{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T09:47:13Z","timestamp":1791884833713,"version":"4.3.4"},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"National Institutes on Drug Abuse","award":["R21DA062849"],"award-info":[{"award-number":["R21DA062849"]}],"id":[{"id":"https:\/\/ror.org\/00fq5cm18","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,2]]},"DOI":"10.1093\/toxsci\/kfag104","type":"journal-article","created":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:30:13Z","timestamp":1787837413000},"source":"Crossref","is-referenced-by-count":0,"title":["Nicotine analogs in e-cigarettes: unrecognized health risks and insufficient regulatory oversight"],"prefix":"10.1093","volume":"209","author":[{"given":"Alexis A","family":"Graham","sequence":"first","affiliation":[{"name":"University of North Carolina at Chapel Hill Center for Environmental Medicine, Asthma, and Lung Biology, , Chapel Hill, NC 27599,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3646-0730","authenticated-orcid":false,"given":"Elizabeth M","family":"Corteselli","sequence":"additional","affiliation":[{"name":"University of North Carolina at Chapel Hill Center for Environmental Medicine, Asthma, and Lung Biology, , Chapel Hill, NC 27599,","place":["United States"]},{"name":"Department of Pediatrics, University of North Carolina at Chapel Hill School of Medicine , Chapel Hill, NC 27599,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,8,27]]},"reference":[{"key":"2026101305062839300_kfag104-B1","author":"California Legislature. 2025. California Health and Safety Code \u00a7 104559.5. California Legislative Information"},{"key":"2026101305062839300_kfag104-B2","author":"European Parliament & Council of the European Union"},{"key":"2026101305062839300_kfag104-B3","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.toxlet.2025.01.007","article-title":"Emerging nicotine analog 6-methyl nicotine increases reactive oxygen species in aerosols and cytotoxicity in human bronchial epithelial cells","volume":"405","author":"Effah","year":"2025","journal-title":"Toxicol Lett"},{"key":"2026101305062839300_kfag104-B4","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1001\/jama.2024.12408","article-title":"Variability in constituents of e-cigarette products containing nicotine analogues","volume":"332","author":"Erythropel","year":"2024","journal-title":"JAMA."},{"key":"2026101305062839300_kfag104-B5","author":"INBIFO","year":"1982"},{"key":"2026101305062839300_kfag104-B6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.18332\/tpc\/187767","article-title":"Marketing of nicotinamide as nicotine replacement in electronic cigarettes and smokeless tobacco","volume":"10","author":"Jabba","year":"2024","journal-title":"Tob Prev Cessat"},{"key":"2026101305062839300_kfag104-B7","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1136\/tc-2023-058469","article-title":"Spree Bar, a vaping system delivering a synthetic nicotine analogue, marketed in the USA as \u2018PMTA exempt.\u2019","volume":"34","author":"Jordt","year":"2025","journal-title":"Tob Control"},{"key":"2026101305062839300_kfag104-B8","author":"U.S. Food and Drug Administration (FDA). 2023. \u201cRegulation and Enforcement of Non-Tobacco Nicotine (NTN) Products.\u201d FDA"},{"key":"2026101305062839300_kfag104-B9","doi-asserted-by":"publisher","first-page":"e2024070484","DOI":"10.1542\/peds.2024-070484","article-title":"Awareness and use of vaping products with a nicotine analogue among adolescents and young adults","volume":"156","author":"Sanchez","year":"2025","journal-title":"Pediatrics."},{"key":"2026101305062839300_kfag104-B10","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1136\/tc-2024-059067","article-title":"Expanding synthetic nicotine commercial market: Aroma King\u2019s \u2018NoNic\u2019 pouches and e-cigarettes","volume":"35","author":"Sanchez","year":"2026","journal-title":"Tob Control."},{"key":"2026101305062839300_kfag104-B11","doi-asserted-by":"publisher","first-page":"5030","DOI":"10.3390\/ijms23095030","article-title":"A review of toxicity mechanism studies of electronic cigarettes on respiratory system","volume":"23","author":"Wang","year":"2022","journal-title":"Int J Mol Sci"},{"key":"2026101305062839300_kfag104-B12","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1111\/j.1360-0443.2005.01014.x","article-title":"Nicotine analogues: a review of tobacco industry research interests","volume":"100","author":"Vagg","year":"2005","journal-title":"Addiction."},{"key":"2026101305062839300_kfag104-B13","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1093\/toxsci\/kfaf107","article-title":"Characterizing oxidative metabolites of 6-methylnicotine (6MN; Aka Metatine): divergent metabolism from nicotine and identification of urinary biomarkers of exposure","volume":"207","author":"Xie","year":"2025","journal-title":"Toxicol Sci"}],"container-title":["Toxicological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/toxsci\/advance-article-pdf\/doi\/10.1093\/toxsci\/kfag104\/70818990\/kfag104.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/toxsci\/article-pdf\/209\/9\/kfag104\/70818990\/kfag104.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/toxsci\/article-pdf\/209\/9\/kfag104\/70818990\/kfag104.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T09:06:35Z","timestamp":1791882395000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/toxsci\/article\/doi\/10.1093\/toxsci\/kfag104\/8771787"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,27]]},"references-count":13,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9,2]]}},"URL":"https:\/\/doi.org\/10.1093\/toxsci\/kfag104","relation":{},"ISSN":["1096-0929"],"issn-type":[{"value":"1096-0929","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,9]]},"published":{"date-parts":[[2026,8,27]]},"article-number":"kfag104"}}