{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T14:45:37Z","timestamp":1787928337946,"version":"build-2784847793"},"reference-count":56,"publisher":"Oxford University Press (OUP)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicol. Sci."],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1093\/toxsci\/kfw106","type":"journal-article","created":{"date-parts":[[2016,6,11]],"date-time":"2016-06-11T05:05:39Z","timestamp":1465621539000},"page":"79-88","source":"Crossref","is-referenced-by-count":50,"title":["Vesicular Monoamine Transporter 2 (VMAT2) Level Regulates MPTP Vulnerability and Clearance of Excess Dopamine in Mouse Striatal Terminals"],"prefix":"10.1093","volume":"153","author":[{"given":"Kelly M.","family":"Lohr","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merry","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlie A.","family":"Hoffman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miranda J.","family":"McDaniel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen A.","family":"Stout","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy R.","family":"Dunn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minzheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison I.","family":"Bernstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary W.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2016,6,10]]},"reference":[{"key":"2016083122413294000_153.1.79.1","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.expneurol.2015.09.016","article-title":"Reduced vesicular monoamine transport disrupts serotonin signaling but does not cause serotonergic degeneration","volume":"275(Pt 1)","author":"Alter","year":"2016","journal-title":"Exp. Neurol"},{"key":"2016083122413294000_153.1.79.2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20904"},{"key":"2016083122413294000_153.1.79.3","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfh153"},{"key":"2016083122413294000_153.1.79.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2012.12.020"},{"key":"2016083122413294000_153.1.79.5","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(08)00922-9"},{"key":"2016083122413294000_153.1.79.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2012.04.011"},{"key":"2016083122413294000_153.1.79.7","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0319-07.2007"},{"key":"2016083122413294000_153.1.79.8","doi-asserted-by":"crossref","first-page":"242","DOI":"10.3389\/fneur.2014.00242","article-title":"Presynaptic mechanisms of L-DOPA-induced dyskinesia: the findings, the debate, and the therapeutic implications","volume":"5","author":"Cenci","year":"2014","journal-title":"Front. Neurol"},{"key":"2016083122413294000_153.1.79.9","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-540-74805-2_4"},{"key":"2016083122413294000_153.1.79.10","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26144"},{"key":"2016083122413294000_153.1.79.11","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.631556"},{"key":"2016083122413294000_153.1.79.12","doi-asserted-by":"crossref","first-page":"5276","DOI":"10.1523\/JNEUROSCI.20-14-05276.2000","article-title":"VMAT-mediated changes in quantal size and vesicular volume","volume":"20","author":"Colliver","year":"2000","journal-title":"J. Neurosci"},{"key":"2016083122413294000_153.1.79.13","doi-asserted-by":"publisher","DOI":"10.3389\/fnana.2011.00059"},{"key":"2016083122413294000_153.1.79.14","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4559-08.2009"},{"key":"2016083122413294000_153.1.79.15","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.22.10993"},{"key":"2016083122413294000_153.1.79.16","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80418-3"},{"key":"2016083122413294000_153.1.79.17","doi-asserted-by":"crossref","first-page":"2424","DOI":"10.1523\/JNEUROSCI.19-07-02424.1999","article-title":"Increased methamphetamine neurotoxicity in heterozygous vesicular monoamine transporter 2 knock-out mice","volume":"19","author":"Fumagalli","year":"1999","journal-title":"J. Neurosci"},{"key":"2016083122413294000_153.1.79.18","doi-asserted-by":"crossref","first-page":"1973","DOI":"10.1046\/j.1471-4159.1998.70051973.x","article-title":"Increased MPTP neurotoxicity in vesicular monoamine transporter 2 heterozygote knockout mice","volume":"70","author":"Gainetdinov","year":"1998","journal-title":"J. Neurochem"},{"key":"2016083122413294000_153.1.79.19","doi-asserted-by":"publisher","DOI":"10.1124\/pr.114.010397"},{"key":"2016083122413294000_153.1.79.20","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddi445"},{"key":"2016083122413294000_153.1.79.21","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s12035-009-8059-y","article-title":"Protective actions of the vesicular monoamine transporter 2 (VMAT2) in monoaminergic neurons","volume":"2","author":"Guillot","year":"2009","journal-title":"Mol. Neurobiol"},{"key":"2016083122413294000_153.1.79.22","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2008.05568.x"},{"key":"2016083122413294000_153.1.79.23","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2012.08.002"},{"key":"2016083122413294000_153.1.79.24","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.5b00277"},{"key":"2016083122413294000_153.1.79.25","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2471"},{"key":"2016083122413294000_153.1.79.26","doi-asserted-by":"publisher","DOI":"10.1021\/cn200119u"},{"key":"2016083122413294000_153.1.79.27","doi-asserted-by":"publisher","DOI":"10.1023\/B:NERE.0000026404.08779.43"},{"key":"2016083122413294000_153.1.79.28","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(92)90425-C"},{"key":"2016083122413294000_153.1.79.29","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.19.9074"},{"key":"2016083122413294000_153.1.79.30","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1402134111"},{"key":"2016083122413294000_153.1.79.31","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.5b00010"},{"key":"2016083122413294000_153.1.79.32","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-483X(00)00374-7"},{"key":"2016083122413294000_153.1.79.33","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2014.10.016"},{"key":"2016083122413294000_153.1.79.34","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2011.05.033"},{"key":"2016083122413294000_153.1.79.35","unstructured":"Miller G. Lohr K. Chen M. Hoffman C. McDaniel M. Stout K. Dunn A. Wang M. (2016). Data from: Vesicular monoamine transporter 2 (VMAT2) level regulates MPTP vulnerability and clearance of excess dopamine in mouse striatal terminals. Dryad Digit. Repos. doi: http:\/\/dx.doi.org\/10.5061\/dryad.d689j."},{"key":"2016083122413294000_153.1.79.36","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.21.16.5321-5331.2001"},{"issue":"1","key":"2016083122413294000_153.1.79.37","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1002\/mds.26103","article-title":"Presynaptic effects of levodopa and their possible role in dyskinesia","volume":"30","author":"Mosharov","year":"2014","journal-title":"Mov. Disord"},{"key":"2016083122413294000_153.1.79.38","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/S0026-895X(25)08549-9","article-title":"Mechanism of the dopamine-releasing actions of amphetamine and cocaine: Plasmalemmal dopamine transporter versus vesicular monoamine transporter","volume":"47","author":"Pifl","year":"1995","journal-title":"Mol. Pharmacol"},{"key":"2016083122413294000_153.1.79.39","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5456-13.2014"},{"key":"2016083122413294000_153.1.79.40","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-4328(01)00419-3"},{"key":"2016083122413294000_153.1.79.41","doi-asserted-by":"crossref","first-page":"7297","DOI":"10.1523\/JNEUROSCI.20-19-07297.2000","article-title":"Synaptic vesicle transporter expression regulates vesicle phenotype and quantal size","volume":"20","author":"Pothos","year":"2000","journal-title":"J. Neurosci"},{"key":"2016083122413294000_153.1.79.42","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1006\/enrs.2001.4264","article-title":"Environmental risk factors and Parkinson\u2019s disease: A metaanalysis","volume":"86","author":"Priyadarshi","year":"2001","journal-title":"Environ. Res"},{"key":"2016083122413294000_153.1.79.43","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2003.12.006"},{"key":"2016083122413294000_153.1.79.44","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1207281"},{"key":"2016083122413294000_153.1.79.45","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1997.6770"},{"key":"2016083122413294000_153.1.79.46","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2202-2-11"},{"key":"2016083122413294000_153.1.79.47","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/S0022-3565(24)39239-0","article-title":"In vitro studies of striatal vesicles containing the vesicular monoamine transporter (VMAT2): Rat versus mouse differences in sequestration of 1-methyl-4-phenylpyridinium","volume":"293","author":"Staal","year":"2000","journal-title":"J. Pharmacol. Exp. Ther"},{"key":"2016083122413294000_153.1.79.48","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.envres.2012.08.014","article-title":"Occupational pesticide exposure and screening tests for neurodegenerative disease among an elderly population in Costa Rica","volume":"120","author":"Steenland","year":"2013","journal-title":"Environ. Res"},{"key":"2016083122413294000_153.1.79.49","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1515\/REVNEURO.2000.11.2-3.159","article-title":"Regulation of quantal size by presynaptic mechanisms","volume":"11","author":"Sulzer","year":"2000","journal-title":"Rev. Neurosci"},{"key":"2016083122413294000_153.1.79.50","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2005.04.003"},{"key":"2016083122413294000_153.1.79.51","doi-asserted-by":"publisher","DOI":"10.1007\/BF03033289"},{"key":"2016083122413294000_153.1.79.52","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.18.9938"},{"key":"2016083122413294000_153.1.79.53","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2013.08.033"},{"key":"2016083122413294000_153.1.79.54","first-page":"124165","article-title":"VMAT2-deficient mice display nigral and extranigral pathology and motor and nonmotor symptoms of Parkinson\u2019s disease","volume":"2011","author":"Taylor","year":"2011","journal-title":"Parkinsons Dis"},{"key":"2016083122413294000_153.1.79.55","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1495-09.2009"},{"key":"2016083122413294000_153.1.79.56","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80419-5"}],"container-title":["Toxicological Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/toxsci\/article-pdf\/153\/1\/79\/11005994\/kfw106.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T21:27:01Z","timestamp":1748986021000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/toxsci\/article-lookup\/doi\/10.1093\/toxsci\/kfw106"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6,10]]},"references-count":56,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2016,8,31]]},"published-print":{"date-parts":[[2016,9]]}},"alternative-id":["10.1093\/toxsci\/kfw106"],"URL":"https:\/\/doi.org\/10.1093\/toxsci\/kfw106","relation":{},"ISSN":["1096-6080","1096-0929"],"issn-type":[{"value":"1096-6080","type":"print"},{"value":"1096-0929","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,10]]}}}