{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T11:20:28Z","timestamp":1777116028310,"version":"3.51.4"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicol. Sci."],"published-print":{"date-parts":[[2016,8]]},"DOI":"10.1093\/toxsci\/kfw098","type":"journal-article","created":{"date-parts":[[2016,6,3]],"date-time":"2016-06-03T02:54:10Z","timestamp":1464922450000},"page":"417-428","source":"Crossref","is-referenced-by-count":38,"title":["Pyrazinamide Induced Rat Cholestatic Liver Injury through Inhibition of FXR Regulatory Effect on Bile Acid Synthesis and Transport"],"prefix":"10.1093","volume":"152","author":[{"given":"Hong-Li","family":"Guo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hozeifa M.","family":"Hassan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Si-Zhe","family":"Dong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping-Ping","family":"Ding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-Xin","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu-Yong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen-Zhou","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2016,6,2]]},"reference":[{"key":"2016072604583465000_152.2.417.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-2115(98)00086-4"},{"key":"2016072604583465000_152.2.417.2","first-page":"289","article-title":"Fatal and severe hepatitis associated with rifampin and pyrazinamide for the treatment of latent tuberculosis infection\u2013New York and Georgia, 2000","volume":"50","author":"Centers for Disease, C., and Prevention","year":"2001","journal-title":"MMWR. Morb. Mortal. Wkly. Rep"},{"key":"2016072604583465000_152.2.417.3","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200802-355OC"},{"key":"2016072604583465000_152.2.417.4","first-page":"194","article-title":"Hepatic functional changes induced by the combined use of isoniazid, pyrazinamide and rifampicin in the treatment of pulmonary tuberculosis","volume":"33","author":"de Souza","year":"1996","journal-title":"Arq. Gastroenterol"},{"key":"2016072604583465000_152.2.417.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2007.06.001"},{"key":"2016072604583465000_152.2.417.6","first-page":"1114","article-title":"Clinical examination of serum bile acids for the diagnosis of hepatobiliary diseases","volume":"37","author":"Fujiwara","year":"1989","journal-title":"Rinsho Byori"},{"key":"2016072604583465000_152.2.417.7","first-page":"249","article-title":"Fulminant liver failure caused by antitubercular drugs. Report of a clinical case","volume":"66","author":"Girotto","year":"2000","journal-title":"Minerva Anestesiol"},{"key":"2016072604583465000_152.2.417.8","doi-asserted-by":"publisher","DOI":"10.1111\/joim.12140"},{"key":"2016072604583465000_152.2.417.9","first-page":"93","article-title":"Variability in the relationship between serum creatinine and creatinine clearance in hypertensives and normotensives with normal renal function","volume":"29","author":"Kadiri","year":"2000","journal-title":"Afr. J. Med. Sci."},{"key":"2016072604583465000_152.2.417.10","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109326200"},{"key":"2016072604583465000_152.2.417.11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2014.04.009"},{"key":"2016072604583465000_152.2.417.12","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/S0022-2275(20)33344-7","article-title":"Differential effects of 17alpha-ethinylestradiol on the neutral and acidic pathways of bile salt synthesis in the rat","volume":"40","author":"Koopen","year":"1999","journal-title":"J. Lipid Res"},{"key":"2016072604583465000_152.2.417.13","doi-asserted-by":"publisher","DOI":"10.1023\/B:REMD.0000045103.00467.9a"},{"key":"2016072604583465000_152.2.417.14","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(00)00050-2"},{"key":"2016072604583465000_152.2.417.15","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.08.029"},{"key":"2016072604583465000_152.2.417.16","doi-asserted-by":"publisher","DOI":"10.1126\/science.284.5418.1362"},{"key":"2016072604583465000_152.2.417.17","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2006.050126"},{"key":"2016072604583465000_152.2.417.18","doi-asserted-by":"publisher","DOI":"10.1378\/chest.123.1.102"},{"key":"2016072604583465000_152.2.417.19","doi-asserted-by":"publisher","DOI":"10.2337\/db13-0299"},{"key":"2016072604583465000_152.2.417.20","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.10.028"},{"key":"2016072604583465000_152.2.417.21","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1016\/S0022-2275(20)32033-2","article-title":"Sphingomyelin exhibits greatly enhanced protection compared with egg yolk phosphatidylcholine against detergent bile salts","volume":"41","author":"Moschetta","year":"2000","journal-title":"J. Lipid Res"},{"key":"2016072604583465000_152.2.417.22","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.05.042"},{"key":"2016072604583465000_152.2.417.23","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-006-0062-9"},{"key":"2016072604583465000_152.2.417.24","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2002.36088"},{"key":"2016072604583465000_152.2.417.25","doi-asserted-by":"crossref","first-page":"359","DOI":"10.33549\/physiolres.932665","article-title":"The effect of heme oxygenase on ganglioside redistribution within hepatocytes in experimental estrogen-induced cholestasis","volume":"63","author":"Petr","year":"2014","journal-title":"Physiol. Res"},{"key":"2016072604583465000_152.2.417.26","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.05988-11"},{"key":"2016072604583465000_152.2.417.27","doi-asserted-by":"publisher","DOI":"10.1038\/86871"},{"key":"2016072604583465000_152.2.417.28","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01866-12"},{"key":"2016072604583465000_152.2.417.29","doi-asserted-by":"publisher","DOI":"10.5588\/ijtld.12.0782"},{"key":"2016072604583465000_152.2.417.30","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.2014.873404"},{"key":"2016072604583465000_152.2.417.31","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)00062-3"},{"key":"2016072604583465000_152.2.417.32","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2619"},{"key":"2016072604583465000_152.2.417.33","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.1999.00596.x"},{"key":"2016072604583465000_152.2.417.34","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2011.22"},{"key":"2016072604583465000_152.2.417.35","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.envres.2006.10.001","article-title":"Implications of gender differences for human health risk assessment and toxicology","volume":"104","author":"Vahter","year":"2007","journal-title":"Environ. Res"},{"key":"2016072604583465000_152.2.417.36","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0000000000000046"},{"key":"2016072604583465000_152.2.417.37","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26939"},{"key":"2016072604583465000_152.2.417.38","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2014.10.009"},{"key":"2016072604583465000_152.2.417.39","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(02)00247-7"},{"key":"2016072604583465000_152.2.417.40","doi-asserted-by":"publisher","DOI":"10.1124\/mol.112.081752"},{"key":"2016072604583465000_152.2.417.41","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00006205"},{"key":"2016072604583465000_152.2.417.42","doi-asserted-by":"publisher","DOI":"10.1002\/jat.2736"}],"container-title":["Toxicological Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/toxsci\/article-pdf\/152\/2\/417\/16691608\/kfw098.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:52:42Z","timestamp":1656636762000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/toxsci\/article-lookup\/doi\/10.1093\/toxsci\/kfw098"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6,2]]},"references-count":42,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2016,7,25]]},"published-print":{"date-parts":[[2016,8]]}},"alternative-id":["10.1093\/toxsci\/kfw098"],"URL":"https:\/\/doi.org\/10.1093\/toxsci\/kfw098","relation":{},"ISSN":["1096-6080","1096-0929"],"issn-type":[{"value":"1096-6080","type":"print"},{"value":"1096-0929","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,2]]}}}