{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T14:21:56Z","timestamp":1790259716579,"version":"4.1.0"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,11]]},"DOI":"10.1093\/toxsci\/kfs222","type":"journal-article","created":{"date-parts":[[2012,7,13]],"date-time":"2012-07-13T21:09:31Z","timestamp":1342213771000},"page":"4-16","source":"Crossref","is-referenced-by-count":68,"title":["Metabolic Activation and Inflammation Reactions Involved in Carbamazepine-Induced Liver Injury"],"prefix":"10.1093","volume":"130","author":[{"given":"Satonori","family":"Higuchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azusa","family":"Yano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shohei","family":"Takai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Tsuneyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuki","family":"Fukami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miki","family":"Nakajima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuyoshi","family":"Yokoi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2012,7,12]]},"reference":[{"key":"key\n\t\t\t\t20170508175141_CIT0001","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.seizure.2005.12.009","article-title":"Antiepileptic drugs and liver disease.","volume":"15","author":"Ahmed","year":"(2006)","journal-title":"Seizure"},{"key":"key\n\t\t\t\t20170508175141_CIT0002","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1093\/toxsci\/kfp235","article-title":"High-mobility group box-1 protein and keratin-18, circulating serum proteins informative of acetaminophen-induced necrosis and apoptosis in vivo.","volume":"112","author":"Antoine","year":"(2009)","journal-title":"Toxicol. Sci."},{"key":"key\n\t\t\t\t20170508175141_CIT0003","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1002\/hep.20800","article-title":"Outcome and prognostic markers in severe drug-induced liver disease.","volume":"42","author":"Bj\u00f6rnsson","year":"(2005)","journal-title":"Hepatology"},{"key":"key\n\t\t\t\t20170508175141_CIT0004","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1111\/j.1600-0404.2008.01009.x","article-title":"Hepatotoxicity associated with antiepileptic drugs.","volume":"118","author":"Bj\u00f6rnsson","year":"(2008)","journal-title":"Acta Neurol. Scand."},{"key":"key\n\t\t\t\t20170508175141_CIT0005","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1084\/jem.20030800","article-title":"The pattern recognition receptor (RAGE) is a counterreceptor for leukocyte integrins: A novel pathway for inflammatory cell recruitment.","volume":"198","author":"Chavakis","year":"(2003)","journal-title":"J. Exp. Med."},{"key":"key\n\t\t\t\t20170508175141_CIT0006","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/BF00562659","article-title":"Plasma kinetics of carbamazepine and its epoxide metabolite in man after single and multiple doses.","volume":"8","author":"Eichelbaum","year":"(1975)","journal-title":"Eur. J. Clin. Pharmacol."},{"key":"key\n\t\t\t\t20170508175141_CIT0009","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1097\/01.fpc.0000199500.46842.4a","article-title":"Genetic susceptibility to carbamazepine-induced cutaneous adverse drug reactions.","volume":"16","author":"Hung","year":"(2006)","journal-title":"Pharmacogenet. Genomics"},{"key":"key\n\t\t\t\t20170508175141_CIT0010","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1093\/toxsci\/65.2.166","article-title":"Mechanisms of hepatotoxicity.","volume":"65","author":"Jaeschke","year":"(2002)","journal-title":"Toxicol. Sci."},{"key":"key\n\t\t\t\t20170508175141_CIT0011","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1124\/jpet.109.162297","article-title":"Pulmonary toxicity and metabolic activation of dauricine in CD-1 mice.","volume":"332","author":"Jin","year":"(2009)","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"key\n\t\t\t\t20170508175141_CIT0012","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1016\/S0140-6736(00)02826-9","article-title":"Epidemiological assessment of drug-induced disease.","volume":"356","author":"Kaufman","year":"(2000)","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20170508175141_CIT0013","first-page":"223","article-title":"Th1\/Th2 balance: The hypothesis, its limitations, and implications for health and disease.","volume":"8","author":"Kidd","year":"(2003)","journal-title":"Altern. Med. Rev."},{"key":"key\n\t\t\t\t20170508175141_CIT0014","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1053\/gast.2001.22441","article-title":"The lymphoid liver: Considerations on pathways to autoimmune injury.","volume":"120","author":"Kita","year":"(2001)","journal-title":"Gastroenterology"},{"key":"key\n\t\t\t\t20170508175141_CIT0015","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1093\/toxsci\/kfp165","article-title":"Halothane-induced liver injury is mediated by interleukin-17 in mice.","volume":"111","author":"Kobayashi","year":"(2009)","journal-title":"Toxicol. Sci."},{"key":"key\n\t\t\t\t20170508175141_CIT0016","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.tox.2010.05.011","article-title":"Interleukin-17 is involved in alpha-naphthylisothiocyanate-induced liver injury in mice.","volume":"275","author":"Kobayashi","year":"(2010)","journal-title":"Toxicology"},{"key":"key\n\t\t\t\t20170508175141_CIT0017","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1038\/modpathol.3800165","article-title":"Improved 1-h rapid immunostaining method using intermittent microwave irradiation: Practicability based on 5 years application in Toyama Medical and Pharmaceutical University Hospital.","volume":"17","author":"Kumada","year":"(2004)","journal-title":"Mod. Pathol."},{"key":"key\n\t\t\t\t20170508175141_CIT0018","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1084\/jem.20041257","article-title":"IL-23 drives a pathogenic T cell population that induces autoimmune inflammation.","volume":"201","author":"Langrish","year":"(2005)","journal-title":"J. Exp. Med."},{"key":"key\n\t\t\t\t20170508175141_CIT0019","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0090-9556(25)07827-4","article-title":"Metabolism of carbamazepine.","volume":"10","author":"Lertratanangkoon","year":"(1982)","journal-title":"Drug Metab. Dispos."},{"key":"key\n\t\t\t\t20170508175141_CIT0020","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1111\/j.1600-065X.2007.00579.x","article-title":"The grateful dead: Damage-associated molecular pattern molecules and reduction\/oxidation regulate immunity.","volume":"220","author":"Lotze","year":"(2007)","journal-title":"Immunol. Rev."},{"key":"key\n\t\t\t\t20170508175141_CIT0021","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1124\/dmd.107.019554","article-title":"Peroxidase-mediated bioactivation of hydroxylated metabolites of carbamazepine and phenytoin.","volume":"36","author":"Lu","year":"(2008)","journal-title":"Drug Metab. Dispos."},{"key":"key\n\t\t\t\t20170508175141_CIT0022","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1111\/j.1462-5822.2010.01540.x","article-title":"Novel interactions of a microbial superantigen with TLR2 and TLR4 differentially regulate IL-17 and Th17-associated cytokines.","volume":"13","author":"Mu","year":"(2011)","journal-title":"Cell. Microbiol."},{"key":"key\n\t\t\t\t20170508175141_CIT0023","volume-title":"Interview Form (Product Information Booklet) of Tegretol\u00ae","author":"Novartis Pharma Co.","year":"2011","edition":"9th ed."},{"key":"key\n\t\t\t\t20170508175141_CIT0024","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jaut.2009.07.011","article-title":"The role of chemokines in the recruitment of lymphocytes to the liver.","volume":"34","author":"Oo","year":"(2009)","journal-title":"J. Autoimmun."},{"key":"key\n\t\t\t\t20170508175141_CIT0025","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.clpt.2006.08.013","article-title":"Transcriptional profiling of genes induced in the livers of patients treated with carbamazepine.","volume":"80","author":"Oscarson","year":"(2006)","journal-title":"Clin. Pharmacol. Ther."},{"key":"key\n\t\t\t\t20170508175141_CIT0026","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0300-483X(00)00303-6","article-title":"Advances in molecular toxicology-towards understanding idiosyncratic drug toxicity.","volume":"153","author":"Park","year":"(2000)","journal-title":"Toxicology"},{"key":"key\n\t\t\t\t20170508175141_CIT0027","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1124\/dmd.107.019562","article-title":"Pathways of carbamazepine bioactivation in vitro. III. The role of human cytochrome P450 enzymes in the formation of 2,3-dihydroxycarbamazepine.","volume":"36","author":"Pearce","year":"(2008)","journal-title":"Drug Metab. Dispos."},{"key":"key\n\t\t\t\t20170508175141_CIT0028","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1124\/dmd.30.11.1170","article-title":"Pathways of carbamazepine bioactivation in vitro I. Characterization of human cytochromes P450 responsible for the formation of 2- and 3-hydroxylated metabolites.","volume":"30","author":"Pearce","year":"(2002)","journal-title":"Drug Metab. Dispos."},{"key":"key\n\t\t\t\t20170508175141_CIT0029","first-page":"35","article-title":"Cocaine N-demethylation and the metabolism-related hepatotoxicity can be prevented by cytochrome P450 3A inhibitors.","volume":"270","author":"Pellinen","year":"(1994)","journal-title":"Eur. J. Pharmacol."},{"key":"key\n\t\t\t\t20170508175141_CIT0030"},{"key":"key\n\t\t\t\t20170508175141_CIT0031","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/j.1365-2125.1992.tb04022.x","article-title":"Detection of an autoantibody directed against human liver microsomal protein in a patient with carbamazepine hypersensitivity.","volume":"33","author":"Pirmohamed","year":"1992","journal-title":"Br. J. Clin. Pharmacol."},{"key":"key\n\t\t\t\t20170508175141_CIT0032","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1016\/0006-2952(92)90696-G","article-title":"An investigation of the formation of cytotoxic, protein-reactive and stable metabolites from carbamazepine in vitro.","volume":"43","author":"Pirmohamed","year":"1992","journal-title":"Biochem. Pharmacol."},{"key":"key\n\t\t\t\t20170508175141_CIT0033","doi-asserted-by":"crossref","first-page":"L329","DOI":"10.1152\/ajplung.00014.2005","article-title":"Toll-like receptor 4 antagonist (E5564) prevents the chronic airway response to inhaled lipopolysaccharide.","volume":"289","author":"Savov","year":"(2005)","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"key\n\t\t\t\t20170508175141_CIT0034","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1038\/nm1551","article-title":"A brief history of T(H)17, the first major revision in the T(H)1\/T(H)2 hypothesis of T cell-mediated tissue damage.","volume":"13","author":"Steinman","year":"(2007)","journal-title":"Nat. Med."},{"key":"key\n\t\t\t\t20170508175141_CIT0035","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/S0168-8278(98)80125-6","article-title":"Protective effect of prostaglandin E1 against ischemia\/reperfusion-induced liver injury: Results of a prospective, randomized study in cirrhotic patients undergoing subsegmentectomy.","volume":"29","author":"Sugawara","year":"(1998)","journal-title":"J. Hepatol."},{"key":"key\n\t\t\t\t20170508175141_CIT0036","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1111\/j.1476-5381.1995.tb13370.x","article-title":"Characterization of the PGE receptor subtype mediating inhibition of superoxide production in human neutrophils.","volume":"114","author":"Talpain","year":"(1995)","journal-title":"Br. J. Pharmacol."},{"key":"key\n\t\t\t\t20170508175141_CIT0037","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1111\/j.1365-2796.2003.01302.x","article-title":"Extracellular role of HMGB1 in inflammation and sepsis.","volume":"255","author":"Wang","year":"(2004)","journal-title":"J. Intern. Med."},{"key":"key\n\t\t\t\t20170508175141_CIT0038","doi-asserted-by":"crossref","first-page":"249","DOI":"10.2337\/db09-0801","article-title":"Hyperglycemia-induced reactive oxygen species increase expression of the receptor for advanced glycation end products (RAGE) and RAGE ligands.","volume":"59","author":"Yao","year":"(2010)","journal-title":"Diabetes"}],"container-title":["Toxicological Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/toxsci\/article-pdf\/130\/1\/4\/16683978\/kfs222.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T01:40:52Z","timestamp":1743730852000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/toxsci\/article-lookup\/doi\/10.1093\/toxsci\/kfs222"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7,12]]},"references-count":36,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2012,7,12]]},"published-print":{"date-parts":[[2012,11]]}},"URL":"https:\/\/doi.org\/10.1093\/toxsci\/kfs222","relation":{},"ISSN":["1096-0929","1096-6080"],"issn-type":[{"value":"1096-0929","type":"electronic"},{"value":"1096-6080","type":"print"}],"subject":[],"published":{"date-parts":[[2012,7,12]]}}}