{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T06:10:19Z","timestamp":1768716619039,"version":"3.49.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,12]]},"DOI":"10.1093\/toxsci\/kfr196","type":"journal-article","created":{"date-parts":[[2011,7,24]],"date-time":"2011-07-24T00:49:20Z","timestamp":1311468560000},"page":"378-387","source":"Crossref","is-referenced-by-count":29,"title":["Calreticulin Binds to Gentamicin and Reduces Drug-Induced Ototoxicity"],"prefix":"10.1093","volume":"124","author":[{"given":"Takatoshi","family":"Karasawa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larry L.","family":"David","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter S.","family":"Steyger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2011,7,23]]},"reference":[{"key":"key\n\t\t\t\t20170508170041_bib1","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1083\/jcb.130.4.847","article-title":"Overexpression of calreticulin increases the Ca2+ capacity of rapidly exchanging Ca2+ stores and reveals aspects of their lumenal microenvironment and function","volume":"130","year":"1995","journal-title":"J. Cell Biol."},{"key":"key\n\t\t\t\t20170508170041_bib2","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1097\/00029330-200606020-00003","article-title":"Aminoglycoside ototoxicity in three murine strains and effects on NKCC1 of stria vascularis","volume":"119","year":"2006","journal-title":"Chin. Med. J. (Engl)"},{"key":"key\n\t\t\t\t20170508170041_bib3","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.heares.2006.12.017","article-title":"Proteomic analysis of cisplatin-induced cochlear damage: Methods and early changes in protein expression","volume":"226","year":"2007","journal-title":"Hear. Res."},{"key":"key\n\t\t\t\t20170508170041_bib4","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/S0025-6196(11)65134-3","article-title":"The aminoglycosides","volume":"74","year":"1999","journal-title":"Mayo Clin. Proc."},{"key":"key\n\t\t\t\t20170508170041_bib5","doi-asserted-by":"crossref","first-page":"21522","DOI":"10.1016\/S0021-9258(20)88216-7","article-title":"Molecular cloning of the high affinity calcium-binding protein (calreticulin) of skeletal muscle sarcoplasmic reticulum","volume":"264","year":"1989","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170508170041_bib6","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1159\/000013861","article-title":"Aminoglycoside antibiotics","volume":"5","year":"2000","journal-title":"Audiol. Neurootol."},{"key":"key\n\t\t\t\t20170508170041_bib7","doi-asserted-by":"crossref","first-page":"7013","DOI":"10.1523\/JNEUROSCI.21-18-07013.2001","article-title":"FM1-43 dye behaves as a permeant blocker of the hair-cell mechanotransducer channel","volume":"21","year":"2001","journal-title":"J. Neurosci."},{"key":"key\n\t\t\t\t20170508170041_bib8","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1096\/fj.09-145482","article-title":"Calreticulin: Non-endoplasmic reticulum functions in physiology and disease","volume":"24","year":"2010","journal-title":"FASEB J."},{"key":"key\n\t\t\t\t20170508170041_bib9","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1097\/01.inf.0000178064.55193.1c","article-title":"Use of antimicrobial agents in United States neonatal and pediatric intensive care patients","volume":"24","year":"2005","journal-title":"Pediatr. Infect. Dis. J."},{"key":"key\n\t\t\t\t20170508170041_bib10","doi-asserted-by":"crossref","first-page":"50776","DOI":"10.1074\/jbc.M209900200","article-title":"Cardiac-specific expression of calcineurin reverses embryonic lethality in calreticulin-deficient mouse","volume":"277","year":"2002","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170508170041_bib11","doi-asserted-by":"crossref","first-page":"12323","DOI":"10.1021\/bi970962r","article-title":"Specific binding of aminoglycosides to a human rRNA construct based on a DNA polymorphism which causes aminoglycoside-induced deafness","volume":"36","year":"1997","journal-title":"Biochemistry"},{"key":"key\n\t\t\t\t20170508170041_bib12","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1152\/physrev.00050.2006","article-title":"In and out of the ER: Protein folding, quality control, degradation, and related human diseases","volume":"87","year":"2007","journal-title":"Physiol. Rev."},{"key":"key\n\t\t\t\t20170508170041_bib13","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1159\/000259227","article-title":"Production of conditionally immortalised cell lines from a transgenic mouse","volume":"2","year":"1997","journal-title":"Audiol. Neurootol."},{"key":"key\n\t\t\t\t20170508170041_bib14","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.bbrc.2004.08.099","article-title":"Gentamicin binds to the lectin site of calreticulin and inhibits its chaperone activity","volume":"323","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"key\n\t\t\t\t20170508170041_bib15","doi-asserted-by":"crossref","first-page":"3730","DOI":"10.1038\/emboj.2009.296","article-title":"Calreticulin-dependent recycling in the early secretory pathway mediates optimal peptide loading of MHC class I molecules","volume":"28","year":"2009","journal-title":"EMBO J."},{"key":"key\n\t\t\t\t20170508170041_bib16","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1080\/00016480802032835","article-title":"Changes in transient receptor potential vanilloid (TRPV) 1, 2, 3 and 4 expression in mouse inner ear following gentamicin challenge","volume":"129","year":"2009","journal-title":"Acta Otolaryngol."},{"key":"key\n\t\t\t\t20170508170041_bib17","doi-asserted-by":"crossref","first-page":"5096","DOI":"10.1073\/pnas.88.12.5096","article-title":"Direct derivation of conditionally immortal cell lines from an H-2Kb-tsA58 transgenic mouse","volume":"88","year":"1991","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"key\n\t\t\t\t20170508170041_bib18","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1159\/000071059","article-title":"A cochlear cell line as an in vitro system for drug ototoxicity screening","volume":"8","year":"2003","journal-title":"Audiol. Neurootol."},{"key":"key\n\t\t\t\t20170508170041_bib19","doi-asserted-by":"crossref","first-page":"e102","DOI":"10.1038\/cddis.2010.80","article-title":"CLIMP-63 is a gentamicin-binding protein that is involved in drug-induced cytotoxicity","volume":"1","year":"2010","journal-title":"Cell Death Dis."},{"key":"key\n\t\t\t\t20170508170041_bib20","doi-asserted-by":"crossref","first-page":"2871","DOI":"10.1242\/jcs.023705","article-title":"TRPV4 enhances the cellular uptake of aminoglycoside antibiotics","volume":"121","year":"2008","journal-title":"J. Cell Sci."},{"key":"key\n\t\t\t\t20170508170041_bib21","first-page":"1","article-title":"Comparative ototoxicity of four aminoglycosidic antibiotics during the critical period of cochlear development in the rat","volume":"405","year":"1983","journal-title":"Funct. Struct. Study Acta Otolaryngol."},{"key":"key\n\t\t\t\t20170508170041_bib22","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1021\/tx0496946","article-title":"Ternary complexes of gentamicin with iron and lipid catalyze formation of reactive oxygen species","volume":"18","year":"2005","journal-title":"Chem. Res. Toxicol."},{"key":"key\n\t\t\t\t20170508170041_bib23","doi-asserted-by":"crossref","first-page":"4084","DOI":"10.1073\/pnas.96.7.4084","article-title":"Gene disruption of p27(Kip1) allows cell proliferation in the postnatal and adult organ of corti","volume":"96","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"key\n\t\t\t\t20170508170041_bib24","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1083\/jcb.200412156","article-title":"Calreticulin signals upstream of calcineurin and MEF2C in a critical Ca(2+)-dependent signaling cascade","volume":"170","year":"2005","journal-title":"J. Cell Biol."},{"key":"key\n\t\t\t\t20170508170041_bib25","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1113\/jphysiol.2005.085951","article-title":"The aminoglycoside antibiotic dihydrostreptomycin rapidly enters mouse outer hair cells through the mechano-electrical transducer channels","volume":"567","year":"2005","journal-title":"J. Physiol."},{"key":"key\n\t\t\t\t20170508170041_bib26","doi-asserted-by":"crossref","first-page":"9332","DOI":"10.1074\/jbc.271.16.9332","article-title":"Overexpression of calreticulin increases intracellular Ca2+ storage and decreases store-operated Ca2+ influx","volume":"271","year":"1996","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170508170041_bib27","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1083\/jcb.144.5.857","article-title":"Calreticulin is essential for cardiac development","volume":"144","year":"1999","journal-title":"J. Cell Biol."},{"key":"key\n\t\t\t\t20170508170041_bib28","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1042\/BJ20081847","article-title":"Calreticulin, a multi-process calcium-buffering chaperone of the endoplasmic reticulum","volume":"417","year":"2009","journal-title":"Biochem. J."},{"key":"key\n\t\t\t\t20170508170041_bib29","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/327389a0","article-title":"Interaction of antibiotics with functional sites in 16S ribosomal RNA","volume":"327","year":"1987","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170508170041_bib30","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1172\/JCI118176","article-title":"Evidence that epithelial glycoprotein 330\/megalin mediates uptake of polybasic drugs","volume":"96","year":"1995","journal-title":"J. Clin. Invest."},{"key":"key\n\t\t\t\t20170508170041_bib31","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1083\/jcb.150.4.731","article-title":"Changes in endoplasmic reticulum luminal environment affect cell sensitivity to apoptosis","volume":"150","year":"2000","journal-title":"J. Cell Biol."},{"key":"key\n\t\t\t\t20170508170041_bib32","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1083\/jcb.200102073","article-title":"Functional specialization of calreticulin domains","volume":"154","year":"2001","journal-title":"J. Cell Biol."},{"key":"key\n\t\t\t\t20170508170041_bib33","doi-asserted-by":"crossref","first-page":"3641","DOI":"10.1016\/j.febslet.2007.04.045","article-title":"ER chaperones in mammalian development and human diseases","volume":"581","year":"2007","journal-title":"FEBS Lett."},{"key":"key\n\t\t\t\t20170508170041_bib34","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1126\/science.275.5296.86","article-title":"Interaction of the thiol-dependent reductase ERp57 with nascent glycoproteins","volume":"275","year":"1997","journal-title":"Science"},{"key":"key\n\t\t\t\t20170508170041_bib35","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1038\/ng0793-289","article-title":"Mitochondrial ribosomal RNA mutation associated with both antibiotic-induced and non-syndromic deafness","volume":"4","year":"1993","journal-title":"Nat. Genet."},{"key":"key\n\t\t\t\t20170508170041_bib36","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1038\/370659a0","article-title":"Interactions of a small RNA with antibiotic and RNA ligands of the 30S subunit","volume":"370","year":"1994","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170508170041_bib37","doi-asserted-by":"crossref","first-page":"3581","DOI":"10.1002\/j.1460-2075.1989.tb08530.x","article-title":"Multiple zones in the sequence of calreticulin (CRP55, calregulin, HACBP), a major calcium binding ER\/SR protein","volume":"8","year":"1989","journal-title":"EMBO J."},{"key":"key\n\t\t\t\t20170508170041_bib38","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/0378-4274(89)90121-5","article-title":"Nephrotoxicity of aminoglycoside antibiotics","volume":"46","year":"1989","journal-title":"Toxicol. Lett."},{"key":"key\n\t\t\t\t20170508170041_bib39","doi-asserted-by":"crossref","first-page":"19599","DOI":"10.1016\/S0021-9258(18)55036-5","article-title":"SSR alpha and associated calnexin are major calcium binding proteins of the endoplasmic reticulum membrane","volume":"266","year":"1991","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170508170041_bib40","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1242\/jcs.02856","article-title":"Beyond lectins: The calnexin\/calreticulin chaperone system of the endoplasmic reticulum","volume":"119","year":"2006","journal-title":"J. Cell Sci."}],"container-title":["Toxicological Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/toxsci\/article-pdf\/124\/2\/378\/16683694\/kfr196.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,28]],"date-time":"2021-11-28T16:32:08Z","timestamp":1638117128000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/toxsci\/article-lookup\/doi\/10.1093\/toxsci\/kfr196"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,7,23]]},"references-count":40,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2011,7,23]]},"published-print":{"date-parts":[[2011,12]]}},"URL":"https:\/\/doi.org\/10.1093\/toxsci\/kfr196","relation":{},"ISSN":["1096-6080","1096-0929"],"issn-type":[{"value":"1096-6080","type":"print"},{"value":"1096-0929","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,7,23]]}}}