{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T12:50:22Z","timestamp":1790167822968,"version":"4.1.0"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,7,1]]},"DOI":"10.1093\/toxsci\/kfi164","type":"journal-article","created":{"date-parts":[[2005,3,30]],"date-time":"2005-03-30T20:24:29Z","timestamp":1112214269000},"page":"116-124","source":"Crossref","is-referenced-by-count":28,"title":["Enhancement of Cyanide-Induced Mitochondrial Dysfunction and Cortical Cell Necrosis by Uncoupling Protein-2"],"prefix":"10.1093","volume":"86","author":[{"given":"L.","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Prabhakaran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. M.","family":"Mills","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. L.","family":"Borowitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. E.","family":"Isom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2005,3,30]]},"reference":[{"key":"key\n\t\t\t\t20171013194152_BIB1","doi-asserted-by":"crossref","unstructured":"Andrews, Z. B., Horvath, B., Barnstable, C. J., Elseworth, J., Yang, L., Beal, M. F., Roth, R. H., Matthews, R. T., and Horvath, T. L. (2005). Uncoupling protein-2 is critical for nigral dopamine cell survival in a mouse model of Parkinson's disease. J. Neurosci.25,184\u2013191.","DOI":"10.1523\/JNEUROSCI.4269-04.2005"},{"key":"key\n\t\t\t\t20171013194152_BIB2","doi-asserted-by":"crossref","unstructured":"Ankarcrona, M., Dypbukt, J. M., Bonfoco, E., Zhivotovsky, G., Orrenius, S., Lipton, S. A., and Nicotera, P. (1995). Glutamate-induced neuronal death: A succession of necrosis or apoptosis depending on mitochondrial function. Neuron15,961\u2013973.","DOI":"10.1016\/0896-6273(95)90186-8"},{"key":"key\n\t\t\t\t20171013194152_BIB3","doi-asserted-by":"crossref","unstructured":"Bechmann, I., Diano, S., Warden, C. H., Bartfai, T., Nitsch, R., and Horvath, T. L. (2002). Brain mitochondrial uncoupling protein 2 (UCP2): A protective stress signal in neuronal injury. Biochem. Pharmacol.64,363\u2013367.","DOI":"10.1016\/S0006-2952(02)01166-8"},{"key":"key\n\t\t\t\t20171013194152_BIB4","doi-asserted-by":"crossref","unstructured":"Budd Haeberlein, S. L. (2004). Mitochondrial function in apoptotic neuronal cell death. Neurochem. Res.29,521\u2013530.","DOI":"10.1023\/B:NERE.0000014823.74782.b7"},{"key":"key\n\t\t\t\t20171013194152_BIB5","doi-asserted-by":"crossref","unstructured":"Busquets, S., Alvarex, B., Van Royen, M., Figueras, T. M., Lopez-Soriano, F. J., and Argiles, J. M. (2001). Increased uncoupling protein-2 gene expression in brain of lipopolysaccharide-injected mice: Role of tumour necrosis factor-\u03b1? Biochim. Biophys. Acta1499,249\u2013256.","DOI":"10.1016\/S0167-4889(00)00126-9"},{"key":"key\n\t\t\t\t20171013194152_BIB6","doi-asserted-by":"crossref","unstructured":"Chang, L. K., and Johnson, E. M. (2002). Cyclosporin A inhibits caspase-independent death of NGF-deprived sympathetic neurons: A potential role for mitochondrial permeability transition. J. Cell Biol.157,771\u2013781.","DOI":"10.1083\/jcb.200112130"},{"key":"key\n\t\t\t\t20171013194152_BIB7","doi-asserted-by":"crossref","unstructured":"Chen, Q., Vasquez, E. J, Moghaddas, S., Hoppel, C. L, and Lesnefsky, E. J. (2003). Production of reactive oxygen species by mitochondria. J. Biol. Chem.278,36027\u201336031.","DOI":"10.1074\/jbc.M304854200"},{"key":"key\n\t\t\t\t20171013194152_BIB8","doi-asserted-by":"crossref","unstructured":"Davey, G. P., Peuchen, S., and Clark, J. B. (1998). Energy thresholds in brain mitochondria. J. Biol. Chem.273,12753\u201312757.","DOI":"10.1074\/jbc.273.21.12753"},{"key":"key\n\t\t\t\t20171013194152_BIB9","doi-asserted-by":"crossref","unstructured":"de Bilbao, F., Arsenijevic, D., Valet, P., Hjel, O. P., Ottersen, O. P., Bouras, C., Raffin, Y., Abou, K., Langhans, W., Collins, S. et al. (2004). Resistance to cerebral ischemic injury in UCP2 knockout mice: Evidence for a role of UCP2 as a regulator of mitochondrial glutathione levels. J. Neurochem.89,1283\u20131292.","DOI":"10.1111\/j.1471-4159.2004.02432.x"},{"key":"key\n\t\t\t\t20171013194152_BIB10","doi-asserted-by":"crossref","unstructured":"Diano, S., Matthew, R. T, Patrylo, P., Yang, L., Beal, M. F., Barnstable, C. J., and Horvath, T. L. (2003). Uncoupling protein 2 prevents neuronal death including that occurring during seizures: A mechanism for pre-conditioning. Endocrinology144,5014\u20135021.","DOI":"10.1210\/en.2003-0667"},{"key":"key\n\t\t\t\t20171013194152_BIB11","doi-asserted-by":"crossref","unstructured":"Duval C., Negre-Salvayre, A., Doglio, A., Salvayre, R., Penicaud, L., and Casteilla, L. (2002). Increased reactive oxygen species production with antisense oligonucleotides directed against uncoupling protein 2 in murine endothelial cells. Biochem. Cell Biol.80,757\u2013764.","DOI":"10.1139\/o02-158"},{"key":"key\n\t\t\t\t20171013194152_BIB12","doi-asserted-by":"crossref","unstructured":"Echtay, K. S., Murphy, M. P., Smith, R. A. J., Talbot, D. A., and Brand, M. D. (2002). Superoxide activates mitochondrial uncoupling protein 2 from the matrix side. J. Biol. Chem.277,47129\u201347135.","DOI":"10.1074\/jbc.M208262200"},{"key":"key\n\t\t\t\t20171013194152_BIB13","doi-asserted-by":"crossref","unstructured":"Elbashir, S. M., Harborth, J., Lendeckel, W., Yalcin, A., Weber, K., and Tuschi, T. (2001). Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature411,494\u2013498.","DOI":"10.1038\/35078107"},{"key":"key\n\t\t\t\t20171013194152_BIB14","doi-asserted-by":"crossref","unstructured":"Horvath, T., Diano, S., and Barnstable, C. (2003). Mitochondrial uncoupling protein 2 in the central nervous system: Neuromodulator and neuroprotector. Biochem. Pharmacol.65,1917\u20131921.","DOI":"10.1016\/S0006-2952(03)00143-6"},{"key":"key\n\t\t\t\t20171013194152_BIB15","doi-asserted-by":"crossref","unstructured":"Jones, D. C., Prabhakaran, K., Gunasekar, P G., Li, L., Shou, Y., Borowitz, J. L., and Isom, G. E. (2003). Cyanide enhancement of dopamine-induced apoptosis in mesencephalic cells involves mitochondrial dysfunction and oxidative stress. Neurotoxicology24,333\u2013342.","DOI":"10.1016\/S0161-813X(03)00042-1"},{"key":"key\n\t\t\t\t20171013194152_BIB16","doi-asserted-by":"crossref","unstructured":"Krichevsky, A. M., and Kosik, K. (2002). RNAi functions in cultured mammalian neurons. Proc. Natl. Acad. Sci. U.S.A.99,11926\u201311929.","DOI":"10.1073\/pnas.182272699"},{"key":"key\n\t\t\t\t20171013194152_BIB17","doi-asserted-by":"crossref","unstructured":"Liao, X. D., Tang, A. H., Chen, Q., Jin, H. J., Wu, C. H., Chen, L. Y., and Wang, S. Q. (2003). Role of Ca2+ signaling in initiation of stretch-induced apoptosis in neonatal heart cells. Biochem. Biophys. Res. Commun.310,405\u2013411.","DOI":"10.1016\/j.bbrc.2003.09.023"},{"key":"key\n\t\t\t\t20171013194152_BIB18","doi-asserted-by":"crossref","unstructured":"Los, M., Mozolu, M., Ferrari, D., Stepczynska, A., Stroh, C., Renz, A., Herceg, Z., Wang, Z-Q., and Schulze-Osthoff, K. (2002). Activation and caspase-mediated inhibition of PARP: A molecular switch between fibroblast necrosis and apoptosis in death receptor signaling. Mol. Biol. Cell13,978\u2013988.","DOI":"10.1091\/mbc.01-05-0272"},{"key":"key\n\t\t\t\t20171013194152_BIB19","doi-asserted-by":"crossref","unstructured":"Mattiasson, G., Shamloo, M., Gido, G., Mathi, K., Tomasevic, G., Yi, S., Warden, C. H., Castilho, R. F., Melchor, T., Gonzalex-Zulueta, M., Nikolich, K., and Wieloch, T. (2003). Uncoupling protein-2 prevents neuronal death and diminishes brain dysfunction after stroke and brain trauma. Nat. Med.9,1062\u20131068.","DOI":"10.1038\/nm903"},{"key":"key\n\t\t\t\t20171013194152_BIB20","doi-asserted-by":"crossref","unstructured":"Mattson, M. P., and Liu, D. (2003). Mitochondrial potassium channels and uncoupling proteins in synaptic plasticity and neuronal cell death. Biochem. Biophys. Res. Commun.302,539\u2013549.","DOI":"10.1016\/S0006-291X(03)00627-2"},{"key":"key\n\t\t\t\t20171013194152_BIB21","doi-asserted-by":"crossref","unstructured":"McManus, M. T., and Sharp, P. A. (2002). Gene silencing in mammals by small interfering RNAs. Nat. Rev. Genet.3,737\u2013747.","DOI":"10.1038\/nrg908"},{"key":"key\n\t\t\t\t20171013194152_BIB22","doi-asserted-by":"crossref","unstructured":"Mills, E. M., Gunasekar, P., Borowitz, J. L., and Isom, G. E. (1999). Differential susceptibility of brain areas to cyanide involves different modes of cell death. Toxicol. Appl. Pharmacol.156,6\u201316.","DOI":"10.1006\/taap.1999.8630"},{"key":"key\n\t\t\t\t20171013194152_BIB23","doi-asserted-by":"crossref","unstructured":"Mills, E. M., Xu, D., Fergusson, M. M., Combs, C. A., Xu, Y., and Finkel, T. (2002). Regulation of cellular oncosis by uncoupling protein 2. J. Biol. Chem.277,27385\u201327392.","DOI":"10.1074\/jbc.M111860200"},{"key":"key\n\t\t\t\t20171013194152_BIB24","doi-asserted-by":"crossref","unstructured":"Negre-Salvayre, A., Hirtz, C., Carrera, G., Cazenave, R., Troly, M., Salvayre, R., Penicaud, L., and Casteilla, L. (1997). A role for uncoupling protein-2 as a regulator of mitochondrial hydrogen peroxide generation. FASEB J.11,809\u2013815.","DOI":"10.1096\/fasebj.11.10.9271366"},{"key":"key\n\t\t\t\t20171013194152_BIB25","doi-asserted-by":"crossref","unstructured":"Pecqueur, C., Alves-Guerra, M-C., Gelly, C., Levi-Meyrueis, C., Couplan, E., Collins, S., Ricquier, D., Bouillaud, F., and Miroux, B. (2002) Uncoupling protein 2, in vivo distribution, induction upon oxidative stress, and evidence for translational regulation. J. Biol. Chem.276,8705\u20138712.","DOI":"10.1074\/jbc.M006938200"},{"key":"key\n\t\t\t\t20171013194152_BIB26","doi-asserted-by":"crossref","unstructured":"Prabhakaran K., Li, L., Borowitz, J. L., and Isom, G. E. (2002). Cyanide induces different modes of death in cortical and mesencephalon cells. J. Pharmacol. Exp. Ther.303,510\u2013519.","DOI":"10.1124\/jpet.102.039453"},{"key":"key\n\t\t\t\t20171013194152_BIB27","unstructured":"Prabhakaran, K., Li, L., Zhang, C., Mills, E. M., Borowitz, J. L., and Isom, G. E. (2003). Uncoupling protein-2 potentiates necrotic death in mesencephalic cells. Soc. Neurosci. (abst)637.13."},{"key":"key\n\t\t\t\t20171013194152_BIB28","doi-asserted-by":"crossref","unstructured":"Prabhakaran, K., Li, L., Borowitz, J. L., and Isom, G. E. (2004). Caspase inhibition switches the mode of death induced by cyanide by enhancing reactive oxygen species generation and PARP-1 activation. Toxicol. Appl. Pharmacol.195,194\u2013202.","DOI":"10.1016\/j.taap.2003.11.012"},{"key":"key\n\t\t\t\t20171013194152_BIB29","doi-asserted-by":"crossref","unstructured":"Rashid, A., Wu, T-C., Huang, C-C., Chen, C-H., Lin, H. Z., Yang, S. Q., Lee, F. Y. J., and Diehl, A. M. (1999). Mitochondrial proteins that regulate apoptosis and necrosis are induced in mouse fatty liver. Hepatology29,1131\u20131138.","DOI":"10.1002\/hep.510290428"},{"key":"key\n\t\t\t\t20171013194152_BIB30","doi-asserted-by":"crossref","unstructured":"Reers, M., Smiley, S. T., Mootola-Hartshorn, C., Chen, A., Lin, M., and Chen, L. B. (1995). Mitochondrial membrane potential monitored by JC-1 dye. Methods Enzymol.260,406\u2013417.","DOI":"10.1016\/0076-6879(95)60154-6"},{"key":"key\n\t\t\t\t20171013194152_BIB31","doi-asserted-by":"crossref","unstructured":"Richard, D., Clavel, S., Huang, Q., Sanchis, D., and Ricquier, D. (2001). Uncoupling protein 2 in the brain: Distribution and function. Biochem. Soc. Trans.29,812\u2013817.","DOI":"10.1042\/bst0290812"},{"key":"key\n\t\t\t\t20171013194152_BIB32","doi-asserted-by":"crossref","unstructured":"Rousset, S., Alves-Guerra, M-C., Mozo, J., Miroux, B., Cassard-Doulcier, A-M., Bouillaud, F., and Ricquier, D. (2004). The biology of mitochondrial uncoupling proteins. Diabetes53,S130\u2013S135.","DOI":"10.2337\/diabetes.53.2007.S130"},{"key":"key\n\t\t\t\t20171013194152_BIB33","doi-asserted-by":"crossref","unstructured":"Shou, Y., Li, L., Prabhakaran, K., Borowitz, J. L., and Isom, G. E. (2003). p38 Mitogen-activated protein kinase contributes to Bax translocation and cytochrome c release in cyanide-induced apoptosis. Toxicol. Sci.75,99\u2013107.","DOI":"10.1093\/toxsci\/kfg157"},{"key":"key\n\t\t\t\t20171013194152_BIB34","doi-asserted-by":"crossref","unstructured":"Shou, Y., Li, L., Prabhakaran, K., Borowitz, J. L, and Isom, G. E. (2004). Calcineurin-mediated Bad translocation regulates cyanide-induced neuronal apoptosis. Biochem. J.379,805\u2013813.","DOI":"10.1042\/bj20031107"},{"key":"key\n\t\t\t\t20171013194152_BIB35","doi-asserted-by":"crossref","unstructured":"Sriram, K., Benkovic, S. A., Miller D. B., and O'Callaghan, J. P. (2002). Obesity exacerbates chemically induced neurodegeneration. Neuroscience115,1335\u20131346.","DOI":"10.1016\/S0306-4522(02)00306-8"},{"key":"key\n\t\t\t\t20171013194152_BIB36","doi-asserted-by":"crossref","unstructured":"Sullivan, P. G., Dube C., Dorenbos, K., Steward, O., and Baram, T. Z. (2003). Mitochondrial uncoupling protein 2 protects the immature brain from excitotoxic neuronal death. Ann. Neurol.53,711\u2013717.","DOI":"10.1002\/ana.10543"},{"key":"key\n\t\t\t\t20171013194152_BIB37","doi-asserted-by":"crossref","unstructured":"Sun, X., and Zemel, M. B. (2004). Role of uncoupling protein 2 (UCP2) expression and 1\u03b1, 25-dihydroxyvitamin D3 in modulating adipocyte apoptosis. FASEB J.18,1430\u20131432.","DOI":"10.1096\/fj.04-1971fje"},{"key":"key\n\t\t\t\t20171013194152_BIB38","doi-asserted-by":"crossref","unstructured":"Teshima, Y., Akao, M., Jones, S. P., and Marban, E. (2003). Uncoupling protein-2 overexpression inhibits mitochondrial death pathway in cardiomyocytes. Circ. Res.93,192\u2013200.","DOI":"10.1161\/01.RES.0000085581.60197.4D"},{"key":"key\n\t\t\t\t20171013194152_BIB39","doi-asserted-by":"crossref","unstructured":"Uchino, S., Yamaguchi, Y., Furuhashi, T., Wang, F. S., Zhang, J. L., Okabe, K., Kihara, S., Yamada, S., Katsutaka, M., and Ogawa, M. (2004). Steatotic liver allografts up-regulate UCP-2 expression and suffer necrosis in rats. J. Surg. Res.120,73\u201382.","DOI":"10.1016\/j.jss.2003.10.010"}],"container-title":["Toxicological Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/toxsci\/article-pdf\/86\/1\/116\/4657144\/kfi164.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,2,7]],"date-time":"2019-02-07T21:58:45Z","timestamp":1549576725000},"score":1,"resource":{"primary":{"URL":"http:\/\/academic.oup.com\/toxsci\/article\/86\/1\/116\/1654111\/Enhancement-of-CyanideInduced-Mitochondrial"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,3,30]]},"references-count":39,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2005,3,30]]},"published-print":{"date-parts":[[2005,7,1]]}},"URL":"https:\/\/doi.org\/10.1093\/toxsci\/kfi164","relation":{},"ISSN":["1096-0929","1096-6080"],"issn-type":[{"value":"1096-0929","type":"electronic"},{"value":"1096-6080","type":"print"}],"subject":[],"published-other":{"date-parts":[[2005,7]]},"published":{"date-parts":[[2005,3,30]]}}}