{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T10:11:39Z","timestamp":1792145499943,"version":"4.4.0"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,12]]},"DOI":"10.1093\/toxsci\/kfs257","type":"journal-article","created":{"date-parts":[[2012,8,23]],"date-time":"2012-08-23T22:36:04Z","timestamp":1345761364000},"page":"383-390","source":"Crossref","is-referenced-by-count":114,"title":["Inherited Effects of Low-Dose Exposure to Methylmercury in Neural Stem Cells"],"prefix":"10.1093","volume":"130","author":[{"given":"Raj","family":"Bose","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Onishchenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Edoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann Marie","family":"Janson Lang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Ceccatelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2012,8,23]]},"reference":[{"key":"key\n\t\t\t\t20170508175322_CIT0001","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1097\/MOP.0b013e32832925cc","article-title":"Epigenetics and environmental chemicals.","volume":"21","author":"Baccarelli","year":"(2009)","journal-title":"Curr. Opin. Pediatr."},{"key":"key\n\t\t\t\t20170508175322_CIT0002","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/j.jaac.2010.06.001","article-title":"Epigenetics and the biological basis of gene x environment interactions.","volume":"49","author":"Bagot","year":"(2010)","journal-title":"J. Am. Acad. Child Adolesc. Psychiatry"},{"key":"key\n\t\t\t\t20170508175322_CIT0003","doi-asserted-by":"crossref","first-page":"e92","DOI":"10.1038\/cddis.2010.60","article-title":"Glucocorticoids induce long-lasting effects in neural stem cells resulting in senescence-related alterations.","volume":"1","author":"Bose","year":"(2010)","journal-title":"Cell Death Dis."},{"key":"key\n\t\t\t\t20170508175322_CIT0004","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.cbi.2010.04.007","article-title":"Methylmercury-induced neurotoxicity and apoptosis.","volume":"188","author":"Ceccatelli","year":"(2010)","journal-title":"Chem. Biol. Interact."},{"key":"key\n\t\t\t\t20170508175322_CIT0005","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1177\/1073858409360281","article-title":"Implications of the functional integration of adult-born hippocampal neurons in anxiety-depression disorders.","volume":"16","author":"David","year":"(2010)","journal-title":"Neuroscientist"},{"key":"key\n\t\t\t\t20170508175322_CIT0006","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.ntt.2006.02.004","article-title":"Impact of prenatal methylmercury exposure on neurobehavioral function at age 14 years.","volume":"28","author":"Debes","year":"(2006)","journal-title":"Neurotoxicol. Teratol."},{"key":"key\n\t\t\t\t20170508175322_CIT0007","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1289\/ehp.02110s5859","article-title":"Investigations of methylmercury-induced alterations in neurogenesis.","volume":"110","author":"Faustman","year":"(2002)","journal-title":"Environ. Health Perspect."},{"key":"key\n\t\t\t\t20170508175322_CIT0008","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.etap.2010.07.003","article-title":"Structure-activity relationship of flavonoids derived from medicinal plants in preventing methylmercury-induced mitochondrial dysfunction.","volume":"30","author":"Franco","year":"(2010)","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"key\n\t\t\t\t20170508175322_CIT0009","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.reprotox.2007.03.002","article-title":"Methylmercury toxicity and functional programming.","volume":"23","author":"Grandjean","year":"(2007)","journal-title":"Reprod. Toxicol."},{"key":"key\n\t\t\t\t20170508175322_CIT0010","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/0009-2797(81)90070-3","article-title":"Binding of methylmercury(II) by HeLa S3 suspension-culture cells: Intracellular methylmercury levels and their effect on DNA replication and protein synthesis.","volume":"36","author":"Gruenwedel","year":"(1981)","journal-title":"Chem. Biol. Interact."},{"key":"key\n\t\t\t\t20170508175322_CIT0011","doi-asserted-by":"crossref","first-page":"e1710","DOI":"10.1371\/journal.pone.0001710","article-title":"SIRT1 overexpression antagonizes cellular senescence with activated ERK\/S6k1 signaling in human diploid fibroblasts.","volume":"3","author":"Huang","year":"(2008)","journal-title":"PLOS ONE"},{"key":"key\n\t\t\t\t20170508175322_CIT0012","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/0306-4522(93)90039-I","article-title":"Chronic nicotine treatment counteracts nigral cell loss induced by a partial mesodiencephalic hemitransection: An analysis of the total number and mean volume of neurons and glia in substantia nigra of the male rat.","volume":"57","author":"Janson","year":"(1993)","journal-title":"Neuroscience"},{"key":"key\n\t\t\t\t20170508175322_CIT0013","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/BF03033570","article-title":"Neurobehavioural and molecular changes induced by methylmercury exposure during development.","volume":"11","author":"Johansson","year":"(2007)","journal-title":"Neurotox. Res."},{"key":"key\n\t\t\t\t20170508175322_CIT0014","first-page":"689","article-title":"An analysis of autopsy brain tissue from infants prenatally exposed to methylmercury.","volume":"16","author":"Lapham","year":"(1995)","journal-title":"Neurotoxicology"},{"key":"key\n\t\t\t\t20170508175322_CIT0015","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1039\/an9719600847","article-title":"Selective atomic-absorption determination of inorganic mercury and methylmercury in undigested biological samples.","volume":"96","author":"Magos","year":"(1971)","journal-title":"Analyst"},{"key":"key\n\t\t\t\t20170508175322_CIT0016","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1007\/s00204-007-0209-2","article-title":"Comparative study of activities in reactive oxygen species production\/defense system in mitochondria of rat brain and liver, and their susceptibility to methylmercury toxicity.","volume":"81","author":"Mori","year":"(2007)","journal-title":"Arch. Toxicol."},{"key":"key\n\t\t\t\t20170508175322_CIT0017","doi-asserted-by":"crossref","first-page":"253","DOI":"10.2131\/jts.36.253","article-title":"Methylmercury inhibits electron transport chain activity and induces cytochrome c release in cerebellum mitochondria.","volume":"36","author":"Mori","year":"(2011)","journal-title":"J. Toxicol. Sci."},{"key":"key\n\t\t\t\t20170508175322_CIT0018","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1038\/sj.bjc.6603636","article-title":"Cellular senescence and chromatin organisation.","volume":"96","author":"Narita","year":"(2007)","journal-title":"Br. J. Cancer"},{"key":"key\n\t\t\t\t20170508175322_CIT0019","doi-asserted-by":"crossref","first-page":"C670","DOI":"10.1152\/ajpcell.00213.2006","article-title":"The mitochondrial energy transduction system and the aging process.","volume":"292","author":"Navarro","year":"(2007)","journal-title":"Am. J. Physiol., Cell Physiol."},{"key":"key\n\t\t\t\t20170508175322_CIT0020","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1111\/j.1471-4159.2008.05484.x","article-title":"Long-lasting depression-like behavior and epigenetic changes of BDNF gene expression induced by perinatal exposure to methylmercury.","volume":"106","author":"Onishchenko","year":"(2008)","journal-title":"J. Neurochem."},{"key":"key\n\t\t\t\t20170508175322_CIT0021","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1093\/toxsci\/kfl199","article-title":"Developmental exposure to methylmercury alters learning and induces depression-like behavior in male mice.","volume":"97","author":"Onishchenko","year":"(2007)","journal-title":"Toxicol. Sci."},{"key":"key\n\t\t\t\t20170508175322_CIT0022","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1006\/taap.1999.8685","article-title":"Induction of the cell cycle regulatory gene p21 (Waf1, Cip1) following methylmercury exposure in vitro and in vivo.","volume":"157","author":"Ou","year":"(1999)","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"key\n\t\t\t\t20170508175322_CIT0023","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1111\/j.1365-294X.2009.04452.x","article-title":"Mercury-associated DNA hypomethylation in polar bear brains via the LUminometric Methylation Assay: A sensitive method to study epigenetics in wildlife.","volume":"19","author":"Pilsner","year":"(2010)","journal-title":"Mol. Ecol."},{"key":"key\n\t\t\t\t20170508175322_CIT0024","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1038\/nn1969","article-title":"Adult hippocampal neurogenesis in depression.","volume":"10","author":"Sahay","year":"(2007)","journal-title":"Nat. Neurosci."},{"key":"key\n\t\t\t\t20170508175322_CIT0025","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.reprotox.2010.10.012","article-title":"Epigenetic transgenerational actions of endocrine disruptors.","volume":"31","author":"Skinner","year":"(2011)","journal-title":"Reprod. Toxicol."},{"key":"key\n\t\t\t\t20170508175322_CIT0026","doi-asserted-by":"crossref","first-page":"e19503","DOI":"10.1371\/journal.pone.0019503","article-title":"DNA methyltransferase controls stem cell aging by regulating BMI1 and EZH2 through microRNAs.","volume":"6","author":"So","year":"(2011)","journal-title":"PLOS ONE"},{"key":"key\n\t\t\t\t20170508175322_CIT0027","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.1128\/MCB.19.3.2109","article-title":"Differential roles for cyclin-dependent kinase inhibitors p21 and p16 in the mechanisms of senescence and differentiation in human fibroblasts.","volume":"19","author":"Stein","year":"(1999)","journal-title":"Mol. Cell. Biol."},{"key":"key\n\t\t\t\t20170508175322_CIT0028","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.mcn.2010.06.006","article-title":"Bmi1 directly represses p21Waf1\/Cip1 in Shh-induced proliferation of cerebellar granule cell progenitors.","volume":"45","author":"Subkhankulova","year":"(2010)","journal-title":"Mol. Cell. Neurosci."},{"key":"key\n\t\t\t\t20170508175322_CIT0029","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1111\/j.1471-4159.2006.03718.x","article-title":"High susceptibility of neural stem cells to methylmercury toxicity: Effects on cell survival and neuronal differentiation.","volume":"97","author":"Tamm","year":"(2006)","journal-title":"J. Neurochem."},{"key":"key\n\t\t\t\t20170508175322_CIT0030","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1097\/WNR.0b013e3282f50ca4","article-title":"Methylmercury inhibits differentiation of rat neural stem cells via Notch signalling.","volume":"19","author":"Tamm","year":"(2008)","journal-title":"Neuroreport"},{"key":"key\n\t\t\t\t20170508175322_CIT0031","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1007\/s10495-007-0172-7","article-title":"Caspase-2 activation in neural stem cells undergoing oxidative stress-induced apoptosis.","volume":"13","author":"Tamm","year":"(2008)","journal-title":"Apoptosis"},{"key":"key\n\t\t\t\t20170508175322_CIT0032","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1093\/toxsci\/kfr134","article-title":"Time-response evaluation by transcriptomics of methylmercury effects on neural differentiation of murine embryonic stem cells.","volume":"122","author":"Theunissen","year":"(2011)","journal-title":"Toxicol. Sci."},{"key":"key\n\t\t\t\t20170508175322_CIT0033","doi-asserted-by":"crossref","first-page":"R139","DOI":"10.1093\/hmg\/ddi100","article-title":"The impact of metabolism on DNA methylation.","volume":"14","author":"Ulrey","year":"(2005)","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170508175322_CIT0034","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1038\/sj.mp.4001476","article-title":"Activation of methionine synthase by insulin-like growth factor-1 and dopamine: A target for neurodevelopmental toxins and thimerosal.","volume":"9","author":"Waly","year":"(2004)","journal-title":"Mol. Psychiatry"},{"key":"key\n\t\t\t\t20170508175322_CIT0035","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.neulet.2010.04.006","article-title":"Bmi-1 regulates self-renewal, proliferation and senescence of human fetal neural stem cells in vitro.","volume":"476","author":"Wang","year":"(2010)","journal-title":"Neurosci. Lett."},{"key":"key\n\t\t\t\t20170508175322_CIT0036","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.brainres.2010.08.069","article-title":"Effects of low level of methylmercury on proliferation of cortical progenitor cells.","volume":"1359","author":"Xu","year":"(2010)","journal-title":"Brain Res."},{"key":"key\n\t\t\t\t20170508175322_CIT0037","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1002\/stem.614","article-title":"Conditional activation of Bmi1 expression regulates self-renewal, apoptosis, and differentiation of neural stem\/progenitor cells in vitro and in vivo.","volume":"29","author":"Yadirgi","year":"(2011)","journal-title":"Stem Cells"},{"key":"key\n\t\t\t\t20170508175322_CIT0038","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/j.envint.2011.03.008","article-title":"Long-term exposure to methylmercury and psychiatric symptoms in residents of Minamata, Japan.","volume":"37","author":"Yorifuji","year":"(2011)","journal-title":"Environ. Int."},{"key":"key\n\t\t\t\t20170508175322_CIT0039","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.cell.2008.01.033","article-title":"Mechanisms and functional implications of adult neurogenesis.","volume":"132","author":"Zhao","year":"(2008)","journal-title":"Cell"}],"container-title":["Toxicological Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/toxsci\/article-pdf\/130\/2\/383\/16686540\/kfs257.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,2]],"date-time":"2019-07-02T23:03:08Z","timestamp":1562108588000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/toxsci\/article-lookup\/doi\/10.1093\/toxsci\/kfs257"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8,23]]},"references-count":39,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2012,8,23]]},"published-print":{"date-parts":[[2012,12]]}},"URL":"https:\/\/doi.org\/10.1093\/toxsci\/kfs257","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.717961632.793464452","asserted-by":"object"}]},"ISSN":["1096-0929","1096-6080"],"issn-type":[{"value":"1096-0929","type":"electronic"},{"value":"1096-6080","type":"print"}],"subject":[],"published":{"date-parts":[[2012,8,23]]}}}