{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:13:40Z","timestamp":1787066020200,"version":"build-2736575974"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,8]]},"DOI":"10.1093\/toxsci\/kfr102","type":"journal-article","created":{"date-parts":[[2011,5,6]],"date-time":"2011-05-06T23:37:27Z","timestamp":1304725047000},"page":"502-511","source":"Crossref","is-referenced-by-count":18,"title":["1,3-Dinitrobenzene\u2013Induced Metabolic Impairment through Selective Inactivation of the Pyruvate Dehydrogenase Complex"],"prefix":"10.1093","volume":"122","author":[{"given":"James A.","family":"Miller","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie A.","family":"Runkle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald B.","family":"Tjalkens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin A.","family":"Philbert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2011,5,6]]},"reference":[{"key":"key\n\t\t\t\t20170315213947_bib1","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1007\/s10571-008-9297-7","article-title":"Metabolic and structural role of thiamine in nervous tissues","volume":"28","year":"2008","journal-title":"Cell. Mol. Neurobiol."},{"key":"key\n\t\t\t\t20170315213947_bib2","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/0378-4347(88)80020-3","article-title":"Determination of 1,3-dinitrobenzene and its metabolites in rat blood by capillary gas chromatography with electron-capture detection","volume":"425","year":"1988","journal-title":"J. Chromatogr."},{"key":"key\n\t\t\t\t20170315213947_bib3","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/0891-5849(94)90197-X","article-title":"Postischemic inhibition of cerebral cortex pyruvate dehydrogenase","volume":"16","year":"1994","journal-title":"Free Radic. Biol. Med."},{"key":"key\n\t\t\t\t20170315213947_bib4","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1017\/S0012162206001617","article-title":"Pyruvate dehydrogenase E3 binding protein (protein X) deficiency","volume":"48","year":"2006","journal-title":"Dev. Med. Child Neurol."},{"key":"key\n\t\t\t\t20170315213947_bib5","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/BF00997071","article-title":"Thiamine-dependent enzyme changes in temporal cortex of patients with Alzheimer's disease","volume":"5","year":"1990","journal-title":"Metab. Brain Dis."},{"key":"key\n\t\t\t\t20170315213947_bib6","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0300-483X(88)90184-9","article-title":"Lesion localisation: implications for the study of functional effects and mechanisms of action","volume":"49","year":"1988","journal-title":"Toxicology"},{"key":"key\n\t\t\t\t20170315213947_bib7","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1080\/15287398109530024","article-title":"1,3-Dinitrobenzene: toxic effects in vivo and in vitro","volume":"7","year":"1981","journal-title":"J. Toxicol. Environ. Health"},{"key":"key\n\t\t\t\t20170315213947_bib8","first-page":"664","article-title":"Metabolism of dinitrobenzenes by rat isolated hepatocytes","volume":"13","year":"1985","journal-title":"Drug Metab. Dispos."},{"key":"key\n\t\t\t\t20170315213947_bib9","doi-asserted-by":"crossref","first-page":"S118","DOI":"10.1139\/y92-253","article-title":"Energy metabolism in developing brain cells","volume":"70","year":"1992","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"key\n\t\t\t\t20170315213947_bib10","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/0009-2797(92)90107-V","article-title":"Reactions of nitrosonitrobenzenes with biological thiols: identification and reactivity of glutathion-S-yl conjugates","volume":"82","year":"1992","journal-title":"Chem. Biol. Interact."},{"key":"key\n\t\t\t\t20170315213947_bib11","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.pediatrneurol.2008.07.013","article-title":"Leigh and Leigh-like syndrome in children and adults","volume":"39","year":"2008","journal-title":"Pediatr. Neurol."},{"key":"key\n\t\t\t\t20170315213947_bib12","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0006-8993(98)00121-8","article-title":"The effect of duration of cerebral ischemia on brain pyruvate dehydrogenase activity, energy metabolites, and blood flow during reperfusion in gerbil brain","volume":"792","year":"1998","journal-title":"Brain Res."},{"key":"key\n\t\t\t\t20170315213947_bib13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0741-8329(01)00156-2","article-title":"Impairment of pyruvate dehydrogenase activity by acetaldehyde","volume":"25","year":"2001","journal-title":"Alcohol"},{"key":"key\n\t\t\t\t20170315213947_bib48"},{"key":"key\n\t\t\t\t20170315213947_bib14","first-page":"83","article-title":"Glutathione depletion increases brain susceptibility to m-dinitrobenzene neurotoxicity","volume":"20","year":"1999","journal-title":"Neurotoxicology"},{"key":"key\n\t\t\t\t20170315213947_bib15","doi-asserted-by":"crossref","first-page":"15835","DOI":"10.1021\/bi981512h","article-title":"Selective inactivation of alpha-ketoglutarate dehydrogenase and pyruvate dehydrogenase: reaction of lipoic acid with 4-hydroxy-2-nonenal","volume":"37","year":"1998","journal-title":"Biochemistry"},{"key":"key\n\t\t\t\t20170315213947_bib49"},{"key":"key\n\t\t\t\t20170315213947_bib16","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1016\/S0891-5849(01)00491-9","article-title":"Protection by thiols of the mitochondrial complexes from 4-hydroxy-2-nonenal","volume":"30","year":"2001","journal-title":"Free Radic. Biol. Med."},{"key":"key\n\t\t\t\t20170315213947_bib17","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1096\/fj.05-4535fje","article-title":"Reversal of mitochondrial defects before ischemia protects the aged heart","volume":"20","year":"2006","journal-title":"FASEB J."},{"key":"key\n\t\t\t\t20170315213947_bib18","doi-asserted-by":"crossref","first-page":"27278","DOI":"10.1074\/jbc.M314148200","article-title":"Immunochemical identification of coenzyme Q0-dihydrolipoamide adducts in the E2 components of the alpha-ketoglutarate and pyruvate dehydrogenase complexes partially explains the cellular toxicity of coenzyme Q0","volume":"279","year":"2004","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170315213947_bib19","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1002\/jnr.20293","article-title":"Pyruvate dehydrogenase complex: metabolic link to ischemic brain injury and target of oxidative stress","volume":"79","year":"2005","journal-title":"J. Neurosci. Res."},{"key":"key\n\t\t\t\t20170315213947_bib21","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s10545-005-5518-0","article-title":"Cerebral ketone body metabolism","volume":"28","year":"2005","journal-title":"J. Inherit. Metab. Dis."},{"key":"key\n\t\t\t\t20170315213947_bib22","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","article-title":"Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays","volume":"65","year":"1983","journal-title":"J. Immunol. Methods."},{"key":"key\n\t\t\t\t20170315213947_bib23","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1002\/glia.10190","article-title":"Recovery from lactacidosis-induced glial cell swelling with the aid of exogenous anion channels","volume":"41","year":"2003","journal-title":"Glia"},{"key":"key\n\t\t\t\t20170315213947_bib24","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1006\/abio.1999.4359","article-title":"Quantitative alpha-ketoglutarate dehydrogenase activity staining in brain sections and in cultured cells","volume":"277","year":"2000","journal-title":"Anal. Biochem."},{"key":"key\n\t\t\t\t20170315213947_bib25","doi-asserted-by":"crossref","first-page":"3224","DOI":"10.1096\/fasebj.4.14.2227213","article-title":"Molecular biology and biochemistry of pyruvate dehydrogenase complexes","volume":"4","year":"1990","journal-title":"FASEB J."},{"key":"key\n\t\t\t\t20170315213947_bib26","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0161-813X(03)00031-7","article-title":"1,3-Dinitrobenzene inhibits mitochondrial complex II in rat and mouse brainstem and cortical astrocytes","volume":"24","year":"2003","journal-title":"Neurotoxicology"},{"key":"key\n\t\t\t\t20170315213947_bib27","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1111\/j.1365-2990.1987.tb00192.x","article-title":"1,3-Dinitrobenzene-induced encephalopathy in rats","volume":"13","year":"1987","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"key\n\t\t\t\t20170315213947_bib28","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1007\/BF03033161","article-title":"Acrolein inhibits NADH-linked mitochondrial enzyme activity: implications for Alzheimer's disease","volume":"5","year":"2003","journal-title":"Neurotox. Res."},{"key":"key\n\t\t\t\t20170315213947_bib29","doi-asserted-by":"crossref","first-page":"407S","DOI":"10.1042\/bst022407s","article-title":"Increased oxidative metabolism and oxidative stress in m-dinitrobenzene neurotoxicity","volume":"22","year":"1994","journal-title":"Biochem. Soc. Trans."},{"key":"key\n\t\t\t\t20170315213947_bib30","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1002\/pro.5560070125","article-title":"From lipoic acid to multi-enzyme complexes","volume":"7","year":"1998","journal-title":"Protein Sci."},{"key":"key\n\t\t\t\t20170315213947_bib31","doi-asserted-by":"crossref","first-page":"8971","DOI":"10.1016\/S0021-9258(19)38795-2","article-title":"Structure-function relationships in dihydrolipoamide acyltransferases","volume":"265","year":"1990","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170315213947_bib32","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1021\/tx0155552","article-title":"1,3-Dinitrobenzene metabolism and GSH depletion","volume":"15","year":"2002","journal-title":"Chem. Res. Toxicol."},{"key":"key\n\t\t\t\t20170315213947_bib33","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.ymgme.2006.05.015","article-title":"Lactic acidemia and mitochondrial disease","volume":"89","year":"2006","journal-title":"Mol. Genet. Metab."},{"key":"key\n\t\t\t\t20170315213947_bib34","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1111\/j.1365-2990.1991.tb00752.x","article-title":"Vascular factors in the neurotoxic damage caused by 1,3-dinitrobenzene in the rat","volume":"17","year":"1991","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"key\n\t\t\t\t20170315213947_bib35","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/0891-5849(94)E0143-7","article-title":"Early metabolic changes during m-dinitrobenzene neurotoxicity and the possible role of oxidative stress","volume":"18","year":"1995","journal-title":"Free Radic. Biol. Med."},{"key":"key\n\t\t\t\t20170315213947_bib36","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/0022-1759(85)90235-2","article-title":"A simple method for the solubilisation of reduced NBT, and its use as a colorimetric assay for activation of human macrophages by gamma-interferon","volume":"82","year":"1985","journal-title":"J. Immunol. Methods."},{"key":"key\n\t\t\t\t20170315213947_bib37","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1161\/01.STR.23.9.1312","article-title":"Prevention of postischemic canine neurological injury through potentiation of brain energy metabolism by acetyl-L-carnitine","volume":"23","year":"1992","journal-title":"Stroke"},{"key":"key\n\t\t\t\t20170315213947_bib38","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1021\/tx025615j","article-title":"Reactive oxygen species are involved in arsenic trioxide inhibition of pyruvate dehydrogenase activity","volume":"16","year":"2003","journal-title":"Chem. Res. Toxicol."},{"key":"key\n\t\t\t\t20170315213947_bib39","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1002\/ana.410170505","article-title":"An immunochemical study of the pyruvate dehydrogenase deficit in Alzheimer's disease brain","volume":"17","year":"1985","journal-title":"Ann. Neurol."},{"key":"key\n\t\t\t\t20170315213947_bib40","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/0003-2697(85)90442-7","article-title":"Measurement of protein using bicinchoninic acid","volume":"150","year":"1985","journal-title":"Anal. Biochem."},{"key":"key\n\t\t\t\t20170315213947_bib41","doi-asserted-by":"crossref","first-page":"19772","DOI":"10.1074\/jbc.M601140200","article-title":"A new level of architectural complexity in the human pyruvate dehydrogenase complex","volume":"281","year":"2006","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170315213947_bib43","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1006\/abbi.1996.0560","article-title":"Reactive oxygen species-mediated inactivation of pyruvate dehydrogenase","volume":"336","year":"1996","journal-title":"Arch. Biochem. Biophys."},{"key":"key\n\t\t\t\t20170315213947_bib44","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1042\/bj2420447","article-title":"Nitroreductase activity of heart lipoamide dehydrogenase","volume":"242","year":"1987","journal-title":"Biochem. J."},{"key":"key\n\t\t\t\t20170315213947_bib45","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.tox.2004.04.007","article-title":"Analysis of changes in energy and redox states in HepG2 hepatoma and C6 glioma cells upon exposure to cadmium","volume":"201","year":"2004","journal-title":"Toxicology"},{"key":"key\n\t\t\t\t20170315213947_bib46","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1089\/adt.2004.2.353","article-title":"96-Well plate assay for sublethal metabolic activity","volume":"2","year":"2004","journal-title":"Assay Drug Dev. Technol."},{"key":"key\n\t\t\t\t20170315213947_bib47","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1042\/bj2570625","article-title":"The 2-oxo acid dehydrogenase complexes: recent advances","volume":"257","year":"1989","journal-title":"Biochem. J."}],"container-title":["Toxicological Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/toxsci\/article-pdf\/122\/2\/502\/10998613\/kfr102.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,22]],"date-time":"2021-11-22T16:44:36Z","timestamp":1637599476000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/toxsci\/article\/1675342\/1,3-Dinitrobenzene\u2013Induced"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,5,6]]},"references-count":47,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2011,5,6]]},"published-print":{"date-parts":[[2011,8]]}},"URL":"https:\/\/doi.org\/10.1093\/toxsci\/kfr102","relation":{},"ISSN":["1096-6080","1096-0929"],"issn-type":[{"value":"1096-6080","type":"print"},{"value":"1096-0929","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,5,6]]}}}