{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T21:30:49Z","timestamp":1791408649743,"version":"4.3.3"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicol. Sci."],"published-print":{"date-parts":[[2016,1]]},"DOI":"10.1093\/toxsci\/kfv213","type":"journal-article","created":{"date-parts":[[2015,10,6]],"date-time":"2015-10-06T20:28:39Z","timestamp":1444163319000},"page":"111-120","source":"Crossref","is-referenced-by-count":27,"title":["The Synthetic Triterpenoid RTA 405 (CDDO-EA) Halts Progression of Liver Fibrosis and Reduces Hepatocellular Carcinoma Size Resulting in Increased Survival in an Experimental Model of Chronic Liver Injury"],"prefix":"10.1093","volume":"149","author":[{"given":"Yonas","family":"Getachew","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank A.","family":"Cusimano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Purva","family":"Gopal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott A.","family":"Reisman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerry W.","family":"Shay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2015,10,5]]},"reference":[{"key":"2016080300130251000_149.1.111.1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-07-3036"},{"key":"2016080300130251000_149.1.111.2","doi-asserted-by":"publisher","DOI":"10.1097\/MOG.0b013e3280b17dfb"},{"key":"2016080300130251000_149.1.111.3","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1172\/JCI18212","article-title":"NADPH oxidase signal transduces angiotensin II in hepatic stellate cells and is critical in hepatic fibrosis","volume":"112","author":"Bataller","year":"2003","journal-title":"J. Clin. Invest."},{"key":"2016080300130251000_149.1.111.4","unstructured":"Council N. R. (National Research Council of the National Academics) (1996). Guide for the Care and Use of Laboratory Animals. National Academy Press, Washington."},{"key":"2016080300130251000_149.1.111.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2009.09.006"},{"key":"2016080300130251000_149.1.111.6","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(03)00666-8"},{"key":"2016080300130251000_149.1.111.7","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-008-0785-8"},{"key":"2016080300130251000_149.1.111.8","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00013.2007"},{"key":"2016080300130251000_149.1.111.9","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.03.003"},{"key":"2016080300130251000_149.1.111.10","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-10-79"},{"key":"2016080300130251000_149.1.111.11","first-page":"785","article-title":"Synthetic triterpenoids inhibit growth, induce apoptosis and suppress pro-survival Akt, mTOR and NF-(Ahmad et\u00a0al.)B signaling proteins in colorectal cancer cells","volume":"30","author":"Gao","year":"2010","journal-title":"Anticancer Res."},{"key":"2016080300130251000_149.1.111.12","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2009.12.019"},{"key":"2016080300130251000_149.1.111.13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2010.07919.x"},{"key":"2016080300130251000_149.1.111.14","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201102031"},{"key":"2016080300130251000_149.1.111.15","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.127.6.2037"},{"key":"2016080300130251000_149.1.111.16","doi-asserted-by":"publisher","DOI":"10.1258\/ebm.2011.011219"},{"key":"2016080300130251000_149.1.111.17","first-page":"349","article-title":"A novel method for accurate collagen and biochemical assessment of pulmonary tissue utilizing one animal","volume":"4","author":"Kliment","year":"2011","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"2016080300130251000_149.1.111.18","doi-asserted-by":"publisher","DOI":"10.1097\/MCC.0b013e3282f6a420"},{"key":"2016080300130251000_149.1.111.19","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcna.2009.03.002"},{"key":"2016080300130251000_149.1.111.20","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2010.090414"},{"key":"2016080300130251000_149.1.111.21","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-4534"},{"key":"2016080300130251000_149.1.111.22","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-10-0197"},{"key":"2016080300130251000_149.1.111.23","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcna.2009.03.005"},{"key":"2016080300130251000_149.1.111.24","first-page":"1","article-title":"Deaths: Preliminary data for 2004","volume":"54","author":"Minino","year":"2006","journal-title":"Nat. Vital Stat. Rep."},{"key":"2016080300130251000_149.1.111.25","first-page":"69","article-title":"The role of gelatinases in colorectal cancer progression and metastasis","volume":"1705","author":"Mook","year":"2004","journal-title":"Biochim. Biophys. Acta"},{"key":"2016080300130251000_149.1.111.26","doi-asserted-by":"crossref","first-page":"6406","DOI":"10.1038\/sj.onc.1208788","article-title":"Methylation silencing of SOCS-3 promotes cell growth and migration by enhancing JAK\/STAT and FAK signalings in human hepatocellular carcinoma","volume":"24","author":"Niwa","year":"2005","journal-title":"Oncogene"},{"key":"2016080300130251000_149.1.111.27","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1209281"},{"key":"2016080300130251000_149.1.111.28","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.10.055"},{"key":"2016080300130251000_149.1.111.29","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2008.12.024"},{"key":"2016080300130251000_149.1.111.30","doi-asserted-by":"publisher","DOI":"10.1007\/BF01609080"},{"key":"2016080300130251000_149.1.111.31","doi-asserted-by":"publisher","DOI":"10.1038\/nm1663"},{"key":"2016080300130251000_149.1.111.32","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-05-2044"},{"key":"2016080300130251000_149.1.111.33","doi-asserted-by":"publisher","DOI":"10.1021\/np100826q"},{"key":"2016080300130251000_149.1.111.34","first-page":"1371","article-title":"Synthetic triterpenoids enhance transforming growth factor beta\/Smad signaling","volume":"63","author":"Suh","year":"2003","journal-title":"Cancer Res."},{"key":"2016080300130251000_149.1.111.35","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00026.2010"},{"key":"2016080300130251000_149.1.111.36","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.3748\/wjg.v12.i12.1918","article-title":"Effects of interleukin-10 on activation and apoptosis of hepatic stellate cells in fibrotic rat liver","volume":"12","author":"Zhang","year":"2006","journal-title":"World J. Gastroenterol."},{"key":"2016080300130251000_149.1.111.37","doi-asserted-by":"publisher","DOI":"10.4161\/cbt.6.10.4763"},{"key":"2016080300130251000_149.1.111.38","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-08-1318"}],"container-title":["Toxicological Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/toxsci\/article-pdf\/149\/1\/111\/16689217\/kfv213.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,31]],"date-time":"2019-08-31T04:13:01Z","timestamp":1567224781000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/toxsci\/article-lookup\/doi\/10.1093\/toxsci\/kfv213"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10,5]]},"references-count":38,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2016,1,4]]},"published-print":{"date-parts":[[2016,1]]}},"alternative-id":["10.1093\/toxsci\/kfv213"],"URL":"https:\/\/doi.org\/10.1093\/toxsci\/kfv213","relation":{},"ISSN":["1096-6080","1096-0929"],"issn-type":[{"value":"1096-6080","type":"print"},{"value":"1096-0929","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,5]]}}}