{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T07:50:27Z","timestamp":1778745027006,"version":"3.51.4"},"reference-count":53,"publisher":"Oxford University Press (OUP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,12]]},"DOI":"10.1093\/toxsci\/kfs244","type":"journal-article","created":{"date-parts":[[2012,8,14]],"date-time":"2012-08-14T00:13:16Z","timestamp":1344903196000},"page":"362-372","source":"Crossref","is-referenced-by-count":41,"title":["Tetramethylenedisulfotetramine Alters Ca2+ Dynamics in Cultured Hippocampal Neurons: Mitigation by NMDA Receptor Blockade and GABAA Receptor-Positive Modulation"],"prefix":"10.1093","volume":"130","author":[{"given":"Zhengyu","family":"Cao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce D.","family":"Hammock","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"McCoy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael A.","family":"Rogawski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pamela J.","family":"Lein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isaac N.","family":"Pessah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2012,8,13]]},"reference":[{"key":"key\n\t\t\t\t20170508173521_CIT0001","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/0896-6273(90)90053-I","article-title":"Excitotoxicity induced by enhanced excitatory neurotransmission in cultured hippocampal pyramidal neurons.","volume":"4","author":"Abele","year":"(1990)","journal-title":"Neuron"},{"issue":"Pt 1","key":"key\n\t\t\t\t20170508173521_CIT0002","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1113\/jphysiol.2004.077446","article-title":"Microelectrode array recordings of cultured hippocampal networks reveal a simple model for transcription and protein synthesis-dependent plasticity.","volume":"564","author":"Arnold","year":"(2005)","journal-title":"J. Physiol. (Lond.)"},{"key":"key\n\t\t\t\t20170508173521_CIT0003","article-title":"Tetramethylenedisulfotetramine","volume-title":"Encyclopedia of Toxicology","author":"Banks","year":"(2012).","edition":"3rd"},{"key":"key\n\t\t\t\t20170508173521_CIT0004","doi-asserted-by":"crossref","first-page":"2640","DOI":"10.1001\/jama.289.20.2640","article-title":"Poisoning by an illegally imported Chinese rodenticide containing tetramethylene-disulfotetramine - New York City, 2002","volume":"289","author":"Barrueto","year":"(2003)","journal-title":"J. Am. Med. Assoc."},{"key":"key\n\t\t\t\t20170508173521_CIT0005","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1111\/j.1476-5381.1975.tb07379.x","article-title":"Tetramethylenedisulphotetramine: An inhibitor of gamma-aminobutyric acid induced depolarization of the isolated superior cervical ganglion of the rat.","volume":"53","author":"Bowery","year":"(1975)","journal-title":"Br. J. Pharmacol."},{"key":"key\n\t\t\t\t20170508173521_CIT0006","doi-asserted-by":"crossref","first-page":"2923","DOI":"10.1093\/hmg\/dds118","article-title":"Clustered burst firing in FMR1 premutation hippocampal neurons: Amelioration with allopregnanolone.","volume":"21","author":"Cao","year":"(2012)","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170508173521_CIT0007","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1093\/toxsci\/kfp312","article-title":"Involvement of caspase activation in azaspiracid-induced neurotoxicity in neocortical neurons.","volume":"114","author":"Cao","year":"(2010)","journal-title":"Toxicol. Sci."},{"key":"key\n\t\t\t\t20170508173521_CIT0008","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1124\/jpet.110.171850","article-title":"Mechanisms of pyrethroid insecticide-induced stimulation of calcium influx in neocortical neurons.","volume":"336","author":"Cao","year":"(2011)","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"key\n\t\t\t\t20170508173521_CIT0009","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/0041-008X(76)90006-5","article-title":"Structure-toxicity relationships of 2,6,7-trioxabicyclo(2.2.2)octanes and related compounds.","volume":"36","author":"Casida","year":"(1976)","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"key\n\t\t\t\t20170508173521_CIT0010","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1021\/np100468n","article-title":"The hoiamides, structurally intriguing neurotoxic lipopeptides from Papua New Guinea marine cyanobacteria.","volume":"73","author":"Choi","year":"(2010)","journal-title":"J. Nat. Prod."},{"key":"key\n\t\t\t\t20170508173521_CIT0011","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1016\/0024-3205(86)90295-X","article-title":"Polychlorocycloalkane insecticide-induced convulsions in mice in relation to disruption of the GABA-regulated chloride ionophore.","volume":"39","author":"Cole","year":"(1986)","journal-title":"Life Sci."},{"key":"key\n\t\t\t\t20170508173521_CIT0012","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00204-003-0509-0","article-title":"Rat poison and food security in the People\u2019s Republic of China: Focus on tetramethylene disulfotetramine (tetramine).","volume":"78","author":"Croddy","year":"(2004)","journal-title":"Arch. Toxicol."},{"key":"key\n\t\t\t\t20170508173521_CIT0013","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/S0091-3057(00)00369-5","article-title":"The effects of neurosteroids on picrotoxin-, bicuculline- and NMDA-induced seizures, and a hypnotic effect of ethanol.","volume":"67","author":"Cz\u0142onkowska","year":"(2000)","journal-title":"Pharmacol. Biochem. Behav."},{"key":"key\n\t\t\t\t20170508173521_CIT0014","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1213\/00000539-199309000-00030","article-title":"Barbiturate-benzodiazepine interactions at the \u03b3-Aminobutyric AcidA receptor in rat cerebral cortical synaptoneurosomes.","volume":"77","author":"DeLorey","year":"(1993)","journal-title":"Anesth. Analg."},{"key":"key\n\t\t\t\t20170508173521_CIT0015","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1093\/toxsci\/kfq157","article-title":"Development of a prolonged calcium plateau in hippocampal neurons in rats surviving status epilepticus induced by the organophosphate diisopropylfluorophosphate.","volume":"116","author":"Deshpande","year":"(2010)","journal-title":"Toxicol. Sci."},{"key":"key\n\t\t\t\t20170508173521_CIT0016","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/0028-3908(75)90094-5","article-title":"Tetramethylenedisulphotetramine and amino acid inhibition in the rat brain.","volume":"14","author":"Dray","year":"(1975)","journal-title":"Neuropharmacology"},{"key":"key\n\t\t\t\t20170508173521_CIT0017","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1021\/tx00020a007","article-title":"Recognition of tetramethylenedisulfotetramine and related sulfamides by the brain GABA-gated chloride channel and a cyclodiene-sensitive monoclonal antibody.","volume":"4","author":"Esser","year":"(1991)","journal-title":"Chem. Res. Toxicol."},{"key":"key\n\t\t\t\t20170508173521_CIT0018","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.ntt.2011.08.001","article-title":"Cortical cultures coupled to Micro-Electrode Arrays: A novel approach to perform in vitro excitotoxicity testing.","volume":"34","author":"Frega","year":"(2012)","journal-title":"Neurotoxicol. Teratol."},{"key":"key\n\t\t\t\t20170508173521_CIT0019","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s00213-003-1717-2","article-title":"Effects of pregnanolone alone and in combination with other positive GABAA modulators on complex behavior in rats.","volume":"173","author":"Gerak","year":"(2004)","journal-title":"Psychopharmacology (Berl.)"},{"key":"key\n\t\t\t\t20170508173521_CIT0020","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1093\/jat\/17.4.199","article-title":"GC\/MS identification of tetramine in samples from human alimentary intoxication and evaluation of artificial carbonic kidneys for the treatment of the victims.","volume":"17","author":"Guan","year":"(1993)","journal-title":"J. Anal. Toxicol."},{"key":"key\n\t\t\t\t20170508173521_CIT0021","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/85109","article-title":"Nuclear calcium signaling controls CREB-mediated gene expression triggered by synaptic activity.","volume":"4","author":"Hardingham","year":"(2001)","journal-title":"Nat. Neurosci."},{"key":"key\n\t\t\t\t20170508173521_CIT0022","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/nn835","article-title":"Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways.","volume":"5","author":"Hardingham","year":"(2002)","journal-title":"Nat. Neurosci."},{"key":"key\n\t\t\t\t20170508173521_CIT0023","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1002\/jps.3030460412","article-title":"The pharmacology of tetramine (tetraethylenedisulfotetramine).","volume":"46","author":"Haskell","year":"(1957)","journal-title":"J. Am. Pharm. Assoc. Am. Pharm. Assoc. (Baltim)."},{"key":"key\n\t\t\t\t20170508173521_CIT0024","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/S0306-4522(00)00416-4","article-title":"Developmental increase in asynchronous GABA release in cultured hippocampal neurons.","volume":"101","author":"Jensen","year":"(2000)","journal-title":"Neuroscience"},{"key":"key\n\t\t\t\t20170508173521_CIT0025","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1152\/jn.1999.82.1.42","article-title":"Activity-dependent depression of GABAergic IPSCs in cultured hippocampal neurons.","volume":"82","author":"Jensen","year":"(1999)","journal-title":"J. Neurophysiol."},{"key":"key\n\t\t\t\t20170508173521_CIT0026","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1513\/pats.201001-003SM","article-title":"The CounterACT Research Network: Basic mechanisms and practical applications.","volume":"7","author":"Jett","year":"(2010)","journal-title":"Proc. Am. Thorac. Soc."},{"key":"key\n\t\t\t\t20170508173521_CIT0027","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1109\/10.238465","article-title":"Simultaneous measurement of intracellular calcium and electrical activity from patterned neural networks in culture.","volume":"40","author":"Jimbo","year":"(1993)","journal-title":"IEEE Trans. Biomed. Eng."},{"key":"key\n\t\t\t\t20170508173521_CIT0028","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/0163-7258(95)02043-8","article-title":"GABAA receptor pharmacology.","volume":"69","author":"Johnston","year":"(1996)","journal-title":"Pharmacol. Ther."},{"key":"key\n\t\t\t\t20170508173521_CIT0029","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.neuro.2010.04.001","article-title":"Microelectrode arrays: A physiologically based neurotoxicity testing platform for the 21st century.","volume":"31","author":"Johnstone","year":"(2010)","journal-title":"Neurotoxicology"},{"key":"key\n\t\t\t\t20170508173521_CIT0030","doi-asserted-by":"crossref","first-page":"7646","DOI":"10.1073\/pnas.0701944104","article-title":"Perinatal exposure to a noncoplanar polychlorinated biphenyl alters tonotopy, receptive fields, and plasticity in rat primary auditory cortex.","volume":"104","author":"Kenet","year":"(2007)","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"key\n\t\t\t\t20170508173521_CIT0031","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/0920-1211(89)90003-X","article-title":"Effects of NMDA antagonists on picrotoxin-, low Mg2+- and low Ca2+- induced epileptogenesis and on evoked changes in extracellular Na+ and Ca2+ concentrations in rat hippocampal slices.","volume":"4","author":"K\u00f6hr","year":"(1989)","journal-title":"Epilepsy Res."},{"key":"key\n\t\t\t\t20170508173521_CIT0032","first-page":"1223","article-title":"Anticonvulsant activity of neurosteroids: Correlation with gamma-aminobutyric acid-evoked chloride current potentiation.","volume":"270","author":"Kokate","year":"(1994)","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"key\n\t\t\t\t20170508173521_CIT0033","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.pneurobio.2003.09.001","article-title":"Neurosteroid modulation of GABAA receptors.","volume":"71","author":"Lambert","year":"(2003)","journal-title":"Prog. Neurobiol."},{"key":"key\n\t\t\t\t20170508173521_CIT0034","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.neuro.2011.10.008","article-title":"Tetramethylenedisulfotetramine intoxication presenting with de novo Status Epilepticus: A case series.","volume":"33","author":"Li","year":"(2012)","journal-title":"Neurotoxicology"},{"key":"key\n\t\t\t\t20170508173521_CIT0035","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1152\/jn.1995.73.1.320","article-title":"Passive and synaptic properties of hippocampal neurons grown in microcultures and in mass cultures.","volume":"73","author":"Mennerick","year":"(1995)","journal-title":"J. Neurophysiol."},{"key":"key\n\t\t\t\t20170508173521_CIT0036","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.neuro.2007.11.005","article-title":"Pyrethroid modulation of spontaneous neuronal excitability and neurotransmission in hippocampal neurons in culture.","volume":"29","author":"Meyer","year":"(2008)","journal-title":"Neurotoxicology"},{"key":"key\n\t\t\t\t20170508173521_CIT0037","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S0091-3057(03)00133-3","article-title":"Anti-conflict-like actions of intralateral septal infusions of allopregnanolone in Wistar rats.","volume":"75","author":"Molina-Hern\u00e1ndez","year":"(2003)","journal-title":"Pharmacol. Biochem. Behav."},{"key":"key\n\t\t\t\t20170508173521_CIT0038","first-page":"31","article-title":"Involvement of GABAergic and NMDA systems in drug-induced convulsions in mice.","volume":"15","author":"Obara","year":"(1995)","journal-title":"Nihon Shinkei Seishin Yakurigaku Zasshi"},{"key":"key\n\t\t\t\t20170508173521_CIT0039","doi-asserted-by":"crossref","first-page":"4490","DOI":"10.1021\/ol101752n","article-title":"Palmyrolide A, an unusually stabilized neuroactive macrolide from Palmyra Atoll cyanobacteria.","volume":"12","author":"Pereira","year":"(2010)","journal-title":"Org. Lett."},{"key":"key\n\t\t\t\t20170508173521_CIT0040","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1006\/taap.2001.9154","article-title":"Role of human GABAA receptor \u03b23 subunit in insecticide toxicity.","volume":"172","author":"Ratra","year":"(2001)","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"key\n\t\t\t\t20170508173521_CIT0041","doi-asserted-by":"crossref","DOI":"10.1093\/med\/9780199746545.003.0077","article-title":"Neurosteroids \u2014 Endogenous regulators of seizure susceptibility and role in the treatment of epilepsy","volume-title":"Jasper\u2019s Basic Mechanisms of the Epilepsies","author":"Reddy","year":"(2012).","edition":"4th"},{"key":"key\n\t\t\t\t20170508173521_CIT0042","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/0306-4492(81)90083-6","article-title":"The action of seven convulsants as antagonists of the GABA response of Limulus neurons.","volume":"70","author":"Roberts","year":"(1981)","journal-title":"Comp. Biochem. Physiol. C, Comp. Pharmacol."},{"key":"key\n\t\t\t\t20170508173521_CIT0043","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.neuro.2008.01.002","article-title":"Complete inhibition of spontaneous activity in neuronal networks in vitro by deltamethrin and permethrin.","volume":"29","author":"Shafer","year":"(2008)","journal-title":"Neurotoxicology"},{"key":"key\n\t\t\t\t20170508173521_CIT0044","doi-asserted-by":"crossref","first-page":"4704","DOI":"10.1021\/ol901438b","article-title":"Alotamide A, a novel neuropharmacological agent from the marine cyanobacterium Lyngbya bouillonii.","volume":"11","author":"Soria-Mercado","year":"(2009)","journal-title":"Org. Lett."},{"key":"key\n\t\t\t\t20170508173521_CIT0045","first-page":"326","article-title":"[35S]t-butylbicyclophosphorothionate binds with high affinity to brain-specific sites coupled to gamma-aminobutyric acid-A and ion recognition sites.","volume":"23","author":"Squires","year":"(1983)","journal-title":"Mol. Pharmacol."},{"key":"key\n\t\t\t\t20170508173521_CIT0046","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1254\/jjp.70.89","article-title":"Intracellular calcium oscillation in cultured rat hippocampal neurons: A model for glutamatergic neurotransmission.","volume":"70","author":"Tanaka","year":"(1996)","journal-title":"Jpn. J. Pharmacol."},{"key":"key\n\t\t\t\t20170508173521_CIT0047","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1002\/jps.2600501014","article-title":"Reduction of tetramine toxicity by sedatives and anticonvulsants.","volume":"50","author":"Voss","year":"(1961)","journal-title":"J. Pharm. Sci."},{"key":"key\n\t\t\t\t20170508173521_CIT0048","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1289\/ehp.1104833","article-title":"PCB-95 modulates the calcium-dependent signaling pathway responsible for activity-dependent dendritic growth.","volume":"120","author":"Wayman","year":"(2012)","journal-title":"Environ. Health Perspect."},{"key":"key\n\t\t\t\t20170508173521_CIT0049","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1016\/j.neuron.2008.08.021","article-title":"Calmodulin-kinases: Modulators of neuronal development and plasticity.","volume":"59","author":"Wayman","year":"(2008)","journal-title":"Neuron"},{"key":"key\n\t\t\t\t20170508173521_CIT0050","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.annemergmed.2004.09.009","article-title":"Tetramethylenedisulfotetramine: Old agent and new terror.","volume":"45","author":"Whitlow","year":"(2005)","journal-title":"Ann. Emerg. Med."},{"key":"key\n\t\t\t\t20170508173521_CIT0051","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.tox.2004.02.003","article-title":"Poison control services in China.","volume":"198","author":"Wu","year":"(2004)","journal-title":"Toxicology"},{"key":"key\n\t\t\t\t20170508173521_CIT0052","doi-asserted-by":"crossref","first-page":"e24","DOI":"10.1016\/j.forsciint.2010.06.025","article-title":"Tetramine poisoning: A case report and review of the literature.","volume":"204","author":"Zhang","year":"(2011)","journal-title":"Forensic Sci. Int."},{"key":"key\n\t\t\t\t20170508173521_CIT0053","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1124\/jpet.111.190579","article-title":"Characterization of seizures induced by acute and repeated exposure to tetramethylenedisulfotetramine.","volume":"341","author":"Zolkowska","year":"(2012)","journal-title":"J. Pharmacol. Exp. Ther."}],"container-title":["Toxicological Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/toxsci\/article-pdf\/130\/2\/362\/16685789\/kfs244.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,2]],"date-time":"2019-07-02T20:36:40Z","timestamp":1562099800000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/toxsci\/article-lookup\/doi\/10.1093\/toxsci\/kfs244"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8,13]]},"references-count":53,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2012,8,13]]},"published-print":{"date-parts":[[2012,12]]}},"URL":"https:\/\/doi.org\/10.1093\/toxsci\/kfs244","relation":{},"ISSN":["1096-0929","1096-6080"],"issn-type":[{"value":"1096-0929","type":"electronic"},{"value":"1096-6080","type":"print"}],"subject":[],"published":{"date-parts":[[2012,8,13]]}}}