{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:02:11Z","timestamp":1790744531169,"version":"4.1.0"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,12]]},"DOI":"10.1093\/toxsci\/kfs238","type":"journal-article","created":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T20:39:23Z","timestamp":1346531963000},"page":"416-426","source":"Crossref","is-referenced-by-count":54,"title":["A Mouse Diversity Panel Approach Reveals the Potential for Clinical Kidney Injury Due to DB289 Not Predicted by Classical Rodent Models"],"prefix":"10.1093","volume":"130","author":[{"given":"Alison H.","family":"Harrill","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina D.","family":"DeSmet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina K.","family":"Wolf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arlene S.","family":"Bridges","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Scott","family":"Eaddy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. Lisa","family":"Kurtz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Ed.","family":"Hall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary F.","family":"Paine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard R.","family":"Tidwell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul B.","family":"Watkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2012,8,31]]},"reference":[{"key":"key\n\t\t\t\t20170508174506_CIT0001","doi-asserted-by":"crossref","first-page":"2741","DOI":"10.1016\/j.febslet.2006.04.035","article-title":"A critical role for the histidine residues in the catalytic function of acyl-CoA:cholesterol acyltransferase catalysis: Evidence for catalytic difference between ACAT1 and ACAT2.","volume":"580","author":"An","year":"(2006)","journal-title":"FEBS Lett."},{"key":"key\n\t\t\t\t20170508174506_CIT0002","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s10709-004-1438-4","article-title":"The mouse phenome project.","volume":"122","author":"Bogue","year":"(2004)","journal-title":"Genetica"},{"key":"key\n\t\t\t\t20170508174506_CIT0003","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1093\/toxsci\/kfi166","article-title":"Hepatic gene expression changes throughout the day in the Fischer rat: Implications for toxicogenomic experiments.","volume":"86","author":"Boorman","year":"(2005)","journal-title":"Toxicol. Sci."},{"key":"key\n\t\t\t\t20170508174506_CIT0004","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1021\/jm00006a009","article-title":"Dicationic diarylfurans as anti-Pneumocystis carinii agents.","volume":"38","author":"Boykin","year":"(1995)","journal-title":"J. Med. Chem."},{"key":"key\n\t\t\t\t20170508174506_CIT0005","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1093\/toxsci\/kfq362","article-title":"Interstrain differences in the liver effects of trichloroethylene in a multistrain panel of inbred mice.","volume":"120","author":"Bradford","year":"(2011)","journal-title":"Toxicol. Sci."},{"key":"key\n\t\t\t\t20170508174506_CIT0006","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.drup.2007.02.004","article-title":"Drugs and drug resistance in African trypanosomiasis.","volume":"10","author":"Delespaux","year":"(2007)","journal-title":"Drug Resist. Updat."},{"key":"key\n\t\t\t\t20170508174506_CIT0007","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1128\/MCB.26.1.354-361.2006","article-title":"Deletion of the gene encoding proprotein convertase 5\/6 causes early embryonic lethality in the mouse.","volume":"26","author":"Essalmani","year":"(2006)","journal-title":"Mol. Cell. Biol."},{"key":"key\n\t\t\t\t20170508174506_CIT0008","doi-asserted-by":"crossref","first-page":"5750","DOI":"10.1073\/pnas.0709428105","article-title":"In vivo functions of the proprotein convertase PC5\/6 during mouse development: Gdf11 is a likely substrate.","volume":"105","author":"Essalmani","year":"(2008)","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"key\n\t\t\t\t20170508174506_CIT0009","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1093\/toxsci\/kfp096","article-title":"Population-based discovery of toxicogenomics biomarkers for hepatotoxicity using a laboratory strain diversity panel.","volume":"110","author":"Harrill","year":"2009","journal-title":"Toxicol. Sci."},{"key":"key\n\t\t\t\t20170508174506_CIT0010","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1101\/gr.090241.108","article-title":"Mouse population-guided resequencing reveals that variants in CD44 contribute to acetaminophen-induced liver injury in humans.","volume":"19","author":"Harrill","year":"2009","journal-title":"Genome Res."},{"key":"key\n\t\t\t\t20170508174506_CIT0011","doi-asserted-by":"crossref","first-page":"36551","DOI":"10.1074\/jbc.M502264200","article-title":"Proprotein convertases [corrected] are responsible for proteolysis and inactivation of endothelial lipase.","volume":"280","author":"Jin","year":"(2005)","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170508174506_CIT0012","doi-asserted-by":"crossref","first-page":"2196","DOI":"10.1111\/j.1523-1755.2005.00325.x","article-title":"Triglyceride accumulation in injured renal tubular cells: Alterations in both synthetic and catabolic pathways.","volume":"67","author":"Johnson","year":"(2005)","journal-title":"Kidney Int."},{"key":"key\n\t\t\t\t20170508174506_CIT0013","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1534\/genetics.107.080101","article-title":"Efficient control of population structure in model organism association mapping.","volume":"178","author":"Kang","year":"(2008)","journal-title":"Genetics"},{"key":"key\n\t\t\t\t20170508174506_CIT0014","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1194\/jlr.M400396-JLR200","article-title":"Wild-type PCSK9 inhibits LDL clearance but does not affect apoB-containing lipoprotein production in mouse and cultured cells.","volume":"46","author":"Lalanne","year":"(2005)","journal-title":"J. Lipid Res."},{"key":"key\n\t\t\t\t20170508174506_CIT0015","doi-asserted-by":"crossref","first-page":"5899","DOI":"10.4049\/jimmunol.178.9.5899","article-title":"NKT cell activation mediates neutrophil IFN-gamma production and renal ischemia-reperfusion injury.","volume":"178","author":"Li","year":"(2007)","journal-title":"J. Immunol."},{"key":"key\n\t\t\t\t20170508174506_CIT0016","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1080\/13547500903067744","article-title":"Comparative analysis of urinary biomarkers for early detection of acute kidney injury following cardiopulmonary bypass.","volume":"14","author":"Liangos","year":"(2009)","journal-title":"Biomarkers"},{"key":"key\n\t\t\t\t20170508174506_CIT0017","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1101\/gr.097212.109","article-title":"An integrative genomic analysis identifies Bhmt2 as a diet-dependent genetic factor protecting against acetaminophen-induced liver toxicity","volume":"20","author":"Liu","year":"(2010)","journal-title":"Genome Res."},{"key":"key\n\t\t\t\t20170508174506_CIT0018","doi-asserted-by":"crossref","first-page":"7100","DOI":"10.1073\/pnas.0402133101","article-title":"Adenoviral-mediated expression of Pcsk9 in mice results in a low-density lipoprotein receptor knockout phenotype.","volume":"101","author":"Maxwell","year":"(2004)","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"key\n\t\t\t\t20170508174506_CIT0019","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1534\/genetics.106.066241","article-title":"Genomewide association analysis in diverse inbred mice: Power and population structure.","volume":"176","author":"McClurg","year":"(2007)","journal-title":"Genetics"},{"key":"key\n\t\t\t\t20170508174506_CIT0020","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1186\/1756-3305-4-234","article-title":"Neglected tropical diseases and the millennium development goals: Why the \u201cother diseases\u201d matter: Reality versus rhetoric.","volume":"4","author":"Molyneux","year":"(2011)","journal-title":"Parasit. Vectors"},{"key":"key\n\t\t\t\t20170508174506_CIT0021","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1002\/jcp.22279","article-title":"The nuclear genes Mtfr1 and Dufd1 regulate mitochondrial dynamic and cellular respiration.","volume":"225","author":"Monticone","year":"(2010)","journal-title":"J. Cell. Physiol."},{"key":"key\n\t\t\t\t20170508174506_CIT0022","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1530\/REP-07-0199","article-title":"Impaired expression of genes coding for reactive oxygen species scavenging enzymes in testes of Mtfr1\/Chppr-deficient mice.","volume":"134","author":"Monticone","year":"(2007)","journal-title":"Reproduction"},{"key":"key\n\t\t\t\t20170508174506_CIT0023","doi-asserted-by":"crossref","first-page":"1886","DOI":"10.1124\/dmd.105.005017","article-title":"Unusual dehydroxylation of antimicrobial amidoxime prodrugs by cytochrome b5 and NADH cytochrome b5 reductase.","volume":"33","author":"Saulter","year":"(2005)","journal-title":"Drug Metab. Dispos."},{"key":"key\n\t\t\t\t20170508174506_CIT0024","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/j.biocel.2008.01.030","article-title":"The activation and physiological functions of the proprotein convertases.","volume":"40","author":"Seidah","year":"(2008)","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"key\n\t\t\t\t20170508174506_CIT0025","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.actatropica.2008.07.006","article-title":"Efficacy of the diamidine DB75 and its prodrug DB289, against murine models of human African trypanosomiasis.","volume":"108","author":"Thuita","year":"(2008)","journal-title":"Acta Trop."},{"key":"key\n\t\t\t\t20170508174506_CIT0026","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1038\/nbt.1623","article-title":"Kidney injury molecule-1 outperforms traditional biomarkers of kidney injury in preclinical biomarker qualification studies.","volume":"28","author":"Vaidya","year":"(2010)","journal-title":"Nat. Biotechnol."},{"key":"key\n\t\t\t\t20170508174506_CIT0027","article-title":"Tissue Kim-1 and urinary clusterin as early indicators of cisplatin-induced acute kidney injury in rats.","author":"Vinken","year":"()","journal-title":"Toxicol. Pathol."},{"key":"key\n\t\t\t\t20170508174506_CIT0028","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1681\/ASN.2010080815","article-title":"Sulfatide-reactive natural killer T cells abrogate ischemia-reperfusion injury.","volume":"22","author":"Yang","year":"(2011)","journal-title":"J. Am. Soc. Nephrol."},{"key":"key\n\t\t\t\t20170508174506_CIT0029","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1086\/430928","article-title":"Efficacy of DB289 in Thai patients with Plasmodium vivax or acute, uncomplicated Plasmodium falciparum infections.","volume":"192","author":"Yeramian","year":"(2005)","journal-title":"J. Infect. Dis."},{"key":"key\n\t\t\t\t20170508174506_CIT0030","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/S0002-9440(10)61745-2","article-title":"Renal cholesterol accumulation: A durable response after acute and subacute renal insults.","volume":"159","author":"Zager","year":"(2001)","journal-title":"Am. J. Pathol."},{"key":"key\n\t\t\t\t20170508174506_CIT0031","doi-asserted-by":"crossref","first-page":"F1334","DOI":"10.1152\/ajprenal.00431.2011","article-title":"Acute unilateral ischemic renal injury induces progressive renal inflammation, lipid accumulation, histone modification, and \u201cend-stage\u201d kidney disease.","volume":"301","author":"Zager","year":"(2011)","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"key\n\t\t\t\t20170508174506_CIT0032","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/j.1523-1755.2005.00061.x","article-title":"Renal tubular triglyceride accumulation following endotoxic, toxic, and ischemic injury.","volume":"67","author":"Zager","year":"(2005)","journal-title":"Kidney Int."},{"key":"key\n\t\t\t\t20170508174506_CIT0033","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1002\/hep.22354","article-title":"Proprotein convertase subtilisin\/kexin type 9 (PCSK9): Hepatocyte-specific low-density lipoprotein receptor degradation and critical role in mouse liver regeneration.","volume":"48","author":"Zaid","year":"(2008)","journal-title":"Hepatology"}],"container-title":["Toxicological Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/toxsci\/article-pdf\/130\/2\/416\/16685606\/kfs238.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T18:02:31Z","timestamp":1744048951000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/toxsci\/article-lookup\/doi\/10.1093\/toxsci\/kfs238"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8,31]]},"references-count":33,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2012,8,31]]},"published-print":{"date-parts":[[2012,12]]}},"URL":"https:\/\/doi.org\/10.1093\/toxsci\/kfs238","relation":{},"ISSN":["1096-0929","1096-6080"],"issn-type":[{"value":"1096-0929","type":"electronic"},{"value":"1096-6080","type":"print"}],"subject":[],"published":{"date-parts":[[2012,8,31]]}}}