{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T17:38:42Z","timestamp":1760204322494},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,8]]},"DOI":"10.1093\/toxsci\/kfn094","type":"journal-article","created":{"date-parts":[[2008,5,16]],"date-time":"2008-05-16T00:14:24Z","timestamp":1210896864000},"page":"397-404","source":"Crossref","is-referenced-by-count":17,"title":["The Inhibition of Embryonic Histone Deacetylases as the Possible Mechanism Accounting for Axial Skeletal Malformations Induced by Sodium Salicylate"],"prefix":"10.1093","volume":"104","author":[{"given":"Francesca","family":"Di Renzo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graziella","family":"Cappelletti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Luisa","family":"Broccia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erminio","family":"Giavini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Menegola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2008,5,14]]},"reference":[{"key":"key\n\t\t\t\t20170315204332_bib1","volume-title":"Materials for the Study of Variation Treated with Special Regard to Discontinuity in the Origin of the Species","year":"1894"},{"key":"key\n\t\t\t\t20170315204332_bib2","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.ab.2006.05.009","article-title":"Measurement of salicylic acid in human serum using stable isotope dilution and gas chromatography-mass spectrometry","volume":"354","year":"2006","journal-title":"Anal. Biochem."},{"key":"key\n\t\t\t\t20170315204332_bib3","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1136\/jcp.54.7.553","article-title":"Salicylic acid in the serum of subjects not taking aspirin. Comparison of salicylic acid concentrations in the serum of vegetarians, non-vegetarians, and patients taking low dose aspirin","volume":"54","year":"2001","journal-title":"J. Clin. Pathol."},{"key":"key\n\t\t\t\t20170315204332_bib4","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1038\/nrd2133","article-title":"Anticancer activities of histone deacetylase inhibitors","volume":"5","year":"2006","journal-title":"Nat. Rev. Drug Discov."},{"key":"key\n\t\t\t\t20170315204332_bib5","doi-asserted-by":"crossref","first-page":"2009","DOI":"10.1096\/fj.06-5987com","article-title":"Therapeutic levels of aspirin and salicylate directly inhibit a model of angiogenesis through a Cox-independent mechanism","volume":"20","year":"2006","journal-title":"FASEB J."},{"key":"key\n\t\t\t\t20170315204332_bib6","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid sensitive method for quantitation of microgram quantities of protein using the principle of protein\u2014dye binding","volume":"72","year":"1976","journal-title":"Anal. Biochem."},{"key":"key\n\t\t\t\t20170315204332_bib7","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1002\/bdrb.10004","article-title":"Comparison of the developmental toxicity of aspirin in rabbits when administered throughout organogenesis or during sensitive windows of development","volume":"68","year":"2003","journal-title":"Birth Defects Res. B"},{"key":"key\n\t\t\t\t20170315204332_bib8","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1002\/tcm.1770070306","article-title":".The potential relationship of maternal toxicity, general stress, and fetal outcome","volume":"7","year":"1987","journal-title":"Teratog. Carcinog. Mutagen."},{"key":"key\n\t\t\t\t20170315204332_bib9","first-page":"31","article-title":"Phenolic compounds, sodium salicylate and related compounds, as inhibitors of tumor cell growth and inducers of apoptosis in mouse leukemia L1210 cells","volume":"19","year":"2005","journal-title":"In Vivo"},{"key":"key\n\t\t\t\t20170315204332_bib10","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/28958","article-title":"Innate immunity. Plants just say NO to pathogens","volume":"394","year":"1998","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170315204332_bib11","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/0962-8924(94)90235-6","article-title":"Salicylic acid, active oxygen species and systemic acquired resistance in plants","volume":"4","year":"1994","journal-title":"Trends Cell Biol."},{"key":"key\n\t\t\t\t20170315204332_bib12","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1093\/toxsci\/kfm115","article-title":"Relationship between embryonic histonic hyperacetylation and axial skeletal defects in mouse exposed to the three HDAC inhibitors apicidin, MS-275, and sodium butyrate","volume":"98","year":"2007","journal-title":"Toxicol. Sci."},{"key":"key\n\t\t\t\t20170315204332_bib13","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.taap.2007.01.001","article-title":"Boric acid inhibits embryonic histone deacetylases: A suggested mechanism to explain boric acid-related teratogenicity","volume":"220","year":"2007","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"key\n\t\t\t\t20170315204332_bib14","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0890-6238(88)80006-6","article-title":"In vitro culture of postimplantation hamster embryos","volume":"2","year":"1988","journal-title":"Reprod. Toxicol."},{"key":"key\n\t\t\t\t20170315204332_bib15","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/S0890-6238(99)00029-5","article-title":"Induction of supernumerary ribs with sodium salicylate","volume":"13","year":"1999","journal-title":"Reprod. Toxicol."},{"key":"key\n\t\t\t\t20170315204332_bib16","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/0041-008X(84)90280-1","article-title":"Embryotoxic effects of salicylates: Role of biotransformation","volume":"74","year":"1984","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"key\n\t\t\t\t20170315204332_bib17","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1073\/pnas.84.5.1417","article-title":"Pharmacokinetics of aspirin and salicylate in relation to inhibition of arachidonate cyclooxygenase and antiinflammatory activity","volume":"84","year":"1987","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"key\n\t\t\t\t20170315204332_bib18","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1038\/nrd772","article-title":"Histone-deacetylase inhibitors: Novel drugs for the treatment of cancer","volume":"1","year":"2002","journal-title":"Nat. Rev. Drug Discov."},{"key":"key\n\t\t\t\t20170315204332_bib19","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1097\/01.cmr.0000195698.58013.53","article-title":"Sodium salicylate inhibits TNF-alpha-induced NF-kappaB activation, cell migration, invasion and ICAM-1 expression in human melanoma cells","volume":"16","year":"2006","journal-title":"Melanoma Res."},{"key":"key\n\t\t\t\t20170315204332_bib21","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1002\/tera.1420080311","article-title":"Skeletal deviations in rats: Malformations or variations?","volume":"8","year":"1973","journal-title":"Teratology"},{"key":"key\n\t\t\t\t20170315204332_bib22","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1002\/tera.1420040104","article-title":"Studies on metabolism and identification of the causative agent in aspirin teratogenesis in rats","volume":"4","year":"1971","journal-title":"Teratology"},{"key":"key\n\t\t\t\t20170315204332_bib23","first-page":"503","article-title":"Sodium salicylate induces apoptosis in HCT116 colorectal cancer cells through activation of p38MAPK","volume":"23","year":"2003","journal-title":"Int. J. Oncol."},{"key":"key\n\t\t\t\t20170315204332_bib24","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0065-230X(02)86002-X","article-title":"Histone acetyltransferases and deacetylases in the control of cell proliferation and differentiation","volume":"86","year":"2002","journal-title":"Adv. Cancer Res."},{"key":"key\n\t\t\t\t20170315204332_bib25","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1111\/j.1365-2184.2006.00390.x","article-title":"Calcium salicylate-mediated apoptosis in human HT-1080 fibrosarcoma cells","volume":"39","year":"2006","journal-title":"Cell Prolif."},{"key":"key\n\t\t\t\t20170315204332_bib26","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1002\/med.20024","article-title":"Histone deacetylation in epigenetics: An attractive target for anticancer therapy","volume":"25","year":"2005","journal-title":"Med. Res. Rev."},{"key":"key\n\t\t\t\t20170315204332_bib27","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1002\/tera.1055","article-title":"Atlas of rat fetal skeleton double stained for bone and cartilage","volume":"64","year":"2001","journal-title":"Teratology"},{"key":"key\n\t\t\t\t20170315204332_bib28","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1002\/bdrc.20082","article-title":"Inhibition of histone deacetylase as a new mechanism of teratogenesis","volume":"78","year":"2006","journal-title":"Birth Defects Res. C"},{"key":"key\n\t\t\t\t20170315204332_bib29","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1002\/bdrb.20053","article-title":"Inhibition of histone deacetylase activity on specific embryonic tissues as a new mechanism for teratogenicity","volume":"74","year":"2005","journal-title":"Birth Defects Res. B"},{"key":"key\n\t\t\t\t20170315204332_bib30","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1038\/nrc1779","article-title":"Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer","volume":"6","year":"2006","journal-title":"Nat. Rev. Cancer"},{"key":"key\n\t\t\t\t20170315204332_bib31","first-page":"502","article-title":"The identification of salicylates as normal constituents of serum: A link between diet and health?","volume":"51","year":"1988","journal-title":"J. Clin. Pathol."},{"key":"key\n\t\t\t\t20170315204332_bib32","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1093\/qjmed\/94.8.445","article-title":"Salicylic acid: A link between aspirin, diet and the prevention of colorectal cancer","volume":"94","year":"2001","journal-title":"Q. J. Med."},{"key":"key\n\t\t\t\t20170315204332_bib33","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/S1091-255X(00)80029-3","article-title":"Sodium salicylate inhibits proliferation and induces G1 cell cycle arrest in human pancreatic cancer cell lines","volume":"4","year":"2000","journal-title":"J. Gastrointest. Surg."},{"key":"key\n\t\t\t\t20170315204332_bib34","first-page":"30","article-title":"Histone deacetylase inhibitors in cancer therapy","volume":"2","year":"2003","journal-title":"Cancer Biol. Ther."},{"key":"key\n\t\t\t\t20170315204332_bib35","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1002\/tera.1420010112","article-title":"Experimental production of congenital cardiovascular malformations in rats by salicylate poisoning","volume":"1","year":"1968","journal-title":"Teratology"},{"key":"key\n\t\t\t\t20170315204332_bib36","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1096\/fj.01-0390rev","article-title":"Cyclooxygenase-independent actions of cyclooxygenase inhibitors","volume":"15","year":"2001","journal-title":"FASEB J."},{"key":"key\n\t\t\t\t20170315204332_bib37","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/newbio231232a0","article-title":"Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs","volume":"231","year":"1971","journal-title":"Nat. New Biol."},{"key":"key\n\t\t\t\t20170315204332_bib38","first-page":"315","article-title":"Experimental production of congenital malformations in rats by salicylate poisoning","volume":"35","year":"1959","journal-title":"Am. J. Pathol."},{"key":"key\n\t\t\t\t20170315204332_bib39","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.reprotox.2004.12.014","article-title":"Vertebral malformations induced by sodium salicylate correlate with shifts in expression domains of Hox genes","volume":"20","year":"2005","journal-title":"Reprod. Toxicol."},{"key":"key\n\t\t\t\t20170315204332_bib40","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1002\/bdra.10031","article-title":"Defects in cervical vertebrae in boric acid-exposed rat embryos are associated with anterior shifts of hox gene expression domains","volume":"67","year":"2003","journal-title":"Birth Defects Res. A"},{"key":"key\n\t\t\t\t20170315204332_bib41","doi-asserted-by":"crossref","first-page":"5541","DOI":"10.1038\/sj.onc.1210620","article-title":"Histone deacetylase inhibitors: Molecular mechanisms of action","volume":"26","year":"2007","journal-title":"Oncogene"}],"container-title":["Toxicological Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/toxsci\/article-pdf\/104\/2\/397\/10999061\/kfn094.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,8,24]],"date-time":"2017-08-24T02:27:32Z","timestamp":1503541652000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/toxsci\/article\/1654167\/The"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,5,14]]},"references-count":40,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2008,5,14]]},"published-print":{"date-parts":[[2008,8]]}},"URL":"https:\/\/doi.org\/10.1093\/toxsci\/kfn094","relation":{},"ISSN":["1096-6080","1096-0929"],"issn-type":[{"value":"1096-6080","type":"print"},{"value":"1096-0929","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,5,14]]}}}