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This study evaluated the effects of binge-like EtOH exposure during early gestation on neurobehavioral, oxidative, and inflammatory outcomes in male and female rat offspring. Pregnant rats received EtOH (3\u2009g\/kg\/day, intragastric gavage) on gestational days 6 to 8, whereas control animals received distilled water. Offspring were evaluated at postnatal day 23 (PN23) and postnatal day 42 (PN42) using the pole, open field, and rotarod tests. The cerebellum was collected for analysis of oxidative stress markers and cytokines. Data were analyzed by two-way ANOVA followed by Tukey\u2019s post hoc test (P\u2009&amp;lt;\u20090.05). EtOH exposure induced locomotor alterations at both PN23 and PN42, mainly characterized by reduced total distance traveled, accompanied by impaired balance and forced locomotion. In the cerebellum, both ages exhibited reduced glutathione levels and total antioxidant capacity, together with increased lipid peroxidation. Cytokine alterations displayed a temporal pattern, with reduced IL-1\u03b2 and TNF-\u03b1 levels at PN23 and increased levels at PN42, whereas IL-6 and IL-10 remained elevated at both time points. Females exhibited more pronounced impairments in spontaneous locomotion, particularly at PN42. These findings demonstrate that brief binge-like EtOH exposure during early gestation is sufficient to induce persistent motor dysfunction accompanied by cerebellar redox imbalance and cytokine dysregulation, with evidence of sex-dependent behavioral susceptibility.<\/jats:p>","DOI":"10.1093\/toxsci\/kfag123","type":"journal-article","created":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T18:23:39Z","timestamp":1789755819000},"source":"Crossref","is-referenced-by-count":0,"title":["Early-gestational binge ethanol exposure induces persistent motor dysfunction associated with cerebellar redox and cytokine dysregulation in rat offspring"],"prefix":"10.1093","volume":"209","author":[{"given":"Paulo Fernando Santos","family":"Mendes","sequence":"first","affiliation":[{"name":"Laboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Par\u00e1 , Bel\u00e9m, PA 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66075-110,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas Villar Pedrosa da Silva","family":"Pantoja","sequence":"additional","affiliation":[{"name":"Laboratory Pharmacology of Inflammation and Behavior, Institute of Health Sciences, Federal University of Par\u00e1 , Bel\u00e9m, PA 66075-110,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luanna de Melo Pereira","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Laboratory of Neuropharmacology and Behavior, Center of Sciences Biological and Health, State University of Par\u00e1, Bel\u00e9m, PA 66087-662,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rommel Mario Rodr\u00edguez","family":"Burbano","sequence":"additional","affiliation":[{"name":"Human Cytogenetics Laboratory, Biological Science Institute, Federal University of Par\u00e1 , Bel\u00e9m, PA 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