{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:33:12Z","timestamp":1791405192214,"version":"4.3.3"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,10]]},"DOI":"10.1093\/toxsci\/kfq209","type":"journal-article","created":{"date-parts":[[2010,7,15]],"date-time":"2010-07-15T02:44:39Z","timestamp":1279161879000},"page":"336-347","source":"Crossref","is-referenced-by-count":77,"title":["Tracking Human Contact Allergens: From Mass Spectrometric Identification of Peptide-Bound Reactive Small Chemicals to Chemical-Specific Naive Human T-Cell Priming"],"prefix":"10.1093","volume":"117","author":[{"given":"Lisa","family":"Dietz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp R.","family":"Esser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonja S.","family":"Schmucker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina","family":"Goette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Richter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Schn\u00f6lzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan F.","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hermann-Josef","family":"Thierse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2010,7,14]]},"reference":[{"key":"key\n\t\t\t\t20170314064924_bib1","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/j.tiv.2007.01.008","article-title":"Investigating protein haptenation mechanisms of skin sensitisers using human serum albumin as a model protein","volume":"21","year":"2007","journal-title":"Toxicol. In Vitro"},{"key":"key\n\t\t\t\t20170314064924_bib2","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1016\/j.tiv.2008.03.006","article-title":"Mass spectrometric identification of covalent adducts of the skin allergen 2,4-dinitro-1-chlorobenzene and model skin proteins","volume":"22","year":"2008","journal-title":"Toxicol. In Vitro"},{"key":"key\n\t\t\t\t20170314064924_bib3","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1093\/toxsci\/kfp030","article-title":"Reactivity profiling: covalent modification of single nucleophile peptides for skin sensitization risk assessment","volume":"108","year":"2009","journal-title":"Toxicol. Sci."},{"key":"key\n\t\t\t\t20170314064924_bib4","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.it.2004.06.003","article-title":"Extravascular T-cell recruitment requires initiation begun by Valpha14+ NKT cells and B-1 B cells","volume":"25","year":"2004","journal-title":"Trends Immunol."},{"key":"key\n\t\t\t\t20170314064924_bib5","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1111\/j.1600-0536.1997.tb00421.x","article-title":"Dinitrohalobenzenes: evaluation of relative skin sensitization potential using the local lymph node assay","volume":"36","year":"1997","journal-title":"Contact Dermatitis"},{"key":"key\n\t\t\t\t20170314064924_bib6","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1002\/elps.1150080203","article-title":"Improved silver staining of plant proteins, RNA and DNA in polyacrylamide gels","volume":"8","year":"1987","journal-title":"Electrophoresis"},{"key":"key\n\t\t\t\t20170314064924_bib7","doi-asserted-by":"crossref","first-page":"2670","DOI":"10.4049\/jimmunol.155.5.2670","article-title":"Heterogeneous T cell responses to beta-lactam-modified self-structures are observed in penicillin-allergic individuals","volume":"155","year":"1995","journal-title":"J. Immunol."},{"key":"key\n\t\t\t\t20170314064924_bib8","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1046\/j.1523-1747.2003.12510.x","article-title":"Thiol antioxidants block the activation of antigen-presenting cells by contact sensitizers","volume":"121","year":"2003","journal-title":"J. Invest. Dermatol."},{"key":"key\n\t\t\t\t20170314064924_bib9","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1097\/ACI.0b013e3283079ea4","article-title":"T regulatory cells in contact hypersensitivity","volume":"8","year":"2008","journal-title":"Curr. Opin. Allergy Clin. Immunol."},{"key":"key\n\t\t\t\t20170314064924_bib10","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1074\/mcp.M500047-MCP200","article-title":"Probing lysine acetylation in proteins: strategies, limitations, and pitfalls of in vitro acetyltransferase assays","volume":"4","year":"2005","journal-title":"Mol. Cell. Proteomics"},{"key":"key\n\t\t\t\t20170314064924_bib11","doi-asserted-by":"crossref","first-page":"5482","DOI":"10.1016\/j.bmc.2008.04.014","article-title":"Sensitization to p-amino aromatic compounds: study of the covalent binding of 2,5-dimethyl-p-benzoquinonediimine to a model peptide by electrospray ionization tandem mass spectrometry","volume":"16","year":"2008","journal-title":"Bioorg. Med. Chem."},{"key":"key\n\t\t\t\t20170314064924_bib12","first-page":"173","article-title":"Innate and adaptive immune responses in contact dermatitis: analogy with infections","volume":"144","year":"2009","journal-title":"G. Ital. Dermatol. Venereol."},{"key":"key\n\t\t\t\t20170314064924_bib13","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1084\/jem.20090504","article-title":"Human naive and memory CD4+ T cell repertoires specific for naturally processed antigens analyzed using libraries of amplified T cells","volume":"206","year":"2009","journal-title":"J. Exp. Med."},{"key":"key\n\t\t\t\t20170314064924_bib14","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1093\/toxsci\/kfh213","article-title":"Development of a peptide reactivity assay for screening contact allergens","volume":"81","year":"2004","journal-title":"Toxicol. Sci."},{"key":"key\n\t\t\t\t20170314064924_bib15","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1093\/toxsci\/kfm064","article-title":"Quantification of chemical peptide reactivity for screening contact allergens: a classification tree model approach","volume":"97","year":"2007","journal-title":"Toxicol. Sci."},{"key":"key\n\t\t\t\t20170314064924_bib16","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/S0887-2333(00)00043-6","article-title":"In vitro human T cell sensitization to haptens by monocyte-derived dendritic cells","volume":"14","year":"2000","journal-title":"Toxicol. In Vitro"},{"key":"key\n\t\t\t\t20170314064924_bib17","doi-asserted-by":"crossref","first-page":"139","DOI":"10.2131\/jts.34.139","article-title":"Modification of cell-surface thiols elicits activation of human monocytic cell line THP-1: possible involvement in effect of haptens 2,4-dinitrochlorobenzene and nickel sulfate","volume":"34","year":"2009","journal-title":"J. Toxicol. Sci."},{"key":"key\n\t\t\t\t20170314064924_bib18","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1038\/jid.2009.271","article-title":"Characterization of p-phenylenediamine-albumin binding sites and T-cell responses to hapten-modified protein","volume":"130","year":"2010","journal-title":"J. Invest. Dermatol."},{"key":"key\n\t\t\t\t20170314064924_bib19","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/jid.2009.229","article-title":"Oxidation of cell surface thiol groups by contact sensitizers triggers the maturation of dendritic cells","volume":"130","year":"2010","journal-title":"J. Invest. Dermatol."},{"key":"key\n\t\t\t\t20170314064924_bib20","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1021\/tx7002239","article-title":"Allergic contact dermatitis-formation, structural requirements, and reactivity of skin sensitizers","volume":"21","year":"2008","journal-title":"Chem. Res. Toxicol."},{"key":"key\n\t\t\t\t20170314064924_bib21","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1111\/j.1365-2222.1996.tb00577.x","article-title":"In vitro primary sensitization of hapten-specific T cells by cultured human epidermal Langerhans cells\u2014a screening predictive assay for contact sensitizers","volume":"26","year":"1996","journal-title":"Clin. Exp. Allergy"},{"key":"key\n\t\t\t\t20170314064924_bib22","article-title":"Molecular aspects of allergic contact dermatitis","volume-title":"Contact Dermatitis","year":"2006","edition":"4th ed."},{"key":"key\n\t\t\t\t20170314064924_bib23","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.4049\/jimmunol.149.8.2569","article-title":"Role of hapten-anchoring peptides in defining hapten-epitopes for MHC-restricted cytotoxic T cells. Cross-reactive TNP-determinants on different peptides","volume":"149","year":"1992","journal-title":"J. Immunol."},{"key":"key\n\t\t\t\t20170314064924_bib24","doi-asserted-by":"crossref","first-page":"678","DOI":"10.4049\/jimmunol.151.2.678","article-title":"Structural complexity of antigenic determinants for class I MHC-restricted, hapten-specific T cells. Two qualitatively differing types of H-2Kb-restricted TNP epitopes","volume":"151","year":"1993","journal-title":"J. Immunol."},{"key":"key\n\t\t\t\t20170314064924_bib25","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1159\/000078765","article-title":"T lymphocyte-mediated immune responses to chemical haptens and metal ions: implications for allergic and autoimmune disease","volume":"134","year":"2004","journal-title":"Int. Arch. Allergy Immunol."},{"key":"key\n\t\t\t\t20170314064924_bib26","article-title":"T cell recognition of chemicals, protein allergens and drugs: towards the development of in vitro assays","journal-title":"Cell Mol. Life. Sci."},{"key":"key\n\t\t\t\t20170314064924_bib27","doi-asserted-by":"crossref","first-page":"247","DOI":"10.2174\/138955706776073493","article-title":"Interactions of chemicals and metal ions with proteins and role for immune responses","volume":"6","year":"2006","journal-title":"Mini Rev. Med. Chem."},{"key":"key\n\t\t\t\t20170314064924_bib28","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.taap.2009.05.001","article-title":"Role of protein haptenation in triggering maturation events in the dendritic cell surrogate cell line THP-1","volume":"238","year":"2009","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"key\n\t\t\t\t20170314064924_bib29","doi-asserted-by":"crossref","first-page":"3308","DOI":"10.1002\/eji.1830251216","article-title":"Characterization of processing requirements and metal cross-reactivities in T cell clones from patients with allergic contact dermatitis to nickel","volume":"25","year":"1995","journal-title":"Eur. J. Immunol."},{"key":"key\n\t\t\t\t20170314064924_bib30","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1093\/toxsci\/kfn194","article-title":"LC-MS-based characterization of the peptide reactivity of chemicals to improve the in vitro prediction of the skin sensitization potential","volume":"106","year":"2008","journal-title":"Toxicol. Sci."},{"key":"key\n\t\t\t\t20170314064924_bib31","doi-asserted-by":"crossref","first-page":"375","DOI":"10.2340\/0001555574375379","article-title":"In vivo studies concerning a pH gradient in human stratum corneum and upper epidermis","volume":"74","year":"1994","journal-title":"Acta Derm. Venereol."},{"key":"key\n\t\t\t\t20170314064924_bib32","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.4049\/jimmunol.148.5.1445","article-title":"Synthetic peptides anchor T cell-specific TNP epitopes to MHC antigens","volume":"148","year":"1992","journal-title":"J. Immunol."},{"key":"key\n\t\t\t\t20170314064924_bib33","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1002\/eji.1830270602","article-title":"Penicilloyl peptides are recognized as T cell antigenic determinants in penicillin allergy","volume":"27","year":"1997","journal-title":"Eur. J. Immunol."},{"key":"key\n\t\t\t\t20170314064924_bib34","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1002\/eji.1830260107","article-title":"T cell recognition of penicillin G: structural features determining antigenic specificity","volume":"26","year":"1996","journal-title":"Eur. J. Immunol."},{"key":"key\n\t\t\t\t20170314064924_bib35","doi-asserted-by":"crossref","first-page":"7576","DOI":"10.4049\/jimmunol.0901064","article-title":"The cutaneous biochemical redox barrier: a component of the innate immune defenses against sensitization by highly reactive environmental xenobiotics","volume":"183","year":"2009","journal-title":"J. Immunol."},{"key":"key\n\t\t\t\t20170314064924_bib36","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1038\/sj.jid.5700581","article-title":"Investigation of mechanisms underlying the T-cell response to the hapten 2,4-dinitrochlorobenzene","volume":"127","year":"2007","journal-title":"J. Invest. Dermatol."},{"key":"key\n\t\t\t\t20170314064924_bib37","article-title":"Mechanisms in allergic contact dermatitis","volume-title":"Contact Dermatitis","year":"2006"},{"key":"key\n\t\t\t\t20170314064924_bib38","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1097\/00130832-200110000-00010","article-title":"Origin and migratory properties of dendritic cells in the skin","volume":"1","year":"2001","journal-title":"Curr. Opin. Allergy Clin. Immunol."},{"key":"key\n\t\t\t\t20170314064924_bib39","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1146\/annurev.immunol.18.1.593","article-title":"The role of chemokine receptors in primary, effector, and memory immune responses","volume":"18","year":"2000","journal-title":"Annu. Rev. Immunol."},{"key":"key\n\t\t\t\t20170314064924_bib40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0300-483X(03)00246-4","article-title":"From xenobiotic chemistry and metabolism to better prediction and risk assessment of skin allergy","volume":"192","year":"2003","journal-title":"Toxicology"},{"key":"key\n\t\t\t\t20170314064924_bib41","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.tiv.2009.02.002","article-title":"Evaluation of changes of cell-surface thiols as a new biomarker for in vitro sensitization test","volume":"23","year":"2009","journal-title":"Toxicol. In Vitro"},{"key":"key\n\t\t\t\t20170314064924_bib42","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.tox.2004.12.015","article-title":"T cell receptor (TCR) interaction with haptens: metal ions as non-classical haptens","volume":"209","year":"2005","journal-title":"Toxicology"},{"key":"key\n\t\t\t\t20170314064924_bib43","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.4049\/jimmunol.172.3.1926","article-title":"Metal-protein complex-mediated transport and delivery of Ni2+ to TCR\/MHC contact sites in nickel-specific human T cell activation","volume":"172","year":"2004","journal-title":"J. Immunol."},{"key":"key\n\t\t\t\t20170314064924_bib44","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.1038\/jid.2008.15","article-title":"Depletion of human peripheral blood lymphocytes in CD25+ cells allows for the sensitive in vitro screening of contact allergens","volume":"128","year":"2008","journal-title":"J. Invest. Dermatol."},{"key":"key\n\t\t\t\t20170314064924_bib45","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1046\/j.1523-1747.1998.00122.x","article-title":"Molecular features of penicillin allergy","volume":"110","year":"1998","journal-title":"J. Invest. Dermatol."}],"container-title":["Toxicological Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/toxsci\/article-pdf\/117\/2\/336\/10977886\/kfq209.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T09:50:13Z","timestamp":1711619413000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/toxsci\/article\/1641747\/Tracking"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,7,14]]},"references-count":45,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2010,7,14]]},"published-print":{"date-parts":[[2010,10]]}},"URL":"https:\/\/doi.org\/10.1093\/toxsci\/kfq209","relation":{},"ISSN":["1096-6080","1096-0929"],"issn-type":[{"value":"1096-6080","type":"print"},{"value":"1096-0929","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,7,14]]}}}