{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T03:42:34Z","timestamp":1788925354156,"version":"build-2803163510"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,8,1]]},"DOI":"10.1093\/toxsci\/kfu099","type":"journal-article","created":{"date-parts":[[2014,5,27]],"date-time":"2014-05-27T01:12:31Z","timestamp":1401153151000},"page":"259-270","source":"Crossref","is-referenced-by-count":56,"title":["Phenobarbital-Mediated Tumor Promotion in Transgenic Mice with Humanized CAR and PXR"],"prefix":"10.1093","volume":"140","author":[{"given":"Albert","family":"Braeuning","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alina","family":"Gavrilov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. Roland","family":"Wolf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin J.","family":"Henderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Schwarz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2014,8,2]]},"reference":[{"key":"key\n\t\t\t\t20171013194857_B1","doi-asserted-by":"crossref","first-page":"7812","DOI":"10.1038\/sj.onc.1204982","article-title":"Selective pressure during tumor promotion by phenobarbital leads to clonal outgrowth of beta-catenin-mutated mouse liver tumors","volume":"20","year":"2001","journal-title":"Oncogene"},{"key":"key\n\t\t\t\t20171013194857_B2","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1023\/A:1020884312053","article-title":"Food intake, water intake, and drinking spout side preference of 28 mouse strains","volume":"32","year":"2002","journal-title":"Behav. Genet."},{"key":"key\n\t\t\t\t20171013194857_B3","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1093\/toxsci\/kfr166","article-title":"Gender-specific interplay of signaling through beta-catenin and CAR in the regulation of xenobiotic-induced hepatocyte proliferation","volume":"123","year":"2011","journal-title":"Toxicol. Sci."},{"key":"key\n\t\t\t\t20171013194857_B4","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1124\/dmd.108.026179","article-title":"Inducibility of drug-metabolizing enzymes by xenobiotics in mice with liver-specific knockout of Ctnnb1","volume":"37","year":"2009","journal-title":"Drug Metab. Dispos."},{"key":"key\n\t\t\t\t20171013194857_B5","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1007\/s00418-010-0747-1","article-title":"Phenotype and growth behavior of residual beta-catenin-positive hepatocytes in livers of beta-catenin-deficient mice","volume":"134","year":"2010","journal-title":"Histochem. Cell Biol."},{"key":"key\n\t\t\t\t20171013194857_B6","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.toxlet.2003.12.018","article-title":"Role of apoptosis for mouse liver growth regulation and tumor promotion: Comparative analysis of mice with high (C3H\/He) and low (C57Bl\/6J) cancer susceptibility","volume":"149","year":"2004","journal-title":"Toxicol. Lett."},{"key":"key\n\t\t\t\t20171013194857_B7","first-page":"465","article-title":"Application of quantitative stereology to the evaluation of enzyme-altered foci in rat liver","volume":"42","year":"1982","journal-title":"Cancer Res."},{"key":"key\n\t\t\t\t20171013194857_B8","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/0147-6513(78)90014-3","article-title":"Is phenobarbital carcinogenic? A follow-up of 8078 epileptics","volume":"1","year":"1978","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"key\n\t\t\t\t20171013194857_B9","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1093\/carcin\/7.2.215","article-title":"Interstrain differences in susceptibility to liver carcinogenesis initiated by N-nitrosodiethylamine and its promotion by phenobarbital in C57BL\/6NCr, C3H\/HeNCrMTV- and DBA\/2NCr mice","volume":"7","year":"1986","journal-title":"Carcinogenesis"},{"key":"key\n\t\t\t\t20171013194857_B10","first-page":"585","article-title":"Physiologically based pharmacokinetics model of primidone and its metabolites phenobarbital and phenylethylmalonamide in humans, rats, and mice","volume":"26","year":"1998","journal-title":"Drug Metab. Dispos."},{"key":"key\n\t\t\t\t20171013194857_B11","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1042\/bj2810359","article-title":"Relative expression of cytochrome P450 isoenzymes in human liver and association with the metabolism of drugs and xenobiotics","volume":"281","year":"1992","journal-title":"Biochem. J."},{"key":"key\n\t\t\t\t20171013194857_B12","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.tox.2013.03.019","article-title":"The time point of beta-catenin knockout in hepatocytes determines their response to xenobiotic activation of the constitutive androstane receptor","volume":"308","year":"2013","journal-title":"Toxicology"},{"key":"key\n\t\t\t\t20171013194857_B13","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1093\/toxsci\/kfu014","article-title":"Dose-response modeling of early molecular and cellular key events in the CAR-mediated hepatocarcinogenesis pathway","volume":"138","year":"2014","journal-title":"Toxicol. Sci."},{"key":"key\n\t\t\t\t20171013194857_B14","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1002\/hep.21082","article-title":"Zonal gene expression in murine liver: Lessons from tumors","volume":"43","year":"2006","journal-title":"Hepatology"},{"key":"key\n\t\t\t\t20171013194857_B15","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/BF00613432","article-title":"Brain concentrations of phenytoin, phenobarbitone and primidone in epileptic patients","volume":"9","year":"1975","journal-title":"Eur. J. Clin. Pharmacol."},{"key":"key\n\t\t\t\t20171013194857_B16","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1016\/j.fct.2009.03.014","article-title":"Effect of chronic phenobarbitone administration on liver tumour formation in the C57BL\/10J mouse","volume":"47","year":"2009","journal-title":"Food Chem. Toxicol."},{"key":"key\n\t\t\t\t20171013194857_B17","article-title":"Fieberkr\u00e4mpfe Wandlung in der Bewertung","volume":"80","year":"1983","journal-title":"Dt. \u00c4rzteblatt"},{"key":"key\n\t\t\t\t20171013194857_B18","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/s00228-002-0429-6","article-title":"Cancer incidence among patients using antiepileptic drugs: A long-term follow-up of 28,000 patients","volume":"58","year":"2002","journal-title":"Eur. J. Clin. Pharmacol."},{"key":"key\n\t\t\t\t20171013194857_B19","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.taap.2013.04.009","article-title":"An integrated approach for prospectively investigating a mode-of-action for rodent liver effects","volume":"270","year":"2013","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"key\n\t\t\t\t20171013194857_B20","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1177\/019262330002800201","article-title":"Paradoxical effects of phenobarbital on mouse hepatocarcinogenesis","volume":"28","year":"2000","journal-title":"Toxicol. Pathol."},{"key":"key\n\t\t\t\t20171013194857_B21","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1093\/toxsci\/kfu038","article-title":"Phenobarbital induces cell cycle transcriptional responses in humanized CAR\/PXR mouse liver","volume":"139","year":"2014","journal-title":"Toxicol. Sci."},{"key":"key\n\t\t\t\t20171013194857_B22","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1124\/dmd.31.4.421","article-title":"Effects of prototypical microsomal enzyme inducers on cytochrome P450 expression in cultured human hepatocytes","volume":"31","year":"2003","journal-title":"Drug Metab. Dispos."},{"key":"key\n\t\t\t\t20171013194857_B23","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1002\/ijc.24167","article-title":"Hepatocarcinogenesis in mice with a conditional knockout of the hepatocyte growth factor receptor c-Met","volume":"124","year":"2009","journal-title":"Int. J. Cancer"},{"key":"key\n\t\t\t\t20171013194857_B24","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1042\/bj2540789","article-title":"Regulation of phenobarbital-inducible cytochrome P-450s in rat and mouse liver following dexamethasone administration and hypophysectomy","volume":"254","year":"1988","journal-title":"Biochem. J."},{"key":"key\n\t\t\t\t20171013194857_B25","first-page":"5087","article-title":"Lack of phenobarbital-mediated promotion of hepatocarcinogenesis in connexin32-null mice","volume":"60","year":"2000","journal-title":"Cancer Res."},{"key":"key\n\t\t\t\t20171013194857_B26","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1093\/jnci\/81.10.803","article-title":"Cancer among epileptic patients exposed to anticonvulsant drugs","volume":"81","year":"1989","journal-title":"J. Natl. Cancer Inst."},{"key":"key\n\t\t\t\t20171013194857_B27","first-page":"294","article-title":"Antiepileptic treatment and risk for hepatobiliary cancer and malignant lymphoma","volume":"55","year":"1995","journal-title":"Cancer Res."},{"key":"key\n\t\t\t\t20171013194857_B28","doi-asserted-by":"crossref","first-page":"e45","DOI":"10.1093\/nar\/29.9.e45","article-title":"A new mathematical model for relative quantification in real-time RT-PCR","volume":"29","year":"2001","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20171013194857_B29","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1093\/carcin\/bgq226","article-title":"Tumor formation in liver of conditional beta-catenin-deficient mice exposed to a diethylnitrosamine\/phenobarbital tumor promotion regimen","volume":"32","year":"2011","journal-title":"Carcinogenesis"},{"key":"key\n\t\t\t\t20171013194857_B30","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1093\/toxsci\/kfq118","article-title":"Human constitutive androstane receptor (CAR) and pregnane X receptor (PXR) support the hypertrophic but not the hyperplastic response to the murine nongenotoxic hepatocarcinogens phenobarbital and chlordane in vivo","volume":"116","year":"2010","journal-title":"Toxicol. Sci."},{"key":"key\n\t\t\t\t20171013194857_B31","doi-asserted-by":"crossref","first-page":"8710","DOI":"10.1073\/pnas.91.18.8710","article-title":"Dissection of NADPH-cytochrome P450 oxidoreductase into distinct functional domains","volume":"91","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"key\n\t\t\t\t20171013194857_B32","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1111\/j.1365-2125.1978.tb01600.x","article-title":"Drug metabolism in epileptics: In vivo and in vitro correlations","volume":"5","year":"1978","journal-title":"Br. J. Clin. Pharmacol."},{"key":"key\n\t\t\t\t20171013194857_B33","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1093\/ajcp\/27.1.13","article-title":"Histochemistry of hepatic phosphatases of a physiologic pH; with special reference to the demonstration of bile canaliculi","volume":"27","year":"1957","journal-title":"Am. J. Clin. Pathol."},{"key":"key\n\t\t\t\t20171013194857_B34","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/0163-7258(96)00067-8","article-title":"Phenobarbital mechanistic data and risk assessment: Enzyme induction, enhanced cell proliferation, and tumor promotion","volume":"71","year":"1996","journal-title":"Pharmacol. Ther."},{"key":"key\n\t\t\t\t20171013194857_B35","doi-asserted-by":"crossref","first-page":"7197","DOI":"10.1158\/0008-5472.CAN-04-1459","article-title":"The orphan nuclear receptor constitutive active\/androstane receptor is essential for liver tumor promotion by phenobarbital in mice","volume":"64","year":"2004","journal-title":"Cancer Res."}],"container-title":["Toxicological Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/toxsci\/article-pdf\/140\/2\/259\/10916234\/kfu099.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,10,14]],"date-time":"2017-10-14T00:00:02Z","timestamp":1507939202000},"score":1,"resource":{"primary":{"URL":"http:\/\/academic.oup.com\/toxsci\/article\/140\/2\/259\/1694352\/PhenobarbitalMediated-Tumor-Promotion-in"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8,1]]},"references-count":35,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2014,8,2]]},"published-print":{"date-parts":[[2014,8,1]]}},"URL":"https:\/\/doi.org\/10.1093\/toxsci\/kfu099","relation":{},"ISSN":["1096-6080","1096-0929"],"issn-type":[{"value":"1096-6080","type":"print"},{"value":"1096-0929","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2014,8]]},"published":{"date-parts":[[2014,8,1]]}}}