{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T01:01:39Z","timestamp":1778547699794,"version":"3.51.4"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,6]]},"DOI":"10.1093\/toxsci\/kfq053","type":"journal-article","created":{"date-parts":[[2010,2,25]],"date-time":"2010-02-25T04:09:13Z","timestamp":1267070953000},"page":"379-390","source":"Crossref","is-referenced-by-count":31,"title":["Methyl Mercury Suppresses the Formation of the Tail Primordium in Developing Zebrafish Embryos"],"prefix":"10.1093","volume":"115","author":[{"given":"Lixin","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nga Yu","family":"Ho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ferenc","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uwe","family":"Str\u00e4hle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2010,2,24]]},"reference":[{"key":"key\n\t\t\t\t20170508165757_bib1","first-page":"36","article-title":"Image processing with ImageJ","volume":"11","year":"2004","journal-title":"Biophotonics Int."},{"key":"key\n\t\t\t\t20170508165757_bib2","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.matbio.2005.03.007","article-title":"Matrix metalloproteinase expression and function during fin regeneration in zebrafish: analysis of MT1-MMP, MMP2 and TIMP2","volume":"24","year":"2005","journal-title":"Matrix Biol."},{"key":"key\n\t\t\t\t20170508165757_bib3","doi-asserted-by":"crossref","first-page":"2189","DOI":"10.1242\/dev.127.10.2189","article-title":"The zebrafish slow-muscle-omitted gene product is required for Hedgehog signal transduction and the development of slow muscle identity","volume":"127","year":"2000","journal-title":"Development"},{"key":"key\n\t\t\t\t20170508165757_bib4","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1182\/blood.V98.3.643","article-title":"Myelopoiesis in the zebrafish, Danio rerio","volume":"98","year":"2001","journal-title":"Blood"},{"key":"key\n\t\t\t\t20170508165757_bib5","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/j.biocel.2008.08.008","article-title":"At environmental doses, dietary methylmercury inhibits mitochondrial energy metabolism in skeletal muscles of the zebra fish (Danio rerio)","volume":"41","year":"2009","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"key\n\t\t\t\t20170508165757_bib6","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1006\/abbi.2000.1727","article-title":"Activation of transcription factors in zebrafish cell cultures by environmental pollutants","volume":"376","year":"2000","journal-title":"Arch. Biochem. Biophys."},{"key":"key\n\t\t\t\t20170508165757_bib7","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0361-9230(01)00458-0","article-title":"Neurotoxicity and molecular effects of methylmercury","volume":"55","year":"2001","journal-title":"Brain Res. Bull."},{"key":"key\n\t\t\t\t20170508165757_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bj3260001","article-title":"Caspases: the executioners of apoptosis","volume":"326","year":"1997","journal-title":"Biochem. J."},{"key":"key\n\t\t\t\t20170508165757_bib9","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1002\/cyto.990130802","article-title":"Features of apoptotic cells measured by flow cytometry","volume":"13","year":"1992","journal-title":"Cytometry"},{"key":"key\n\t\t\t\t20170508165757_bib10","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.ntt.2006.06.002","article-title":"Methylmercury and neurodevelopment: longitudinal analysis of the Seychelles child development cohort","volume":"28","year":"2006","journal-title":"Neurotoxicol. Teratol."},{"key":"key\n\t\t\t\t20170508165757_bib11","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.jns.2007.06.036","article-title":"Minamata disease revisited: an update on the acute and chronic manifestations of methyl mercury poisoning","volume":"262","year":"2007","journal-title":"J. Neurol. Sci."},{"key":"key\n\t\t\t\t20170508165757_bib12","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1002\/gene.1038","article-title":"Morphant technology in model developmental system","volume":"30","year":"2001","journal-title":"Genesis"},{"key":"key\n\t\t\t\t20170508165757_bib13","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/j.ydbio.2006.11.004","article-title":"Cooperation of sonic hedgehog enhancers in midline expression","volume":"301","year":"2007","journal-title":"Dev. Biol."},{"key":"key\n\t\t\t\t20170508165757_bib14","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1038\/nmeth.1396","article-title":"Automated high-throughput mapping of promoter-enhancer interactions in zebrafish embryos","volume":"6","year":"2009","journal-title":"Nat. Methods"},{"key":"key\n\t\t\t\t20170508165757_bib15","first-page":"2167","article-title":"Developmental neurotoxicity of industrial chemicals","volume":"16","year":"2006","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20170508165757_bib16","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/1471-213X-7-75","article-title":"Hedgehog signaling patterns the outgrowth of unpaired skeletal appendages in zebrafish","volume":"7","year":"2007","journal-title":"BMC Dev. Biol."},{"key":"key\n\t\t\t\t20170508165757_bib17","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1038\/4601080a","article-title":"Chemical regulators have overreached","volume":"460","year":"2009","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170508165757_bib18","first-page":"1117","article-title":"Molecular mimicry in mercury toxicology","volume":"19","year":"2006","journal-title":"Chem. Res. Toxicol."},{"key":"key\n\t\t\t\t20170508165757_bib19","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/aja.1002030302","article-title":"Stages of embryonic development of the zebrafish","volume":"203","year":"1995","journal-title":"Dev. Dyn."},{"key":"key\n\t\t\t\t20170508165757_bib20","doi-asserted-by":"crossref","first-page":"12108","DOI":"10.1073\/pnas.0803147105","article-title":"Localizing organomercury uptake and accumulation in zebrafish larvae at the tissue and cellular level","volume":"105","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"key\n\t\t\t\t20170508165757_bib21","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1007\/s10126-008-9113-x","article-title":"Detection of mercury in aquatic environments using EPRE reporter zebrafish","volume":"10","year":"2008","journal-title":"Mar. Biotechnol."},{"key":"key\n\t\t\t\t20170508165757_bib22","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1002\/dvdy.21853","article-title":"gfap and nestin reporter lines reveal characteristics of neural progenitors in the adult zebrafish brain","volume":"238","year":"2009","journal-title":"Dev. Dyn."},{"key":"key\n\t\t\t\t20170508165757_bib23","doi-asserted-by":"crossref","first-page":"3889","DOI":"10.1242\/dev.127.18.3889","article-title":"Direct action of the nodal-related signal cyclops in induction of sonic hedgehog in the ventral midline of the CNS","volume":"127","year":"2000","journal-title":"Development"},{"key":"key\n\t\t\t\t20170508165757_bib24","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1242\/dev.126.10.2103","article-title":"Intronic enhancers control expression of zebrafsih sonic hedgehog in floor plate and notochord","volume":"126","year":"1999","journal-title":"Development"},{"key":"key\n\t\t\t\t20170508165757_bib25","doi-asserted-by":"crossref","first-page":"2805","DOI":"10.1093\/jn\/137.12.2805","article-title":"Nutrient and methyl mercury exposure from consuming fish","volume":"137","year":"2007","journal-title":"J. Nutr."},{"key":"key\n\t\t\t\t20170508165757_bib26","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1093\/nar\/21.5.1087","article-title":"Cloning of the zebrafish krox-20 gene (krx-20) and its expression during hindbrain development","volume":"21","year":"1993","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20170508165757_bib27","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/S0197-0186(03)00029-9","article-title":"Effect of methylmercury on glutamate metabolism in cerebellar astrocytes in culture","volume":"43","year":"2003","journal-title":"Neurochem. Int."},{"key":"key\n\t\t\t\t20170508165757_bib28","doi-asserted-by":"crossref","first-page":"e78","DOI":"10.1371\/journal.pgen.0030078","article-title":"p53 activation by knockdown technologies","volume":"3","year":"2007","journal-title":"PLoS Genet."},{"key":"key\n\t\t\t\t20170508165757_bib29","volume-title":"Molecular Cloning: A Laboratory Manual","year":"1989"},{"key":"key\n\t\t\t\t20170508165757_bib30","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/S0166-445X(00)00128-4","article-title":"Delayed effects of embryonic exposure of zebrafish (Danio rerio) to methylmercury (MeHg)","volume":"51","year":"2001","journal-title":"Aquat. Toxicol."},{"key":"key\n\t\t\t\t20170508165757_bib31","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/S0166-445X(99)00044-2","article-title":"The teratogenic effects of methylmercury on early development of the zebrafish, Danio rerio","volume":"48","year":"2000","journal-title":"Aquat. Toxicol."},{"key":"key\n\t\t\t\t20170508165757_bib32","first-page":"2115","article-title":"A chemodosimeter approach to fluorescent sensing and imaging of inorganic and methylmercury species","volume":"16","year":"2009","journal-title":"Chem. Commun."},{"key":"key\n\t\t\t\t20170508165757_bib33","doi-asserted-by":"crossref","first-page":"2983","DOI":"10.1242\/dev.125.15.2983","article-title":"Sonic hedgehog is not required for the induction of medial floor plate cells in the zebrafish","volume":"125","year":"1998","journal-title":"Development"},{"key":"key\n\t\t\t\t20170508165757_bib34","first-page":"229","article-title":"Exposure to Hg2+ and Pb2+ changes NTPDase and ecto-5\u2032-nucleotidase activities in central nervous system of zebrafish (Danio rerio)","volume":"21","year":"2006","journal-title":"Toxicology"},{"key":"key\n\t\t\t\t20170508165757_bib35","doi-asserted-by":"crossref","first-page":"3849","DOI":"10.1242\/dev.01247","article-title":"Sonic hedgehog, secreted by amacrine cells, acts as a short-range signal to direct differentiation and lamination in the zebrafish retina","volume":"131","year":"2004","journal-title":"Development"},{"key":"key\n\t\t\t\t20170508165757_bib36","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/0168-9525(94)90221-6","article-title":"A simple and efficient procedure for non-isotopic in situ hybridization to sectioned material","volume":"10","year":"1994","journal-title":"Trends Genet."},{"key":"key\n\t\t\t\t20170508165757_bib37","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1242\/dev.123.1.255","article-title":"Genetic analysis of fin formation in the zebrafish, Danio rerio","volume":"123","year":"1996","journal-title":"Development"},{"key":"key\n\t\t\t\t20170508165757_bib38","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.neuro.2004.03.001","article-title":"Cerebrospinal fluid S100B increases reversibly in neonates of methyl mercury-intoxicated pregnant rats","volume":"25","year":"2004","journal-title":"Neurotoxicology"},{"key":"key\n\t\t\t\t20170508165757_bib39","volume-title":"The Zebrafish Book","year":"1993"},{"key":"key\n\t\t\t\t20170508165757_bib40","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1242\/jcs.66.1.205","article-title":"An analysis of in vivo cell migration during teleost fin morphogenesis","volume":"66","year":"1984","journal-title":"J. Cell Sci."},{"key":"key\n\t\t\t\t20170508165757_bib41","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.reprotox.2009.04.013","article-title":"Zebrafish embryos as models for embryotoxic and teratological effects of chemicals","volume":"28","year":"2009","journal-title":"Reprod. Toxicol."},{"key":"key\n\t\t\t\t20170508165757_bib42","doi-asserted-by":"crossref","first-page":"R227","DOI":"10.1186\/gb-2007-8-10-r227","article-title":"Transcriptional profiling reveals barcode-like toxicogenomic responses in the zebrafish embryo","volume":"8","year":"2007","journal-title":"Genome Biol."},{"key":"key\n\t\t\t\t20170508165757_bib43","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.ydbio.2008.09.028","article-title":"Gene expression and functional analysis of zebrafish larval fin fold regeneration","volume":"325","year":"2009","journal-title":"Dev. Biol."}],"container-title":["Toxicological Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/toxsci\/article-pdf\/115\/2\/379\/16682354\/kfq053.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,24]],"date-time":"2021-10-24T03:03:44Z","timestamp":1635044624000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/toxsci\/article-lookup\/doi\/10.1093\/toxsci\/kfq053"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,2,24]]},"references-count":43,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2010,2,24]]},"published-print":{"date-parts":[[2010,6]]}},"URL":"https:\/\/doi.org\/10.1093\/toxsci\/kfq053","relation":{},"ISSN":["1096-6080","1096-0929"],"issn-type":[{"value":"1096-6080","type":"print"},{"value":"1096-0929","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,2,24]]}}}