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Res."},{"key":"key\n\t\t\t\t20170315220526_bib63","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/BF00971853","article-title":"Concentrations of physiologically important metal ions in glial cells cultured from chick cerebral cortex","volume":"13","year":"1988","journal-title":"Neurochem. Res."},{"key":"key\n\t\t\t\t20170315220526_bib64","doi-asserted-by":"crossref","first-page":"2799","DOI":"10.1093\/hmg\/9.19.2799","article-title":"Dominant phenotypes produced by the HD mutation in STHdh(Q111) striatal cells","volume":"9","year":"2000","journal-title":"Hum. Mol. 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