{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T14:44:11Z","timestamp":1790001851787,"version":"4.0.1"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,10]]},"DOI":"10.1093\/toxsci\/kfr178","type":"journal-article","created":{"date-parts":[[2011,7,8]],"date-time":"2011-07-08T22:28:57Z","timestamp":1310164137000},"page":"460-470","source":"Crossref","is-referenced-by-count":91,"title":["Acetyl Tributyl Citrate, the Most Widely Used Phthalate Substitute Plasticizer, Induces Cytochrome P450 3A through Steroid and Xenobiotic Receptor"],"prefix":"10.1093","volume":"123","author":[{"given":"Akira","family":"Takeshita","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junko","family":"Igarashi-Migitaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazusa","family":"Nishiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideyo","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Takeuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriyuki","family":"Koibuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2011,7,8]]},"reference":[{"key":"key\n\t\t\t\t20170508174025_bib1","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1038\/clpt.1980.115","article-title":"Rifampicin and vitamin D metabolism","volume":"27","year":"1980","journal-title":"Clin. Pharmacol. Ther."},{"key":"key\n\t\t\t\t20170508174025_bib2","volume-title":"Review of Exposure and Toxicity Data for Phthalate Substitutes","author":"Consumer Product Safety Commission","year":"2010"},{"key":"key\n\t\t\t\t20170508174025_bib3","volume-title":"Opinion on the Toxicological Characteristics and Risks of Certain Citrates and Adipates Used as a Substitute for Phthalates as Plasticisers in Certain Soft PVC Products","author":"European Commission","year":"1999"},{"key":"key\n\t\t\t\t20170508174025_bib4","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1124\/jpet.105.098160","article-title":"Differential regulation of hepatic CYP2B6 and CYP3A4 genes by constitutive androstane receptor but not pregnane X receptor","volume":"317","year":"2006","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"key\n\t\t\t\t20170508174025_bib5","doi-asserted-by":"crossref","first-page":"14581","DOI":"10.1074\/jbc.M010173200","article-title":"Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin","volume":"276","year":"2001","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170508174025_bib6","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1101\/gad.14.2.121","article-title":"The coregulator exchange in transcriptional functions of nuclear receptors","volume":"14","year":"2000","journal-title":"Genes Dev."},{"key":"key\n\t\t\t\t20170508174025_bib7","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1124\/mol.56.6.1329","article-title":"The orphan human pregnane X receptor mediates the transcriptional activation of CYP3A4 by rifampicin through a distal enhancer module","volume":"56","year":"1999","journal-title":"Mol. Pharmacol."},{"key":"key\n\t\t\t\t20170508174025_bib8","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1530\/eje.1.01990","article-title":"Differential expression of p160 steroid receptor coactivators in the rat testis and epididymis","volume":"153","year":"2005","journal-title":"Eur. J. Endocrinol."},{"key":"key\n\t\t\t\t20170508174025_bib9","volume-title":"IMS Health Reports U.S. Prescription Sales Grew 5.1 Percent in 2009, to $300.3 Billion","author":"Intercontinental Medical Statistics (IMS)","year":"2010"},{"key":"key\n\t\t\t\t20170508174025_bib10","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1053\/jhep.2003.50094","article-title":"CYP3A4 inducible model for in vitro analysis of human drug metabolism using a bioartificial liver","volume":"37","year":"2003","journal-title":"Hepatology"},{"key":"key\n\t\t\t\t20170508174025_bib11","volume-title":"Frequently Asked Questions on PVDC Products (Japanese)","author":"Japan Hygienic Association of Vinylidene Chloride","year":"2010"},{"key":"key\n\t\t\t\t20170508174025_bib12","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1210\/mend.14.1.0409","article-title":"The pregnane X receptor: a promiscuous xenobiotic receptor that has diverged during evolution","volume":"14","year":"2000","journal-title":"Mol. Endocrinol."},{"key":"key\n\t\t\t\t20170508174025_bib13","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1124\/dmd.107.017418","article-title":"HepaRG cells as an in vitro model for evaluation of cytochrome P450 induction in humans","volume":"36","year":"2008","journal-title":"Drug Metab. Dispos."},{"key":"key\n\t\t\t\t20170508174025_bib14","first-page":"10","article-title":"Acetyltributyl citrate","volume-title":"Handbook of Pharmaceutical Excipients","year":"2006"},{"key":"key\n\t\t\t\t20170508174025_bib15","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1210\/er.2001-0038","article-title":"The nuclear pregnane X receptor: a key regulator of xenobiotic metabolism","volume":"23","year":"2002","journal-title":"Endocr. Rev."},{"key":"key\n\t\t\t\t20170508174025_bib16","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0092-8674(00)80900-9","article-title":"An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway","volume":"92","year":"1998","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170508174025_bib17","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1124\/mol.108.051904","article-title":"Nuclear xenobiotic receptor pregnane X receptor locks corepressor silencing mediator for retinoid and thyroid hormone receptors (SMRT) onto the CYP24A1 promoter to attenuate vitamin D3 activation","volume":"75","year":"2009","journal-title":"Mol. Pharmacol."},{"key":"key\n\t\t\t\t20170508174025_bib18","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1111\/j.1478-3231.2006.01410.x","article-title":"A comprehensive gene expression analysis of human hepatocellular carcinoma cell lines as components of a bioartificial liver using a radial flow bioreactor","volume":"27","year":"2007","journal-title":"Liver Int."},{"key":"key\n\t\t\t\t20170508174025_bib19","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1590\/S0004-282X2004000600003","article-title":"Bone mineral density and serum levels of 25 OH vitamin D in chronic users of antiepileptic drugs","volume":"62","year":"2004","journal-title":"Arq. Neuropsiquiatr."},{"key":"key\n\t\t\t\t20170508174025_bib20","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S0009-2797(01)00163-6","article-title":"Pregnane X receptor: molecular basis for species differences in CYP3A induction by xenobiotics","volume":"134","year":"2001","journal-title":"Chem. Biol. Interact."},{"key":"key\n\t\t\t\t20170508174025_bib21","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1124\/dmd.30.7.795","article-title":"CYP3A4 induction by drugs: correlation between a pregnane X receptor reporter gene assay and CYP3A4 expression in human hepatocytes","volume":"30","year":"2002","journal-title":"Drug Metab. Dispos."},{"key":"key\n\t\t\t\t20170508174025_bib22","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1210\/mend.14.3.0424","article-title":"Endocrine disrupting chemicals, phthalic acid and nonylphenol, activate Pregnane X receptor-mediated transcription","volume":"14","year":"2000","journal-title":"Mol. Endocrinol."},{"key":"key\n\t\t\t\t20170508174025_bib23","doi-asserted-by":"crossref","first-page":"2875","DOI":"10.1016\/S0149-2918(03)80340-5","article-title":"Bioequivalence and other unresolved issues in generic drug substitution","volume":"25","year":"2003","journal-title":"Clin. Ther."},{"key":"key\n\t\t\t\t20170508174025_bib24","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1289\/ehp.10853","article-title":"Activation of steroid and xenobiotic receptor (SXR, NR1I2) and its orthologs in laboratory, toxicologic, and genome model species","volume":"116","year":"2008","journal-title":"Environ. Health Perspect."},{"key":"key\n\t\t\t\t20170508174025_bib25","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1248\/jhs.55.281","article-title":"Leaching of the plasticizer, acetyl tributyl citrate: (ATBC) from plastic kitchen wrap","volume":"55","year":"2009","journal-title":"J. Health Sci."},{"key":"key\n\t\t\t\t20170508174025_bib26","volume-title":"Estimated Numbers of Employees Potentially Exposed to Specific Agents.","author":"National Institute for Occupational Safety and Health","year":"1983"},{"key":"key\n\t\t\t\t20170508174025_bib27","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1097\/FPC.0b013e3280143dfc","article-title":"Effects of rifampicin on global gene expression in human small intestine","volume":"17","year":"2007","journal-title":"Pharmacogenet. Genomics"},{"key":"key\n\t\t\t\t20170508174025_bib28","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.bcp.2009.08.017","article-title":"Intestinal cell-specific vitamin D receptor (VDR)-mediated transcriptional regulation of CYP3A4 gene","volume":"79","year":"2010","journal-title":"Biochem. Pharmacol."},{"key":"key\n\t\t\t\t20170508174025_bib29","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1677\/joe.1.06664","article-title":"The endocrine disrupting chemical, diethylhexyl phthalate, activates MDR1 gene expression in human colon cancer LS174T cells","volume":"190","year":"2006","journal-title":"J. Endocrinol."},{"key":"key\n\t\t\t\t20170508174025_bib30","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1530\/eje.0.1450513","article-title":"Bisphenol-A, an environmental estrogen, activates the human orphan nuclear receptor, steroid and xenobiotic receptor-mediated transcription","volume":"145","year":"2001","journal-title":"Eur. J. Endocrinol."},{"key":"key\n\t\t\t\t20170508174025_bib31","doi-asserted-by":"crossref","first-page":"32453","DOI":"10.1074\/jbc.M111245200","article-title":"Putative role of the orphan nuclear receptor SXR (steroid and xenobiotic receptor) in the mechanism of CYP3A4 inhibition by xenobiotics","volume":"277","year":"2002","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170508174025_bib32","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1124\/mol.60.6.1399","article-title":"Transcriptional control of intestinal cytochrome P-4503A by 1\u03b1,25-dihydroxy vitamin D3","volume":"60","year":"2001","journal-title":"Mol. Pharmacol."},{"key":"key\n\t\t\t\t20170508174025_bib33","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1038\/nm815","article-title":"The orphan nuclear receptor HNF4\u03b1 determines PXR- and CAR-mediated xenobiotic induction of CYP3A4","volume":"9","year":"2003","journal-title":"Nat. Med."},{"key":"key\n\t\t\t\t20170508174025_bib34","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1007\/s11095-010-0170-2","article-title":"Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells","volume":"27","year":"2010","journal-title":"Pharm. Res."},{"key":"key\n\t\t\t\t20170508174025_bib35","volume-title":"Robust Summaries of Reliable Studies and QSAR Model Data, Acetyl Tributyl Citrate (ATBC)","author":"U.S. Environmental Protection Agency","year":"2003"},{"key":"key\n\t\t\t\t20170508174025_bib36","volume-title":"Inactive Ingredients Database Download","author":"U.S. Food and Drug Administration (USFDA)","year":"2010"},{"key":"key\n\t\t\t\t20170508174025_bib37","volume-title":"Inactive Ingredient Search for Approved Drug Products","author":"U.S. Food and Drug Administration (USFDA)","year":"2010"},{"key":"key\n\t\t\t\t20170508174025_bib38","doi-asserted-by":"crossref","first-page":"3583","DOI":"10.1172\/JCI33435","article-title":"Knockout of cytochrome P450 3A yields new mouse models for understanding xenobiotic metabolism","volume":"117","year":"2007","journal-title":"J. Clin. Invest."},{"key":"key\n\t\t\t\t20170508174025_bib39","doi-asserted-by":"crossref","first-page":"3667","DOI":"10.1002\/j.1460-2075.1996.tb00736.x","article-title":"TIF2, a 160 kDa transcriptional mediator for the ligand-dependent activation function AF-2 of nuclear receptors","volume":"15","year":"1996","journal-title":"EMBO J."},{"key":"key\n\t\t\t\t20170508174025_bib40","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1124\/mol.105.017392","article-title":"Intestinal and hepatic CYP3A4 catalyze hydroxylation of 1\u03b1,25-dihydroxyvitamin D3: implications for drug-induced osteomalacia","volume":"69","year":"2006","journal-title":"Mol. Pharmacol."},{"key":"key\n\t\t\t\t20170508174025_bib41","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.2217\/14622416.9.11.1695","article-title":"PXR: a xenobiotic receptor of diverse function implicated in pharmacogenetics","volume":"9","year":"2008","journal-title":"Pharmacogenomics"},{"key":"key\n\t\t\t\t20170508174025_bib42","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1172\/JCI27793","article-title":"Steroid and xenobiotic receptor and vitamin D receptor crosstalk mediates CYP24 expression and drug-induced osteomalacia","volume":"116","year":"2006","journal-title":"J. Clin. Invest."},{"key":"key\n\t\t\t\t20170508174025_bib43","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1124\/dmd.104.000299","article-title":"Tocotrienols activate the steroid and xenobiotic receptor, SXR, and selectively regulate expression of its target genes","volume":"32","year":"2004","journal-title":"Drug Metab. Dispos."},{"key":"key\n\t\t\t\t20170508174025_bib44","first-page":"e001","article-title":"The steroid and xenobiotic receptor (SXR), beyond xenobiotic metabolism","volume":"7","year":"2009","journal-title":"Nucl. Recept. Signal."}],"container-title":["Toxicological Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/toxsci\/article-pdf\/123\/2\/460\/16682863\/kfr178.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,8]],"date-time":"2024-04-08T11:43:23Z","timestamp":1712576603000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/toxsci\/article-lookup\/doi\/10.1093\/toxsci\/kfr178"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,7,8]]},"references-count":44,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2011,7,8]]},"published-print":{"date-parts":[[2011,10]]}},"URL":"https:\/\/doi.org\/10.1093\/toxsci\/kfr178","relation":{},"ISSN":["1096-6080","1096-0929"],"issn-type":[{"value":"1096-6080","type":"print"},{"value":"1096-0929","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,7,8]]}}}