{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T09:20:08Z","timestamp":1791192008710,"version":"4.1.0"},"reference-count":116,"publisher":"Oxford University Press (OUP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,6]]},"DOI":"10.1093\/toxsci\/kft078","type":"journal-article","created":{"date-parts":[[2013,3,28]],"date-time":"2013-03-28T02:54:56Z","timestamp":1364439296000},"page":"320-341","source":"Crossref","is-referenced-by-count":65,"title":["Evaluation of Perturbations in Serum Thyroid Hormones During Human Pregnancy Due to Dietary Iodide and Perchlorate Exposure Using a Biologically Based Dose-Response Model"],"prefix":"10.1093","volume":"133","author":[{"given":"Annie","family":"Lumen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David R.","family":"Mattie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey W.","family":"Fisher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2013,3,27]]},"reference":[{"key":"key\n\t\t\t\t20170508190604_CIT0001","first-page":"195","article-title":"The physiological changes in thyroid function during pregnancy","volume":"27","year":"(1964)","journal-title":"Clin. Sci"},{"key":"key\n\t\t\t\t20170508190604_CIT0002","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1210\/endo-95-4-1078","article-title":"A model of iodine kinetics in the dog","volume":"95","year":"(1974)","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170508190604_CIT0003","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1172\/JCI103072","article-title":"The iodide trapping and binding functions of the thyroid","volume":"34","year":"(1955)","journal-title":"J. Clin. Invest"},{"key":"key\n\t\t\t\t20170508190604_CIT0004","first-page":"109","article-title":"Intracellular pathways of iodothyroinine metabolism","volume-title":"The Thyroid","year":"(2005)"},{"key":"key\n\t\t\t\t20170508190604_CIT0005","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1289\/ehp.9466","article-title":"Urinary perchlorate and thyroid hormone levels in adolescent and adult men and women living in the United States","volume":"114","year":"(2006)","journal-title":"Environ. Health Perspect"},{"key":"key\n\t\t\t\t20170508190604_CIT0006","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1210\/jc.2004-1821","article-title":"The effect of perchlorate, thiocyanate, and nitrate on thyroid function in workers exposed to perchlorate long-term","volume":"90","year":"(2005)","journal-title":"J. Clin. Endocrinol. Metab"},{"key":"key\n\t\t\t\t20170508190604_CIT0007","doi-asserted-by":"crossref","first-page":"2721","DOI":"10.1210\/jc.2006-0184","article-title":"Effects of six months of daily low-dose perchlorate exposure on thyroid function in healthy volunteers","volume":"91","year":"(2006)","journal-title":"J. Clin. Endocrinol. Metab"},{"key":"key\n\t\t\t\t20170508190604_CIT0008","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1136\/jcp.39.5.475","article-title":"Histometry of normal thyroid in man","volume":"39","year":"(1986)","journal-title":"J. Clin. Pathol"},{"key":"key\n\t\t\t\t20170508190604_CIT0009","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1177\/074823379701300401","article-title":"Physiological parameter values for physiologically based pharmacokinetic models","volume":"13","year":"(1997)","journal-title":"Toxicol. Ind. Health"},{"key":"key\n\t\t\t\t20170508190604_CIT0010","first-page":"1013","article-title":"The maturation of thyroid function in the perinatal period and during childhood","volume-title":"The Thyroid","year":"(2005)"},{"key":"key\n\t\t\t\t20170508190604_CIT0011","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1210\/edrv-14-2-194","article-title":"Thyroid function and hyperfunction during gestation","volume":"14","year":"(1993)","journal-title":"Endocr. Rev"},{"key":"key\n\t\t\t\t20170508190604_CIT0012","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1089\/thy.2010.0077","article-title":"Iodine status of the U.S. population, National Health and Nutrition Examination Survey, 2005\u20132006 and 2007\u20132008","volume":"21","year":"(2011)","journal-title":"Thyroid"},{"key":"key\n\t\t\t\t20170508190604_CIT0013","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1007\/BF02093716","article-title":"Determination of thyroid volume by ultrasound from the neonatal period to late adolescence","volume":"150","year":"(1991)","journal-title":"Eur. J. Pediatr"},{"key":"key\n\t\t\t\t20170508190604_CIT0014","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1210\/jcem-8-9-717","article-title":"The collection of radioactive iodine by the human fetal thyroid","volume":"8","year":"(1948)","journal-title":"J. Clin. Endocrinol. Metab"},{"key":"key\n\t\t\t\t20170508190604_CIT0015","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1172\/JCI108456","article-title":"An assessment of daily production and significance of thyroidal secretion of 3, 3\u2019, 5\u2019-triiodothyronine (reverse T3) in man","volume":"58","year":"(1976)","journal-title":"J. Clin. Invest"},{"key":"key\n\t\t\t\t20170508190604_CIT0016","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1080\/15287390600755216","article-title":"Perchlorate and radioiodide kinetics across life stages in the human: Using PBPK models to predict dosimetry and thyroid inhibition and sensitive subpopulations based on developmental stage","volume":"70","year":"(2007)","journal-title":"J. Toxicol. Environ. Health Part A"},{"key":"key\n\t\t\t\t20170508190604_CIT0017","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1093\/toxsci\/kfg081","article-title":"Predicting fetal perchlorate dose and inhibition of iodide kinetics during gestation: A physiologically-based pharmacokinetic analysis of perchlorate and iodide kinetics in the rat","volume":"73","year":"(2003)","journal-title":"Toxicol. Sci"},{"key":"key\n\t\t\t\t20170508190604_CIT0018","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1089\/thy.2009.0356","article-title":"Parameters of thyroid function throughout and after pregnancy in an iodine-deficient population","volume":"20","year":"(2010)","journal-title":"Thyroid"},{"key":"key\n\t\t\t\t20170508190604_CIT0019","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.beem.2004.03.012","article-title":"Maternal thyroid hormones early in pregnancy and fetal brain development","volume":"18","year":"(2004)","journal-title":"Best Pract. Res. Clin. Endocrinol. Metab"},{"key":"key\n\t\t\t\t20170508190604_CIT0020","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1089\/thy.1998.8.1185","article-title":"Screening for congenital hypothyroidism used as an indicator of the degree of iodine deficiency and of its control","volume":"8","year":"(1998)","journal-title":"Thyroid"},{"key":"key\n\t\t\t\t20170508190604_CIT0021","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1136\/pmj.77.906.217","article-title":"Iodine deficiency as a cause of brain damage","volume":"77","year":"(2001)","journal-title":"Postgrad. Med. J"},{"key":"key\n\t\t\t\t20170508190604_CIT0022","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1210\/jcem-34-5-891","article-title":"Circulating thyroid hormones in endemic goiter","volume":"34","year":"(1972)","journal-title":"J. Clin. Endocrinol. Metab"},{"key":"key\n\t\t\t\t20170508190604_CIT0023","first-page":"264","article-title":"Iodine deficiency","volume-title":"The Thyroid","year":"(2005)"},{"key":"key\n\t\t\t\t20170508190604_CIT0024","first-page":"539","article-title":"Peripheral distribution and metabolism of the thyroid hormones: A primarily quantitative assessment","volume":"2","year":"(1976)","journal-title":"Pharmacol. Ther. B"},{"key":"key\n\t\t\t\t20170508190604_CIT0025","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1210\/jcem-27-12-1749","article-title":"Thyroxine turnover during human pregnancy","volume":"27","year":"(1967)","journal-title":"J. Clin. Endocrinol. Metab"},{"key":"key\n\t\t\t\t20170508190604_CIT0026","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1365-2265.1995.tb01886.x","article-title":"Large goitre as a maladaptation to iodine deficiency","volume":"43","year":"(1995)","journal-title":"Clin. Endocrinol. (Oxf)"},{"key":"key\n\t\t\t\t20170508190604_CIT0027","first-page":"423","article-title":"Recherches sur l\u2019elimination des perchlorates, sur leur repartition dans les organes et sur leur toxicite [Research on the elimination of perchlorate, its distribution in organs and its toxicity]","volume":"20","year":"(1938)","journal-title":"Bull. Soc. Chim. Biol"},{"key":"key\n\t\t\t\t20170508190604_CIT0028","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1210\/jcem-29-4-595","article-title":"Studies of serum triiodothyronine concentration in maternal and cord blood: Transfer of triiodothyronine across the human placenta","volume":"29","year":"(1969)","journal-title":"J. Clin. Endocrinol. Metab"},{"key":"key\n\t\t\t\t20170508190604_CIT0029","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/BF01864829","article-title":"Zur Pharmakologie der Perchloratwirkung [The pharmacology of the perchlorate effect]","volume":"144","year":"(1929)","journal-title":"Naunyn-Schmiedebergs Arch. Exp. Pathol. Pharmakol"},{"key":"key\n\t\t\t\t20170508190604_CIT0030","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1089\/thy.2007.0388","article-title":"Extensions, validation, and clinical applications of a feedback control system simulator of the hypothalamo-pituitary-thyroid axis","volume":"18","year":"(2008)","journal-title":"Thyroid"},{"key":"key\n\t\t\t\t20170508190604_CIT0031","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1089\/thy.2009.0349","article-title":"TSH regulation dynamics in central and extreme primary hypothyroidism","volume":"20","year":"(2010)","journal-title":"Thyroid"},{"key":"key\n\t\t\t\t20170508190604_CIT0032","volume-title":"Vitamin and Mineral Requirements in Human Nutrition","author":"FAO and WHO","year":"(2005)","edition":"2nd ed"},{"key":"key\n\t\t\t\t20170508190604_CIT0033","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1210\/jcem-24-8-733","article-title":"Whole-body counting of 131-i-labeled triiodothyronine","volume":"24","year":"(1964)","journal-title":"J. Clin. Endocrinol. Metab"},{"key":"key\n\t\t\t\t20170508190604_CIT0034","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1210\/jcem-33-4-647","article-title":"Thyroidal thyronine and non-thyronine iodine secretion in euthyroid subjects","volume":"33","year":"(1971)","journal-title":"J. Clin. Endocrinol. Metab"},{"key":"key\n\t\t\t\t20170508190604_CIT0035","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1210\/edrv.18.3.0300","article-title":"The regulation of thyroid function in pregnancy: Pathways of endocrine adaptation from physiology to pathology","volume":"18","year":"(1997)","journal-title":"Endocr. Rev"},{"key":"key\n\t\t\t\t20170508190604_CIT0036","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1089\/thy.2006.16.947","article-title":"Iodine nutrition requirements during pregnancy","volume":"16","year":"(2006)","journal-title":"Thyroid"},{"key":"key\n\t\t\t\t20170508190604_CIT0037","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1089\/thy.2000.10.871","article-title":"The potential repercussions of maternal, fetal, and neonatal hypothyroxinemia on the progeny","volume":"10","year":"(2000)","journal-title":"Thyroid"},{"key":"key\n\t\t\t\t20170508190604_CIT0038","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1530\/acta.0.1030034","article-title":"Kinetics of the iodide trapping mechanism in normal and pathological human thyroid slices","volume":"103","year":"(1983)","journal-title":"Acta Endocrinol"},{"key":"key\n\t\t\t\t20170508190604_CIT0039","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1289\/ehp.02110927","article-title":"Health effects assessment for environmental perchlorate contamination: The dose response for inhibition of thyroidal radioiodine uptake in humans","volume":"110","year":"(2002)","journal-title":"Environ. Health Perspect"},{"issue":"1 Pt 1","key":"key\n\t\t\t\t20170508190604_CIT0040","first-page":"58","article-title":"Increased urinary excretion of triiodothyronine (T3) and thyroxine (T4) and decreased serum thyreotropic hormone (TSH) induced by motion sickness","volume":"49","year":"(1978)","journal-title":"Aviat. Space. Environ. Med"},{"key":"key\n\t\t\t\t20170508190604_CIT0041","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1056\/NEJM199908193410801","article-title":"Maternal thyroid deficiency during pregnancy and subsequent neuropsychological development of the child","volume":"341","year":"(1999)","journal-title":"N. Engl. J. Med"},{"key":"key\n\t\t\t\t20170508190604_CIT0042","first-page":"281","article-title":"The radioiodine uptake of the human thyroid in pregnancy","volume":"17","year":"(1958)","journal-title":"Clin. Sci"},{"key":"key\n\t\t\t\t20170508190604_CIT0043","doi-asserted-by":"crossref","first-page":"4227","DOI":"10.1210\/jc.2010-0415","article-title":"Maternal thyroid function during early pregnancy and cognitive functioning in early childhood: The generation R study","volume":"95","year":"(2010)","journal-title":"J. Clin. Endocrinol. Metab"},{"key":"key\n\t\t\t\t20170508190604_CIT0044","first-page":"36","article-title":"Thyroid function in cord blood","volume":"21","year":"(2000)","journal-title":"Saudi Med. J"},{"key":"key\n\t\t\t\t20170508190604_CIT0045","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1210\/jcem-15-6-661","article-title":"The accumulation of radioactive iodine by human fetal thyroids","volume":"15","year":"(1955)","journal-title":"J. Clin. Endocrinol. Metab"},{"key":"key\n\t\t\t\t20170508190604_CIT0046","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1210\/jcem.87.2.8182","article-title":"Serum TSH, T(4), and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III)","volume":"87","year":"(2002)","journal-title":"J. Clin. Endocrinol. Metab"},{"key":"key\n\t\t\t\t20170508190604_CIT0047","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1210\/jc.2002-021291","article-title":"Type 3 iodothyronine deiodinase is highly expressed in the human uteroplacental unit and in fetal epithelium","volume":"88","year":"(2003)","journal-title":"J. Clin. Endocrinol. Metab"},{"key":"key\n\t\t\t\t20170508190604_CIT0048","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1038\/jes.2010.31","article-title":"Estimating perchlorate exposure from food and tap water based on US biomonitoring and occurrence data","volume":"21","year":"(2011)","journal-title":"J. Expo. Sci. Environ. Epidemiol"},{"key":"key\n\t\t\t\t20170508190604_CIT0049","doi-asserted-by":"crossref","first-page":"4097","DOI":"10.1210\/jc.2004-0573","article-title":"Human fetal and cord serum thyroid hormones: Developmental trends and interrelationships","volume":"89","year":"(2004)","journal-title":"J. Clin. Endocrinol. Metab"},{"key":"key\n\t\t\t\t20170508190604_CIT0050","volume-title":"The Physiology of Human Pregnancy","year":"(1971)","edition":"2nd ed"},{"key":"key\n\t\t\t\t20170508190604_CIT0051","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1172\/JCI108053","article-title":"Estimation of thyroxine and triiodothyronine distribution and of the conversion rate of thyroxine to triiodothyronine in man","volume":"55","year":"(1975)","journal-title":"J. Clin. Invest"},{"key":"key\n\t\t\t\t20170508190604_CIT0052","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1210\/jcem-55-5-890","article-title":"Sequential deiodination of thyroxine in human thyroid gland","volume":"55","year":"(1982)","journal-title":"J. Clin. Endocrinol. Metab"},{"key":"key\n\t\t\t\t20170508190604_CIT0053","first-page":"206","article-title":"[Demonstration of perchlorate in the urine]","volume":"30","year":"(1973)","journal-title":"Beitr. Gerichtl. Med"},{"issue":"1 Pt 1","key":"key\n\t\t\t\t20170508190604_CIT0054","first-page":"E90","article-title":"Thyroxine and triiodothyronine distribution and metabolism in thyroxine-replaced athyreotic dogs and normal humans","volume":"264","year":"(1993)","journal-title":"Am. J. Physiol"},{"key":"key\n\t\t\t\t20170508190604_CIT0055","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1002\/uog.2832","article-title":"Fetal cardiac output, distribution to the placenta and impact of placental compromise","volume":"28","year":"(2006)","journal-title":"Ultrasound Obstet. Gynecol"},{"key":"key\n\t\t\t\t20170508190604_CIT0056","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1081\/DCT-100100114","article-title":"Effects of TCDD on thyroid hormone homeostasis in the rat","volume":"23","year":"(2000)","journal-title":"Drug Chem. Toxicol"},{"key":"key\n\t\t\t\t20170508190604_CIT0057","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1542\/peds.2005-0227","article-title":"Neonatal effects of maternal hypothyroxinemia during early pregnancy","volume":"117","year":"(2006)","journal-title":"Pediatrics"},{"key":"key\n\t\t\t\t20170508190604_CIT0058","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1006\/bbrc.1996.1473","article-title":"Establishment and characterization of a Chinese hamster ovary cell line, CHO-4J, stably expressing a number of Na+\/I- symporters","volume":"227","year":"(1996)","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"key\n\t\t\t\t20170508190604_CIT0059","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/0016-6480(85)90108-X","article-title":"Thyroid hormone binding in serum of 15 vertebrate species: Isolation of thyroxine-binding globulin and prealbumin analogs","volume":"58","year":"(1985)","journal-title":"Gen. Comp. Endocrinol"},{"key":"key\n\t\t\t\t20170508190604_CIT0060","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/0026-0495(84)90203-8","article-title":"Mechanisms governing the relative proportions of thyroxine and 3,5,3\u2019-triiodothyronine in thyroid secretion","volume":"33","year":"(1984)","journal-title":"Metabolism"},{"key":"key\n\t\t\t\t20170508190604_CIT0500","first-page":"e261","article-title":"Free T4 immunoassays are flawed during pregnancy","volume-title":"Am. J. Obstet. Gynecol","year":"(2009)"},{"key":"key\n\t\t\t\t20170508190604_CIT0061","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.beem.2009.08.009","article-title":"Perchlorate, iodine and the thyroid","volume":"24","year":"(2010)","journal-title":"Best Pract. Res. Clin. Endocrinol. Metab"},{"key":"key\n\t\t\t\t20170508190604_CIT0062","first-page":"3545","article-title":"Circulating iodide concentrations during and after pregnancy","volume":"83","year":"(1998)","journal-title":"J. Clin. Endocrinol. Metab"},{"key":"key\n\t\t\t\t20170508190604_CIT0063","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.placenta.2010.01.013","article-title":"Expression of thyroid hormone transporters in the human placenta and changes associated with intrauterine growth restriction","volume":"31","year":"(2010)","journal-title":"Placenta"},{"key":"key\n\t\t\t\t20170508190604_CIT0064","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/0020-7101(95)01115-U","article-title":"Mathematical representation of organ growth in the human embryo\/fetus","volume":"39","year":"(1995)","journal-title":"Int. J. Biomed. Comput"},{"key":"key\n\t\t\t\t20170508190604_CIT0065","first-page":"227","article-title":"Maternal hypothyroxinemia: Psychoneurological deficits of progeny","volume":"21","year":"(1991)","journal-title":"Ann. Clin. Lab. Sci"},{"key":"key\n\t\t\t\t20170508190604_CIT0066","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1289\/ehp.0800111","article-title":"Competitive inhibition of thyroidal uptake of dietary iodide by perchlorate does not describe perturbations in rat serum total T4 and TSH","volume":"117","year":"(2009)","journal-title":"Environ. Health Perspect"},{"key":"key\n\t\t\t\t20170508190604_CIT0067","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1093\/toxsci\/kfm312","article-title":"A biologically based dose-response model for dietary iodide and the hypothalamic-pituitary-thyroid axis in the adult rat: Evaluation of iodide deficiency","volume":"102","year":"(2008)","journal-title":"Toxicol. Sci"},{"key":"key\n\t\t\t\t20170508190604_CIT0068","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1038\/jes.2009.50","article-title":"Drinking water contribution to aggregate perchlorate intake of reproductive-age women in the United States estimated by dietary intake simulation and analysis of urinary excretion data","volume":"20","year":"(2010)","journal-title":"J. Expo. Sci. Environ. Epidemiol"},{"key":"key\n\t\t\t\t20170508190604_CIT0069","first-page":"25","article-title":"PBPK model for radioactive iodide and perchlorate kinetics and perchlorate-induced inhibition of iodide uptake in humans","volume":"83","year":"(2005)","journal-title":"Toxicol. Sci"},{"key":"key\n\t\t\t\t20170508190604_CIT0501","first-page":"256","article-title":"PBPK predictions of perchlorate distribution and its effect on thyroid uptake of radioiodide in the male rat","volume-title":"Toxicol. Sci","year":"(2003)"},{"key":"key\n\t\t\t\t20170508190604_CIT0070","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1111\/j.1365-2265.2011.04007.x","article-title":"Maternal thyroid function in different conditions of iodine nutrition in pregnant women exposed to mild-moderate iodine deficiency: An observational study","volume":"74","year":"2011","journal-title":"Clin. Endocrinol. (Oxf)"},{"key":"key\n\t\t\t\t20170508190604_CIT0071","first-page":"463029","article-title":"Doubts and Concerns about Isolated Maternal Hypothyroxinemia","volume":"2011","year":"2011","journal-title":"J. Thyroid Res"},{"key":"key\n\t\t\t\t20170508190604_CIT0072","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1136\/adc.25.123.242","article-title":"Red cell and plasma volume in newborn infants","volume":"25","year":"(1950)","journal-title":"Arch. Dis. Child"},{"key":"key\n\t\t\t\t20170508190604_CIT0073","first-page":"3975","article-title":"Is neuropsychological development related to maternal hypothyroidism or to maternal hypothyroxinemia?","volume":"85","year":"(2000)","journal-title":"J. Clin. Endocrinol. Metab"},{"key":"key\n\t\t\t\t20170508190604_CIT0075","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1038\/sj.jes.7500648","article-title":"US Food and Drug Administration\u2019s Total Diet Study: Dietary intake of perchlorate and iodine","volume":"18","year":"(2008)","journal-title":"J. Expo. Sci. Environ. Epidemiol"},{"key":"key\n\t\t\t\t20170508190604_CIT0076","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1172\/JCI106835","article-title":"Simultaneous measurement of thyroxine and triiodothyronine peripheral turnover kinetics in man","volume":"51","year":"(1972)","journal-title":"J. Clin. Invest"},{"key":"key\n\t\t\t\t20170508190604_CIT0077","volume-title":"Health Implications of Perchlorate Ingestion","author":"NRC","year":"(2005)"},{"key":"key\n\t\t\t\t20170508190604_CIT0078","first-page":"86","article-title":"Ontogenesis of thyroid function and interactions with maternal function","volume":"10","year":"(2007)","journal-title":"Endocr. Dev"},{"key":"key\n\t\t\t\t20170508190604_CIT0079","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1089\/thy.2005.15.917","article-title":"The effects of iodine deficiency on thyroid hormone deiodination","volume":"15","year":"(2005)","journal-title":"Thyroid"},{"key":"key\n\t\t\t\t20170508190604_CIT0080","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1210\/jcem-26-4-425","article-title":"An analysis of published data on thyroxine turnover in human subjects","volume":"26","year":"1966","journal-title":"J. Clin. Endocrinol. Metab"},{"key":"key\n\t\t\t\t20170508190604_CIT0081","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1210\/jcem-26-12-1293","article-title":"Dependence of renal clearance of radioiodide on sex, age and thyroidal status","volume":"26","year":"1966","journal-title":"J. Clin. Endocrinol. Metab"},{"key":"key\n\t\t\t\t20170508190604_CIT0082","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.tem.2011.02.002","article-title":"Delivery of maternal thyroid hormones to the fetus","volume":"22","year":"(2011)","journal-title":"Trends Endocrinol. Metab"},{"key":"key\n\t\t\t\t20170508190604_CIT0083","first-page":"116","article-title":"Iodine: Deficiency and therapeutic considerations","volume":"13","year":"(2008)","journal-title":"Altern. Med. Rev"},{"key":"key\n\t\t\t\t20170508190604_CIT0084","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1111\/j.1365-2265.2012.04407.x","article-title":"Perchlorate and thiocyanate exposure and thyroid function in first-trimester pregnant women from Greece","volume":"77","year":"(2012)","journal-title":"Clin. Endocrinol. (Oxf)"},{"key":"key\n\t\t\t\t20170508190604_CIT0085","doi-asserted-by":"crossref","first-page":"412","DOI":"10.4158\/EP10293.OR","article-title":"Effect of environmental perchlorate on thyroid function in pregnant women from C\u00f3rdoba, Argentina, and Los Angeles, California","volume":"17","year":"(2011)","journal-title":"Endocr. Pract"},{"key":"key\n\t\t\t\t20170508190604_CIT0086","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1046\/j.1365-2265.2003.01822.x","article-title":"Maternal hypothyroxinaemia during early pregnancy and subsequent child development: A 3-year follow-up study","volume":"59","year":"(2003)","journal-title":"Clin. Endocrinol. (Oxf)"},{"key":"key\n\t\t\t\t20170508190604_CIT0087","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1046\/j.1365-2265.1999.00639.x","article-title":"Low maternal free thyroxine concentrations during early pregnancy are associated with impaired psychomotor development in infancy","volume":"50","year":"(1999)","journal-title":"Clin. Endocrinol. (Oxf)"},{"key":"key\n\t\t\t\t20170508190604_CIT0088","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.reprotox.2007.07.004","article-title":"Iodide concentrations in matched maternal serum, cord serum, and amniotic fluid from preterm and term human pregnancies","volume":"25","year":"(2008)","journal-title":"Reprod. Toxicol"},{"key":"key\n\t\t\t\t20170508190604_CIT0089","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1002\/mnfr.201000655","article-title":"Tutorial on physiologically based kinetic modeling in molecular nutrition and food research","volume":"55","year":"(2011)","journal-title":"Mol. Nutr. Food Res"},{"key":"key\n\t\t\t\t20170508190604_CIT0090","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1210\/jcem-52-4-671","article-title":"Interrelationships among serum thyroxine, triiodothyronine, reverse triiodothyronine, and thyroid-stimulating hormone in iodine-deficient pregnant women and their offspring: Effects of iodine supplementation","volume":"52","year":"(1981)","journal-title":"J. Clin. Endocrinol. Metab"},{"key":"key\n\t\t\t\t20170508190604_CIT0091","doi-asserted-by":"crossref","first-page":"2840","DOI":"10.1210\/jcem.82.9.4203","article-title":"Maternal iodine status and thyroid volume during pregnancy: Correlation with neonatal iodine intake","volume":"82","year":"(1997)","journal-title":"J. Clin. Endocrinol. Metab"},{"key":"key\n\t\t\t\t20170508190604_CIT0092","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1097\/FTD.0b013e31815709ac","article-title":"Gestation-specific thyroxine and thyroid stimulating hormone levels in the United States and worldwide","volume":"29","year":"(2007)","journal-title":"Ther. Drug Monit"},{"key":"key\n\t\t\t\t20170508190604_CIT0093","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1097\/JOM.0b013e3181fd6fa7","article-title":"Perchlorate in drinking water during pregnancy and neonatal thyroid hormone levels in California","volume":"52","year":"(2010)","journal-title":"J. Occup. Environ. Med"},{"key":"key\n\t\t\t\t20170508190604_CIT0094","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1530\/EJE-07-0249","article-title":"Evaluation of maternal thyroid function during pregnancy: The importance of using gestational age-specific reference intervals","volume":"157","year":"(2007)","journal-title":"Eur. J. Endocrinol"},{"key":"key\n\t\t\t\t20170508190604_CIT0095","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1089\/thy.2005.15.963","article-title":"Long-term environmental exposure to perchlorate through drinking water and thyroid function during pregnancy and the neonatal period","volume":"15","year":"(2005)","journal-title":"Thyroid"},{"key":"key\n\t\t\t\t20170508190604_CIT0096","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/S0002-9378(99)70546-6","article-title":"Urinary incontinence in pregnancy and the puerperium: A prospective study","volume":"181","year":"(1999)","journal-title":"Am. J. Obstet. Gynecol"},{"key":"key\n\t\t\t\t20170508190604_CIT0097","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1089\/thy.1992.2.207","article-title":"Fetal thyroid function","volume":"2","year":"(1992)","journal-title":"Thyroid"},{"key":"key\n\t\t\t\t20170508190604_CIT0098","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1111\/j.1365-2265.2004.02047.x","article-title":"The sodium-iodide symporter protein is always present at a low expression and confined to the cell membrane in nonfunctioning nonadenomatous nodules of toxic nodular goitre","volume":"61","year":"(2004)","journal-title":"Clin. Endocrinol. (Oxf)"},{"key":"key\n\t\t\t\t20170508190604_CIT0099","author":"USEPA","year":"(2005)"},{"key":"key\n\t\t\t\t20170508190604_CIT0100","volume-title":"Inhibition of the Sodium-Iodide Symporter by Perchlorate: An Evaluation of Life Stage Sensitivity Using Physiologically-Based Pharmacokinetic (PBPK) Modeling. Draft for Review and Public Comment. EPA\/600\/R-08\/106A","author":"USEPA","year":"(2009)"},{"key":"key\n\t\t\t\t20170508190604_CIT0101","volume-title":"Exposure Factors Handbook","author":"USEPA","year":"(2011)"},{"key":"key\n\t\t\t\t20170508190604_CIT0102","author":"USEPA","year":"(2012)"},{"key":"key\n\t\t\t\t20170508190604_CIT0103","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/0300-9629(93)90031-X","article-title":"Comparative aspects of iodine conservation in mammals","volume":"106","year":"(1993)","journal-title":"Comp. Biochem. Physiol. Comp. Physiol"},{"key":"key\n\t\t\t\t20170508190604_CIT0104","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1089\/thy.1999.9.19","article-title":"Increased risk of maternal thyroid failure with pregnancy progression in an iodine deficient area with major iodine deficiency disorders","volume":"9","year":"(1999)","journal-title":"Thyroid"},{"key":"key\n\t\t\t\t20170508190604_CIT0105","doi-asserted-by":"crossref","first-page":"6054","DOI":"10.1210\/jc.2004-0571","article-title":"Attention deficit and hyperactivity disorders in the offspring of mothers exposed to mild-moderate iodine deficiency: A possible novel iodine deficiency disorder in developed countries","volume":"89","year":"(2004)","journal-title":"J. Clin. Endocrinol. Metab"},{"key":"key\n\t\t\t\t20170508190604_CIT0106","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1056\/NEJM198907063210103","article-title":"Maternal-fetal transfer of thyroxine in congenital hypothyroidism due to a total organification defect or thyroid agenesis","volume":"321","year":"(1989)","journal-title":"N. Engl. J. Med"},{"key":"key\n\t\t\t\t20170508190604_CIT0107","volume-title":"Vascular Biology of the Placenta","year":"(2010)"},{"key":"key\n\t\t\t\t20170508190604_CIT0108","first-page":"1","volume-title":"Assessment of the Iodine Deficiency Disorders and Monitoring Their Elimination. A Guide for Programme Managers. (WHO\/NHD\/01.1)","author":"WHO, UNICEF, and ICCIDD","year":"(2001)","edition":"2nd ed"},{"key":"key\n\t\t\t\t20170508190604_CIT0109","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/S0021-9258(18)57335-X","article-title":"Plasma inorganic iodide as a homeostatic regulator of thyroid function","volume":"174","year":"(1948)","journal-title":"J. Biol. Chem"},{"key":"key\n\t\t\t\t20170508190604_CIT0110","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1111\/j.1365-2265.2010.03910.x","article-title":"Trimester- and method-specific reference intervals for thyroid tests in pregnant Chinese women: Methodology, euthyroid definition and iodine status can influence the setting of reference intervals","volume":"74","year":"(2011)","journal-title":"Clin. Endocrinol. (Oxf)"},{"key":"key\n\t\t\t\t20170508190604_CIT0111","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1089\/thy.2007.0108","article-title":"The adverse effects of mild-to-moderate iodine deficiency during pregnancy and childhood: A review","volume":"17","year":"(2007)","journal-title":"Thyroid"},{"key":"key\n\t\t\t\t20170508190604_CIT0112","doi-asserted-by":"crossref","first-page":"668S","DOI":"10.3945\/ajcn.2008.26811C","article-title":"Iodine deficiency in pregnancy and the effects of maternal iodine supplementation on the offspring: A review","volume":"89","year":"(2009)","journal-title":"Am. J. Clin. Nutr"},{"key":"key\n\t\t\t\t20170508190604_CIT0113","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.semcdb.2011.07.009","article-title":"The role of iodine in human growth and development","volume":"22","year":"(2011)","journal-title":"Semin. Cell Dev. Biol"},{"key":"key\n\t\t\t\t20170508190604_CIT0114","first-page":"935","article-title":"Thyroid hormone action in fetal brain development and potential for disruption by environmental chemicals","volume":"21","year":"(2000)","journal-title":"Neurotoxicology"},{"key":"key\n\t\t\t\t20170508190604_CIT0115","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1111\/j.1365-2826.2004.01243.x","article-title":"Timing of thyroid hormone action in the developing brain: Clinical observations and experimental findings","volume":"16","year":"(2004)","journal-title":"J. Neuroendocrinol"}],"container-title":["Toxicological Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/toxsci\/article-pdf\/133\/2\/320\/16686172\/kft078.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,12]],"date-time":"2022-02-12T15:17:12Z","timestamp":1644679032000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/toxsci\/article-lookup\/doi\/10.1093\/toxsci\/kft078"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3,27]]},"references-count":116,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2013,3,27]]},"published-print":{"date-parts":[[2013,6]]}},"URL":"https:\/\/doi.org\/10.1093\/toxsci\/kft078","relation":{},"ISSN":["1096-6080","1096-0929"],"issn-type":[{"value":"1096-6080","type":"print"},{"value":"1096-0929","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3,27]]}}}