate evaluation for human orofacial clefts","volume":"66","author":"Barrow","year":"2002","journal-title":"Teratology"},{"key":"2026071514004229400_kfag078-B3","doi-asserted-by":"crossref","first-page":"e745","DOI":"10.1212\/NXI.0000000000000745","article-title":"Oligodendrocyte ARNT2 expression is altered in models of 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