{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T20:01:39Z","timestamp":1774123299766,"version":"3.50.1"},"reference-count":61,"publisher":"Oxford University Press (OUP)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,5]]},"DOI":"10.1093\/toxsci\/kfq034","type":"journal-article","created":{"date-parts":[[2010,2,2]],"date-time":"2010-02-02T01:51:33Z","timestamp":1265075493000},"page":"267-285","source":"Crossref","is-referenced-by-count":16,"title":["Acute Exposure to Ozone Exacerbates Acetaminophen-Induced Liver Injury in Mice"],"prefix":"10.1093","volume":"115","author":[{"given":"Daher","family":"Ibrahim Aibo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neil P.","family":"Birmingham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan","family":"Lewandowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane F.","family":"Maddox","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert A.","family":"Roth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia E.","family":"Ganey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James G.","family":"Wagner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jack R.","family":"Harkema","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2010,2,1]]},"reference":[{"key":"key\n\t\t\t\t20170315185646_bib1","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/0891-5849(94)00233-A","article-title":"Acetaminophen-induced hepatic injury in mice: the role of lipid peroxidation and effects of pretreatment with coenzyme Q10 and alpha-tocopherol","volume":"19","year":"1995","journal-title":"Free Radic. Biol. Med."},{"key":"key\n\t\t\t\t20170315185646_bib2","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1161\/CIRCRESAHA.107.164970","article-title":"Ambient particulate pollutants in the ultrafine range promote early atherosclerosis and systemic oxidative stress","volume":"102","year":"2008","journal-title":"Circ. Res."},{"key":"key\n\t\t\t\t20170315185646_bib3","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1093\/toxsci\/kfn091","article-title":"Plasminogen activator inhibitor-1 limits liver injury and facilitates regeneration after acetaminophen overdose","volume":"104","year":"2008","journal-title":"Toxicol. Sci."},{"key":"key\n\t\t\t\t20170315185646_bib4","doi-asserted-by":"crossref","first-page":"2372","DOI":"10.1001\/jama.292.19.2372","article-title":"Ozone and short-term mortality in 95 US urban communities, 1987\u20132000","volume":"292","year":"2004","journal-title":"JAMA"},{"key":"key\n\t\t\t\t20170315185646_bib5","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S1383-5718(02)00176-6","article-title":"Inhalation of ozone induces DNA strand breaks and inflammation in mice","volume":"520","year":"2002","journal-title":"Mutat. Res."},{"key":"key\n\t\t\t\t20170315185646_bib6","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/0041-008X(92)90112-6","article-title":"The role of the nucleus and other compartments in toxic cell death produced by alkylating hepatotoxicants","volume":"113","year":"1992","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"key\n\t\t\t\t20170315185646_bib59","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1126\/science.274.5291.1379","article-title":"Liver failure and defective regeneration in interleukin-6-deficient mice","volume":"274","year":"1996","journal-title":"Science"},{"key":"key\n\t\t\t\t20170315185646_bib60","first-page":"89","article-title":"The use of quadrants and test systems in stereology, including magnification corrections","volume":"125","year":"1980","journal-title":"J. Microsc."},{"key":"key\n\t\t\t\t20170315185646_bib7","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1053\/jhep.2002.33162","article-title":"Role of CCR2 in macrophage migration into the liver during acetaminophen-induced hepatotoxicity in the mouse","volume":"35","year":"2002","journal-title":"Hepatology"},{"key":"key\n\t\t\t\t20170315185646_bib8","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1038\/nrc2468","article-title":"Hypoxia, HIF1 and glucose metabolism in the solid tumour","volume":"8","year":"2008","journal-title":"Nat. Rev. Cancer"},{"key":"key\n\t\t\t\t20170315185646_bib10","doi-asserted-by":"crossref","first-page":"S45","DOI":"10.1002\/hep.20969","article-title":"Liver regeneration","volume":"43","year":"2006","journal-title":"Hepatology"},{"key":"key\n\t\t\t\t20170315185646_bib11","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1002\/hep.21779","article-title":"Role of the coagulation system in acetaminophen-induced hepatotoxicity in mice","volume":"46","year":"2007","journal-title":"Hepatology"},{"key":"key\n\t\t\t\t20170315185646_bib12","doi-asserted-by":"crossref","first-page":"277","DOI":"10.4161\/cc.7.3.5328","article-title":"Protective mechanisms of p53-p21-pRb proteins against DNA damage-induced cell death","volume":"7","year":"2008","journal-title":"Cell Cycle"},{"key":"key\n\t\t\t\t20170315185646_bib13","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1001\/jama.290.14.1859","article-title":"Association of low-level ozone and fine particles with respiratory symptoms in children with asthma","volume":"290","year":"2003","journal-title":"JAMA"},{"key":"key\n\t\t\t\t20170315185646_bib61","first-page":"295","article-title":"The pulmonary and extrapulmonary effects of ozone","volume":"65","year":"1978","journal-title":"Ciba Found. Symp."},{"key":"key\n\t\t\t\t20170315185646_bib14","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/0041-008X(81)90008-9","article-title":"Influence of ozone on pentobarbital-induced sleeping time in mice, rats, and hamsters","volume":"61","year":"1981","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"key\n\t\t\t\t20170315185646_bib15","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1016\/S0002-9440(10)64995-4","article-title":"Exaggerated hepatic injury due to acetaminophen challenge in mice lacking C-C chemokine receptor 2","volume":"156","year":"2000","journal-title":"Am. J. Pathol."},{"key":"key\n\t\t\t\t20170315185646_bib16","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1093\/mutage\/9.2.93","article-title":"Genotoxicity of paracetamol in mice and rats","volume":"9","year":"1994","journal-title":"Mutagenesis"},{"key":"key\n\t\t\t\t20170315185646_bib17","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1016\/j.freeradbiomed.2008.09.008","article-title":"Role of metallothionein in lung inflammation induced by ozone exposure in mice","volume":"45","year":"2008","journal-title":"Free Radic. Biol. Med."},{"key":"key\n\t\t\t\t20170315185646_bib18","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.mrgentox.2005.04.004","article-title":"Mechanism of site-specific DNA damage induced by ozone","volume":"585","year":"2005","journal-title":"Mutat. Res."},{"key":"key\n\t\t\t\t20170315185646_bib19","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0378-4274(03)00239-X","article-title":"The role of oxidant stress and reactive nitrogen species in acetaminophen hepatotoxicity","volume":"144","year":"2003","journal-title":"Toxicol. Lett."},{"key":"key\n\t\t\t\t20170315185646_bib20","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.bbrc.2006.02.143","article-title":"Induction of the nuclear factor HIF-1alpha in acetaminophen toxicity: evidence for oxidative stress","volume":"343","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"key\n\t\t\t\t20170315185646_bib21","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/j.tiv.2008.02.001","article-title":"Interspecies differences in acetaminophen sensitivity of human, rat, and mouse primary hepatocytes","volume":"22","year":"2008","journal-title":"Toxicol. In Vitro"},{"key":"key\n\t\t\t\t20170315185646_bib22","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1056\/NEJMoa0803894","article-title":"Long-term ozone exposure and mortality","volume":"360","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"key\n\t\t\t\t20170315185646_bib23","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1080\/019021499270448","article-title":"Inflammatory and antioxidant gene expression in C57BL\/6J mice after lethal and sublethal ozone exposures","volume":"25","year":"1999","journal-title":"Exp. Lung Res."},{"key":"key\n\t\t\t\t20170315185646_bib24","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0022-3565(25)29664-1","article-title":"Acetaminophen-induced hepatic necrosis. II. Role of covalent binding in vivo","volume":"187","year":"1973","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"key\n\t\t\t\t20170315185646_bib25","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1177\/153537020623100903","article-title":"Metallothionein redox cycle and function","volume":"231","year":"2006","journal-title":"Exp. Biol. Med."},{"key":"key\n\t\t\t\t20170315185646_bib26","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1183\/09031936.95.08061030","article-title":"Short-term effects of air pollution on health: a European approach using epidemiological time-series data. The APHEA project: background, objectives, design","volume":"8","year":"1995","journal-title":"Eur. Respir. J."},{"key":"key\n\t\t\t\t20170315185646_bib27","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1016\/j.bbrc.2003.09.088","article-title":"MCP-1 deficiency is associated with reduced intimal hyperplasia after arterial injury","volume":"310","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"key\n\t\t\t\t20170315185646_bib28","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1002\/hep.20437","article-title":"Mitochondrial permeability transition in acetaminophen-induced necrosis and apoptosis of cultured mouse hepatocytes","volume":"40","year":"2004","journal-title":"Hepatology"},{"key":"key\n\t\t\t\t20170315185646_bib29","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1002\/hep.510310123","article-title":"Increased toxin-induced liver injury and fibrosis in interleukin-6-deficient mice","volume":"31","year":"2000","journal-title":"Hepatology"},{"key":"key\n\t\t\t\t20170315185646_bib30","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1093\/aje\/kwp032","article-title":"Are the short-term effects of air pollution restricted to cardiorespiratory diseases?","volume":"169","year":"2009","journal-title":"Am. J. Epidemiol."},{"key":"key\n\t\t\t\t20170315185646_bib31","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1002\/hep.20948","article-title":"Acetaminophen-induced acute liver failure: results of a United States multicenter, prospective study","volume":"42","year":"2005","journal-title":"Hepatology"},{"key":"key\n\t\t\t\t20170315185646_bib32","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.taap.2005.02.001","article-title":"Systemic responses to inhaled ozone in mice: cachexia and down-regulation of liver xenobiotic metabolizing genes","volume":"208","year":"2005","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"key\n\t\t\t\t20170315185646_bib33","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/S0022-3565(24)38172-8","article-title":"Metallothionein-I\/II knockout mice are sensitive to acetaminophen-induced hepatotoxicity","volume":"289","year":"1999","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"key\n\t\t\t\t20170315185646_bib34","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/S0002-9440(10)61717-8","article-title":"Wound healing in MIP-1alpha(-\/-) and MCP-1(-\/-) mice","volume":"159","year":"2001","journal-title":"Am. J. Pathol."},{"key":"key\n\t\t\t\t20170315185646_bib35","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1016\/0140-6736(90)93063-U","article-title":"Management of paracetamol poisoning complicated by enzyme induction due to alcohol or drugs","volume":"335","year":"1990","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20170315185646_bib36","first-page":"277","article-title":"Uptake and fate of ozone in the respiratory tract","volume":"82\u201383","year":"1995","journal-title":"Toxicol. Lett."},{"key":"key\n\t\t\t\t20170315185646_bib37","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.2105\/AJPH.85.10.1361","article-title":"Ambient air pollution and hospitalization for congestive heart failure among elderly people in seven large US cities","volume":"85","year":"1995","journal-title":"Am. J. Public Health"},{"key":"key\n\t\t\t\t20170315185646_bib38","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1124\/dmd.30.4.446","article-title":"Determination of acetaminophen-protein adducts in mouse liver and serum and human serum after hepatotoxic doses of acetaminophen using high-performance liquid chromatography with electrochemical detection","volume":"30","year":"2002","journal-title":"Drug Metab. Dispos."},{"key":"key\n\t\t\t\t20170315185646_bib39","doi-asserted-by":"crossref","first-page":"2913","DOI":"10.1161\/CIRCULATIONAHA.104.517110","article-title":"Diabetes enhances vulnerability to particulate air pollution-associated impairment in vascular reactivity and endothelial function","volume":"111","year":"2005","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20170315185646_bib40","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1038\/nature04871","article-title":"Hypoxia signalling in cancer and approaches to enforce tumour regression","volume":"441","year":"2006","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170315185646_bib41","doi-asserted-by":"crossref","first-page":"1447S","DOI":"10.1093\/jn\/130.5.1447S","article-title":"The antioxidant properties of zinc","volume":"130","year":"2000","journal-title":"J. Nutr."},{"key":"key\n\t\t\t\t20170315185646_bib42","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0891-5849(92)90060-T","article-title":"How far does ozone penetrate into the pulmonary air\/tissue boundary before it reacts?","volume":"12","year":"1992","journal-title":"Free Radic. Biol. Med."},{"key":"key\n\t\t\t\t20170315185646_bib43","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/0891-5849(95)02033-7","article-title":"The cascade mechanism to explain ozone toxicity: the role of lipid ozonation products","volume":"19","year":"1995","journal-title":"Free Radic. Biol. Med."},{"key":"key\n\t\t\t\t20170315185646_bib44","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/0041-008X(90)90254-R","article-title":"Early loss of large genomic DNA in vivo with accumulation of Ca2+ in the nucleus during acetaminophen-induced liver injury","volume":"106","year":"1990","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"key\n\t\t\t\t20170315185646_bib45","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1006\/bbrc.2001.4576","article-title":"Expression profiling of acetaminophen liver toxicity in mice using microarray technology","volume":"282","year":"2001","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"key\n\t\t\t\t20170315185646_bib46","first-page":"246","article-title":"Novel mechanisms of protection against acetaminophen hepatotoxicity in mice by glutathione and N-acetylcysteine","volume":"51","year":"2009","journal-title":"Hepatology"},{"key":"key\n\t\t\t\t20170315185646_bib47","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1002\/hep.21593","article-title":"Chronic intermittent hypoxia predisposes to liver injury","volume":"45","year":"2007","journal-title":"Hepatology"},{"key":"key\n\t\t\t\t20170315185646_bib48","doi-asserted-by":"crossref","first-page":"15238","DOI":"10.1016\/S0021-9258(17)36597-3","article-title":"Cytoplasmic metallothionein overexpression protects NIH 3T3 cells from tert-butyl hydroperoxide toxicity","volume":"269","year":"1994","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170315185646_bib49","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1038\/nrc1187","article-title":"Targeting HIF-1 for cancer therapy","volume":"3","year":"2003","journal-title":"Nat. Rev. Cancer"},{"key":"key\n\t\t\t\t20170315185646_bib50","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1189\/jlb.0506356","article-title":"MCP-1 deficiency causes altered inflammation with impaired skeletal muscle regeneration","volume":"81","year":"2007","journal-title":"J. Leukoc. Biol."},{"key":"key\n\t\t\t\t20170315185646_bib51","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/0002-9343(92)90687-7","article-title":"Severe hepatotoxicity in a patient receiving both acetaminophen and zidovudine","volume":"93","year":"1992","journal-title":"Am. J. Med."},{"key":"key\n\t\t\t\t20170315185646_bib52","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1289\/ehp.98106s61307","article-title":"Role of tissue repair in toxicologic interactions among hepatotoxic organics","volume":"106","year":"1998","journal-title":"Environ. Health Perspect."},{"key":"key\n\t\t\t\t20170315185646_bib53","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1006\/rtph.1998.1280","article-title":"Toxicant-inflicted injury and stimulated tissue repair are opposing toxicodynamic forces in predictive toxicology","volume":"29","year":"1999","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"key\n\t\t\t\t20170315185646_bib54","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1038\/nrm1489","article-title":"Liver regeneration: from myth to mechanism","volume":"5","year":"2004","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"key":"key\n\t\t\t\t20170315185646_bib55","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/0006-2952(87)90412-6","article-title":"Species differences in the hepatotoxicity of paracetamol are due to differences in the rate of conversion to its cytotoxic metabolite","volume":"36","year":"1987","journal-title":"Biochem. Pharmacol."},{"key":"key\n\t\t\t\t20170315185646_bib9","volume-title":"Air Quality Criteria for O3 and Related Photochemical Oxidants (Final)","author":"U.S. Environmental Protection Agency (U.S. EPA)","year":"2008"},{"key":"key\n\t\t\t\t20170315185646_bib56","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1177\/154411130201300603","article-title":"P21Waf1 control of epithelial cell cycle and cell fate","volume":"13","year":"2002","journal-title":"Crit. Rev. Oral. Biol. Med."},{"key":"key\n\t\t\t\t20170315185646_bib57","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/0300-483X(88)90224-7","article-title":"Increased levels of hepatic metallothionein in rat and mouse after injection of acetaminophen","volume":"53","year":"1988","journal-title":"Toxicology"},{"key":"key\n\t\t\t\t20170315185646_bib58","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1006\/taap.2000.8968","article-title":"Synergistic hepatotoxicity from coexposure to bacterial endotoxin and the pyrrolizidine alkaloid monocrotaline","volume":"166","year":"2000","journal-title":"Toxicol. Appl. Pharmacol."}],"container-title":["Toxicological Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/toxsci\/article-pdf\/115\/1\/267\/10991341\/kfq034.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,17]],"date-time":"2025-02-17T05:40:08Z","timestamp":1739770808000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/toxsci\/article\/1636094\/Acute"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,2,1]]},"references-count":61,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2010,2,1]]},"published-print":{"date-parts":[[2010,5]]}},"URL":"https:\/\/doi.org\/10.1093\/toxsci\/kfq034","relation":{},"ISSN":["1096-6080","1096-0929"],"issn-type":[{"value":"1096-6080","type":"print"},{"value":"1096-0929","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,2,1]]}}}