{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T11:11:48Z","timestamp":1789989108401,"version":"4.0.1"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,12]]},"DOI":"10.1093\/toxsci\/kfp234","type":"journal-article","created":{"date-parts":[[2009,10,6]],"date-time":"2009-10-06T00:25:37Z","timestamp":1254788737000},"page":"297-302","source":"Crossref","is-referenced-by-count":47,"title":["Toxicity Testing in the 21st Century: A View from the Chemical Industry"],"prefix":"10.1093","volume":"112","author":[{"given":"James S.","family":"Bus","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard A.","family":"Becker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2009,10,4]]},"reference":[{"key":"key\n\t\t\t\t20170315182854_bib1","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1093\/toxsci\/kfn255","article-title":"Toxicity testing in the 21st century: bringing the vision to life","volume":"107","year":"2009","journal-title":"Toxicol. Sci."},{"key":"key\n\t\t\t\t20170315182854_bib2","article-title":"Consideration of \u201cdose\u201d in evaluation of toxcast\u2122 data: use of biomonitoring and pharmacokinetic data","year":"2009"},{"key":"key\n\t\t\t\t20170315182854_bib3","doi-asserted-by":"crossref","first-page":"2454","DOI":"10.1016\/j.fct.2007.05.030","article-title":"Tiered toxicity testing: evaluation of toxicity-based decision triggers for human health hazard characterization","volume":"45","year":"2007","journal-title":"Food Chem. Toxicol."},{"key":"key\n\t\t\t\t20170315182854_bib4","first-page":"151","article-title":"The extension of molecular and computational information to risk assessment and regulatory decision making","volume-title":"Genomic Approaches for Cross-Species Extrapolation in Toxicology","year":"2007"},{"key":"key\n\t\t\t\t20170315182854_bib5","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1126\/science.1154619","article-title":"Transforming environmental health protection","volume":"319","year":"2008","journal-title":"Science"},{"key":"key\n\t\t\t\t20170315182854_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/toxsci\/49.1.1","article-title":"Stimulating research to improve the scientific basis of risk assessment","volume":"49","year":"1999","journal-title":"Toxicol. Sci."},{"key":"key\n\t\t\t\t20170315182854_bib7","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1191\/0960327105ht517oa","article-title":"Evidence-based toxicology: a comprehensive framework for causation","volume":"24","year":"2005","journal-title":"Hum. Exp. Toxicol."},{"key":"key\n\t\t\t\t20170315182854_bib8","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.yrtph.2006.08.004","article-title":"Biomonitoring equivalents: a screening approach for interpreting biomonitoring results from a public health perspective","volume":"47","year":"2007","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"key\n\t\t\t\t20170315182854_bib9","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1191\/0960327106het648oa","article-title":"Toward an evidence-based toxicology","volume":"25","year":"2006","journal-title":"Hum. Exp. Toxicol."},{"key":"key\n\t\t\t\t20170315182854_bib10","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1093\/toxsci\/kfp088","article-title":"Toxicity testing in the 21st century: a view from the pharmaceutical industry","volume":"110","year":"2009","journal-title":"Toxicol. Sci."},{"key":"key\n\t\t\t\t20170315182854_bib23","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.taap.2006.12.024","article-title":"Mixtures in the real world: The importance of plant self-defense toxicants, mycotoxins and the human diet","volume":"223","year":"2007","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"key\n\t\t\t\t20170315182854_bib11","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1093\/toxsci\/kfp008","article-title":"Pragmatic challenges for the vision of toxicity testing in the 21st century in a regulatory context: another Ames test? or a new edition of \u201cthe Red Book\u201d?","volume":"108","year":"2009","journal-title":"Toxicol. Sci."},{"key":"key\n\t\t\t\t20170315182854_bib12","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/j.yrtph.2008.02.008","article-title":"Foreword: biomonitoring equivalents special issue","volume":"51","year":"2008","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"key\n\t\t\t\t20170315182854_bib13","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1093\/toxsci\/kfi198","article-title":"Gene expression changes induced in the testis by transplacental exposure to high and low doses of 17\u03b1-ethynyl estradiol, genistein, or bishphenol A","volume":"86","year":"2005","journal-title":"Toxicol. Sci."},{"key":"key\n\t\t\t\t20170315182854_bib14","volume-title":"Toxicity Testing in the 21st Century. A Vision and a Strategy","author":"National Research Council, Committee on Toxicity Testing and Assessment of Environmental Agents, Board of Environmental Studies and Toxicology, Institute for Laboratory Animal Research","year":"2007"},{"key":"key\n\t\t\t\t20170315182854_bib15","volume-title":"Applications of Toxicogenomic Technologies to Predictive Toxicology and Risk Assessment","author":"National Research Council, Committee on Applications of Toxicogenomic Technologies to Predictive Toxicology, Board of Environmental Studies and Toxicology, Board of Life Studies, Division of Earth and Life Studies","year":"2007"},{"key":"key\n\t\t\t\t20170315182854_bib16","volume-title":"Science and Decisions, Advancing Risk Assessment","author":"National Research Council, Committee on Improving Risk Analysis Approaches Used by the U.S. EPA, Board of Environmental Studies and Toxicology, Division of Earth and Life Studies","year":"2008"},{"key":"key\n\t\t\t\t20170315182854_bib17","volume-title":"Phthalates and Cumulative Risk Assessment, The Task Ahead","author":"National Research Council, Committee on the Health Risks of Phthalates, Board of Environmental Studies and Toxicology, Division of Earth and Life Studies","year":"2008"},{"key":"key\n\t\t\t\t20170315182854_bib18","volume-title":"Guidance Document on the Validation of (Quantitative) Structure-Activity Relationships [(Q)Sar] Models","author":"Organization for Economic Cooperation and Development (OECD)","year":"2007"},{"key":"key\n\t\t\t\t20170315182854_bib19","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1093\/toxsci\/kfm068","article-title":"Genetic toxicity assessment: employing the best science for human safety evaluation Part VI: when salt and sugar and vegetables are positive, how can genotoxicity data serve to inform risk assessment?","volume":"98","year":"2007","journal-title":"Toxicol. Sci."},{"key":"key\n\t\t\t\t20170315182854_bib20","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.taap.2005.06.010","article-title":"Strategies to assess systemic exposure of chemicals I subchronic\/chronic diet and drinking water studies","volume":"211","year":"2006","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"key\n\t\t\t\t20170315182854_bib21","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1006\/rtph.2002.1570","article-title":"Support of science-based decisions concerning the evaluation of the toxicology of mixtures: a new beginning","volume":"36","year":"2002","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"key\n\t\t\t\t20170315182854_bib22","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1093\/toxsci\/kfm092","article-title":"Method to integrate benchmark dose estimates with genomic data to assess the functional effects of chemical exposure","volume":"98","year":"2007","journal-title":"Toxicol. Sci."}],"container-title":["Toxicological Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/toxsci\/article-pdf\/112\/2\/297\/10988481\/kfp234.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T01:09:53Z","timestamp":1558573793000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/toxsci\/article\/1718695\/Toxicity"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,10,4]]},"references-count":23,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2009,10,4]]},"published-print":{"date-parts":[[2009,12]]}},"URL":"https:\/\/doi.org\/10.1093\/toxsci\/kfp234","relation":{},"ISSN":["1096-6080","1096-0929"],"issn-type":[{"value":"1096-6080","type":"print"},{"value":"1096-0929","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,10,4]]}}}