{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T15:29:17Z","timestamp":1759073357518},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,4]]},"DOI":"10.1093\/toxsci\/kft006","type":"journal-article","created":{"date-parts":[[2013,1,19]],"date-time":"2013-01-19T05:14:09Z","timestamp":1358572449000},"page":"409-418","source":"Crossref","is-referenced-by-count":7,"title":["Comparative Toxicological Study of the Novel Protein Phosphatase Inhibitor 19-Epi-Okadaic Acid in Primary Cultures of Rat Cerebellar Cells"],"prefix":"10.1093","volume":"132","author":[{"given":"Maria-Teresa","family":"Fern\u00e1ndez-S\u00e1nchez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Cabrera-Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amaia","family":"Ferrero-Gutierrez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anabel","family":"P\u00e9rez-G\u00f3mez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia G.","family":"Cruz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio H.","family":"Daranas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 J.","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"Norte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonello","family":"Novelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2013,1,18]]},"reference":[{"key":"key\n\t\t\t\t20170508190238_CIT0001","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1042\/bj2560283","article-title":"Inhibitory effect of a marine-sponge toxin, okadaic acid, on protein phosphatases. Specificity and kinetics","volume":"256","year":"(1988)","journal-title":"Biochem. J."},{"key":"key\n\t\t\t\t20170508190238_CIT0002","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","year":"(1976)","journal-title":"Anal. Biochem."},{"key":"key\n\t\t\t\t20170508190238_CIT0003","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1042\/bj3390241","article-title":"Methylated C-terminal leucine residue of PP2A catalytic subunit is important for binding of regulatory Balpha subunit","volume":"339","year":"(1999)","journal-title":"Biochem. J."},{"key":"key\n\t\t\t\t20170508190238_CIT0004","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1126\/science.1325671","article-title":"Regulation of protein serine-threonine phosphatase type-2A by tyrosine phosphorylation","volume":"257","year":"(1992)","journal-title":"Science"},{"key":"key\n\t\t\t\t20170508190238_CIT0005","doi-asserted-by":"crossref","first-page":"3045","DOI":"10.1021\/ol071099i","article-title":"19-epi-okadaic acid, a novel protein phosphatase inhibitor with enhanced selectivity","volume":"9","year":"(2007)","journal-title":"Org. Lett."},{"key":"key\n\t\t\t\t20170508190238_CIT0006","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.toxicon.2009.11.005","article-title":"Dinoflagellate polyether within the yessotoxin, pectenotoxin and okadaic acid toxin groups: Characterization, analysis and human health implications","volume":"56","year":"(2010)","journal-title":"Toxicon"},{"key":"key\n\t\t\t\t20170508190238_CIT0007","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1021\/np030110u","article-title":"Identification of new okadaic acid derivatives from laboratory cultures of Prorocentrum lima","volume":"66","year":"(2003)","journal-title":"J. Nat. Prod."},{"key":"key\n\t\t\t\t20170508190238_CIT0008","first-page":"PL157","article-title":"The marine toxin okadaic acid is a potent neurotoxin for cultured cerebellar neurons","volume":"49","year":"(1991)","journal-title":"Life Sci."},{"key":"key\n\t\t\t\t20170508190238_CIT0009","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1111\/j.1749-6632.1993.tb18306.x","article-title":"Neurotoxic effect of okadaic acid, a seafood-related toxin, on cultured cerebellar neurons","volume":"679","year":"(1993)","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"key\n\t\t\t\t20170508190238_CIT0010","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/S0014-5793(96)01192-1","article-title":"Inhibition of protein phosphatases induces IGF-1-blocked neurotrophin-insensitive neuronal apoptosis","volume":"398","year":"(1996)","journal-title":"FEBS Lett."},{"key":"key\n\t\t\t\t20170508190238_CIT0011","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.1016\/j.freeradbiomed.2008.01.029","article-title":"Inhibition of protein phosphatases impairs the ability of astrocytes to detoxify hydrogen peroxide","volume":"44","year":"(2008)","journal-title":"Free Radic. Biol. Med."},{"key":"key\n\t\t\t\t20170508190238_CIT0012","first-page":"554","article-title":"Detection of PSP, ASP and DSP toxins by neuronal bioassay: comparison with HPLC and mouse bioassay","year":"(1998)"},{"key":"key\n\t\t\t\t20170508190238_CIT0013","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.neuro.2010.10.007","article-title":"Application of micro-electrode arrays (MEAs) as an emerging technology for developmental neurotoxicity: Evaluation of domoic acid-induced effects in primary cultures of rat cortical neurons","volume":"32","year":"(2011)","journal-title":"Neurotoxicology"},{"key":"key\n\t\t\t\t20170508190238_CIT0014","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/0041-0101(91)90021-I","article-title":"Liquid chromatography-linked protein phosphatase bioassay; a highly sensitive marine bioscreen for okadaic acid and related diarrhetic shellfish toxins","volume":"29","year":"(1991)","journal-title":"Toxicon"},{"key":"key\n\t\t\t\t20170508190238_CIT0015","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/S0041-0101(98)00184-6","article-title":"Efficient isolation of the rare diarrhoeic shellfish toxin, dinophysistoxin-2, from marine phytoplankton","volume":"37","year":"(1999)","journal-title":"Toxicon"},{"issue":"Pt 3","key":"key\n\t\t\t\t20170508190238_CIT0016","first-page":"417","article-title":"Protein phosphatase 2A: A highly regulated family of serine\/threonine phosphatases implicated in cell growth and signalling","volume":"353","year":"(2001)","journal-title":"Biochem. J."},{"key":"key\n\t\t\t\t20170508190238_CIT0017","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S1046-5928(03)00141-4","article-title":"Parallel purification of three catalytic subunits of the protein serine\/threonine phosphatase 2A family (PP2A\u00a9, PP4\u00a9, and PP6\u00a9) and analysis of the interaction of PP2A\u00a9 with alpha4 protein","volume":"31","year":"(2003)","journal-title":"Protein Expr. Purif."},{"key":"key\n\t\t\t\t20170508190238_CIT0018","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1006\/excr.2001.5223","article-title":"Caspase-3 is actively involved in okadaic acid-induced lens epithelial cell apoptosis","volume":"266","year":"(2001)","journal-title":"Exp. Cell Res."},{"key":"key\n\t\t\t\t20170508190238_CIT0019","doi-asserted-by":"crossref","first-page":"22081","DOI":"10.1074\/jbc.271.36.22081","article-title":"The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm","volume":"271","year":"(1996)","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170508190238_CIT0020","doi-asserted-by":"crossref","first-page":"26123","DOI":"10.1074\/jbc.270.44.26123","article-title":"Identification of a new family of protein phosphatase 2A regulatory subunits","volume":"270","year":"(1995)","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170508190238_CIT0021","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1006\/bbrc.2001.5596","article-title":"Tautomycetin is a novel and specific inhibitor of serine\/threonine protein phosphatase type 1, PP1","volume":"287","year":"(2001)","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"key\n\t\t\t\t20170508190238_CIT0022","doi-asserted-by":"crossref","first-page":"69","DOI":"10.2331\/suisan.48.69","article-title":"Identification of okadaic acid as a toxic component of a marine dinoflagellate Prorocentrum lima","volume":"48","year":"(1982)","journal-title":"Bull Jpn Soc. Sci. Fish"},{"key":"key\n\t\t\t\t20170508190238_CIT0023","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1093\/carcin\/11.10.1837","article-title":"Structure-activity relationship within a series of okadaic acid derivatives","volume":"11","year":"(1990)","journal-title":"Carcinogenesis"},{"key":"key\n\t\t\t\t20170508190238_CIT0024","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/0006-8993(88)90765-2","article-title":"Glutamate becomes neurotoxic via the N-methyl-D-aspartate receptor when intracellular energy levels are reduced","volume":"451","year":"(1988)","journal-title":"Brain Res."},{"key":"key\n\t\t\t\t20170508190238_CIT0025","first-page":"489","article-title":"Identification of 19-epi-okadaic acid, a new diarrhetic shellfish poisoning toxin, by liquid chromatography with mass spectrometry detection","volume":"6","year":"(2008)","journal-title":"Mar. Drugs"},{"key":"key\n\t\t\t\t20170508190238_CIT0026","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1093\/toxsci\/kfh139","article-title":"The marine toxin dinophysistoxin-2 induces differential apoptotic death of rat cerebellar neurons and astrocytes","volume":"80","year":"(2004)","journal-title":"Toxicol. Sci."},{"key":"key\n\t\t\t\t20170508190238_CIT0027","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/sj.cdd.4400476","article-title":"Emerging roles of caspase-3 in apoptosis","volume":"6","year":"(1999)","journal-title":"Cell Death Differ."},{"key":"key\n\t\t\t\t20170508190238_CIT0028","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/356397a0","article-title":"Social controls on cell survival and cell death","volume":"356","year":"(1992)","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170508190238_CIT0029","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1002\/nt.2620020508","article-title":"Highly sensitive assay of okadaic acid using protein phosphatase and paranitrophenyl phosphate","volume":"2","year":"(1994)","journal-title":"Nat. Toxins"},{"key":"key\n\t\t\t\t20170508190238_CIT0030","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/S0169-328X(03)00253-5","article-title":"Involvement of the transcription factor E2F1\/Rb in kainic acid-induced death of murine cerebellar granule cells","volume":"116","year":"(2003)","journal-title":"Brain Res. Mol. Brain Res."},{"key":"key\n\t\t\t\t20170508190238_CIT0031","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1002\/(SICI)1096-9861(19980323)392:4<515::AID-CNE8>3.0.CO;2-3","article-title":"Brain protein phosphatase 2A: Developmental regulation and distinct cellular and subcellular localization by B subunits","volume":"392","year":"(1998)","journal-title":"J. Comp. Neurol."},{"key":"key\n\t\t\t\t20170508190238_CIT0032","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0006-8993(99)01536-X","article-title":"Aluminum-induced degeneration of astrocytes occurs via apoptosis and results in neuronal death","volume":"835","year":"(1999)","journal-title":"Brain Res."},{"key":"key\n\t\t\t\t20170508190238_CIT0033","first-page":"23","article-title":"Small-molecule inhibitors of ser\/thr protein phosphatases: Specificity, use and common forms of abuse","volume":"365","year":"(2007)","journal-title":"Methods Mol. Biol."},{"key":"key\n\t\t\t\t20170508190238_CIT0034","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1042\/bj2750233","article-title":"Inhibitory effect of okadaic acid on the p-nitrophenyl phosphate phosphatase activity of protein phosphatases","volume":"275","year":"(1991)","journal-title":"Biochem. J."},{"key":"key\n\t\t\t\t20170508190238_CIT0035","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1038\/ng762","article-title":"MID1, mutated in Opitz syndrome, encodes an ubiquitin ligase that targets phosphatase 2A for degradation","volume":"29","year":"(2001)","journal-title":"Nat. Genet."},{"key":"key\n\t\t\t\t20170508190238_CIT0036","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/0041-0101(96)00027-X","article-title":"A protein phosphatase 2A inhibition assay for a fast and sensitive assessment of okadaic acid contamination in mussels","volume":"34","year":"(1996)","journal-title":"Toxicon"},{"key":"key\n\t\t\t\t20170508190238_CIT0037","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1006\/abio.1997.2127","article-title":"A fluorescent microplate assay for diarrheic shellfish toxins","volume":"248","year":"(1997)","journal-title":"Anal. Biochem."},{"key":"key\n\t\t\t\t20170508190238_CIT0038","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/S0955-0674(99)00074-5","article-title":"Protein phosphatase 2A: A panoply of enzymes","volume":"12","year":"(2000)","journal-title":"Curr. Opin. Cell Biol."},{"key":"key\n\t\t\t\t20170508190238_CIT0039","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.molcel.2009.02.015","article-title":"From promiscuity to precision: Protein phosphatases get a makeover","volume":"33","year":"(2009)","journal-title":"Mol. Cell"},{"key":"key\n\t\t\t\t20170508190238_CIT0500","first-page":"279","article-title":"Caspase-3 is actively involved in okadaic acid-induced lens epithelial cell apoptosis","volume-title":"Exp. Cell Res","year":"(2001)"},{"key":"key\n\t\t\t\t20170508190238_CIT0040","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1038\/284555a0","article-title":"Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation","volume":"284","year":"(1980)","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170508190238_CIT0041","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1016\/S0040-4020(01)96469-5","article-title":"Diarrhetic shellfish toxins","volume":"41","year":"(1985)","journal-title":"Tetrahedron"}],"container-title":["Toxicological Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/toxsci\/article-pdf\/132\/2\/409\/16685047\/kft006.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,8]],"date-time":"2019-07-08T14:09:28Z","timestamp":1562594968000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/toxsci\/article-lookup\/doi\/10.1093\/toxsci\/kft006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1,18]]},"references-count":42,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2013,1,18]]},"published-print":{"date-parts":[[2013,4]]}},"URL":"https:\/\/doi.org\/10.1093\/toxsci\/kft006","relation":{},"ISSN":["1096-6080","1096-0929"],"issn-type":[{"value":"1096-6080","type":"print"},{"value":"1096-0929","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1,18]]}}}