{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T02:55:54Z","timestamp":1791255354505,"version":"4.1.0"},"reference-count":51,"publisher":"Oxford University Press (OUP)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,5]]},"DOI":"10.1093\/toxsci\/kfq022","type":"journal-article","created":{"date-parts":[[2010,1,28]],"date-time":"2010-01-28T02:10:02Z","timestamp":1264644602000},"page":"98-108","source":"Crossref","is-referenced-by-count":68,"title":["Disruption of CLOCK-BMAL1 Transcriptional Activity Is Responsible for Aryl Hydrocarbon Receptor\u2013Mediated Regulation of Period1 Gene"],"prefix":"10.1093","volume":"115","author":[{"given":"Can-Xin","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacey L.","family":"Krager","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duan-Fang","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shelley A.","family":"Tischkau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2010,1,27]]},"reference":[{"key":"key\n\t\t\t\t20170508170249_bib1","doi-asserted-by":"crossref","first-page":"10","DOI":"10.2152\/jmi.52.10","article-title":"Background exposure to PCDDs\/PCDFs\/PCBs and its potential health effects: a review of epidemiologic studies","volume":"52","year":"2005","journal-title":"J. Med. Invest."},{"key":"key\n\t\t\t\t20170508170249_bib2","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1016\/S0960-9822(01)00445-6","article-title":"Visualization of mPer1 transcription in vitro: NMDA induces a rapid phase shift of mPer1 gene in cultured SCN","volume":"11","year":"2001","journal-title":"Curr. Biol."},{"key":"key\n\t\t\t\t20170508170249_bib3","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1289\/ehp.98106625","article-title":"The Seveso studies on early and long-term effects of dioxin exposure: a review","volume":"106","year":"1998","journal-title":"Environ. Health Perspect."},{"key":"key\n\t\t\t\t20170508170249_bib4","first-page":"R561","article-title":"Period gene expression in mouse endocrine tissues","volume":"285","year":"2003","journal-title":"Am. J. Physiol."},{"key":"key\n\t\t\t\t20170508170249_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BFb0030908","article-title":"Aryl hydrocarbon or dioxin receptor: biologic and toxic responses","volume":"125","year":"1994","journal-title":"Rev. Physiol. Biochem. Pharmacol."},{"key":"key\n\t\t\t\t20170508170249_bib6","doi-asserted-by":"crossref","first-page":"4143","DOI":"10.1182\/blood-2003-03-0779","article-title":"Circadian clock genes oscillate in human peripheral blood mononuclear cells","volume":"102","year":"2003","journal-title":"Blood"},{"key":"key\n\t\t\t\t20170508170249_bib7","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1210\/me.2006-0052","article-title":"Reciprocal regulation of brain and muscle Arnt-like protein 1 and peroxisome proliferator-activated receptor alpha defines a novel positive feedback loop in the rodent liver circadian clock","volume":"20","year":"2006","journal-title":"Mol. Endocrinol."},{"key":"key\n\t\t\t\t20170508170249_bib8","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/S0165-0173(03)00171-1","article-title":"A molecular perspective of human circadian rhythm disorders","volume":"42","year":"2003","journal-title":"Brain Res."},{"key":"key\n\t\t\t\t20170508170249_bib9","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1128\/MCB.18.1.525","article-title":"Constitutive activation of the aromatic hydrocarbon receptor","volume":"18","year":"1998","journal-title":"Mol. Cell. Biol."},{"key":"key\n\t\t\t\t20170508170249_bib10","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1093\/carcin\/bgi075","article-title":"Deregulated expression of the PER1, PER2 and PER3 genes in breast cancers","volume":"26","year":"2005","journal-title":"Carcinogenesis"},{"key":"key\n\t\t\t\t20170508170249_bib11","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/nature01314","article-title":"Rhythmic histone acetylation underlies transcription in the mammalian circadian clock","volume":"421","year":"2003","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170508170249_bib12","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.yfrne.2007.03.001","article-title":"The relationship between nutrition and circadian rhythms in mammals","volume":"28","year":"2007","journal-title":"Front Neuroendocrinol."},{"key":"key\n\t\t\t\t20170508170249_bib13","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0092-8674(02)00961-3","article-title":"The circadian gene Period2 plays an important role in tumor suppression and DNA damage response in vivo","volume":"111","year":"2002","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170508170249_bib14","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.1124\/mol.105.021006","article-title":"The aryl hydrocarbon receptor agonist 2,3,7,8-tetrachlorodibenzo-p-dioxin alters the circadian rhythms, quiescence, and expression of clock genes in murine hematopoietic stem and progenitor cells","volume":"69","year":"2006","journal-title":"Mol. Pharmacol."},{"key":"key\n\t\t\t\t20170508170249_bib15","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1126\/science.280.5369.1564","article-title":"Role of the CLOCK protein in the mammalian circadian mechanism","volume":"280","year":"1998","journal-title":"Science"},{"key":"key\n\t\t\t\t20170508170249_bib16","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.molcel.2006.03.038","article-title":"The circadian gene per1 plays an important role in cell growth and DNA damage control in human cancer cells","volume":"22","year":"2006","journal-title":"Mol. Cell"},{"key":"key\n\t\t\t\t20170508170249_bib17","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1158\/1078-0432.CCR-06-1730","article-title":"Epigenetic silencing of the candidate tumor suppressor gene Per1 in non-small cell lung cancer","volume":"13","year":"2007","journal-title":"Clin. Cancer Res."},{"key":"key\n\t\t\t\t20170508170249_bib18","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1126\/science.286.5440.768","article-title":"Light-independent role of CRY1 and CRY2 in the mammalian circadian clock","volume":"286","year":"1999","journal-title":"Science"},{"key":"key\n\t\t\t\t20170508170249_bib19","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1097\/00001648-199705000-00005","article-title":"Serum dioxin and diabetes mellitus in veterans of Operation Ranch Hand","volume":"8","year":"1997","journal-title":"Epidemiology"},{"key":"key\n\t\t\t\t20170508170249_bib20","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1159\/000243163","article-title":"In vivo circadian rhythms in gonadotropin releasing hormone neurons","volume":"91","year":"2010","journal-title":"Neuroendocrinology."},{"key":"key\n\t\t\t\t20170508170249_bib21","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1006\/geno.2000.6166","article-title":"The human and mouse Period1 genes: five well-conserved Eboxes additively contribute to the enhancement of mPer1 transcription","volume":"65","year":"2000","journal-title":"Genomics"},{"key":"key\n\t\t\t\t20170508170249_bib22","doi-asserted-by":"crossref","first-page":"8581","DOI":"10.1074\/jbc.272.13.8581","article-title":"Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway","volume":"272","year":"1997","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170508170249_bib23","doi-asserted-by":"crossref","first-page":"5474","DOI":"10.1073\/pnas.95.10.5474","article-title":"The basic-helix-loop-helix-PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factors","volume":"95","year":"1998","journal-title":"Proc. Natl Acad. Sci. U.S.A."},{"key":"key\n\t\t\t\t20170508170249_bib24","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1046\/j.1365-2443.2002.00579.x","article-title":"Zebrafish CRY represses transcription mediated by CLOCK-BMAL heterodimer without inhibiting its binding to DNA","volume":"7","year":"2002","journal-title":"Genes Cells"},{"key":"key\n\t\t\t\t20170508170249_bib25","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1095\/biolreprod.106.050732","article-title":"Circadian clock gene expression in the ovary: effects of luteinizing hormone","volume":"75","year":"2006","journal-title":"Biol. Reprod."},{"key":"key\n\t\t\t\t20170508170249_bib26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0006-291X(02)02938-8","article-title":"Structural and functional analysis of 3\u2019 untranslated region of mouse Period1 mRNA","volume":"301","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"key\n\t\t\t\t20170508170249_bib27","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1002\/mnfr.200500247","article-title":"Risk assessments of polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans, and dioxin-like polychlorinated biphenyls in food","volume":"50","year":"2006","journal-title":"Mol. Nutr. Food Res."},{"key":"key\n\t\t\t\t20170508170249_bib28","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1016\/S0076-6879(05)93045-0","article-title":"The circadian clock and tumor suppression by mammalian period genes","volume":"393","year":"2005","journal-title":"Methods Enzymol."},{"key":"key\n\t\t\t\t20170508170249_bib29","first-page":"1391","article-title":"Ovarian hormones enhance 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated increases in cell proliferation and preneoplastic foci in a two-stage model for rat hepatocarcinogenesis","volume":"51","year":"1991","journal-title":"Cancer Res."},{"key":"key\n\t\t\t\t20170508170249_bib30","doi-asserted-by":"crossref","first-page":"29013","DOI":"10.1074\/jbc.M404315200","article-title":"The aryl hydrocarbon receptor displaces p300 from E2F-dependent promoters and represses S phase-specific gene expression","volume":"279","year":"2004","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170508170249_bib31","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1126\/science.1086271","article-title":"Control mechanism of the circadian clock for timing of cell division in vivo","volume":"302","year":"2003","journal-title":"Science"},{"key":"key\n\t\t\t\t20170508170249_bib32","doi-asserted-by":"crossref","first-page":"5901","DOI":"10.1113\/jphysiol.2008.159566","article-title":"High-fat feeding alters the clock synchronization to light","volume":"586","year":"2008","journal-title":"J. Physiol."},{"key":"key\n\t\t\t\t20170508170249_bib33","first-page":"101","article-title":"The 3111T\/C polymorphism of hClock is associated with evening preference and delayed sleep timing in a Japanese population sample","volume":"133","year":"2005","journal-title":"Am J Med. Genet."},{"key":"key\n\t\t\t\t20170508170249_bib34","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S0890-6238(02)00024-2","article-title":"Alteration in ovarian gene expression in response to 2,3,7,8-tetrachlorodibenzo-p-dioxin: reduction of cyclooxygenase-2 in the blockage of ovulation","volume":"16","year":"2002","journal-title":"Reprod. Toxicol."},{"key":"key\n\t\t\t\t20170508170249_bib35","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/0006-8993(72)90054-6","article-title":"Loss of a circadian adrenal corticosterone rhythm following suprachiasmatic lesions in the rat","volume":"42","year":"1972","journal-title":"Brain Res."},{"key":"key\n\t\t\t\t20170508170249_bib36","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1177\/0748730408316022","article-title":"Behavioral rhythmicity of mice lacking AhR and attenuation of light-induced phase shift by 2,3,7,8-tetrachlorodibenzo-p-dioxin","volume":"23","year":"2008","journal-title":"J. Biol. Rhythms"},{"key":"key\n\t\t\t\t20170508170249_bib37","doi-asserted-by":"crossref","first-page":"6278","DOI":"10.1128\/MCB.24.14.6278-6287.2004","article-title":"Circadian and light-induced transcription of clock gene Per1 depends on histone acetylation and deacetylation","volume":"24","year":"2004","journal-title":"Mol. Cell. Biol."},{"key":"key\n\t\t\t\t20170508170249_bib38","doi-asserted-by":"crossref","first-page":"41519","DOI":"10.1074\/jbc.M304564200","article-title":"Genome-wide expression analysis of mouse liver reveals CLOCK-regulated circadian output genes","volume":"278","year":"2003","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170508170249_bib39","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0009-2797(02)00065-0","article-title":"The mechanism of AH receptor protein down-regulation (degradation) and its impact on AH receptor-mediated gene regulation","volume":"141","year":"2002","journal-title":"Chem. Biol Interact."},{"key":"key\n\t\t\t\t20170508170249_bib40","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.taap.2008.10.016","article-title":"Disruption of period gene expression alters the inductive effects of dioxin on the AhR signaling pathway in the mouse liver","volume":"234","year":"2009","journal-title":"Toxicol. Applied Pharmacol."},{"key":"key\n\t\t\t\t20170508170249_bib50","doi-asserted-by":"crossref","first-page":"11148","DOI":"10.1021\/bi050948b","article-title":"The transactivation domain of the Ah receptor is a key determinant of cellular localization and ligand-independent nucleocytoplasmic shuttling properties","volume":"44","year":"2005","journal-title":"Biochemistry"},{"key":"key\n\t\t\t\t20170508170249_bib41","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1006\/bbrc.1998.9634","article-title":"Daily cycle of bHLH-PAS proteins, Ah receptor and Arnt, in multiple tissues of female Sprague-Dawley rats","volume":"252","year":"1998","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"key\n\t\t\t\t20170508170249_bib42","doi-asserted-by":"crossref","first-page":"6406","DOI":"10.1073\/pnas.0609625104","article-title":"Mania-like behavior induced by disruption of Clock","volume":"104","year":"2007","journal-title":"Proc. Natl Acad. Sci. U.S.A."},{"key":"key\n\t\t\t\t20170508170249_bib43","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1146\/annurev.cellbio.12.1.55","article-title":"Ah receptor signaling pathways","volume":"12","year":"1996","journal-title":"Ann. Rev. Cell Dev. Biol."},{"key":"key\n\t\t\t\t20170508170249_bib44","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1073\/pnas.69.6.1583","article-title":"Circadian rhythms in drinking behavior and locomoter activity of rats are eliminated by hypothalamic lesions","volume":"69","year":"1972","journal-title":"Proc. Natl Acad. Sci. U.S.A."},{"key":"key\n\t\t\t\t20170508170249_bib45","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0009-2797(02)00066-2","article-title":"DNA binding and protein interactions of the AHR\/ARNT heterodimer that facilitate gene activation","volume":"141","year":"2002","journal-title":"Chem. Biol. Interact."},{"key":"key\n\t\t\t\t20170508170249_bib46","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1046\/j.1365-2443.2000.00363.x","article-title":"Transactivation mechanisms of mouse clock transcription factors, mClock and mArnt3","volume":"5","year":"2000","journal-title":"Genes Cells"},{"key":"key\n\t\t\t\t20170508170249_bib51","doi-asserted-by":"crossref","first-page":"7728","DOI":"10.1073\/pnas.102075599","article-title":"Bimodal regulation of mPeriod promoters by CREB-dependent signaling and CLOCK\/BMAL1 activity","volume":"99","year":"2002","journal-title":"Proc Natl Acad Sci U S A."},{"key":"key\n\t\t\t\t20170508170249_bib47","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1126\/science.1108750","article-title":"Obesity and metabolic syndrome in circadian Clock mutant mice","volume":"308","year":"2005","journal-title":"Science"},{"key":"key\n\t\t\t\t20170508170249_bib48","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S1046-2023(02)00006-3","article-title":"Identification of unknown target genes of human transcription factors using chromatin immunoprecipitation","volume":"26","year":"2002","journal-title":"Methods"},{"key":"key\n\t\t\t\t20170508170249_bib49","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/1476-069X-6-19","article-title":"Sarcoma risk and dioxin emissions from incinerators and industrial plants: a population-based case-control study (Italy)","volume":"6","year":"2007","journal-title":"Environ. Health"}],"container-title":["Toxicological Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/toxsci\/article-pdf\/115\/1\/98\/16680872\/kfq022.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,25]],"date-time":"2019-05-25T11:42:20Z","timestamp":1558784540000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/toxsci\/article-lookup\/doi\/10.1093\/toxsci\/kfq022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,1,27]]},"references-count":51,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2010,1,27]]},"published-print":{"date-parts":[[2010,5]]}},"URL":"https:\/\/doi.org\/10.1093\/toxsci\/kfq022","relation":{},"ISSN":["1096-6080","1096-0929"],"issn-type":[{"value":"1096-6080","type":"print"},{"value":"1096-0929","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,1,27]]}}}