{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T08:13:37Z","timestamp":1789028017912,"version":"build-2803163510"},"reference-count":58,"publisher":"Oxford University Press (OUP)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicol. Sci."],"published-print":{"date-parts":[[2016,7]]},"DOI":"10.1093\/toxsci\/kfw065","type":"journal-article","created":{"date-parts":[[2016,4,12]],"date-time":"2016-04-12T21:30:10Z","timestamp":1460496610000},"page":"40-52","source":"Crossref","is-referenced-by-count":76,"title":["Generation of a New Model Rat:\n                    <i>Nrf2<\/i>\n                    Knockout Rats Are Sensitive to Aflatoxin B\n                    <sub>1<\/sub>\n                    Toxicity"],"prefix":"10.1093","volume":"152","author":[{"given":"Keiko","family":"Taguchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Misaki","family":"Takaku","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia A.","family":"Egner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanobu","family":"Morita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takehito","family":"Kaneko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoji","family":"Mashimo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas W.","family":"Kensler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2016,4,12]]},"reference":[{"key":"2016062709342166000_152.1.40.1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.115.6.1173"},{"key":"2016062709342166000_152.1.40.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2015.01.010"},{"key":"2016062709342166000_152.1.40.3","doi-asserted-by":"publisher","DOI":"10.1021\/tx060108d"},{"key":"2016062709342166000_152.1.40.4","doi-asserted-by":"publisher","DOI":"10.1021\/tx034106u"},{"key":"2016062709342166000_152.1.40.5","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1099\/00221287-144-6-1611","article-title":"PAGE analysis of the heteroduplexes formed between PCR-amplified 16S rRNA genes: Estimation of sequence similarity and rDNA complexity","volume":"144","author":"Espejo","year":"1998","journal-title":"Microbiol-Uk"},{"key":"2016062709342166000_152.1.40.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2005.08.162"},{"key":"2016062709342166000_152.1.40.7","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.01191-13"},{"key":"2016062709342166000_152.1.40.8","doi-asserted-by":"crossref","first-page":"80","DOI":"10.2183\/pjab1945.51.80","article-title":"Spontaneous diabetes produced by selective breeding of normal wistar rats","volume":"51","author":"Goto","year":"1975","journal-title":"Proc. Jpn. Acad"},{"key":"2016062709342166000_152.1.40.9","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2013.06.024"},{"key":"2016062709342166000_152.1.40.10","doi-asserted-by":"publisher","DOI":"10.2131\/jts.37.491"},{"key":"2016062709342166000_152.1.40.11","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks827"},{"key":"2016062709342166000_152.1.40.12","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1997.6943"},{"key":"2016062709342166000_152.1.40.13","doi-asserted-by":"publisher","DOI":"10.1101\/gr.9.11.1013"},{"key":"2016062709342166000_152.1.40.14","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-13-0430"},{"key":"2016062709342166000_152.1.40.15","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfu056"},{"key":"2016062709342166000_152.1.40.16","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/6.5.759"},{"key":"2016062709342166000_152.1.40.17","doi-asserted-by":"crossref","first-page":"S28","DOI":"10.1093\/toxsci\/kfq283","article-title":"Aflatoxin: a 50-year odyssey of mechanistic and translational toxicology","volume":"120 Suppl 1","author":"Kensler","year":"2011","journal-title":"Toxicol. Sci"},{"key":"2016062709342166000_152.1.40.18","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.24.16.7130-7139.2004"},{"key":"2016062709342166000_152.1.40.19","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(93)90471-X"},{"key":"2016062709342166000_152.1.40.20","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.12.006"},{"key":"2016062709342166000_152.1.40.21","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1310"},{"key":"2016062709342166000_152.1.40.22","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2008.06.004"},{"key":"2016062709342166000_152.1.40.23","doi-asserted-by":"publisher","DOI":"10.1111\/dgd.12110"},{"key":"2016062709342166000_152.1.40.24","doi-asserted-by":"crossref","unstructured":"Mashimo T. Takizawa A. Voigt B. Yoshimi K. Hiai H. Kuramoto T. Serikawa T. (2010). Generation of knockout rats with X-Linked severe combined immunodeficiency (X-SCID) using zinc-finger nucleases. PLoS One 5,","DOI":"10.1371\/journal.pone.0008870"},{"key":"2016062709342166000_152.1.40.25","doi-asserted-by":"publisher","DOI":"10.1042\/bj3000117"},{"key":"2016062709342166000_152.1.40.26","doi-asserted-by":"publisher","DOI":"10.1021\/tx3000945"},{"key":"2016062709342166000_152.1.40.27","doi-asserted-by":"publisher","DOI":"10.1021\/tx3000945"},{"key":"2016062709342166000_152.1.40.28","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2012.05.016"},{"key":"2016062709342166000_152.1.40.29","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-07-5003"},{"key":"2016062709342166000_152.1.40.30","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2005.10.185"},{"key":"2016062709342166000_152.1.40.31","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2006.01.013"},{"key":"2016062709342166000_152.1.40.32","doi-asserted-by":"crossref","first-page":"H478","DOI":"10.1152\/ajpheart.00586.2015","article-title":"The Nrf2 knockout rat: a new animal model to study ndothelial dysfunction, oxidant stress, and microvascular rarefaction","volume":"310","author":"Priestley","year":"2015","journal-title":"Am. J. Physiol. Heart Circ. Physiol"},{"key":"2016062709342166000_152.1.40.33","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfp003"},{"key":"2016062709342166000_152.1.40.34","doi-asserted-by":"publisher","DOI":"10.1021\/tx050251r"},{"key":"2016062709342166000_152.1.40.35","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0030420"},{"key":"2016062709342166000_152.1.40.36","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfu109"},{"key":"2016062709342166000_152.1.40.37","first-page":"595","article-title":"Rapid emergence of carcinogen-induced hyperplastic lesions in a new model for the sequential analysis of liver carcinogenesis","volume":"88","author":"Solt","year":"1977","journal-title":"Am. J. Pathol"},{"key":"2016062709342166000_152.1.40.38","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0400282101"},{"key":"2016062709342166000_152.1.40.39","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00065-13"},{"key":"2016062709342166000_152.1.40.40","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.01384-13"},{"key":"2016062709342166000_152.1.40.41","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.01591-09"},{"key":"2016062709342166000_152.1.40.42","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2443.2010.01473.x"},{"key":"2016062709342166000_152.1.40.43","doi-asserted-by":"crossref","unstructured":"Taguchi K. Yamamoto M. (2015). Keap1-Nrf2 regulatory system and cancer, Chapter 17. In Inoue J and Takekawa M. Protein modifications in pathogenic dysregulation of signaling. Springer Japan, 269-285.","DOI":"10.1007\/978-4-431-55561-2_17"},{"key":"2016062709342166000_152.1.40.44","doi-asserted-by":"publisher","DOI":"10.1038\/ng1248"},{"key":"2016062709342166000_152.1.40.45","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgn095"},{"key":"2016062709342166000_152.1.40.46","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2443.2007.01118.x"},{"key":"2016062709342166000_152.1.40.47","first-page":"179","article-title":"Aflatoxin albumin adducts: a basis for comparative carcinogenesis between animals and humans","volume":"5","author":"Wild","year":"1996","journal-title":"Cancer Epidemiol. Biomarkers Prev"},{"key":"2016062709342166000_152.1.40.48","doi-asserted-by":"publisher","DOI":"10.1093\/mutage\/17.6.471"},{"key":"2016062709342166000_152.1.40.49","first-page":"183","article-title":"Rats with congenital tremor and curled whiskers and hair","volume":"34","author":"Yamada","year":"1985","journal-title":"Jikken Dobutsu"},{"key":"2016062709342166000_152.1.40.50","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0097419"},{"key":"2016062709342166000_152.1.40.51","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.7.1.46"},{"key":"2016062709342166000_152.1.40.52","doi-asserted-by":"publisher","DOI":"10.1111\/j.1356-9597.2004.00753.x"},{"key":"2016062709342166000_152.1.40.53","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-3823"},{"key":"2016062709342166000_152.1.40.54","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.138636"},{"key":"2016062709342166000_152.1.40.55","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27790"},{"key":"2016062709342166000_152.1.40.56","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-09-0589"},{"key":"2016062709342166000_152.1.40.57","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0059122"},{"key":"2016062709342166000_152.1.40.58","doi-asserted-by":"publisher","DOI":"10.1038\/srep06420"}],"container-title":["Toxicological Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/toxsci\/article-pdf\/152\/1\/40\/10992636\/kfw065.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,6]],"date-time":"2019-09-06T10:45:13Z","timestamp":1567766713000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/toxsci\/article-lookup\/doi\/10.1093\/toxsci\/kfw065"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4,12]]},"references-count":58,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2016,6,27]]},"published-print":{"date-parts":[[2016,7]]}},"alternative-id":["10.1093\/toxsci\/kfw065"],"URL":"https:\/\/doi.org\/10.1093\/toxsci\/kfw065","relation":{},"ISSN":["1096-6080","1096-0929"],"issn-type":[{"value":"1096-6080","type":"print"},{"value":"1096-0929","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4,12]]}}}