{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T11:30:24Z","timestamp":1792236624759,"version":"4.4.0"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,1]]},"DOI":"10.1093\/toxsci\/kfm206","type":"journal-article","created":{"date-parts":[[2007,8,9]],"date-time":"2007-08-09T20:34:31Z","timestamp":1186691671000},"page":"132-139","source":"Crossref","is-referenced-by-count":167,"title":["The PPAR\u03b1-Humanized Mouse: A Model to Investigate Species Differences in Liver Toxicity Mediated by PPAR\u03b1"],"prefix":"10.1093","volume":"101","author":[{"given":"Qian","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomokazu","family":"Nagano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yatrik","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Connie","family":"Cheung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinji","family":"Ito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank J.","family":"Gonzalez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2007,8,9]]},"reference":[{"key":"key\n\t\t\t\t20170508165929_bib1","doi-asserted-by":"crossref","first-page":"27117","DOI":"10.1016\/S0021-9258(19)61487-0","article-title":"Regulation of the liver fatty acid-binding protein gene by hepatocyte nuclear factor 1alpha (HNF1alpha). Alterations in fatty acid homeostasis in HNF1alpha-deficient mice","volume":"275","year":"2000","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170508165929_bib2","doi-asserted-by":"crossref","first-page":"S29","DOI":"10.1016\/0021-9150(96)05854-6","article-title":"Transcriptional control of triglyceride metabolism: Fibrates and fatty acids change the expression of the LPL and apo C-III genes by activating the nuclear receptor PPAR","volume":"124","year":"1996","journal-title":"Atherosclerosis"},{"key":"key\n\t\t\t\t20170508165929_bib3","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1146\/annurev.med.53.082901.104018","article-title":"The mechanisms of action of PPARs","volume":"53","year":"2002","journal-title":"Annu. Rev. Med."},{"key":"key\n\t\t\t\t20170508165929_bib4","doi-asserted-by":"crossref","first-page":"2999","DOI":"10.1073\/pnas.0307323101","article-title":"Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers","volume":"101","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"key\n\t\t\t\t20170508165929_bib5","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1080\/01926230590522095","article-title":"Molecular mechanisms of hepatocarcinogenesis in transgenic mouse models of liver cancer","volume":"33","year":"2005","journal-title":"Toxicol. Pathol."},{"key":"key\n\t\t\t\t20170508165929_bib6","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1093\/toxsci\/kfi273","article-title":"Gene expression profiling of the PPAR-alpha agonist ciprofibrate in the cynomolgus monkey liver","volume":"88","year":"2005","journal-title":"Toxicol. Sci."},{"key":"key\n\t\t\t\t20170508165929_bib7","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1080\/01926230490451680","article-title":"Peroxisome proliferators and receptor-mediated hepatic carcinogenesis","volume":"32","year":"2004","journal-title":"Toxicol. Pathol."},{"key":"key\n\t\t\t\t20170508165929_bib8","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1006\/rtph.1997.1163","article-title":"Do peroxisome proliferating compounds pose a hepatocarcinogenic hazard to humans?","volume":"27","year":"1998","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"key\n\t\t\t\t20170508165929_bib9","doi-asserted-by":"crossref","first-page":"291","DOI":"10.3727\/000000001783992533","article-title":"Identification of novel peroxisome proliferator-activated receptor alpha (PPARalpha) target genes in mouse liver using cDNA microarray analysis","volume":"9","year":"2001","journal-title":"Gene. Expr."},{"key":"key\n\t\t\t\t20170508165929_bib10","doi-asserted-by":"crossref","first-page":"3849","DOI":"10.1158\/0008-5472.CAN-04-0322","article-title":"Diminished hepatocellular proliferation in mice humanized for the nuclear receptor peroxisome proliferator-activated receptor alpha","volume":"64","year":"2004","journal-title":"Cancer Res."},{"key":"key\n\t\t\t\t20170508165929_bib11","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0014-5793(98)00603-6","article-title":"Ecto-ATP diphosphohydrolase\/CD39 is overexpressed in differentiated human melanomas","volume":"430","year":"1998","journal-title":"FEBS Lett."},{"key":"key\n\t\t\t\t20170508165929_bib12","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1124\/mol.104.005389","article-title":"Regulation of human hepatic hydroxysteroid sulfotransferase gene expression by the peroxisome proliferator-activated receptor alpha transcription factor","volume":"67","year":"2005","journal-title":"Mol. Pharmacol."},{"key":"key\n\t\t\t\t20170508165929_bib13","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0304-3835(99)00195-0","article-title":"CD24 is a marker for human breast carcinoma","volume":"143","year":"1999","journal-title":"Cancer Lett."},{"key":"key\n\t\t\t\t20170508165929_bib14","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1016\/S0022-2275(20)37159-5","article-title":"Mitochondrion is the principal target for nutritional and pharmacological control of triglyceride metabolism","volume":"38","year":"1997","journal-title":"J. Lipid Res."},{"key":"key\n\t\t\t\t20170508165929_bib15","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1042\/bj2030161","article-title":"Cytochrome P-450 induction by clofibrate. Purification and properties of a hepatic cytochrome P-450 relatively specific for the 12- and 11-hydroxylation of dodecanoic acid (lauric acid)","volume":"203","year":"1982","journal-title":"Biochem. J."},{"key":"key\n\t\t\t\t20170508165929_bib16","first-page":"85","article-title":"Peroxisome proliferator-activated receptor (PPAR) alpha activation and its consequences in humans","volume":"102\u2013103","year":"1998","journal-title":"Toxicol. Lett."},{"key":"key\n\t\t\t\t20170508165929_bib17","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1080\/713608372","article-title":"PPARalpha agonist-induced rodent tumors: Modes of action and human relevance","volume":"33","year":"2003","journal-title":"Crit. Rev. Toxicol."},{"key":"key\n\t\t\t\t20170508165929_bib18","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.1073\/pnas.73.6.2043","article-title":"A fatty acyl-CoA oxidizing system in rat liver peroxisomes; enhancement by clofibrate, a hypolipidemic drug","volume":"73","year":"1976","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"key\n\t\t\t\t20170508165929_bib19","doi-asserted-by":"crossref","first-page":"3012","DOI":"10.1128\/MCB.15.6.3012","article-title":"Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators","volume":"15","year":"1995","journal-title":"Mol. Cell. Biol."},{"key":"key\n\t\t\t\t20170508165929_bib20","first-page":"4776","article-title":"Addition of peroxisome proliferator-activated receptor alpha to guinea pig hepatocytes confers increased responsiveness to peroxisome proliferators","volume":"59","year":"1999","journal-title":"Cancer Res."},{"key":"key\n\t\t\t\t20170508165929_bib21","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1093\/carcin\/bgi329","article-title":"Differential susceptibility of mice humanized for peroxisome proliferator-activated receptor {alpha} to Wy-14,643-induced liver tumorigenesis","volume":"27","year":"2006","journal-title":"Carcinogenesis"},{"key":"key\n\t\t\t\t20170508165929_bib22","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1093\/carcin\/18.11.2029","article-title":"Role of PPAR alpha in the mechanism of action of the nongenotoxic carcinogen and peroxisome proliferator Wy-14,643","volume":"18","year":"1997","journal-title":"Carcinogenesis"},{"key":"key\n\t\t\t\t20170508165929_bib23","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1007\/s00109-005-0678-9","article-title":"Peroxisome proliferator-activated receptor-alpha and liver cancer: Where do we stand?","volume":"83","year":"2005","journal-title":"J. Mol. Med."},{"key":"key\n\t\t\t\t20170508165929_bib24","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/283397a0","article-title":"Hypolipidaemic hepatic peroxisome proliferators form a novel class of chemical carcinogens","volume":"283","year":"1980","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170508165929_bib25","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1126\/science.1198095","article-title":"Hepatic peroxisome proliferation: Induction by two novel compounds structurally unrelated to clofibrate","volume":"190","year":"1975","journal-title":"Science"},{"key":"key\n\t\t\t\t20170508165929_bib26","doi-asserted-by":"crossref","first-page":"4238","DOI":"10.1128\/MCB.00317-07","article-title":"Peroxisome proliferator-activated receptor alpha regulates a microRNA-mediated signaling cascade responsible for hepatocellular proliferation","volume":"27","year":"2007","journal-title":"Mol. Cell. Biol."},{"key":"key\n\t\t\t\t20170508165929_bib27","doi-asserted-by":"crossref","first-page":"267","DOI":"10.2174\/0929867033368295","article-title":"Recent advances in peroxisome proliferator-activated receptor science","volume":"10","year":"2003","journal-title":"Curr. Med. Chem."},{"key":"key\n\t\t\t\t20170508165929_bib28","doi-asserted-by":"crossref","first-page":"5598","DOI":"10.1021\/bi00072a015","article-title":"cDNA cloning, chromosomal mapping, and functional characterization of the human peroxisome proliferator activated receptor","volume":"32","year":"1993","journal-title":"Biochemistry"},{"key":"key\n\t\t\t\t20170508165929_bib29","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1124\/mol.104.007278","article-title":"Constitutive expression of peroxisome proliferator-activated receptor alpha-regulated genes in dwarf mice","volume":"67","year":"2005","journal-title":"Mol. Pharmacol."},{"key":"key\n\t\t\t\t20170508165929_bib30","doi-asserted-by":"crossref","first-page":"2149","DOI":"10.1016\/S0002-9440(10)65085-7","article-title":"Expression of stress-response and cell proliferation genes in renal cell carcinoma induced by oxidative stress","volume":"156","year":"2000","journal-title":"Am. J. Pathol."},{"key":"key\n\t\t\t\t20170508165929_bib31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/toxsci\/47.1.1","article-title":"Peroxisome proliferator-activated receptors (PPARS) and carcinogenesis","volume":"47","year":"1999","journal-title":"Toxicol. Sci."},{"key":"key\n\t\t\t\t20170508165929_bib32","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1002\/(SICI)1097-4644(2000)77:34+<61::AID-JCB11>3.0.CO;2-S","article-title":"Differential expression of genes by tumor cells of a low or a high malignancy phenotype: The case of murine and human Ly-6 proteins","volume":"77","year":"2000","journal-title":"J. Cell. Biochem."},{"key":"key\n\t\t\t\t20170508165929_bib33","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1006\/taap.2002.9540","article-title":"Gene expression changes induced in mouse liver by di(2-ethylhexyl) phthalate","volume":"185","year":"2002","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"key\n\t\t\t\t20170508165929_bib34","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1152\/physiolgenomics.00064.2003","article-title":"Liver gene expression in rats in response to the peroxisome proliferator-activated receptor-alpha agonist ciprofibrate","volume":"15","year":"2003","journal-title":"Physiol. Genomics."},{"key":"key\n\t\t\t\t20170508165929_bib35","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1006\/bbrc.2001.6319","article-title":"Microarray analysis of gene expression changes in mouse liver induced by peroxisome proliferator- activated receptor alpha agonists","volume":"290","year":"2002","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"key\n\t\t\t\t20170508165929_bib36","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1093\/carcin\/bgm046","article-title":"Hepatocyte-restricted constitutive activation of PPAR{alpha} induces hepatoproliferation but not hepatocarcinogenesis","volume":"28","year":"2007","journal-title":"Carcinogenesis"}],"container-title":["Toxicological Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/toxsci\/article-pdf\/101\/1\/132\/16678572\/kfm206.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,21]],"date-time":"2021-08-21T10:09:38Z","timestamp":1629540578000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/toxsci\/article-lookup\/doi\/10.1093\/toxsci\/kfm206"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,8,9]]},"references-count":36,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2007,8,9]]},"published-print":{"date-parts":[[2008,1]]}},"URL":"https:\/\/doi.org\/10.1093\/toxsci\/kfm206","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1104090.560074","asserted-by":"object"}]},"ISSN":["1096-6080","1096-0929"],"issn-type":[{"value":"1096-6080","type":"print"},{"value":"1096-0929","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,8,9]]}}}