{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T01:28:05Z","timestamp":1790299685489,"version":"4.1.0"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,6]]},"DOI":"10.1093\/toxsci\/kft076","type":"journal-article","created":{"date-parts":[[2013,3,28]],"date-time":"2013-03-28T02:54:56Z","timestamp":1364439296000},"page":"289-297","source":"Crossref","is-referenced-by-count":54,"title":["Specific Pesticide-Dependent Increases in \u03b1-Synuclein Levels in Human Neuroblastoma (SH-SY5Y) and Melanoma (SK-MEL-2) Cell Lines"],"prefix":"10.1093","volume":"133","author":[{"given":"Areski","family":"Chorfa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"B\u00e9temps","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Morignat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corinne","family":"Lazizzera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Hogeveen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thibault","family":"Andrieu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Baron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2013,3,27]]},"reference":[{"key":"key\n\t\t\t\t20170315204509_CIT0001","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1038\/459924a","article-title":"Cell biology: Beyond the prion principle","volume":"459","year":"(2009)","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170315204509_CIT0002","doi-asserted-by":"crossref","first-page":"e39465","DOI":"10.1371\/journal.pone.0039465","article-title":"Alpha-synuclein cell-to-cell transfer and seeding in grafted dopaminergic neurons in vivo","volume":"7","year":"(2012)","journal-title":"PLoS ONE"},{"key":"key\n\t\t\t\t20170315204509_CIT0003","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1002\/mds.1105","article-title":"Parkinsonism after glycine-derivate exposure","volume":"16","year":"(2001)","journal-title":"Mov. Disord"},{"key":"key\n\t\t\t\t20170315204509_CIT0004","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.neulet.2005.11.012","article-title":"Gastric alpha-synuclein immunoreactive inclusions in Meissner\u2019s and Auerbach\u2019s plexuses in cases staged for Parkinson\u2019s disease-related brain pathology","volume":"396","year":"(2006)","journal-title":"Neurosci. Lett"},{"key":"key\n\t\t\t\t20170315204509_CIT0005","doi-asserted-by":"crossref","first-page":"4546","DOI":"10.1073\/pnas.80.14.4546","article-title":"A primate model of parkinsonism: Selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine","volume":"80","year":"(1983)","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"key\n\t\t\t\t20170315204509_CIT0006","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1016\/S0140-6736(04)17103-1","article-title":"Alpha-synuclein locus duplication as a cause of familial Parkinson\u2019s disease","volume":"364","year":"(2004)","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20170315204509_CIT0007","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/0022-1759(86)90368-6","article-title":"Rapid colorimetric assay for cell growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability","volume":"89","year":"(1986)","journal-title":"J. Immunol. Methods"},{"key":"key\n\t\t\t\t20170315204509_CIT0008","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1289\/ehp.0901518","article-title":"Pesticide use and cutaneous melanoma in pesticide applicators in the agricultural heath study","volume":"118","year":"(2010)","journal-title":"Environ. Health Perspect"},{"key":"key\n\t\t\t\t20170315204509_CIT0009","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1002\/ana.10846","article-title":"Comparison of kindreds with parkinsonism and alpha-synuclein genomic multiplications","volume":"55","year":"(2004)","journal-title":"Ann. Neurol"},{"key":"key\n\t\t\t\t20170315204509_CIT0010","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1212\/01.wnl.0000254458.17630.c5","article-title":"Phenotypic variation in a large Swedish pedigree due to SNCA duplication and triplication","volume":"68","year":"(2007)","journal-title":"Neurology"},{"key":"key\n\t\t\t\t20170315204509_CIT0011","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/S0006-8993(02)02422-8","article-title":"MPP+ increases alpha-synuclein expression and ERK\/MAP-kinase phosphorylation in human neuroblastoma SH-SY5Y cells","volume":"935","year":"(2002)","journal-title":"Brain Res"},{"key":"key\n\t\t\t\t20170315204509_CIT0012","doi-asserted-by":"crossref","first-page":"e38","DOI":"10.1093\/nar\/gkn084","article-title":"Elevated alpha-synuclein mRNA levels in individual UV-laser-microdissected dopaminergic substantia nigra neurons in idiopathic Parkinson\u2019s disease","volume":"36","year":"(2008)","journal-title":"Nucleic Acids Res"},{"key":"key\n\t\t\t\t20170315204509_CIT0013","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1111\/j.1749-6632.2009.04365.x","article-title":"Parkinson\u2019s disease: The dual hit theory revisited","volume":"1170","year":"(2009)","journal-title":"Ann. N. Y. Acad. Sci"},{"key":"key\n\t\t\t\t20170315204509_CIT0014","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1016\/S0140-6736(04)17104-3","article-title":"Causal relation between alpha-synuclein gene duplication and familial Parkinson\u2019s disease","volume":"364","year":"(2004)","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20170315204509_CIT0015","doi-asserted-by":"crossref","first-page":"e19622","DOI":"10.1371\/journal.pone.0019622","article-title":"\u03b1-Synuclein expression selectively affects tumorigenesis in mice modeling Parkinson\u2019s disease","volume":"6","year":"(2011)","journal-title":"PLoS ONE"},{"key":"key\n\t\t\t\t20170315204509_CIT0016","doi-asserted-by":"crossref","first-page":"6355","DOI":"10.1523\/JNEUROSCI.6119-09.2010","article-title":"Methylation regulates alpha-synuclein expression and is decreased in Parkinson\u2019s disease patients\u2019 brains","volume":"30","year":"(2010)","journal-title":"J. Neurosci"},{"key":"key\n\t\t\t\t20170315204509_CIT0017","doi-asserted-by":"crossref","first-page":"e46817","DOI":"10.1371\/journal.pone.0046817","article-title":"Increased neuronal \u03b1-synuclein pathology associates with its accumulation in oligodendrocytes in mice modeling \u03b1-synucleinopathies","volume":"7","year":"(2012)","journal-title":"PLoS ONE"},{"key":"key\n\t\t\t\t20170315204509_CIT0018","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/s00401-010-0658-1","article-title":"Protein coding of neurodegenerative dementias: The neuropathological basis of biomarker diagnostics","volume":"119","year":"(2010)","journal-title":"Acta Neuropathol"},{"key":"key\n\t\t\t\t20170315204509_CIT0019","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1126\/science.6823561","article-title":"Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis","volume":"219","year":"(1983)","journal-title":"Science"},{"key":"key\n\t\t\t\t20170315204509_CIT0020","doi-asserted-by":"crossref","first-page":"e23939","DOI":"10.1371\/journal.pone.0023939","article-title":"Improved immunodetection of endogenous \u03b1-synuclein","volume":"6","year":"(2011)","journal-title":"PLoS ONE"},{"key":"key\n\t\t\t\t20170315204509_CIT0021","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1038\/nrneurol.2010.145","article-title":"Cell-to-cell transmission of non-prion protein aggregates","volume":"6","year":"(2010)","journal-title":"Nat. Rev. Neurol"},{"key":"key\n\t\t\t\t20170315204509_CIT0022","doi-asserted-by":"crossref","first-page":"e15522","DOI":"10.1371\/journal.pone.0015522","article-title":"CpG demethylation enhances alpha-synuclein expression and affects the pathogenesis of Parkinson\u2019s disease","volume":"5","year":"(2010)","journal-title":"PLoS ONE"},{"key":"key\n\t\t\t\t20170315204509_CIT0023","doi-asserted-by":"crossref","first-page":"e10481","DOI":"10.1371\/journal.pone.0010481","article-title":"Parkinson\u2019s disease-related protein, alpha-synuclein, in malignant melanoma","volume":"5","year":"(2010)","journal-title":"PLoS ONE"},{"key":"key\n\t\t\t\t20170315204509_CIT0024","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.yrtph.2011.07.006","article-title":"Epidemiologic studies of glyphosate and non-cancer health outcomes: A review","volume":"61","year":"(2011)","journal-title":"Regul. Toxicol. Pharmacol"},{"key":"key\n\t\t\t\t20170315204509_CIT0025","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1093\/hmg\/ddl030","article-title":"Multiple candidate gene analysis identifies alpha-synuclein as a susceptibility gene for sporadic Parkinson\u2019s disease","volume":"15","year":"(2006)","journal-title":"Hum. Mol. Genet"},{"key":"key\n\t\t\t\t20170315204509_CIT0026","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.neuro.2011.03.004","article-title":"Biochemical and toxicological evidence of neurological effects of pesticides: The example of Parkinson\u2019s disease","volume":"32","year":"(2011)","journal-title":"Neurotoxicology"},{"key":"key\n\t\t\t\t20170315204509_CIT0027","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.jneumeth.2010.08.010","article-title":"Production of a monoclonal antibody, against human \u03b1-synuclein, in a subpopulation of C57BL\/6J mice, presenting a deletion of the \u03b1-synuclein locus","volume":"192","year":"(2010)","journal-title":"J. Neurosci. Methods"},{"key":"key\n\t\t\t\t20170315204509_CIT0028","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.1016\/j.neurobiolaging.2011.06.022","article-title":"Prion-like acceleration of a synucleinopathy in a transgenic mouse model","volume":"33","year":"(2012)","journal-title":"Neurobiol. Aging"},{"key":"key\n\t\t\t\t20170315204509_CIT0029","doi-asserted-by":"crossref","first-page":"658","DOI":"10.2353\/ajpath.2007.060359","article-title":"Pesticide exposure exacerbates alpha-synucleinopathy in an A53T transgenic mouse model","volume":"170","year":"(2007)","journal-title":"Am. J. Pathol"},{"key":"key\n\t\t\t\t20170315204509_CIT0030","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.1002\/ijc.25912","article-title":"The association between Parkinson\u2019s disease and melanoma","volume":"128","year":"(2011)","journal-title":"Int. J. Cancer"},{"key":"key\n\t\t\t\t20170315204509_CIT0031","doi-asserted-by":"crossref","first-page":"e45183","DOI":"10.1371\/journal.pone.0045183","article-title":"The role of alpha- synuclein in melanin synthesis in melanoma and dopaminergic neuronal cells","volume":"7","year":"(2012)","journal-title":"PLoS ONE"},{"key":"key\n\t\t\t\t20170315204509_CIT0032","doi-asserted-by":"crossref","first-page":"e8762","DOI":"10.1371\/journal.pone.0008762","article-title":"Progression of Parkinson\u2019s disease pathology is reproduced by intragastric administration of rotenone in mice","volume":"5","year":"(2010)","journal-title":"PLoS ONE"},{"key":"key\n\t\t\t\t20170315204509_CIT0033","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1038\/srep00898","article-title":"Environmental toxins trigger PD-like progression via increased alpha-synuclein release from enteric neurons in mice","volume":"2","year":"(2012)","journal-title":"Sci. Rep"},{"key":"key\n\t\t\t\t20170315204509_CIT0034","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1126\/science.1090278","article-title":"alpha-Synuclein locus triplication causes Parkinson\u2019s disease","volume":"302","year":"(2003)","journal-title":"Science"},{"key":"key\n\t\t\t\t20170315204509_CIT0035","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.jmb.2007.07.008","article-title":"Residual structure, backbone dynamics, and interactions within the synuclein family","volume":"372","year":"(2007)","journal-title":"J. Mol. Biol"},{"key":"key\n\t\t\t\t20170315204509_CIT0036","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1289\/ehp.1002839","article-title":"Rotenone, paraquat, and Parkinson\u2019s disease","volume":"119","year":"(2011)","journal-title":"Environ. Health Perspect"},{"key":"key\n\t\t\t\t20170315204509_CIT0037","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1007\/s12035-012-8329-y","article-title":"\u03b1-Synuclein elevation in human neurodegenerative diseases: Experimental, pathogenetic, and therapeutic implications","volume":"47","year":"(2013)","journal-title":"Mol. Neurobiol"},{"key":"key\n\t\t\t\t20170315204509_CIT0038","doi-asserted-by":"crossref","first-page":"e30745","DOI":"10.1371\/journal.pone.0030745","article-title":"Paraquat, but not maneb, induces synucleinopathy and tauopathy in striata of mice through inhibition of proteasomal and autophagic pathways","volume":"7","year":"(2012)","journal-title":"PLoS ONE"}],"container-title":["Toxicological Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/toxsci\/article-pdf\/133\/2\/289\/10990074\/kft076.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,11]],"date-time":"2019-07-11T12:49:02Z","timestamp":1562849342000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/toxsci\/article\/1616106\/Specific"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3,27]]},"references-count":38,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2013,3,27]]},"published-print":{"date-parts":[[2013,6]]}},"URL":"https:\/\/doi.org\/10.1093\/toxsci\/kft076","relation":{},"ISSN":["1096-6080","1096-0929"],"issn-type":[{"value":"1096-6080","type":"print"},{"value":"1096-0929","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3,27]]}}}