{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T22:39:17Z","timestamp":1773873557028,"version":"3.50.1"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,12]]},"DOI":"10.1093\/toxsci\/kfn183","type":"journal-article","created":{"date-parts":[[2008,9,9]],"date-time":"2008-09-09T00:44:36Z","timestamp":1220921076000},"page":"488-496","source":"Crossref","is-referenced-by-count":37,"title":["Dioxin Causes Ventral Prostate Agenesis by Disrupting Dorsoventral Patterning in Developing Mouse Prostate"],"prefix":"10.1093","volume":"106","author":[{"given":"Chad M.","family":"Vezina","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah Hicks","family":"Allgeier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert W.","family":"Moore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tien-Min","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey C.","family":"Bemis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heather A.","family":"Hardin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas A.","family":"Gasiewicz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard E.","family":"Peterson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2008,9,8]]},"reference":[{"key":"key\n\t\t\t\t20170508171919_bib1","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1093\/toxsci\/kfg238","article-title":"Lack of expression of EGF and TGF-\u03b1 in the fetal mouse alters formation of prostatic epithelial buds and influences the response to TCDD","volume":"76","year":"2003","journal-title":"Toxicol. Sci."},{"key":"key\n\t\t\t\t20170508171919_bib2","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1242\/dev.02310","article-title":"Regulation of early lung morphogenesis: Questions, facts and controversies","volume":"133","year":"2006","journal-title":"Development"},{"key":"key\n\t\t\t\t20170508171919_bib3","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1126\/science.8392225","article-title":"Separable regulatory elements governing myogenin transcription in mouse embryogenesis","volume":"261","year":"1993","journal-title":"Science"},{"key":"key\n\t\t\t\t20170508171919_bib4","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/0168-9525(96)10030-5","article-title":"Limbs: a model for pattern formation within the vertebrate body plan","volume":"12","year":"1996","journal-title":"Trends Genet."},{"key":"key\n\t\t\t\t20170508171919_bib5","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1002\/jez.1402050203","article-title":"The possible influence of temporal factors in androgenic responsiveness of urogenital tissue recombinants from wild-type and androgen-insensitive (Tfm) mice","volume":"205","year":"1978","journal-title":"J. Exp. Zool."},{"key":"key\n\t\t\t\t20170508171919_bib6","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0012-1606(03)00250-1","article-title":"FGF-10 plays an essential role in the growth of the fetal prostate","volume":"261","year":"2003","journal-title":"Dev. Biol."},{"key":"key\n\t\t\t\t20170508171919_bib7","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1093\/toxsci\/67.1.63","article-title":"Persistent abnormalities in the rat mammary gland following gestational and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)","volume":"67","year":"2002","journal-title":"Toxicol. Sci."},{"key":"key\n\t\t\t\t20170508171919_bib8","first-page":"66","article-title":"Permissive and instructive induction of adult rodent prostatic epithelium by heterotypic urogenital sinus mesenchyme","volume":"2","year":"1993","journal-title":"Epithelial Cell Biol."},{"key":"key\n\t\t\t\t20170508171919_bib9","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0925-4773(98)00038-0","article-title":"Expression of ARNT, ARNT2, HIF1\u03b1, HIF2\u03b1 and Ah receptor mRNAs in the developing mouse","volume":"73","year":"1998","journal-title":"Mech. Dev."},{"key":"key\n\t\t\t\t20170508171919_bib10","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.taap.2005.07.010","article-title":"Interference by 2,3,7,8-tetrachlorodibenzo-p-dioxin with cultured mouse submandibular gland branching morphogenesis involves reduced epidermal growth factor receptor signaling","volume":"212","year":"2006","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"key\n\t\t\t\t20170508171919_bib11","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.taap.2003.12.004","article-title":"Aryl hydrocarbon receptors in urogenital sinus mesenchyme mediate the inhibition of prostatic epithelial bud formation by 2,3,7,8-tetrachlorodibenzo-p-dioxin","volume":"196","year":"2004","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"key\n\t\t\t\t20170508171919_bib12","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1093\/toxsci\/kfh111","article-title":"Evidence that inhibited prostatic epithelial bud formation in 2,3,7,8-tetrachlorodibenzo-p-dioxin-exposed C57BL\/6J fetal mice is not due to interruption of androgen signaling in the urogenital sinus","volume":"79","year":"2004","journal-title":"Toxicol. Sci."},{"key":"key\n\t\t\t\t20170508171919_bib13","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1093\/toxsci\/70.2.227","article-title":"In utero and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin in the C57BL\/6J mouse prostate: Lobe-specific effects on branching morphogenesis","volume":"70","year":"2002","journal-title":"Toxicol. Sci."},{"key":"key\n\t\t\t\t20170508171919_bib14","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.taap.2007.06.006","article-title":"Gestational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin alters retinoid homeostasis in maternal and perinatal tissues of the Holtzman rat","volume":"224","year":"2007","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"key\n\t\t\t\t20170508171919_bib33","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1080\/152873901316981312","article-title":"Role of the aryl hydrocarbon receptor in the development of control and 2,3,7,8-tetrachlorodibenzo-p-dioxin-exposed male mice","volume":"64","year":"2001","journal-title":"J Toxicol Environ Health A."},{"key":"key\n\t\t\t\t20170508171919_bib15","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1093\/toxsci\/68.2.479","article-title":"Effects of aryl hydrocarbon receptor null mutation and in utero and lactational 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure on prostate and seminal vesicle development in C57BL\/6 mice","volume":"68","year":"2002","journal-title":"Toxicol. Sci."},{"key":"key\n\t\t\t\t20170508171919_bib16","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1093\/toxsci\/kfg218","article-title":"Region-specific inhibition of prostatic epithelial bud formation in the urogenital sinus of C57BL\/6 mice exposed in utero to 2,3,7,8-tetrachlorodibenzo-p-dioxin","volume":"76","year":"2003","journal-title":"Toxicol. Sci."},{"key":"key\n\t\t\t\t20170508171919_bib17","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1097\/01.ju.0000124989.02257.38","article-title":"2,3,7,8-Tetrachlorodibenzo-p-dioxin inhibits prostatic epithelial bud formation by acting directly on the urogenital sinus","volume":"172","year":"2004","journal-title":"J. Urol."},{"key":"key\n\t\t\t\t20170508171919_bib18","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1093\/toxsci\/69.1.202","article-title":"Critical windows of vulnerability for effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on prostate and seminal vesicle development in C57BL\/6 mice","volume":"69","year":"2002","journal-title":"Toxicol. Sci."},{"key":"key\n\t\t\t\t20170508171919_bib19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0070-2153(07)81001-5","article-title":"Models of biological pattern formation: From elementary steps to the organization of embryonic axes","volume":"81","year":"2008","journal-title":"Curr. Top. Dev. Biol."},{"key":"key\n\t\t\t\t20170508171919_bib20","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1006\/taap.2002.9490","article-title":"Effect of in utero and lactational 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure on rat molar development: the role of exposure time","volume":"184","year":"2002","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"key\n\t\t\t\t20170508171919_bib21","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s10911-006-9029-x","article-title":"The mammary bud as a skin appendage: Unique and shared aspects of development","volume":"11","year":"2006","journal-title":"J. Mammary Gland Biol. Neoplasia"},{"key":"key\n\t\t\t\t20170508171919_bib22","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1126\/science.256.5060.1193","article-title":"Identification of the Ah receptor nuclear translocator protein (Arnt) as a component of the DNA binding form of the Ah receptor","volume":"256","year":"1992","journal-title":"Science"},{"key":"key\n\t\t\t\t20170508171919_bib23","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S0070-2153(07)81012-X","article-title":"Tooth morphogenesis in vivo, in vitro, and in silico","volume":"81","year":"2008","journal-title":"Curr. Top. Dev. Biol."},{"key":"key\n\t\t\t\t20170508171919_bib25","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1095\/biolreprod34.5.961","article-title":"Morphogenesis of ductal networks in the mouse prostate","volume":"34","year":"1986","journal-title":"Biol. Reprod."},{"key":"key\n\t\t\t\t20170508171919_bib26","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1677\/joe.0.1140131","article-title":"Change of mosaic pattern by androgens during prostatic bud formation in XTfm\/X+ heterozygous female mice","volume":"114","year":"1987","journal-title":"J. Endocrinol."},{"key":"key\n\t\t\t\t20170508171919_bib27","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1111\/j.1432-0436.2008.00293.x","article-title":"The role of Sox9 in prostate development","volume":"76","year":"2008","journal-title":"Differentiation"},{"key":"key\n\t\t\t\t20170508171919_bib28","doi-asserted-by":"crossref","first-page":"3693","DOI":"10.1242\/dev.126.16.3693","article-title":"Prostatic growth and development are regulated by FGF10","volume":"126","year":"1999","journal-title":"Development"},{"key":"key\n\t\t\t\t20170508171919_bib29","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1242\/dev.129.8.1905","article-title":"The role of smooth muscle in regulating prostatic induction","volume":"129","year":"2002","journal-title":"Development"},{"key":"key\n\t\t\t\t20170508171919_bib30","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.semcdb.2007.01.006","article-title":"Salivary gland development","volume":"18","year":"2007","journal-title":"Semin. Cell Dev. Biol."},{"key":"key\n\t\t\t\t20170508171919_bib31","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1006\/taap.1998.8444","article-title":"Aryl hydrocarbon receptor activation in genital tubercle, palate, and other embryonic tissues in 2,3,7,8-tetrachlorodibenzo-p-dioxin-responsive lacZ mice","volume":"151","year":"1998","journal-title":"Toxicol. Appl. Pharmacol."}],"container-title":["Toxicological Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/toxsci\/article-pdf\/106\/2\/488\/16679429\/kfn183.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,16]],"date-time":"2021-09-16T04:47:09Z","timestamp":1631767629000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/toxsci\/article-lookup\/doi\/10.1093\/toxsci\/kfn183"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,9,8]]},"references-count":31,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2008,9,8]]},"published-print":{"date-parts":[[2008,12]]}},"URL":"https:\/\/doi.org\/10.1093\/toxsci\/kfn183","relation":{},"ISSN":["1096-6080","1096-0929"],"issn-type":[{"value":"1096-6080","type":"print"},{"value":"1096-0929","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,9,8]]}}}