{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T17:54:27Z","timestamp":1790963667488,"version":"4.1.0"},"reference-count":96,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 ES029177"],"award-info":[{"award-number":["R01 ES029177"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R35 ES035011"],"award-info":[{"award-number":["R35 ES035011"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30 ES001247"],"award-info":[{"award-number":["P30 ES001247"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P20 GM130422"],"award-info":[{"award-number":["P20 GM130422"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Airborne micro- and nano-plastics (MNPs) are emerging environmental toxicants which may affect lung cellular functions. Deposition of MNPs in lungs of susceptible individuals, e.g. smokers, is not known. We determined the deposition of MNPs in the lungs of smokers and nonsmokers. Lung tissues from age- and sex-matched smokers (n\u2009=\u20099) and nonsmokers (n\u2009=\u200910) were analyzed to quantify: (i) microplastic levels using pyro-GC\/MS, and (ii) heavy metal accumulation using ICP-MS, given the synergistic environmental effects of these pollutants. Py-GC\/MS analysis showed a relatively higher level of MNPs in the lungs of smokers (43.67\u2009mcg\/gm) as compared with nonsmokers (34.53\u2009mcg\/gm). We observed a significant increase in the levels of polyethylene (PE; q\u2009=\u20090.0128), polyvinyl chloride (PVC; q\u2009=\u20090.0013), and polyurethane (PU; q\u2009=\u20090.0485) polymers in the lungs of smokers. Pairwise comparisons of elemental analyses results found an increase in the levels of cadmium (Cd) in the lungs of smokers. Importantly, we observed a strong association (R2\u00a0=\u00a00.6392; P\u2009=\u20090.005) between the amounts of accumulated PE and levels of Cd in the lungs of nonsmokers versus smokers. Overall, our results show a positive correlation between bioaccumulation of PE and Cd in the lungs based on smoking status.<\/jats:p>","DOI":"10.1093\/toxsci\/kfag121","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T11:48:15Z","timestamp":1788954495000},"source":"Crossref","is-referenced-by-count":0,"title":["Deposition of polyethylene micro- and nano-plastics is associated with accumulation of cadmium in lungs of smokers: a pilot study"],"prefix":"10.1093","volume":"209","author":[{"given":"Gagandeep","family":"Kaur","sequence":"first","affiliation":[{"name":"Department of Environmental Medicine, University of Rochester Medical Center , Rochester, NY,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md Imam","family":"Faizan","sequence":"additional","affiliation":[{"name":"Department of Environmental Medicine, University of Rochester Medical Center , Rochester, NY,","place":["United 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Pharmaceutical Sciences, College of Pharmacy, University of New Mexico Health Sciences , Albuquerque, NM,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2274-2454","authenticated-orcid":false,"given":"Irfan","family":"Rahman","sequence":"additional","affiliation":[{"name":"Department of Environmental Medicine, University of Rochester Medical Center , Rochester, NY,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,9,9]]},"reference":[{"key":"2026100213113155400_kfag121-B1","doi-asserted-by":"publisher","first-page":"101581","DOI":"10.1016\/j.rsma.2020.101581","article-title":"First evaluation of microplastics in two commercial fish species from the lagoons of Bizerte and Ghar El Melh (Northern Tunisia)","volume":"41","author":"Abidli","year":"2021","journal-title":"Reg Stud Mar 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