{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T18:19:28Z","timestamp":1787681968838,"version":"build-2784847793"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"vor","delay-in-days":12,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Foundation for Chemistry Research & Initiatives (FCRI) in coordination"},{"name":"American Chemistry Council\u2019s Polycarbonate\/BPA Global Group"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The objective of this investigation was to determine whether direct addition of BPA to cultured primary mouse or human na\u00efve CD4+ T cells promotes IL-17A production and Th17 cell differentiation and to assess the role of aryl hydrocarbon receptor (AHR) in promoting IL-17A regulation. Kinetic studies showed IL-17 concentrations peaked by day 4 post-activation in the mouse and on day 6 in human CD4+ T cells under Th17 polarizing and nonpolarizing conditions. AHR activation in murine CD4+ T cells by TCDD or FICZ promoted IL-17A and IL-22 secretion compared with vehicle controls under non-Th17 polarizing conditions. In contrast, AHR antagonism by CH223191 promoted IL-17 production in human CD4+ T cells while IL-22 secretion was reduced compared with controls. AHR activation by FICZ in human CD4+ T cells decreased IL-17 while increasing IL-22 secretion. Conversely, AHR antagonism in murine CD4+ T cells suppressed IL-17A and IL-22 responses. BPA treatment of CD4+ T cells from either species did not produce a significant increase in IL-17A-positive cells or increased IL-17 secretion, whereas FICZ and CH223191 treatment induced IL-17A increases under nonpolarizing and\/or polarizing conditions in CD4+ T cells from mouse and human, respectively. These studies suggest that BPA treatment of mature, na\u00efve CD4+ T cells from either species does not induce IL-17A or IL-22 secretion, whereas AHR activation inversely regulates IL-17A responses between species. These results confirm published results showing CD4+ T cells are refractory to BPA-mediated effects on IL-17, suggesting reported BPA effects in murine CD4+ T cells may be strain-dependent.<\/jats:p>","DOI":"10.1093\/toxsci\/kfag101","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T13:46:58Z","timestamp":1786628818000},"source":"Crossref","is-referenced-by-count":0,"title":["<i>In vitro<\/i>\n                    characterization of the role of aryl hydrocarbon receptor and bisphenol A on IL-17A regulation in mouse and human CD4+ T cells"],"prefix":"10.1093","volume":"209","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8911-8843","authenticated-orcid":false,"given":"Lance K","family":"Blevins","sequence":"first","affiliation":[{"name":"Institute for Integrative Toxicology , Michigan State University, East Lansing, MI 48824,","place":["United States"]},{"name":"Michigan State University , East Lansing, MI 48824,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert B","family":"Crawford","sequence":"additional","affiliation":[{"name":"Institute for Integrative Toxicology , Michigan State University, East Lansing, MI 48824,","place":["United States"]},{"name":"Michigan State University , East Lansing, MI 48824,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norbert E","family":"Kaminski","sequence":"additional","affiliation":[{"name":"Institute for Integrative Toxicology , Michigan State University, East Lansing, MI 48824,","place":["United States"]},{"name":"Michigan State University , East Lansing, MI 48824,","place":["United States"]},{"name":"Department of Toxicology & Pharmacology , Michigan State University, East Lansing, MI 48824,","place":["United States"]},{"name":"Center for Research on Ingredient Safety , Michigan State University, East Lansing, MI 48824,","place":["United 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