{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T08:00:12Z","timestamp":1777190412150,"version":"3.51.4"},"reference-count":59,"publisher":"Oxford University Press (OUP)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,11,1]]},"DOI":"10.1093\/toxsci\/kfu163","type":"journal-article","created":{"date-parts":[[2014,8,15]],"date-time":"2014-08-15T08:41:43Z","timestamp":1408092103000},"page":"158-166","source":"Crossref","is-referenced-by-count":33,"title":["Autoantibodies Associated with Prenatal and Childhood Exposure to Environmental Chemicals in Faroese Children"],"prefix":"10.1093","volume":"142","author":[{"given":"Christa E.","family":"Osuna","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Grandjean","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P\u00e1l","family":"Weihe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hassan A. N.","family":"El-Fawal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2014,8,14]]},"reference":[{"key":"key\n\t\t\t\t20171012043850_B1","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1080\/15287394.2013.765369","article-title":"Autoantibodies to nervous system-specific proteins are elevated in sera of flight crew members: Biomarkers for nervous system injury","volume":"76","author":"Abou-Donia","year":"2013","journal-title":"J. Toxicol. Environ. Health. Part A"},{"key":"key\n\t\t\t\t20171012043850_B2","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/0006-8993(88)90581-1","article-title":"Uptake of methylmercury in the rat brain: Effects of amino acids","volume":"462","author":"Aschner","year":"1988","journal-title":"Brain Res."},{"key":"key\n\t\t\t\t20171012043850_B3","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/s10517-007-0300-y","article-title":"Autoantibodies to myosin light chains in the blood as early marker of myocardial injury after aortocoronary bypass surgery","volume":"144","author":"Bledzhyants","year":"2007","journal-title":"Bull. Experiment. Biol. Med."},{"key":"key\n\t\t\t\t20171012043850_B4","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1212\/WNL.56.4.529","article-title":"Antibodies to brain antigens following stroke","volume":"56","author":"Bornstein","year":"2001","journal-title":"Neurology"},{"key":"key\n\t\t\t\t20171012043850_B5","first-page":"1018","article-title":"Blood mercury levels in young children and childbearing-aged women\u2014United States, 1999\u20132002","volume":"53","author":"CDC","year":"2004","journal-title":"MMWR"},{"key":"key\n\t\t\t\t20171012043850_B6","first-page":"75","article-title":"Increased prevalence and coincidence of antinuclear and antithyroid antibodies in the population exposed to high levels of polychlorinated pollutants cocktail","volume":"43","author":"Cebecauer","year":"2009","journal-title":"Endocrine Regulations"},{"key":"key\n\t\t\t\t20171012043850_B7","first-page":"5","article-title":"Polychlorinated biphenyls: Persistent pollutants with immunological, neurological, and endocrinological consequences","volume":"16","author":"Crinnion","year":"2011","journal-title":"Altern. Med. Rev."},{"key":"key\n\t\t\t\t20171012043850_B8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/toxsci\/kfr218","article-title":"Exactly the same but different: Promiscuity and diversity in the molecular mechanisms of action of the aryl hydrocarbon (dioxin) receptor","volume":"124","author":"Denison","year":"2011","journal-title":"Toxicol. Sci."},{"key":"key\n\t\t\t\t20171012043850_B9","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1177\/0192623311428473","article-title":"Immunotoxicity of perfluorinated compounds: Recent developments","volume":"40","author":"DeWitt","year":"2012","journal-title":"Toxicol. Pathol."},{"key":"key\n\t\t\t\t20171012043850_B10","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1146\/annurev-immunol-020711-075041","article-title":"Brain-reactive antibodies and disease","volume":"31","author":"Diamond","year":"2013","journal-title":"Annu. Rev. Immunol."},{"key":"key\n\t\t\t\t20171012043850_B11","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1289\/ehp.1205351","article-title":"Serum polyfluoroalkyl concentrations, asthma outcomes, and immunological markers in a case-control study of Taiwanese children","volume":"121","author":"Dong","year":"2013","journal-title":"Environ. Health Perspect."},{"key":"key\n\t\t\t\t20171012043850_B12","first-page":"531","article-title":"Exposure to methylmercury results in serum autoantibodies to neurotypic and gliotypic proteins","volume":"17","author":"El-Fawal","year":"1996","journal-title":"Neurotoxicology"},{"key":"key\n\t\t\t\t20171012043850_B13","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.ntt.2008.01.005","article-title":"Antibodies to neural proteins in organophosphorus-induced delayed neuropathy (OPIDN) and its amelioration","volume":"30","author":"El-Fawal","year":"2008","journal-title":"Neurotoxicol. Teratol."},{"key":"key\n\t\t\t\t20171012043850_B14","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.neuro.2007.09.009","article-title":"Autoantibodies to neurotypic and gliotypic proteins as biomarkers of neurotoxicity: Assessment of trimethyltin (TMT)","volume":"29","author":"El-Fawal","year":"2008","journal-title":"Neurotoxicology"},{"key":"key\n\t\t\t\t20171012043850_B15","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1289\/ehp.99107s5767","article-title":"Neuroimmunotoxicology: Humoral assessment of neurotoxicity and autoimmune mechanisms","volume":"107","author":"El-Fawal","year":"1999","journal-title":"Environ. Health Perspect."},{"key":"key\n\t\t\t\t20171012043850_B16","doi-asserted-by":"crossref","first-page":"1874","DOI":"10.1093\/clinchem\/41.12.1874","article-title":"Markers of neurotoxicity: From behavior to autoantibodies against brain proteins","volume":"41","author":"Evans","year":"1995","journal-title":"Clin. Chem."},{"key":"key\n\t\t\t\t20171012043850_B17","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.ijheh.2013.01.004","article-title":"Polychlorinated biphenyls, mercury, and antinuclear antibody positivity, NHANES 2003\u20132004","volume":"216","author":"Gallagher","year":"2013","journal-title":"Int. J. Hyg. Environ. Health"},{"key":"key\n\t\t\t\t20171012043850_B18","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/S0026-895X(25)14997-3","article-title":"Cytosolic receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin. Evidence for a homologous nature among various mammalian species","volume":"26","author":"Gasiewicz","year":"1984","journal-title":"Mol. Pharmacol."},{"key":"key\n\t\t\t\t20171012043850_B19","doi-asserted-by":"crossref","first-page":"4479","DOI":"10.4049\/jimmunol.0713927","article-title":"Transcriptional modulation of the immune response by peroxisome proliferator-activated receptor-{alpha} agonists in autoimmune disease","volume":"182","author":"Gocke","year":"2009","journal-title":"J. Immunol."},{"key":"key\n\t\t\t\t20171012043850_B20","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1001\/jama.2011.2034","article-title":"Serum vaccine antibody concentrations in children exposed to perfluorinated compounds","volume":"307","author":"Grandjean","year":"2012","journal-title":"JAMA"},{"key":"key\n\t\t\t\t20171012043850_B21","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1289\/ehp.1002289","article-title":"Allergy and sensitization during childhood associated with prenatal and lactational exposure to marine pollutants","volume":"118","author":"Grandjean","year":"2010","journal-title":"Environ. Health Perspect."},{"key":"key\n\t\t\t\t20171012043850_B22","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1006\/enrs.1993.1062","article-title":"Neurobehavioral effects of intrauterine mercury exposure: Potential sources of bias","volume":"61","author":"Grandjean","year":"1993","journal-title":"Environ. Res."},{"key":"key\n\t\t\t\t20171012043850_B23","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1006\/enrs.1995.1064","article-title":"Relation of a seafood diet to mercury, selenium, arsenic, and polychlorinated biphenyl and other organochlorine concentrations in human milk","volume":"71","author":"Grandjean","year":"1995","journal-title":"Environ. Res."},{"key":"key\n\t\t\t\t20171012043850_B24","doi-asserted-by":"crossref","first-page":"373","DOI":"10.3109\/1547691X.2012.755580","article-title":"Pre-natal exposure to perfluoroalkyl substances may be associated with altered vaccine antibody levels and immune-related health outcomes in early childhood","volume":"10","author":"Granum","year":"2013","journal-title":"J. Immunotoxicol."},{"key":"key\n\t\t\t\t20171012043850_B25","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1055\/s-0029-1220768","article-title":"Polychlorinated biphenyls affect thyroid function and induce autoimmunity in Sprague-Dawley rats","volume":"41","author":"Gu","year":"2009","journal-title":"Hormone Metabolic Res."},{"key":"key\n\t\t\t\t20171012043850_B26","doi-asserted-by":"crossref","first-page":"8151","DOI":"10.1021\/es103712g","article-title":"Perfluorochemical (PFC) exposure in children: Associations with impaired response inhibition","volume":"45","author":"Gump","year":"2011","journal-title":"Environ. Sci. Technol."},{"key":"key\n\t\t\t\t20171012043850_B27","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s12199-008-0058-5","article-title":"Environmental and biological monitoring of persistent fluorinated compounds in Japan and their toxicities","volume":"14","author":"Harada","year":"2009","journal-title":"Environ. Health Prev. Med."},{"key":"key\n\t\t\t\t20171012043850_B28","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.chroma.2008.10.113","article-title":"A sensitive method for determination of a broad range of perfluorinated compounds in serum suitable for large-scale human biomonitoring","volume":"1216","author":"Haug","year":"2009","journal-title":"J. Chromatogr. A"},{"key":"key\n\t\t\t\t20171012043850_B29","doi-asserted-by":"crossref","first-page":"353","DOI":"10.3961\/jpmph.2012.45.6.353","article-title":"Methylmercury exposure and health effects","volume":"45","author":"Hong","year":"2012","journal-title":"J. Prevent. Med. Public Health"},{"key":"key\n\t\t\t\t20171012043850_B30","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1016\/j.neuro.2012.10.016","article-title":"Does developmental exposure to perflurooctanoic acid (PFOA) induce immunopathologies commonly observed in neurodevelopmental disorders","volume":"33","author":"Hu","year":"2012","journal-title":"Neurotoxicology"},{"key":"key\n\t\t\t\t20171012043850_B31","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1507\/endocrj.46.765","article-title":"Expression of Ah receptor and dioxin-related genes in human uterine endometrium in women with or without endometriosis","volume":"46","author":"Igarashi","year":"1999","journal-title":"Endocr. J."},{"key":"key\n\t\t\t\t20171012043850_B32","doi-asserted-by":"crossref","first-page":"8037","DOI":"10.1021\/es1043613","article-title":"Trends in exposure to polyfluoroalkyl chemicals in the U.S. population: 1999\u20132008","volume":"45","author":"Kato","year":"2011","journal-title":"Environ. Sci. Technol."},{"key":"key\n\t\t\t\t20171012043850_B33","doi-asserted-by":"crossref","first-page":"a003996","DOI":"10.1101\/cshperspect.a003996","article-title":"Ryanodine receptors: Structure, expression, molecular details, and function in calcium release","volume":"2","author":"Lanner","year":"2010","journal-title":"Cold Spring Harbor Perspect. Biol."},{"key":"key\n\t\t\t\t20171012043850_B34","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1093\/toxsci\/kfm128","article-title":"Perfluoroalkyl acids: A review of monitoring and toxicological findings","volume":"99","author":"Lau","year":"2007","journal-title":"Toxicol. Sci."},{"key":"key\n\t\t\t\t20171012043850_B35","doi-asserted-by":"crossref","first-page":"7954","DOI":"10.1021\/es2011622","article-title":"Polyfluorinated compounds: Past, present, and future","volume":"45","author":"Lindstrom","year":"2011","journal-title":"Environ. Sci. Technol."},{"key":"key\n\t\t\t\t20171012043850_B36","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1093\/aje\/kwr328","article-title":"Prenatal exposure to mercury and infant neurodevelopment in a multicenter cohort in Spain: Study of potential modifiers","volume":"175","author":"Llop","year":"2012","journal-title":"Am. J. Epidemiol."},{"key":"key\n\t\t\t\t20171012043850_B37","doi-asserted-by":"crossref","first-page":"e56805","DOI":"10.1371\/journal.pone.0056805","article-title":"Consequences of repeated blood-brain barrier disruption in football players","volume":"8","author":"Marchi","year":"2013","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20171012043850_B38","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1007\/s00204-012-0822-6","article-title":"Neurotoxic effects of perfluoroalkylated compounds: Mechanisms of action and environmental relevance","volume":"86","author":"Mariussen","year":"2012","journal-title":"Arch. Toxicol."},{"key":"key\n\t\t\t\t20171012043850_B39","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1111\/j.1432-1033.1982.tb06518.x","article-title":"Cytosolic and nuclear binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin to the Ah receptor in extra-hepatic tissues of rats and mice","volume":"123","author":"Mason","year":"1982","journal-title":"Eur. J. Biochem."},{"key":"key\n\t\t\t\t20171012043850_B40","doi-asserted-by":"crossref","first-page":"7590","DOI":"10.1073\/pnas.79.23.7590","article-title":"High actin concentrations in brain dendritic spines and postsynaptic densities","volume":"79","author":"Matus","year":"1982","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"key\n\t\t\t\t20171012043850_B41","first-page":"615","article-title":"Autoimmune mechanisms in chronic hepatitis B and delta virus infections","volume":"7","author":"McFarlane","year":"1995","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"key\n\t\t\t\t20171012043850_B42","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1172\/JCI29943","article-title":"Newborn humans manifest autoantibodies to defined self molecules detected by antigen microarray informatics","volume":"117","author":"Merbl","year":"2007","journal-title":"J. Clin. Invest."},{"key":"key\n\t\t\t\t20171012043850_B43","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1007\/s004010050394","article-title":"Apoptotic process of cerebellar degeneration in experimental methylmercury intoxication of rats","volume":"91","author":"Nagashima","year":"1996","journal-title":"Acta Neuropathol."},{"key":"key\n\t\t\t\t20171012043850_B44","doi-asserted-by":"crossref","first-page":"e60726","DOI":"10.1371\/journal.pone.0060726","article-title":"Natural IgG autoantibodies are abundant and ubiquitous in human sera, and their number is influenced by age, gender, and disease","volume":"8","author":"Nagele","year":"2013","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20171012043850_B45","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1096\/fasebj.12.14.1559","article-title":"Isolation of cDNA clones coding for IgE autoantigens with serum IgE from atopic dermatitis patients","volume":"12","author":"Natter","year":"1998","journal-title":"FASEB J."},{"key":"key\n\t\t\t\t20171012043850_B46","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1385\/IR:36:1:3","article-title":"Apoptosis and autoimmunity","volume":"36","author":"Navratil","year":"2006","journal-title":"Immunol. Res."},{"key":"key\n\t\t\t\t20171012043850_B47","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1080\/15287390701457688","article-title":"Age-specific reference ranges for polychlorinated biphenyls (PCB) based on the NHANES 2001\u20132002 survey","volume":"70","author":"Nichols","year":"2007","journal-title":"J. Toxicol. Environ. Health A"},{"key":"key\n\t\t\t\t20171012043850_B48","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/s002040050075","article-title":"Evaluation of mercury in hair, blood and muscle as biomarkers for methylmercury exposure in male and female mice","volume":"68","author":"Nielsen","year":"1994","journal-title":"Arch. Toxicol."},{"key":"key\n\t\t\t\t20171012043850_B49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.yexcr.2004.08.004","article-title":"Desmin: A major intermediate filament protein essential for the structural integrity and function of muscle","volume":"301","author":"Paulin","year":"2004","journal-title":"Exp. Cell Res."},{"key":"key\n\t\t\t\t20171012043850_B50","doi-asserted-by":"crossref","first-page":"5545","DOI":"10.1073\/pnas.082114899","article-title":"T-bet regulates IgG class switching and pathogenic autoantibody production","volume":"99","author":"Peng","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"key\n\t\t\t\t20171012043850_B51","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.envres.2012.03.007","article-title":"Perfluorooctanoic acid (PFOA), an emerging drinking water contaminant: A critical review of recent literature","volume":"116","author":"Post","year":"2012","journal-title":"Environ. Res."},{"key":"key\n\t\t\t\t20171012043850_B52","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1038\/nature06880","article-title":"Control of T(reg) and T(H)17 cell differentiation by the aryl hydrocarbon receptor","volume":"453","author":"Quintana","year":"2008","journal-title":"Nature"},{"key":"key\n\t\t\t\t20171012043850_B53","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1007\/s00204-010-0538-4","article-title":"Identification and distribution of mercury species in rat tissues following administration of thimerosal or methylmercury","volume":"84","author":"Rodrigues","year":"2010","journal-title":"Arch. Toxicol."},{"key":"key\n\t\t\t\t20171012043850_B54","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1939-4551-6-8","article-title":"Association between autoimmune reactions and severity of atopic dermatitis in children with herpes virus infection","volume":"6","author":"Samoylikov","year":"2013","journal-title":"Wld Allergy Org. J."},{"key":"key\n\t\t\t\t20171012043850_B55","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/nri2508","article-title":"B-cell responses to vaccination at the extremes of age","volume":"9","author":"Siegrist","year":"2009","journal-title":"Nat. Rev. Immunol."},{"key":"key\n\t\t\t\t20171012043850_B56","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1289\/ehp.11253","article-title":"Developmental neurotoxicity of perfluorinated chemicals modeled in vitro","volume":"116","author":"Slotkin","year":"2008","journal-title":"Environ. Health Perspect."},{"key":"key\n\t\t\t\t20171012043850_B57","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0378-4274(98)00022-8","article-title":"The effect of methylmercury on skeletal muscle in the rat: A histopathological study","volume":"94","author":"Usuki","year":"1998","journal-title":"Toxicol. Lett."},{"key":"key\n\t\t\t\t20171012043850_B58","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1093\/toxsci\/kfl014","article-title":"Differential activation of nuclear receptors by perfluorinated fatty acid analogs and natural fatty acids: A comparison of human, mouse, and rat peroxisome proliferator-activated receptor-alpha, -beta, and -gamma, liver X receptor-beta, and retinoid X receptor-alpha","volume":"92","author":"Vanden Heuvel","year":"2006","journal-title":"Toxicol. Sci."},{"key":"key\n\t\t\t\t20171012043850_B59","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1038\/labinvest.2008.53","article-title":"Autoantibodies and neurodegeneration in multiple sclerosis","volume":"88","author":"Vyshkina","year":"2008","journal-title":"Laboratory Invest."}],"container-title":["Toxicological Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/toxsci\/article-pdf\/142\/1\/158\/16690248\/kfu163.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,4]],"date-time":"2025-05-04T06:43:08Z","timestamp":1746340988000},"score":1,"resource":{"primary":{"URL":"http:\/\/academic.oup.com\/toxsci\/article\/142\/1\/158\/1707685\/Autoantibodies-Associated-with-Prenatal-and"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8,14]]},"references-count":59,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2014,8,14]]},"published-print":{"date-parts":[[2014,11,1]]}},"URL":"https:\/\/doi.org\/10.1093\/toxsci\/kfu163","relation":{},"ISSN":["1096-0929","1096-6080"],"issn-type":[{"value":"1096-0929","type":"electronic"},{"value":"1096-6080","type":"print"}],"subject":[],"published-other":{"date-parts":[[2014,11]]},"published":{"date-parts":[[2014,8,14]]}}}