{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T16:41:30Z","timestamp":1771605690471,"version":"3.50.1"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,4]]},"DOI":"10.1093\/toxsci\/kfn008","type":"journal-article","created":{"date-parts":[[2008,1,29]],"date-time":"2008-01-29T01:25:11Z","timestamp":1201569911000},"page":"433-443","source":"Crossref","is-referenced-by-count":51,"title":["Role of Tissue Kallikrein in Prevention and Recovery of Gentamicin-Induced Renal Injury"],"prefix":"10.1093","volume":"102","author":[{"given":"Grant","family":"Bledsoe","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Yu","family":"Yao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makato","family":"Hagiwara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brandon","family":"Mizell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Teuton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Grass","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lee","family":"Chao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"Chao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2008,1,27]]},"reference":[{"key":"key\n\t\t\t\t20170315220557_bib1","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1016\/0306-3623(95)00049-6","article-title":"Gentamicin nephrotoxicity in humans and animals: Some recent research","volume":"26","year":"1995","journal-title":"Gen. Pharmacol."},{"key":"key\n\t\t\t\t20170315220557_bib2","doi-asserted-by":"crossref","first-page":"F953","DOI":"10.1152\/ajprenal.00329.2004","article-title":"Identification of persistently altered gene expression in the kidney after functional recovery from ischemic acute renal failure","volume":"288","year":"2005","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"key\n\t\t\t\t20170315220557_bib3","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1089\/152308602762197452","article-title":"Apoptotic pathways of oxidative damage to renal tubular epithelial cells","volume":"4","year":"2002","journal-title":"Antioxid. Redox Signal."},{"key":"key\n\t\t\t\t20170315220557_bib4","first-page":"1","article-title":"Bioregulation of kinins: Kallikreins, kininogens, and kininases","volume":"44","year":"1992","journal-title":"Pharmacol. Rev."},{"key":"key\n\t\t\t\t20170315220557_bib5","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1093\/ndt\/gfi225","article-title":"Kallikrein\/kinin protects against gentamicin-induced nephrotoxicity by inhibition of inflammation and apoptosis","volume":"21","year":"2006","journal-title":"Nephrol. Dial. Transplant."},{"key":"key\n\t\t\t\t20170315220557_bib6","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1089\/hum.2006.17.545","article-title":"Reversal of renal fibrosis, inflammation, and glomerular hypertrophy by kallikrein gene delivery","volume":"17","year":"2006","journal-title":"Hum. Gene Ther."},{"key":"key\n\t\t\t\t20170315220557_bib7","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.1016\/0006-2952(79)90226-0","article-title":"Isozymes of rat urinary kallikrein","volume":"28","year":"1979","journal-title":"Biochem. Pharmacol."},{"key":"key\n\t\t\t\t20170315220557_bib8","doi-asserted-by":"crossref","first-page":"H1001","DOI":"10.1152\/ajpheart.00716.2003","article-title":"Superoxide, H2O2, and iron are required for TNF-alpha-induced MCP-1 gene expression in endothelial cells: Role of Rac1 and NADPH oxidase","volume":"286","year":"2004","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"key\n\t\t\t\t20170315220557_bib9","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0014-2999(02)01749-1","article-title":"A role for superoxide in gentamicin-mediated nephropathy in rats","volume":"450","year":"2002","journal-title":"Eur. J. Pharmacol."},{"key":"key\n\t\t\t\t20170315220557_bib10","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1172\/JCI6974","article-title":"Inhibition of apoptosis induced by ischemia-reperfusion prevents inflammation","volume":"104","year":"1999","journal-title":"J. Clin. Invest."},{"key":"key\n\t\t\t\t20170315220557_bib11","first-page":"F926","article-title":"Macrophages, monocyte chemoattractant peptide-1, and TGF-beta 1 in experimental hydronephrosis","volume":"266","year":"1994","journal-title":"Am. J. Physiol."},{"key":"key\n\t\t\t\t20170315220557_bib12","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1093\/toxsci\/56.1.229","article-title":"Gentamicin-induced apoptosis in renal cell lines and embryonic rat fibroblasts","volume":"56","year":"2000","journal-title":"Toxicol. Sci."},{"key":"key\n\t\t\t\t20170315220557_bib13","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1093\/ndt\/15.8.1175","article-title":"The protective effect of taurine against gentamicin-induced acute tubular necrosis in rats","volume":"15","year":"2000","journal-title":"Nephrol. Dial. Transplant."},{"key":"key\n\t\t\t\t20170315220557_bib14","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/S0955-0674(98)80147-6","article-title":"Oxygen radicals and signaling","volume":"10","year":"1998","journal-title":"Curr. Opin. Cell Biol."},{"key":"key\n\t\t\t\t20170315220557_bib15","first-page":"633","article-title":"Role of myofibroblasts, macrophages, transforming growth factor-beta endothelin, angiotensin-II, and fibronectin in the progression of tubulointerstitial nephritis induced by gentamicin","volume":"15","year":"2002","journal-title":"J. Nephrol."},{"key":"key\n\t\t\t\t20170315220557_bib16","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1161\/01.RES.74.6.1141","article-title":"Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells","volume":"74","year":"1994","journal-title":"Circ. Res."},{"key":"key\n\t\t\t\t20170315220557_bib17","first-page":"355","article-title":"Role of the prostaglandin and kallikrein-kinin systems in aminoglycoside-induced acute renal failure","volume":"18","year":"1985","journal-title":"Braz. J. Med. Biol. Res."},{"key":"key\n\t\t\t\t20170315220557_bib18","first-page":"589","article-title":"A light and electron microscopic analysis of gentamicin nephrotoxicity in rats","volume":"82","year":"1976","journal-title":"Am. J. Pathol."},{"key":"key\n\t\t\t\t20170315220557_bib19","doi-asserted-by":"crossref","first-page":"147","DOI":"10.3109\/10408448809014903","article-title":"Kidney tissue repair after nephrotoxic injury: Biochemical and morphological characterization","volume":"19","year":"1988","journal-title":"Crit. Rev. Toxicol."},{"key":"key\n\t\t\t\t20170315220557_bib20","doi-asserted-by":"crossref","first-page":"724","DOI":"10.5694\/j.1326-5377.1992.tb121517.x","article-title":"Drug-induced renal disease","volume":"156","year":"1992","journal-title":"Med. J. Aust."},{"key":"key\n\t\t\t\t20170315220557_bib21","first-page":"186","article-title":"Mechanisms of repair after kidney injury","volume":"16","year":"2003","journal-title":"J. Nephrol."},{"key":"key\n\t\t\t\t20170315220557_bib22","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1128\/AAC.43.5.1003","article-title":"Aminoglycosides: Nephrotoxicity","volume":"43","year":"1999","journal-title":"Antimicrob. Agents Chemother."},{"key":"key\n\t\t\t\t20170315220557_bib23","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1046\/j.1523-1755.1998.00867.x","article-title":"Human kallikrein gene delivery protects against gentamycin-induced nephrotoxicity in rats","volume":"53","year":"1998","journal-title":"Kidney Int."},{"key":"key\n\t\t\t\t20170315220557_bib24","doi-asserted-by":"crossref","first-page":"159","DOI":"10.2133\/dmpk.19.159","article-title":"Molecular aspects of renal handling of aminoglycosides and strategies for preventing the nephrotoxicity","volume":"19","year":"2004","journal-title":"Drug Metab. Pharmacokinet."},{"key":"key\n\t\t\t\t20170315220557_bib25","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/0014-4800(88)90070-6","article-title":"Light and electron microscopic characterization of the proliferative response induced by tobramycin in rat kidney cortex","volume":"48","year":"1988","journal-title":"Exp. Mol. Pathol."},{"key":"key\n\t\t\t\t20170315220557_bib26","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1124\/jpet.102.035022","article-title":"Mechanisms of renal cell repair and regeneration after acute renal failure","volume":"304","year":"2003","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"key\n\t\t\t\t20170315220557_bib27","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1161\/01.ATV.20.3.645","article-title":"Angiotensin II stimulates endothelial vascular cell adhesion molecule-1 via nuclear factor-kappaB activation induced by intracellular oxidative stress","volume":"20","year":"2000","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"key\n\t\t\t\t20170315220557_bib28","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1023\/A:1009680229931","article-title":"Role of apoptosis of renal tubular cells in acute renal failure: Therapeutic implications","volume":"6","year":"2001","journal-title":"Apoptosis"},{"key":"key\n\t\t\t\t20170315220557_bib29","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1681\/ASN.V111152","article-title":"Chemokines, chemokine receptors, and renal disease: From basic science to pathophysiologic and therapeutic studies","volume":"11","year":"2000","journal-title":"J. Am. Soc. Nephrol."},{"key":"key\n\t\t\t\t20170315220557_bib30","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S0891-5849(98)00207-X","article-title":"Formation of reactive oxygen species following bioactivation of gentamicin","volume":"26","year":"1999","journal-title":"Free Radic. Biol. Med."},{"key":"key\n\t\t\t\t20170315220557_bib31","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1002\/jlb.63.6.732","article-title":"Differential regulation of endothelial cell adhesion molecule expression by nitric oxide donors and antioxidants","volume":"63","year":"1998","journal-title":"J. Leukoc. Biol."},{"key":"key\n\t\t\t\t20170315220557_bib32","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/0003-2697(83)90019-2","article-title":"Assay method for myeloperoxidase in human polymorphonuclear leukocytes","volume":"132","year":"1983","journal-title":"Anal. Biochem."},{"key":"key\n\t\t\t\t20170315220557_bib33","first-page":"631","article-title":"Cytokine expression, upregulation of intercellular adhesion molecule-1, and leukocyte infiltration in experimental tubulointerstitial nephritis","volume":"70","year":"1994","journal-title":"Lab. Invest."},{"key":"key\n\t\t\t\t20170315220557_bib34","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1023\/A:1007059616914","article-title":"Secretion of MCP-1 and IL-6 by cytokine stimulated production of reactive oxygen species in endothelial cells","volume":"206","year":"2000","journal-title":"Mol. Cell. Biochem."},{"key":"key\n\t\t\t\t20170315220557_bib35","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1097\/00007890-199301000-00032","article-title":"Regulation of cytokine-stimulated vascular cell adhesion molecule-1 expression in renal tubular epithelial cells","volume":"55","year":"1993","journal-title":"Transplantation"},{"key":"key\n\t\t\t\t20170315220557_bib36","doi-asserted-by":"crossref","first-page":"F622","DOI":"10.1152\/ajprenal.00427.2004","article-title":"Kallikrein gene transfer reduces renal fibrosis, hypertrophy, and proliferation in DOCA-salt hypertensive rats","volume":"289","year":"2005","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"key\n\t\t\t\t20170315220557_bib37","doi-asserted-by":"crossref","first-page":"33011","DOI":"10.1074\/jbc.M305352200","article-title":"Overexpression of interferon-gamma-inducible GTPase inhibits coxsackievirus B3-induced apoptosis through the activation of the phosphatidylinositol 3-kinase\/Akt pathway and inhibition of viral replication","volume":"278","year":"2003","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170315220557_bib38","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1111\/j.1523-1755.2004.00794.x","article-title":"Tissue kallikrein attenuates salt-induced renal fibrosis by inhibition of oxidative stress","volume":"66","year":"2004","journal-title":"Kidney Int."}],"container-title":["Toxicological Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/toxsci\/article-pdf\/102\/2\/433\/10998597\/kfn008.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T21:50:46Z","timestamp":1630619446000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/toxsci\/article\/1674306\/Role"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,1,27]]},"references-count":38,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2008,1,27]]},"published-print":{"date-parts":[[2008,4]]}},"URL":"https:\/\/doi.org\/10.1093\/toxsci\/kfn008","relation":{},"ISSN":["1096-6080","1096-0929"],"issn-type":[{"value":"1096-6080","type":"print"},{"value":"1096-0929","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,1,27]]}}}