{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T05:41:08Z","timestamp":1762407668863},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,10]]},"DOI":"10.1093\/toxsci\/kfn140","type":"journal-article","created":{"date-parts":[[2008,7,11]],"date-time":"2008-07-11T20:24:14Z","timestamp":1215807854000},"page":"360-367","source":"Crossref","is-referenced-by-count":23,"title":["The orl Rat with Inherited Cryptorchidism Has Increased Susceptibility to the Testicular Effects of In Utero Dibutyl Phthalate Exposure"],"prefix":"10.1093","volume":"105","author":[{"given":"Kamin J.","family":"Johnson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzanne M.","family":"McCahan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoli","family":"Si","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liam","family":"Campion","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Revital","family":"Herrmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia S.","family":"Barthold","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2008,7,10]]},"reference":[{"key":"key\n\t\t\t\t20170508154202_bib1","doi-asserted-by":"crossref","first-page":"352","DOI":"10.2164\/jandrol.107.003970","article-title":"Altered expression of muscle- and cytoskeleton-related genes in a rat strain with inherited cryptorchidism","volume":"29","year":"2008","journal-title":"J. Androl."},{"key":"key\n\t\t\t\t20170508154202_bib2","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1016\/j.juro.2006.06.063","article-title":"Failure of shortening and inversion of the perinatal gubernaculum in the cryptorchid Long-Evans orl rat","volume":"176","year":"2006","journal-title":"J. Urol."},{"key":"key\n\t\t\t\t20170508154202_bib3","article-title":"Role of hormones, genes and environment in human cryptorchidism","year":"2008","journal-title":"Endocr. Rev."},{"key":"key\n\t\t\t\t20170508154202_bib4","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1111\/j.1365-2605.2005.00563.x","article-title":"Disruption of reproductive development in male rat offspring following in utero exposure to phthalate esters","volume":"29","year":"2006","journal-title":"Int. J. Androl."},{"key":"key\n\t\t\t\t20170508154202_bib5","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1093\/toxsci\/kfm049","article-title":"Fetal mouse phthalate exposure shows that gonocyte multinucleation is not associated with decreased testicular testosterone","volume":"97","year":"2007","journal-title":"Toxicol. Sci."},{"key":"key\n\t\t\t\t20170508154202_bib6","first-page":"96","article-title":"Adverse effects of environmental antiandrogens and androgens on reproductive development in mammals","year":"2006","journal-title":"Int. J. Androl."},{"key":"key\n\t\t\t\t20170508154202_bib7","article-title":"Fifteen years after \u201cWingspread\u201d\u2013\u2013environmental endocrine disrupters and human and wildlife health: Where we are today and where we need to go","year":"2008","journal-title":"Toxicol. Sci."},{"key":"key\n\t\t\t\t20170508154202_bib8","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1080\/01926230590896145","article-title":"Morphology of the fetal rat testis preserved in different fixatives","volume":"33","year":"2005","journal-title":"Toxicol. Pathol."},{"key":"key\n\t\t\t\t20170508154202_bib9","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1038\/nrg1578","article-title":"Gene-environment interactions in human diseases","volume":"6","year":"2005","journal-title":"Nat. Rev. Genet."},{"key":"key\n\t\t\t\t20170508154202_bib10","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1210\/endo-129-3-1409","article-title":"Time-specific androgen blockade with flutamide inhibits testicular descent in the rat","volume":"129","year":"1991","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170508154202_bib11","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1095\/biolreprod.107.064006","article-title":"Sertoli cell development and function in an animal model of testicular dysgenesis syndrome","volume":"78","year":"2008","journal-title":"Biol. Reprod."},{"key":"key\n\t\t\t\t20170508154202_bib12","first-page":"259","article-title":"Anatomical and functional aspects of testicular descent and cryptorchidism","volume":"18","year":"1997","journal-title":"Endocr. Rev."},{"key":"key\n\t\t\t\t20170508154202_bib13","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1530\/jrf.0.0840701","article-title":"Suprainguinal ectopic scrota of TS inbred rats","volume":"84","year":"1988","journal-title":"J. Reprod. Fertil."},{"key":"key\n\t\t\t\t20170508154202_bib14","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1095\/biolreprod.107.062950","article-title":"Mapping gene expression changes in the fetal rat testis following acute dibutyl phthalate exposure defines a complex temporal cascade of responding cell types","volume":"77","year":"2007","journal-title":"Biol. Reprod."},{"key":"key\n\t\t\t\t20170508154202_bib15","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1210\/en.2003-1055","article-title":"Regulation of Sertoli cell number and activity by follicle-stimulating hormone and androgen during postnatal development in the mouse","volume":"145","year":"2004","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170508154202_bib16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ydbio.2004.02.018","article-title":"Molecular and genetic regulation of testis descent and external genitalia development","volume":"270","year":"2004","journal-title":"Dev. Biol."},{"key":"key\n\t\t\t\t20170508154202_bib17","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1093\/toxsci\/kfh169","article-title":"Dose-dependent alterations in gene expression and testosterone synthesis in the fetal testes of male rats exposed to di (n-butyl) phthalate","volume":"81","year":"2004","journal-title":"Toxicol. Sci."},{"key":"key\n\t\t\t\t20170508154202_bib18","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1289\/ehp.8075","article-title":"Human breast milk contamination with phthalates and alterations of endogenous reproductive hormones in infants three months of age","volume":"114","year":"2006","journal-title":"Environ. Health Perspect."},{"key":"key\n\t\t\t\t20170508154202_bib19","doi-asserted-by":"crossref","first-page":"4536","DOI":"10.1210\/en.2005-0676","article-title":"Expression of insulin-like factor 3 protein in the rat testis during fetal and postnatal development and in relation to cryptorchidism induced by in utero exposure to di(n-Butyl) phthalate","volume":"146","year":"2005","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170508154202_bib20","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/0022-4731(89)90144-1","article-title":"Testicular steroid sulfatase in a cryptorchid rat strain","volume":"34","year":"1989","journal-title":"J. Steroid. Biochem."},{"key":"key\n\t\t\t\t20170508154202_bib21","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1093\/toxsci\/43.1.47","article-title":"Male reproductive tract malformations in rats following gestational and lactational exposure to di(n-butyl) phthalate: An antiandrogenic mechanism?","volume":"43","year":"1998","journal-title":"Toxicol. Sci."},{"key":"key\n\t\t\t\t20170508154202_bib22","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/10364","article-title":"Cryptorchidism in mice mutant for Insl3","volume":"22","year":"1999","journal-title":"Nat. Genet."},{"key":"key\n\t\t\t\t20170508154202_bib23","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1210\/endo-122-3-787","article-title":"Evidence from Sertoli cell-depleted rats indicates that spermatid number in adults depends on numbers of Sertoli cells produced during perinatal development","volume":"122","year":"1988","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170508154202_bib24","article-title":"Relationship between androgen action in the \u2018male programming window', fetal sertoli cell number and adult testis size in the rat","year":"2008","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170508154202_bib25","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.1210\/en.2006-1622","article-title":"Role of androgens in fetal testis development and dysgenesis","volume":"148","year":"2007","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170508154202_bib26","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1093\/toxsci\/64.2.233","article-title":"Altered gene profiles in fetal rat testes after in utero exposure to di(n-butyl) phthalate","volume":"64","year":"2001","journal-title":"Toxicol. Sci."},{"key":"key\n\t\t\t\t20170508154202_bib27","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1210\/endo-129-2-741","article-title":"Effects of flutamide and finasteride on rat testicular descent","volume":"129","year":"1991","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170508154202_bib28","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1289\/ehp.8100","article-title":"Decrease in anogenital distance among male infants with prenatal phthalate exposure","volume":"113","year":"2005","journal-title":"Environ. Health Perspect."},{"key":"key\n\t\t\t\t20170508154202_bib29","doi-asserted-by":"crossref","first-page":"2674","DOI":"10.1210\/en.2004-1630","article-title":"The role of androgens in Sertoli cell proliferation and functional maturation: Studies in mice with total or Sertoli cell-selective ablation of the androgen receptor","volume":"146","year":"2005","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170508154202_bib30","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1095\/biolreprod.105.042382","article-title":"Differential steroidogenic gene expression in the fetal adrenal gland versus the testis and rapid and dynamic response of the fetal testis to di(n-butyl) phthalate","volume":"73","year":"2005","journal-title":"Biol. Reprod."},{"key":"key\n\t\t\t\t20170508154202_bib31","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1159\/000181051","article-title":"The embryology of testicular descent","volume":"30","year":"1988","journal-title":"Horm. Res."},{"key":"key\n\t\t\t\t20170508154202_bib32","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.toxlet.2007.03.004","article-title":"Differential expression of the phthalate syndrome in male Sprague-Dawley and Wistar rats after in utero DEHP exposure","volume":"170","year":"2007","journal-title":"Toxicol. Lett."},{"key":"key\n\t\t\t\t20170508154202_bib33","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.toxlet.2003.09.012","article-title":"Phthalate ester-induced gubernacular lesions are associated with reduced insl3 gene expression in the fetal rat testis","volume":"146","year":"2004","journal-title":"Toxicol. Lett."},{"key":"key\n\t\t\t\t20170508154202_bib34","doi-asserted-by":"crossref","first-page":"13498","DOI":"10.1073\/pnas.212474399","article-title":"Generation and characterization of androgen receptor knockout (ARKO) mice: An in vivo model for the study of androgen functions in selective tissues","volume":"99","year":"2002","journal-title":"Proc. Natl Acad. Sci. U.S.A."},{"key":"key\n\t\t\t\t20170508154202_bib35","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1210\/mend.13.5.0272","article-title":"Targeted disruption of the Insl3 gene causes bilateral cryptorchidism","volume":"13","year":"1999","journal-title":"Mol. Endocrinol."}],"container-title":["Toxicological Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/toxsci\/article-pdf\/105\/2\/360\/10940490\/kfn140.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,8,23]],"date-time":"2017-08-23T21:45:33Z","timestamp":1503524733000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/toxsci\/article-lookup\/doi\/10.1093\/toxsci\/kfn140"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,7,10]]},"references-count":35,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2008,7,10]]},"published-print":{"date-parts":[[2008,10]]}},"URL":"https:\/\/doi.org\/10.1093\/toxsci\/kfn140","relation":{},"ISSN":["1096-6080","1096-0929"],"issn-type":[{"value":"1096-6080","type":"print"},{"value":"1096-0929","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,7,10]]}}}